{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:17:49Z","timestamp":1789413469941,"version":"build-2803163510"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010677","name":"H2020 Health","doi-asserted-by":"publisher","award":["825828"],"award-info":[{"award-number":["825828"]}],"id":[{"id":"10.13039\/100010677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010665","name":"EU Framework Programme for Research and Innovation Marie Sk\u0142odowska-Curie Actions","doi-asserted-by":"publisher","award":["860303"],"award-info":[{"award-number":["860303"]}],"id":[{"id":"10.13039\/100010665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ijpx.2025.100324","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T11:40:42Z","timestamp":1740656442000},"page":"100324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice"],"prefix":"10.1016","volume":"9","author":[{"given":"Pol","family":"Escud\u00e9 Martinez de Castilla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariona","family":"Estap\u00e9 Senti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrun","family":"Erkens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wytske M.","family":"van Weerden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sander A.A.","family":"Kooijmans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel H.","family":"Fens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter","family":"Vader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond M.","family":"Schiffelers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2025.100324_bb0005","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/s41568-022-00496-9","article-title":"Cancer nanomedicine","volume":"22","author":"Bhatia","year":"2022","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.ijpx.2025.100324_bb0010","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/j.apsb.2020.10.005","article-title":"Small interfering RNA for cancer treatment: overcoming hurdles in delivery","volume":"10","author":"Charbe","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"key":"10.1016\/j.ijpx.2025.100324_bb0015","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0005-2736(02)00661-2","article-title":"Rate of biodistribution of STEALTH\u00ae liposomes to tumor and skin: influence of liposome diameter and implications for toxicity and therapeutic activity","volume":"1609","author":"Charrois","year":"2003","journal-title":"Biochim. Biophys. Acta Biomembr."},{"key":"10.1016\/j.ijpx.2025.100324_bb0020","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1016\/j.ymthe.2017.03.013","article-title":"Lipid nanoparticle systems for enabling gene therapies","volume":"25","author":"Cullis","year":"2017","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ijpx.2025.100324_bb0025","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1021\/nn901919w","article-title":"Gadolinium chloride augments tumor-specific imaging of targeted quantum dots in Vivo","volume":"4","author":"Diagaradjane","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2025.100324_bb0030","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jconrel.2023.07.054","article-title":"Lipid nanoparticles for siRNA delivery in cancer treatment","volume":"361","author":"El Moukhtari","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2025.100324_bb0035","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.201700375","article-title":"State-of-the-art design and rapid-mixing production techniques of lipid nanoparticles for nucleic acid delivery","volume":"2","author":"Evers","year":"2018","journal-title":"Small Methods"},{"key":"10.1016\/j.ijpx.2025.100324_bb0040","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/j.2042-7158.1956.tb12186.x","article-title":"The anticoagulant activity of dextran sulphate","volume":"8","author":"Forwell","year":"2011","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.ijpx.2025.100324_bb0045","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s11671-021-03628-6","article-title":"Nanoparticles for cancer therapy: current progress and challenges","volume":"16","author":"Gavas","year":"2021","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.ijpx.2025.100324_bb0050","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/IAI.00583-13","article-title":"Liposomal cholesterol delivery activates the macrophage innate immune arm to facilitate intracellular leishmania donovani killing","volume":"82","author":"Ghosh","year":"2014","journal-title":"Infect. Immun."},{"key":"10.1016\/j.ijpx.2025.100324_bb0055","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1021\/ar300048p","article-title":"Lipid-based nanoparticles for siRNA delivery in cancer therapy: paradigms and challenges","volume":"45","author":"Gomes-da-Silva","year":"2012","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.ijpx.2025.100324_bb0060","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.2174\/0929866527666200413100120","article-title":"Liposome Circulation Time is Prolonged by CD47 Coating","volume":"27","author":"Hayat","year":"2020","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.ijpx.2025.100324_bb0065","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1210\/er.2002-0032","article-title":"Androgen receptor in prostate cancer","volume":"25","author":"Heinlein","year":"2004","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.ijpx.2025.100324_bb0070","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41578-021-00358-0","article-title":"Lipid nanoparticles for mRNA delivery","volume":"6","author":"Hou","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.ijpx.2025.100324_bb0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41392-020-0207-x","article-title":"Therapeutic siRNA: state of the art","volume":"5","author":"Hu","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ijpx.2025.100324_bb0080","doi-asserted-by":"crossref","DOI":"10.1002\/smsc.202300084","article-title":"Precision localization of lipid-based nanoparticles by dual-fluorescent labeling for accurate and high-resolution imaging in living cells","volume":"3","author":"Huang","year":"2023","journal-title":"Small Sci."},{"key":"10.1016\/j.ijpx.2025.100324_bb0085","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1172\/JCI104729","article-title":"N. Studies of the reticuloendothelial system (res). I. Measurement of the phagocytic capacity of the res in man and dog*","volume":"42","author":"Iio","year":"1963","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100324_bb0090","doi-asserted-by":"crossref","first-page":"8529","DOI":"10.1002\/anie.201203263","article-title":"Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in\u00a0Vivo**","volume":"51","author":"Jayaraman","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ijpx.2025.100324_bb0095","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1172\/JCI66895","article-title":"Nanoparticle clearance is governed by Th1\/Th2 immunity and strain background","volume":"123","author":"Jones","year":"2013","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100324_bb0100","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0006-291X(75)80433-5","article-title":"The effect of particle size and charge on the clearance rates of liposomes and liposome encapsulated drugs","volume":"63","author":"Juliano","year":"1975","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.ijpx.2025.100324_bb0105","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.nano.2016.12.014","article-title":"Design of lipid nanoparticles for in vitro and in vivo delivery of plasmid DNA","volume":"13","author":"Kulkarni","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijpx.2025.100324_bb0110","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.00416","article-title":"Nanoparticle interactions with the immune system: clinical implications for liposome-based cancer chemotherapy","volume":"8","author":"La-Beck","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpx.2025.100324_bb0115","doi-asserted-by":"crossref","first-page":"16069","DOI":"10.1038\/natrevmats.2016.69","article-title":"Cancer nanomedicine: is targeting our target?","volume":"1","author":"Lammers","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.ijpx.2025.100324_bb0120","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2016.43","article-title":"A Glu-urea-Lys ligand-conjugated lipid nanoparticle\/siRNA system inhibits androgen receptor expression in vivo","volume":"5","author":"Lee","year":"2016","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ijpx.2025.100324_bb0125","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1021\/mp800049w","article-title":"Pharmacokinetics and biodistribution of nanoparticles","volume":"5","author":"Li","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijpx.2025.100324_bb0130","doi-asserted-by":"crossref","DOI":"10.1126\/stke.3272006pe14","article-title":"Detecting cryptic epitopes created by nanoparticles","volume":"2006","author":"Lynch","year":"2006","journal-title":"Sci. STKE"},{"key":"10.1016\/j.ijpx.2025.100324_bb0135","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/s41578-023-00552-2","article-title":"The protein corona from nanomedicine to environmental science","volume":"8","author":"Mahmoudi","year":"2023","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.ijpx.2025.100324_bb0140","first-page":"987","article-title":"Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes","volume":"54","author":"Martin","year":"1994","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpx.2025.100324_bb0145","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/nnano.2012.207","article-title":"Biomolecular coronas provide the biological identity of nanosized materials","volume":"7","author":"Monopoli","year":"2012","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijpx.2025.100324_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2013.66","article-title":"Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles","volume":"2","author":"Mui","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ijpx.2025.100324_bb0155","doi-asserted-by":"crossref","DOI":"10.1038\/mtna.2013.66","article-title":"Influence of polyethylene glycol lipid desorption rates on pharmacokinetics and pharmacodynamics of siRNA lipid nanoparticles","volume":"2","author":"Mui","year":"2013","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.ijpx.2025.100324_bb0160","doi-asserted-by":"crossref","first-page":"22720","DOI":"10.1039\/C8NR07755J","article-title":"Dissociation of fluorescently labeled lipids from liposomes in biological environments challenges the interpretation of uptake studies","volume":"10","author":"M\u00fcnter","year":"2018","journal-title":"Nanoscale"},{"key":"10.1016\/j.ijpx.2025.100324_bb0165","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0169-409X(99)00041-1","article-title":"The size of liposomes: a factor which affects their targeting efficiency to tumors and therapeutic activity of liposomal antitumor drugs","volume":"40","author":"Nagayasu","year":"1999","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpx.2025.100324_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103479","article-title":"The mRNA-LNP platform\u2019s lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory","volume":"24","author":"Ndeupen","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.ijpx.2025.100324_bb0175","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1002\/ijc.27502","article-title":"Effective delivery of chemotherapeutic nanoparticles by depleting host Kupffer cells","volume":"131","author":"Ohara","year":"2012","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.ijpx.2025.100324_bb0180","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/s41563-020-0755-z","article-title":"The dose threshold for nanoparticle tumour delivery","volume":"19","author":"Ouyang","year":"2020","journal-title":"Nat. Mater."},{"key":"10.1016\/j.ijpx.2025.100324_bb0185","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.1073\/pnas.80.21.6518","article-title":"Suppression of liver uptake of liposomes by dextran sulfate 500","volume":"80","author":"Patel","year":"1983","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpx.2025.100324_bb0190","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1021\/acs.nanolett.8b00432","article-title":"A direct comparison of in vitro and in vivo nucleic acid delivery mediated by hundreds of nanoparticles reveals a weak correlation","volume":"18","author":"Paunovska","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.ijpx.2025.100324_bb0195","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1021\/acsptsci.3c00185","article-title":"Looking back, moving forward: lipid nanoparticles as a promising frontier in gene delivery","volume":"6","author":"Pozzi","year":"2023","journal-title":"ACS Pharmacol. Transl. Sci."},{"issue":"220","key":"10.1016\/j.ijpx.2025.100324_bb0200","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1126\/science.6836294","article-title":"Liposomal blockade of the reticuloendothelial system: improved tumor imaging with small unilamellar vesicles","volume":"1979","author":"Proffitt","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.ijpx.2025.100324_bb0205","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jconrel.2022.06.051","article-title":"Lipid nanoparticles to silence androgen receptor variants for prostate cancer therapy","volume":"349","author":"Quick","year":"2022","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2025.100324_bb0210","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.neo.2015.08.004","article-title":"Doxil synergizes with cancer immunotherapies to enhance antitumor responses in syngeneic mouse models","volume":"17","author":"Rios-Doria","year":"2015","journal-title":"Neoplasia"},{"key":"10.1016\/j.ijpx.2025.100324_bb0215","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12195-019-00573-4","article-title":"Cell subtypes within the Liver microenvironment differentially interact with lipid nanoparticles","volume":"12","author":"Sago","year":"2019","journal-title":"Cell. Mol. Bioeng."},{"key":"10.1016\/j.ijpx.2025.100324_bb0220","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.addr.2020.06.002","article-title":"Lipid nanoparticles for nucleic acid delivery: current perspectives","volume":"154\u2013155","author":"Samaridou","year":"2020","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpx.2025.100324_bb0225","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1021\/acs.nanolett.0c00752","article-title":"A nanoprimer to Improve the systemic delivery of siRNA and mRNA","volume":"20","author":"Saunders","year":"2020","journal-title":"Nano Lett."},{"key":"10.1016\/j.ijpx.2025.100324_bb0230","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1369\/0022155411410885","article-title":"Biodistribution of small interfering RNA at the organ and cellular levels after lipid nanoparticle-mediated delivery","volume":"59","author":"Shi","year":"2011","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.ijpx.2025.100324_bb0235","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1080\/1061186X.2016.1191081","article-title":"Coencapsulation of alendronate and doxorubicin in pegylated liposomes: a novel formulation for chemoimmunotherapy of cancer","volume":"24","author":"Shmeeda","year":"2016","journal-title":"J. Drug Target."},{"key":"10.1016\/j.ijpx.2025.100324_bb0240","doi-asserted-by":"crossref","first-page":"319","DOI":"10.7150\/thno.18078","article-title":"Improved tumor uptake by optimizing liposome based RES blockade strategy","volume":"7","author":"Sun","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpx.2025.100324_bb0245","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1021\/acsnano.9b05679","article-title":"Overcoming the reticuloendothelial system barrier to drug delivery with a \u201cDon\u2019t-Eat-Us\u201d strategy","volume":"13","author":"Tang","year":"2019","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2025.100324_bb0250","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1713390114","article-title":"Effect of removing Kupffer cells on nanoparticle tumor delivery","volume":"114","author":"Tavares","year":"2017","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.ijpx.2025.100324_bb0255","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41565-019-0567-y","article-title":"Smart cancer nanomedicine","volume":"14","author":"van der Meel","year":"2019","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijpx.2025.100324_bb0260","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202103025","article-title":"Modular lipid nanoparticle platform technology for siRNA and lipophilic prodrug delivery","volume":"17","author":"van der Meel","year":"2021","journal-title":"Small"},{"key":"10.1016\/j.ijpx.2025.100324_bb0265","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1172\/JCI105029","article-title":"Studies of the reticuloendothelial system (RES). III. Blockade of the RES in man *","volume":"43","author":"Wagner","year":"1964","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100324_bb0270","doi-asserted-by":"crossref","first-page":"5761","DOI":"10.1021\/ja910675v","article-title":"What the cell \u201cSees\u201d in bionanoscience","volume":"132","author":"Walczyk","year":"2010","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijpx.2025.100324_bb0275","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1021\/ja2084338","article-title":"Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake","volume":"134","author":"Walkey","year":"2012","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.ijpx.2025.100324_bb0280","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.biomaterials.2016.07.003","article-title":"Efficient production and enhanced tumor delivery of engineered extracellular vesicles","volume":"105","author":"Watson","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2025.100324_bb0285","doi-asserted-by":"crossref","first-page":"16014","DOI":"10.1038\/natrevmats.2016.14","article-title":"Analysis of nanoparticle delivery to tumours","volume":"1","author":"Wilhelm","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.ijpx.2025.100324_bb0290","doi-asserted-by":"crossref","first-page":"13738","DOI":"10.1038\/s41598-017-14221-2","article-title":"A chloroquine-induced macrophage-preconditioning strategy for improved nanodelivery","volume":"7","author":"Wolfram","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2025.100324_bb0295","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jconrel.2016.01.020","article-title":"Nanoparticle\u2013liver interactions: cellular uptake and hepatobiliary elimination","volume":"240","author":"Zhang","year":"2016","journal-title":"J. Control. Release"}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672500009X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672500009X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T20:45:30Z","timestamp":1762634730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259015672500009X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":59,"alternative-id":["S259015672500009X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2025.100324","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reticuloendothelial system blockade does not enhance siRNA-LNP circulation or tumor accumulation in mice","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2025.100324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100324"}}