{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:57:48Z","timestamp":1790614668126,"version":"4.1.0"},"reference-count":273,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T00:00:00Z","timestamp":1754611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005046","name":"Natural Science Foundation of Heilongjiang Province","doi-asserted-by":"publisher","award":["ZD2016013"],"award-info":[{"award-number":["ZD2016013"]}],"id":[{"id":"10.13039\/501100005046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81671814"],"award-info":[{"award-number":["81671814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008253","name":"Shaoxing University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","award":["2023LHLG007"],"award-info":[{"award-number":["2023LHLG007"]}],"id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijpx.2025.100372","type":"journal-article","created":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T21:54:56Z","timestamp":1754862896000},"page":"100372","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries"],"prefix":"10.1016","volume":"10","author":[{"given":"Mingdong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanbo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialin","family":"Fang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haotian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haisheng","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2025.100372_bb0005","doi-asserted-by":"crossref","first-page":"359","DOI":"10.5435\/00124635-201106000-00006","article-title":"Four common types of bursitis: diagnosis and management","volume":"19","author":"Aaron","year":"2011","journal-title":"Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.ijpx.2025.100372_bb0010","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1007\/s00167-022-07295-7","article-title":"Particulate cartilage and platelet-rich plasma treatment for knee chondral defects in sheep","volume":"31","author":"Alcaide Ruggiero","year":"2023","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"10.1016\/j.ijpx.2025.100372_bb0015","doi-asserted-by":"crossref","first-page":"S19","DOI":"10.1016\/S0140-6736(15)60334-8","article-title":"Effect of platelet-rich plasma on healing tissues in acute ruptured Achilles tendon: a human immunohistochemistry study","volume":"385","author":"Alsousou","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2025.100372_bb0020","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1159\/000477353","article-title":"A review of platelet-rich plasma: history, biology, mechanism of action, and classification","volume":"4","author":"Alves","year":"2017","journal-title":"Skin Appendage Disord."},{"key":"10.1016\/j.ijpx.2025.100372_bb0025","article-title":"Photobiomodulation (\u03bb=808nm) and platelet-rich plasma (PRP) for the treatment of acute rheumatoid arthritis in wistar rats","volume":"12","author":"Amanda Bezerra","year":"2021","journal-title":"J. Lasers Med. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0030","first-page":"116","article-title":"Prospective aspects of regeneration in orthopaedics: a review","volume":"32","author":"Amit","year":"2020","journal-title":"J. Pharm. Res. Int."},{"key":"10.1016\/j.ijpx.2025.100372_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11914-020-00643-x","article-title":"The use of platelet-rich plasma (PRP) for the management of non-union fractures","volume":"19","author":"Andersen","year":"2021","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.ijpx.2025.100372_bb0040","doi-asserted-by":"crossref","first-page":"717","DOI":"10.2217\/rme-2018-0042","article-title":"A contemporary view of platelet-rich plasma therapies: moving toward refined clinical protocols and precise indications","volume":"13","author":"Andia","year":"2018","journal-title":"Regen. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0045","doi-asserted-by":"crossref","first-page":"13043","DOI":"10.3390\/ijms241713043","article-title":"Advances in platelet rich plasma-derived extracellular vesicles for regenerative medicine: a systematic-narrative review","volume":"24","author":"Anitua","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0050","doi-asserted-by":"crossref","first-page":"341","DOI":"10.15562\/ism.v13i1.1232","article-title":"Platelet-rich plasma (PRP) on orthopedic clinical daily practice: a literature review","volume":"13","author":"Anthony","year":"2022","journal-title":"Intisari Sains Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0055","doi-asserted-by":"crossref","first-page":"8580","DOI":"10.3390\/ijms22168580","article-title":"Platelet-derived extracellular vesicles for regenerative medicine","volume":"22","author":"Antich Rossell\u00f3","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0060","doi-asserted-by":"crossref","first-page":"2004","DOI":"10.1177\/0363546520924011","article-title":"Intra-articular injection of pure platelet-rich plasma is the most effective treatment for joint pain by modulating synovial inflammation and calcitonin gene-related peptide expression in a rat arthritis model","volume":"48","author":"Araya","year":"2020","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0065","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1042\/CS20140623","article-title":"Dynamic microvesicle release and clearance within the cardiovascular system: triggers and mechanisms","volume":"129","author":"Ayers","year":"2015","journal-title":"Clin. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0070","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.bjoms.2012.05.014","article-title":"Effect of different doses of transforming growth factor-\u03b2\u2081 on cartilage and subchondral bone in osteoarthritic temporomandibular joints","volume":"51","author":"B","year":"2013","journal-title":"Br. J. Oral Maxillofac. Surg."},{"key":"10.1016\/j.ijpx.2025.100372_bb0075","doi-asserted-by":"crossref","first-page":"300","DOI":"10.4103\/0970-9290.186231","article-title":"Antimicrobial effect of platelet-rich plasma and platelet-rich fibrin","volume":"27","author":"Badade","year":"2016","journal-title":"Indian J. Dent. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21249716","article-title":"PLGA-PEG nanoparticles show minimal risks of interference with platelet function of human platelet-rich plasma","volume":"21","author":"Bakhaidar","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0085","doi-asserted-by":"crossref","unstructured":"Bakker A.C. van de Loo F.A. van Beuningen H.M. Sime P. van Lent P.L. van der Kraan P.M. Richards C.D. van den Berg W.B. 2001 Overexpression of active TGF-beta-1 in the murine knee joint: evidence for synovial-layer-dependent chondro-osteophyte formation Osteoarthr. Cartil. 9 128 136.","DOI":"10.1053\/joca.2000.0368"},{"key":"10.1016\/j.ijpx.2025.100372_bb0090","doi-asserted-by":"crossref","first-page":"18612","DOI":"10.1038\/s41598-021-98365-2","article-title":"Author Correction: Platelet-rich plasma (PRP) in osteoarthritis (OA) knee: Correct dose critical for long term clinical efficacy","volume":"11","author":"Bansal","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2025.100372_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/9933283","article-title":"Niosome as an effective nanoscale solution for the treatment of microbial infections","volume":"2023","author":"Barani","year":"2023","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijpx.2025.100372_bb0100","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1038\/s41467-021-23232-7","article-title":"Polymer-free corticosteroid dimer implants for controlled and sustained drug delivery","volume":"12","author":"Battiston","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2025.100372_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2018.00644","article-title":"Computer simulation of TSP1 inhibition of VEGF-Akt-eNOS: an angiogenesis triple threat","volume":"9","author":"Bazzazi","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0110","first-page":"205","article-title":"Knee osteoarthritis prevalence, risk factors, pathogenesis and features: part I","volume":"2","author":"Behzad","year":"2011","journal-title":"PubMed"},{"key":"10.1016\/j.ijpx.2025.100372_bb0115","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0363546520909397","article-title":"Platelet-rich plasma versus hyaluronic acid for knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials","volume":"49","author":"Belk","year":"2021","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1002\/jcp.22274","article-title":"Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: mechanisms of NF-\u03baB inhibition via HGF","volume":"225","author":"Bendinelli","year":"2010","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0125","first-page":"29","article-title":"Advances with platelet-rich plasma for bone healing","volume":"2024","author":"Blake","year":"2024","journal-title":"Biologics"},{"key":"10.1016\/j.ijpx.2025.100372_bb0130","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/art.21795","article-title":"Connective tissue growth factor\/CCN2 overexpression in mouse synovial lining results in transient fibrosis and cartilage damage","volume":"54","author":"Blaney Davidson","year":"2006","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb0135","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ejp.1846","article-title":"Platelet-rich plasma and cytokines in neuropathic pain: a narrative review and a clinical perspective","volume":"26","author":"Bohren","year":"2022","journal-title":"Eur. J. Pain"},{"key":"10.1016\/j.ijpx.2025.100372_bb0140","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/s41551-020-0565-2","article-title":"High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays","volume":"4","author":"Brandenberg","year":"2020","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijpx.2025.100372_bb0145","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1177\/0363546517746112","article-title":"Concentrations of blood components in commercial platelet-rich plasma separation systems: a review of the literature","volume":"47","author":"BW","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0150","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1093\/gerona\/glac118","article-title":"Anti-inflammatory and chondroprotective effects of platelet-derived growth factor-BB on osteoarthritis rat models","volume":"78","author":"Cai","year":"2023","journal-title":"J. Gerontol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0155","article-title":"Temporomandibular joint osteoarthritis: pathogenic mechanisms involving the cartilage and subchondral bone, and potential therapeutic strategies for joint regeneration","volume":"24","author":"Cardoneanu","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0160","doi-asserted-by":"crossref","first-page":"6591717","DOI":"10.1155\/2016\/6591717","article-title":"Platelet-rich plasma: the choice of activation method affects the release of bioactive molecules","volume":"2016","author":"Cavallo","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.ijpx.2025.100372_bb0165","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.cytogfr.2021.11.003","article-title":"Applications of the regenerative capacity of platelets in modern medicine","volume":"64","author":"Cecerska Hery\u0107","year":"2022","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0170","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/01.ASW.0000396302.05959.d3","article-title":"Use of platelet-rich plasma and hyaluronic acid in the loss of substance with bone exposure","volume":"24","author":"Cervelli","year":"2011","journal-title":"Adv. Skin Wound Care"},{"key":"10.1016\/j.ijpx.2025.100372_bb0175","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.2106\/JBJS.16.01374","article-title":"A call for standardization in platelet-rich plasma preparation protocols and composition reporting: a systematic review of the clinical orthopaedic literature","volume":"99","author":"Chahla","year":"2017","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.ijpx.2025.100372_bb0180","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1023\/A:1025034925152","article-title":"Polymeric growth factor delivery strategies for tissue engineering","volume":"20","author":"Chen","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119477","article-title":"Nanocomposites drug delivery systems for the healing of bone fractures","volume":"585","author":"Chen","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2025.100372_bb0190","doi-asserted-by":"crossref","first-page":"5312","DOI":"10.1073\/pnas.79.17.5312","article-title":"Serum contains a platelet-derived transforming growth factor","volume":"79","author":"Childs","year":"1982","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpx.2025.100372_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/polym12081712","article-title":"Micro-clotting of platelet-rich plasma upon loading in hydrogel microspheres leads to prolonged protein release and slower microsphere degradation","volume":"12","author":"Choi","year":"2020","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ijpx.2025.100372_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105771","article-title":"Therapeutic effect of platelet-rich plasma improves bladder overactivity in the pathogenesis of ketamine-induced ulcerative cystitis in a rat model","volume":"23","author":"Chueh","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0205","article-title":"Platelet-derived extracellular vesicles ameliorate intervertebral disc degeneration by alleviating mitochondrial dysfunction","volume":"18","author":"Dai","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ijpx.2025.100372_bb0210","doi-asserted-by":"crossref","first-page":"232","DOI":"10.2174\/1573397116666201113090629","article-title":"Evaluating the efficacy of intra-articular injections of platelet rich plasma (PRP) in rheumatoid arthritis patients and its impact on inflammatory cytokines, disease activity and quality of life","volume":"17","author":"Dalia","year":"2021","journal-title":"Curr. Rheumatol. Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8059622","article-title":"Leukocyte-rich platelet-rich plasma as an effective source of molecules that modulate local immune and inflammatory cell responses","volume":"2022","author":"Dejnek","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0220","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.arthro.2012.04.148","article-title":"Platelet-rich plasma: the PAW classification system","volume":"28","author":"DeLong","year":"2012","journal-title":"Arthroscopy"},{"key":"10.1016\/j.ijpx.2025.100372_bb0225","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1007\/s00590-023-03570-6","article-title":"Platelet-rich plasma in chronic Achilles tendinopathy","volume":"33","author":"Desouza","year":"2023","journal-title":"Eur. J. Orthop. Surg. Traumatol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0230","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1177\/0363546518814532","article-title":"Platelet-rich plasma versus hyaluronic acid injections for the treatment of knee osteoarthritis: results at 5 years of a double-blind, randomized controlled trial","volume":"47","author":"Di Martino","year":"2019","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0235","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.tibtech.2008.11.009","article-title":"Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF)","volume":"27","author":"Dohan Ehrenfest","year":"2009","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0240","doi-asserted-by":"crossref","first-page":"3","DOI":"10.32098\/mltj.01.2014.02","article-title":"Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives","volume":"4","author":"Dohan Ehrenfest","year":"2014","journal-title":"Muscles Ligaments Tendons J."},{"key":"10.1016\/j.ijpx.2025.100372_bb0245","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1248\/bpb.b22-00206","article-title":"Berberine encapsulated in exosomes derived from platelet-rich plasma promotes chondrogenic differentiation of the bone marrow mesenchymal stem cells via the Wnt\/\u03b2-catenin pathway","volume":"45","author":"Dong","year":"2022","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.ijpx.2025.100372_bb0250","doi-asserted-by":"crossref","DOI":"10.1177\/20417314231172584","article-title":"Osteoarthritis models: from animals to tissue engineering","volume":"14","author":"Dou","year":"2023","journal-title":"J. Tissue Eng."},{"key":"10.1016\/j.ijpx.2025.100372_bb0255","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s12891-021-04910-5","article-title":"Bone marrow aspirate concentrate versus platelet-rich plasma for treating knee osteoarthritis: a one-year non-randomized retrospective comparative study","volume":"23","author":"El-Kadiry","year":"2022","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.ijpx.2025.100372_bb0260","doi-asserted-by":"crossref","first-page":"eabi5918","DOI":"10.1126\/sciadv.abi5918","article-title":"Biological resurfacing in a canine model of hip osteoarthritis","volume":"7","author":"Estes","year":"2021","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ijpx.2025.100372_bb0265","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.3390\/ijms21207794","article-title":"Platelet-rich plasma: new performance understandings and therapeutic considerations in 2020","volume":"21","author":"Everts","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0270","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1089\/ten.teb.2019.0292","article-title":"Platelet-rich plasma therapy in the treatment of diseases associated with orthopedic injuries","volume":"26","author":"Fang","year":"2020","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0275","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1902\/jop.2016.150487","article-title":"Combination of controlled release platelet-rich plasma alginate beads and bone morphogenetic protein-2 genetically modified mesenchymal stem cells for bone regeneration","volume":"87","author":"Fernandes","year":"2016","journal-title":"J. Periodontol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0280","doi-asserted-by":"crossref","DOI":"10.3390\/ma17020319","article-title":"Polymersomes as the next attractive generation of drug delivery systems: definition, synthesis and applications","volume":"17","author":"Fonseca","year":"2024","journal-title":"Materials"},{"key":"10.1016\/j.ijpx.2025.100372_bb0285","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1177\/0363546516648644","article-title":"BioCartilage improves cartilage repair compared with microfracture alone in an equine model of full-thickness cartilage loss","volume":"44","author":"Fortier","year":"2016","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0290","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1038\/s41551-021-00810-0","article-title":"Enhanced tendon healing by a tough hydrogel with an adhesive side and high drug-loading capacity","volume":"6","author":"Freedman","year":"2022","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijpx.2025.100372_bb0295","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s40520-020-01515-1","article-title":"Alternative and complementary therapies in osteoarthritis and cartilage repair","volume":"32","author":"Fuggle","year":"2020","journal-title":"Aging Clin. Exp. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0300","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1002\/jbm.a.36720","article-title":"Fabrication and properties of an injectable sodium alginate\/PRP composite hydrogel as a potential cell carrier for cartilage repair","volume":"107","author":"Gao","year":"2019","journal-title":"J. Biomed. Mater. Res. A"},{"key":"10.1016\/j.ijpx.2025.100372_bb0305","doi-asserted-by":"crossref","first-page":"e381","DOI":"10.3928\/01477447-20230426-02","article-title":"Arthroscopic excision of pigmented villonodular synovitis of the trochanteric bursa","volume":"46","author":"Garrasi","year":"2023","journal-title":"Orthopedics"},{"key":"10.1016\/j.ijpx.2025.100372_bb0310","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19051314","article-title":"Novel ex vivo human osteochondral explant model of knee and spine osteoarthritis enables assessment of inflammatory and drug treatment responses","volume":"19","author":"Geurts","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0315","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/path.842","article-title":"The angiogenic pathway \u201cvascular endothelial growth factor\/flk-1(KDR)-receptor\u201d in rheumatoid arthritis and osteoarthritis","volume":"194","author":"Giatromanolaki","year":"2001","journal-title":"J. Pathol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0320","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1046\/j.1537-2995.1990.30891020337.x","article-title":"Fibrin glue: the perfect operative sealant?","volume":"30","author":"Gibble","year":"1990","journal-title":"Transfusion"},{"key":"10.1016\/j.ijpx.2025.100372_bb0325","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.895022","article-title":"A platelet-rich plasma-derived biologic clears staphylococcus aureus biofilms while mitigating cartilage degeneration and joint inflammation in a clinically relevant large animal infectious arthritis model","volume":"12","author":"Gilbertie","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0330","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2478\/v10039-009-0035-2","article-title":"Role of adipokines in complications related to obesity: a review","volume":"54","author":"Gnaci\u0144ska","year":"2009","journal-title":"Adv. Med. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0335","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.oto.2012.01.002","article-title":"Platelet-rich plasma preparations for biological therapy: applications and limits","volume":"22","author":"Gobbi","year":"2012","journal-title":"Oper. Tech. Orthop."},{"key":"10.1016\/j.ijpx.2025.100372_bb0340","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.injury.2008.06.025","article-title":"The clinical use of platelet-rich plasma in the promotion of bone healing: a systematic review","volume":"40","author":"Griffin","year":"2009","journal-title":"Injury"},{"key":"10.1016\/j.ijpx.2025.100372_bb0345","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.fas.2014.11.005","article-title":"Long-term beneficial effects of platelet-rich plasma for non-insertional Achilles tendinopathy","volume":"21","author":"Guelfi","year":"2015","journal-title":"Foot Ankle Surg."},{"key":"10.1016\/j.ijpx.2025.100372_bb0350","doi-asserted-by":"crossref","first-page":"81","DOI":"10.7150\/thno.16803","article-title":"Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model","volume":"7","author":"Guo","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpx.2025.100372_bb0355","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1080\/17474086.2021.1860002","article-title":"Evidence-based indications of platelet-rich plasma therapy","volume":"14","author":"Gupta","year":"2021","journal-title":"Expert Rev. Hematol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0360","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10092134","article-title":"Common medications which should be stopped prior to platelet-rich plasma injection","volume":"10","author":"Gupta","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ijpx.2025.100372_bb0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.injury.2023.111212","article-title":"Platelet-rich plasma-derived exosomes promote rotator cuff tendon-bone healing","volume":"55","author":"Han","year":"2024","journal-title":"Injury"},{"key":"10.1016\/j.ijpx.2025.100372_bb0370","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/jth.14223","article-title":"The use of platelets in regenerative medicine and proposal for a new classification system: guidance from the SSC of the ISTH","volume":"16","author":"Harrison","year":"2018","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.ijpx.2025.100372_bb0375","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1177\/0363546511401576","article-title":"Platelet activation by collagen provides sustained release of anabolic cytokines","volume":"39","author":"Harrison","year":"2011","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0380","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/S0140-6736(18)32208-6","article-title":"T-cell large granular lymphocytic leukaemia in the context of rheumatoid arthritis","volume":"392","author":"Hasanov","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2025.100372_bb0385","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13075-023-03200-w","article-title":"Regenerative effects of platelet-rich plasma releasate injection in rabbit discs degenerated by intradiscal injection of condoliase","volume":"25","author":"Hasegawa","year":"2023","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ijpx.2025.100372_bb0390","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1002\/art.11094","article-title":"Inflammation and angiogenesis in osteoarthritis","volume":"48","author":"Haywood","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb0395","doi-asserted-by":"crossref","first-page":"237","DOI":"10.7150\/thno.21945","article-title":"Exosome theranostics: biology and translational medicine","volume":"8","author":"He","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpx.2025.100372_bb0400","doi-asserted-by":"crossref","first-page":"1543604","DOI":"10.1155\/2022\/1543604","article-title":"Role of platelet-rich plasma gel in promoting wound healing based on medical images of wounds","volume":"2022","author":"He","year":"2022","journal-title":"Contrast Media Mol. Imaging"},{"key":"10.1016\/j.ijpx.2025.100372_bb0405","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1038\/s41578-021-00279-y","article-title":"Engineering organoids","volume":"6","author":"Hofer","year":"2021","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.ijpx.2025.100372_bb0410","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jor.20453","article-title":"Accelerated fracture healing in the geriatric, osteoporotic rat with recombinant human platelet-derived growth factor-bb and an injectable beta-tricalcium phosphate\/collagen matrix","volume":"26","author":"Hollinger","year":"2008","journal-title":"J. Orthop. Res."},{"issue":"175","key":"10.1016\/j.ijpx.2025.100372_bb0415","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1166\/mex.2022.2130","article-title":"New polymer nano-biomaterials in rehabilitation nursing of orthopedic surgery injuries","volume":"12","author":"Hou","year":"2022","journal-title":"Mater. Express"},{"key":"10.1016\/j.ijpx.2025.100372_bb0420","doi-asserted-by":"crossref","first-page":"2287705","DOI":"10.1080\/07853890.2023.2287705","article-title":"The value of platelet-rich plasma-derived extracellular vesicles in modern medicine","volume":"55","author":"Hou","year":"2023","journal-title":"Ann. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0425","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1177\/0363546516637176","article-title":"Platelet-rich plasma activates proinflammatory signaling pathways and induces oxidative stress in tendon fibroblasts","volume":"44","author":"Hudgens","year":"2016","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0430","doi-asserted-by":"crossref","first-page":"11110","DOI":"10.1074\/jbc.M609040200","article-title":"Basic fibroblast growth factor stimulates matrix metalloproteinase-13 via the molecular cross-talk between the mitogen-activated protein kinases and protein kinase Cdelta pathways in human adult articular chondrocytes","volume":"282","author":"Im","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpx.2025.100372_bb0435","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22052619","article-title":"Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee","volume":"22","author":"Jang","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0440","doi-asserted-by":"crossref","first-page":"863","DOI":"10.2106\/00004623-199306000-00007","article-title":"Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization","volume":"75","author":"Jiranek","year":"1993","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.ijpx.2025.100372_bb0445","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s12178-018-9514-z","article-title":"The economics and regulation of PRP in the evolving field of orthopedic biologics","volume":"11","author":"Jones","year":"2018","journal-title":"Curr. Rev. Musculoskelet. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0450","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3109\/17435390.2010.506250","article-title":"Silver nanoparticles enhance thrombus formation through increased platelet aggregation and procoagulant activity","volume":"5","author":"Jun","year":"2011","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.ijpx.2025.100372_bb0455","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.ijpx.2025.100372_bb0460","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1002\/1529-0131(200201)46:1<130::AID-ART10020>3.0.CO;2-D","article-title":"Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4","volume":"46","author":"Kanbe","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb0465","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.ijbiomac.2020.04.129","article-title":"In-vitro and in-vivo evaluation of polymeric microsphere formulation for colon targeted delivery of 5-fluorouracil using biocompatible natural gum katira","volume":"158","author":"Karan","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0470","doi-asserted-by":"crossref","first-page":"7677","DOI":"10.3390\/ijms24087677","article-title":"Advances in platelet-rich plasma treatment for spinal diseases: a systematic review","volume":"24","author":"Kawabata","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0475","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/jama.2021.6986","article-title":"Effect of platelet-rich plasma injection vs sham injection on tendon dysfunction in patients with chronic midportion Achilles tendinopathy: a randomized clinical trial","volume":"326","author":"Kearney","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.ijpx.2025.100372_bb0480","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1051\/ject\/200436128","article-title":"Comparison of methods for point of care preparation of autologous platelet gel","volume":"36","author":"Kevy","year":"2004","journal-title":"J Extra Corpor Technol"},{"key":"10.1016\/j.ijpx.2025.100372_bb0485","doi-asserted-by":"crossref","DOI":"10.1089\/ten.teb.2024.0285","article-title":"Application of platelet-rich plasma-based scaffolds in soft and hard tissue regeneration","author":"Khandan-Nasab","year":"2025","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119269","article-title":"Axial pharmaceutical properties of liposome in cancer therapy: recent advances and perspectives","volume":"581","author":"Kiaie","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2025.100372_bb0495","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1056\/NEJMra0912273","article-title":"Nanomedicine","volume":"363","author":"Kim","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0500","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.actbio.2022.03.033","article-title":"Long-term anti-inflammatory effects of injectable celecoxib nanoparticle hydrogels for Achilles tendon regeneration","volume":"144","author":"Kim","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpx.2025.100372_bb0505","doi-asserted-by":"crossref","first-page":"5118","DOI":"10.1016\/j.biomaterials.2006.05.031","article-title":"Repair of segmental bone defects in rabbit tibiae using a complex of \u03b2-tricalcium phosphate, type I collagen, and fibroblast growth factor-2","volume":"27","author":"Komaki","year":"2006","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2025.100372_bb0510","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1471-2474-11-220","article-title":"Platelet autologous growth factors decrease the osteochondral regeneration capability of a collagen-hydroxyapatite scaffold in a sheep model","volume":"11","author":"Kon","year":"2010","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.ijpx.2025.100372_bb0515","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.actbio.2021.10.049","article-title":"Comparative tribology II-Measurable biphasic tissue properties have predictable impacts on cartilage rehydration and lubricity","volume":"138","author":"Kupratis","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpx.2025.100372_bb0520","first-page":"415","article-title":"Gonarthrosis\u2013pathomechanism and diagnosis","volume":"17","author":"Kwiatkowski","year":"2004","journal-title":"Pol. Merkur. Lekarski"},{"key":"10.1016\/j.ijpx.2025.100372_bb0525","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1097\/CORR.0000000000001312","article-title":"CORR synthesis: what is the role of platelet-rich plasma injection in the treatment of tendon disorders?","volume":"478","author":"LaBelle","year":"2020","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0530","doi-asserted-by":"crossref","first-page":"2103222","DOI":"10.1002\/advs.202103222","article-title":"Exosome processing and characterization approaches for research and technology development","volume":"9","author":"Lai","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0535","doi-asserted-by":"crossref","first-page":"565","DOI":"10.2217\/rme-2017-0042","article-title":"Contributions for classification of platelet rich plasma - proposal of a new classification: MARSPILL","volume":"12","author":"Lana","year":"2017","journal-title":"Regen. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0540","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/j.otsm.2016.12.002","article-title":"Platelet-rich plasma: formulations, preparations, constituents, and their effects","volume":"25","author":"Lansdown","year":"2017","journal-title":"Operat. Tech. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0545","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.1172\/JCI43230","article-title":"CTGF directs fibroblast differentiation from human mesenchymal stem\/stromal cells and defines connective tissue healing in a rodent injury model","volume":"120","author":"Lee","year":"2010","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100372_bb0550","article-title":"Emerging potential of exosomes in regenerative medicine for temporomandibular joint osteoarthritis","volume":"21","author":"Lee","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0555","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1039\/D1BM01873F","article-title":"VEGF-attenuated platelet-rich plasma improves therapeutic effect on cartilage repair","volume":"10","author":"Lee","year":"2022","journal-title":"Biomater. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0560","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1002\/hep.28735","article-title":"Extracellular vesicles carry microRNA-195 to intrahepatic cholangiocarcinoma and improve survival in a rat model","volume":"65","author":"Li","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.ijpx.2025.100372_bb0565","doi-asserted-by":"crossref","first-page":"2100362","DOI":"10.1002\/marc.202100362","article-title":"Hydrogel Composites with Different Dimensional Nanoparticles for Bone Regeneration","volume":"42","author":"Li","year":"2021","journal-title":"Macromol. Rapid Commun."},{"key":"10.1016\/j.ijpx.2025.100372_bb0570","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.jos.2021.01.006","article-title":"The application of platelet-rich plasma in the treatment of knee osteoarthritis: a literature review","volume":"27","author":"Li","year":"2022","journal-title":"J. Orthop. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0575","article-title":"3D-printed hydrogel particles containing PRP laden with TDSCs promote tendon repair in a rat model of tendinopathy","volume":"21","author":"Li","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0580","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1039\/D3MH01641B","article-title":"Fabrication of polymeric microspheres for biomedical applications","volume":"11","author":"Li","year":"2024","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.ijpx.2025.100372_bb0585","doi-asserted-by":"crossref","DOI":"10.1177\/19476035221118419","article-title":"Platelet rich plasma in the repair of articular cartilage injury: a narrative review","volume":"13","author":"Liang","year":"2022","journal-title":"Cartilage"},{"key":"10.1016\/j.ijpx.2025.100372_bb0590","article-title":"Update on the pathomechanism, diagnosis, and treatment options for rheumatoid arthritis","volume":"9","author":"Lin","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.ijpx.2025.100372_bb0595","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2021.707584","article-title":"Platelet-rich plasma as a potential new strategy in the endometrium treatment in assisted reproductive technology","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0600","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1250533","article-title":"Growth factors in the treatment of Achilles tendon injury","volume":"11","author":"Lin","year":"2023","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0605","first-page":"236","article-title":"The use of hydrogel microspheres as cell and drug delivery carriers for bone, cartilage, and soft tissue regeneration","volume":"5","author":"Lin","year":"2024","journal-title":"Biomater. Transl."},{"key":"10.1016\/j.ijpx.2025.100372_bb0610","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2337\/dc08-0763","article-title":"Increased matrix metalloproteinase-9 predicts poor wound healing in diabetic foot ulcers","volume":"32","author":"Liu","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.ijpx.2025.100372_bb0615","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.actbio.2017.05.023","article-title":"An in situ photocrosslinkable platelet rich plasma \u2013 Complexed hydrogel glue with growth factor controlled release ability to promote cartilage defect repair","volume":"62","author":"Liu","year":"2017","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpx.2025.100372_bb0620","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s13018-019-1529-7","article-title":"Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt\/\u03b2-catenin signaling pathway","volume":"14","author":"Liu","year":"2019","journal-title":"J. Orthop. Surg. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0625","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144963","article-title":"Keratinocyte-derived microvesicle particles mediate ultraviolet B radiation\u2013induced systemic immunosuppression","volume":"131","author":"Liu","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100372_bb0630","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.joca.2015.04.019","article-title":"Heparin-binding epidermal growth factor-like growth factor (HB-EGF) is increased in osteoarthritis and regulates chondrocyte catabolic and anabolic activities","volume":"23","author":"Long","year":"2015","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijpx.2025.100372_bb0635","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/JSA.0000000000000185","article-title":"Achilles Tendinopathy","volume":"26","author":"Longo","year":"2018","journal-title":"Sports Med. Arthrosc. Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0640","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.3390\/ijms20051075","article-title":"Assessment of the efficacy of platelet-rich plasma in the treatment of traumatic canine fractures","volume":"20","author":"L\u00f3pez","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0645","doi-asserted-by":"crossref","first-page":"507","DOI":"10.2147\/TCRM.S288196","article-title":"Non-surgical treatment of knee osteoarthritis: multidisciplinary Italian consensus on best practice","volume":"17","author":"Lorenzo","year":"2021","journal-title":"Ther. Clin. Risk Manag."},{"key":"10.1016\/j.ijpx.2025.100372_bb0650","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1002\/art.34533","article-title":"Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice","volume":"64","author":"Louer","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb0655","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2020.563203","article-title":"Peptide-enriched silk fibroin sponge and trabecular titanium composites to enhance bone ingrowth of prosthetic implants in an ovine model of bone gaps","volume":"8","author":"Lovati","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0660","first-page":"9658","article-title":"Platelet rich plasma-derived microvesicles increased in vitro wound healing","volume":"24","author":"Lovisolo","year":"2020","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0665","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1563\/1548-1336(2001)027<0038:PPAISG>2.3.CO;2","article-title":"Platelet-rich plasma application in sinus graft surgery: Part I\u2013background and processing techniques","volume":"27","author":"Lozada","year":"2001","journal-title":"J. Oral Implantol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0670","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1016\/j.ajpath.2011.02.039","article-title":"Blockade of TSP1-dependent TGF-\u03b2 activity reduces renal injury and proteinuria in a murine model of diabetic nephropathy","volume":"178","author":"Lu","year":"2011","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0675","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.3389\/fphar.2019.01554","article-title":"AMD3100 attenuates post-traumatic osteoarthritis by maintaining transforming growth factor-\u03b21-induced expression of tissue inhibitor of metalloproteinase-3 via the phosphatidylinositol 3-kinase\/Akt pathway","volume":"10","author":"Lu","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0680","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1007\/s00264-014-2406-y","article-title":"Angiogenic cytokine expression profiles in plasma and synovial fluid of primary knee osteoarthritis","volume":"38","author":"Mabey","year":"2014","journal-title":"Int. Orthop."},{"key":"10.1016\/j.ijpx.2025.100372_bb0685","doi-asserted-by":"crossref","DOI":"10.1136\/bmjsem-2015-000060","article-title":"DEPA classification: a proposal for standardising PRP use and a retrospective application of available devices","volume":"2","author":"Magalon","year":"2016","journal-title":"BMJ Open Sport Exerc. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0690","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1089\/ten.tec.2020.0309","article-title":"Current models for development of disease-modifying osteoarthritis drugs","volume":"27","author":"Makarczyk","year":"2021","journal-title":"Tissue Eng. Part C Methods"},{"issue":"40","key":"10.1016\/j.ijpx.2025.100372_bb0695","article-title":"Platelet-rich plasma in dermatology: new insights on the cellular mechanism of skin repair and regeneration","volume":"14","author":"Manole","year":"2024","journal-title":"Life"},{"key":"10.1016\/j.ijpx.2025.100372_bb0700","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1148\/rg.220051","article-title":"Interpretation of cartilage damage at routine clinical MRI: how to match arthroscopic findings","volume":"42","author":"Markhardt","year":"2022","journal-title":"RadioGraphics"},{"key":"10.1016\/j.ijpx.2025.100372_bb0705","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2015.00290","article-title":"The influence of platelet-derived products on angiogenesis and tissue repair: a concise update","volume":"6","author":"Mart\u00ednez","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0710","doi-asserted-by":"crossref","first-page":"937","DOI":"10.3390\/ijms25020937","article-title":"Mesenchymal stem cells cultured in a 3D microgel environment containing platelet-rich plasma significantly modify their chondrogenesis-related miRNA expression","volume":"25","author":"Mata","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0715","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.pmrj.2015.02.005","article-title":"A call for a standard classification system for future biologic research: the rationale for new PRP nomenclature","volume":"7","author":"Mautner","year":"2015","journal-title":"PM R"},{"key":"10.1016\/j.ijpx.2025.100372_bb0720","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41584-019-0202-1","article-title":"Spontaneous dog osteoarthritis - a one medicine vision","volume":"15","author":"Meeson","year":"2019","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0725","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0002-9440(10)65266-2","article-title":"Tumor necrosis factor-alpha mediates orthopedic implant osteolysis","volume":"154","author":"Merkel","year":"1999","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0730","first-page":"150","article-title":"Evaluation of the effects of platelet-rich plasma (PRP) therapy involved in the healing of sports-related soft tissue injuries","volume":"32","author":"Middleton","year":"2012","journal-title":"Iowa Orthop. J."},{"key":"10.1016\/j.ijpx.2025.100372_bb0735","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.2174\/138920112800624283","article-title":"Sports medicine applications of platelet rich plasma","volume":"13","author":"Mishra","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0740","doi-asserted-by":"crossref","first-page":"516","DOI":"10.5603\/FM.a2019.0104","article-title":"Comparative study of osteoarthritis induced by monoiodoacetate and papain in rabbit temporomandibular joints: macroscopic and microscopic analysis","volume":"79","author":"Molinet","year":"2020","journal-title":"Folia Morphol. (Warsz)"},{"key":"10.1016\/j.ijpx.2025.100372_bb0745","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1164\/rccm.201410-1765OC","article-title":"Therapeutic effects of human mesenchymal stem cell-derived microvesicles in severe pneumonia in mice","volume":"192","author":"Monsel","year":"2015","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0750","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3113\/FAI.2012.0379","article-title":"Platelet rich plasma treatment for chronic Achilles tendinosis","volume":"33","author":"Monto","year":"2012","journal-title":"Foot Ankle Int."},{"key":"10.1016\/j.ijpx.2025.100372_bb0755","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1007\/s43032-021-00579-2","article-title":"Use of Intra-uterine Injection of Platelet-rich Plasma (PRP) for endometrial receptivity and thickness: a literature review of the mechanisms of action","volume":"28","author":"Mouanness","year":"2021","journal-title":"Reprod. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0760","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1160\/TH14-11-0999","article-title":"A review of platelet secretion assays for the diagnosis of inherited platelet secretion disorders","volume":"114","author":"Mumford","year":"2015","journal-title":"Thromb. Haemost."},{"key":"10.1016\/j.ijpx.2025.100372_bb0765","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.1074\/jbc.275.5.3687","article-title":"Potent inhibition of the master chondrogenic factor Sox9 gene by interleukin-1 and tumor necrosis factor-alpha","volume":"275","author":"Murakami","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpx.2025.100372_bb0770","doi-asserted-by":"crossref","first-page":"3355","DOI":"10.1172\/JCI35298","article-title":"The FGF system has a key role in regulating vascular integrity","volume":"118","author":"Murakami","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100372_bb0775","doi-asserted-by":"crossref","first-page":"467","DOI":"10.3109\/09537104.2016.1143922","article-title":"Cytokine, chemokine, and growth factor profile of platelet-rich plasma","volume":"27","author":"Mussano","year":"2016","journal-title":"Platelets"},{"key":"10.1016\/j.ijpx.2025.100372_bb0780","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2020.08.001","article-title":"New era for outcomes and management of rheumatoid arthritis: Facing the individualized treatment challenge","volume":"88","author":"Myasoedova","year":"2021","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.ijpx.2025.100372_bb0785","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1089\/ten.2006.0042","article-title":"Intervertebral disc regeneration using platelet-rich plasma and biodegradable gelatin hydrogel microspheres","volume":"13","author":"Nagae","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.ijpx.2025.100372_bb0790","first-page":"1772","article-title":"Hepatocyte growth factor (HGF), HGF activator, and c-Met in synovial tissues in rheumatoid arthritis and osteoarthritis","volume":"28","author":"Nagashima","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0795","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.otsr.2015.11.002","article-title":"Investigating the effect of intra-articular PRP injection on pain and function improvement in patients with distal radius fracture","volume":"102","author":"Namazi","year":"2016","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0800","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232314720","article-title":"Comparative efficiency of gene-activated matrices based on chitosan hydrogel and PRP impregnated with BMP2 polyplexes for bone regeneration","volume":"23","author":"Nedorubova","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0805","doi-asserted-by":"crossref","first-page":"3062","DOI":"10.1177\/0363546515608481","article-title":"Comparison of the cellular composition and cytokine-release kinetics of various platelet-rich plasma preparations","volume":"43","author":"Oh","year":"2015","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0810","doi-asserted-by":"crossref","first-page":"4548","DOI":"10.1038\/s41467-018-06979-4","article-title":"Cloaking nanoparticles with protein corona shield for targeted drug delivery","volume":"9","author":"Oh","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2025.100372_bb0815","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.joca.2004.06.009","article-title":"Expression and localization of connective tissue growth factor (CTGF\/Hcs24\/CCN2) in osteoarthritic cartilage","volume":"12","author":"Omoto","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.ijpx.2025.100372_bb0820","doi-asserted-by":"crossref","first-page":"17797","DOI":"10.1002\/anie.202101964","article-title":"Recent advances in polymeric nanoparticles for enhanced fluorescence and photoacoustic imaging","volume":"60","author":"Ong","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.ijpx.2025.100372_bb0825","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.3390\/ijms22137224","article-title":"Effects of extracellular vesicles from blood-derived products on osteoarthritic chondrocytes within an inflammation model","volume":"22","author":"Otahal","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0830","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.jclinepi.2021.03.001","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"134","author":"Page","year":"2021","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0835","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.119851","article-title":"PRP-chitosan thermoresponsive hydrogel combined with black phosphorus nanosheets as injectable biomaterial for biotherapy and phototherapy treatment of rheumatoid arthritis","volume":"239","author":"Pan","year":"2020","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2025.100372_bb0840","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.diabres.2004.11.007","article-title":"Relationship of obesity and visceral adiposity with serum concentrations of CRP, TNF-alpha and IL-6","volume":"69","author":"Park","year":"2005","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.ijpx.2025.100372_bb0845","doi-asserted-by":"crossref","DOI":"10.4142\/jvs.23281","article-title":"Effect of platelet-rich plasma in Achilles tendon allograft in rabbits","volume":"25","author":"Park","year":"2024","journal-title":"J. Vet. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0850","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.addr.2011.12.006","article-title":"Polymeric nanoparticles for drug delivery to the central nervous system","volume":"64","author":"Patel","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb0855","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00018-021-04105-0","article-title":"The essential anti-angiogenic strategies in cartilage engineering and osteoarthritic cartilage repair","volume":"79","author":"Pei","year":"2022","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0860","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1186\/s12929-023-00962-y","article-title":"Platelet-derived biomaterial with hyaluronic acid alleviates temporal-mandibular joint osteoarthritis: clinical trial from dish to human","volume":"30","author":"Peng","year":"2023","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0865","doi-asserted-by":"crossref","DOI":"10.3390\/cells13090743","article-title":"Clinical phenotypes, serological biomarkers, and synovial features defining seropositive and seronegative rheumatoid arthritis: a literature review","volume":"13","author":"Perera","year":"2024","journal-title":"Cells"},{"key":"10.1016\/j.ijpx.2025.100372_bb0870","doi-asserted-by":"crossref","first-page":"2816","DOI":"10.1002\/art.38758","article-title":"Disturbed cartilage and joint homeostasis resulting from a loss of mitogen-inducible gene 6 in a mouse model of joint dysfunction","volume":"66","author":"Pest","year":"2014","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb0875","article-title":"Treatment of large cartilage defects in the knee by hydrogel-based autologous chondrocyte implantation: two-year results of a prospective, multicenter, single-arm phase III trial","volume":"13","author":"Philipp","year":"2022","journal-title":"Cartilage"},{"key":"10.1016\/j.ijpx.2025.100372_bb0880","doi-asserted-by":"crossref","first-page":"7010","DOI":"10.3390\/ijms25137010","article-title":"Chondrotoxicity of intra-articular injection treatment: a scoping review","volume":"25","author":"Pirri","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0885","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/J.ENG.2017.01.007","article-title":"Tethering of Gly-Arg-Gly-Asp-Ser-Pro-Lys peptides on Mg-doped hydroxyapatite","volume":"3","author":"Pistone","year":"2017","journal-title":"Engineering"},{"key":"10.1016\/j.ijpx.2025.100372_bb0890","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1600-0501.2008.01525.x","article-title":"Effect of platelet-rich plasma on bone regeneration in dentistry: a systematic review","volume":"19","author":"Plachokova","year":"2008","journal-title":"Clin. Oral Implants Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0895","doi-asserted-by":"crossref","first-page":"60","DOI":"10.5435\/00124635-201201000-00008","article-title":"Nanotechnology in orthopaedics","volume":"20","author":"Pleshko","year":"2012","journal-title":"Am. Acad. Orthop. Surg."},{"key":"10.1016\/j.ijpx.2025.100372_bb0900","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1186\/s13075-022-02893-9","article-title":"CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145\/HGF axis in osteoarthritis","volume":"24","author":"Que","year":"2022","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ijpx.2025.100372_bb0905","doi-asserted-by":"crossref","first-page":"15908","DOI":"10.3390\/ijms232415908","article-title":"Tissue-protective and anti-inflammatory landmark of PRP-treated mesenchymal stromal cells secretome for osteoarthritis","volume":"23","author":"Ragni","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0910","first-page":"535","article-title":"Limb saving with a combination of allogenic platelets-rich plasma, fibrin glue, and collagen matrix in an open fracture of the Tibia: a case report","volume":"11","author":"Rahimi","year":"2023","journal-title":"Arch. Bone Jt. Surg."},{"key":"10.1016\/j.ijpx.2025.100372_bb0915","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1002\/art.11223","article-title":"Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis","volume":"48","author":"Rantap\u00e4\u00e4 Dahlqvist","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb0920","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/10837450.2022.2162543","article-title":"Microfluidics in drug delivery: review of methods and applications","volume":"28","author":"Rawas-Qalaji","year":"2023","journal-title":"Pharm. Dev. Technol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0925","doi-asserted-by":"crossref","first-page":"8739473","DOI":"10.1155\/2018\/8739473","article-title":"Role of Epidermal Growth Factor Receptor (EGFR) and its ligands in kidney inflammation and damage","volume":"2018","author":"Rayego Mateos","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijpx.2025.100372_bb0930","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1177\/0363546515580787","article-title":"Effect of leukocyte concentration on the efficacy of platelet-rich plasma in the treatment of knee osteoarthritis","volume":"44","author":"Riboh","year":"2016","journal-title":"Am. J. Sports Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0935","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1016\/j.jaad.2018.09.033","article-title":"Treatment of male pattern alopecia with platelet-rich plasma: a double-blind controlled study with analysis of platelet number and growth factor levels","volume":"80","author":"Rodrigues","year":"2019","journal-title":"J. Am. Acad. Dermatol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0940","article-title":"Intra-articular platelet-rich plasma injections in knee osteoarthritis: a review of their current molecular mechanisms of action and their degree of efficacy","volume":"23","author":"Rodr\u00edguez-Merch\u00e1n","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0945","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1002\/biof.1917","article-title":"Platelet-activating factor and microvesicle particles as potential mediators for the toxicity associated with intoxicated thermal burn injury","volume":"48","author":"Rohan","year":"2022","journal-title":"BioFactors"},{"key":"10.1016\/j.ijpx.2025.100372_bb0950","first-page":"1","article-title":"Comparison and investigation of exosomes derived from platelet-rich plasma activated by different agonists","volume":"2021","author":"Rui","year":"2021","journal-title":"Cell Transplant."},{"key":"10.1016\/j.ijpx.2025.100372_bb0955","first-page":"ZC10","article-title":"A comparison of platelet count and enrichment percentages in the Platelet Rich Plasma (PRP) obtained following preparation by three different methods","volume":"9","author":"Sabarish","year":"2015","journal-title":"J. Clin. Diagn. Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb0960","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1016\/j.biopha.2018.11.072","article-title":"Nano-hydroxy apatite\/chitosan\/gelatin scaffolds enriched by a combination of platelet-rich plasma and fibrin glue enhance proliferation and differentiation of seeded human dental pulp stem cells","volume":"109","author":"Sadeghinia","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpx.2025.100372_bb0965","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197204","article-title":"Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs","volume":"13","author":"Sample","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpx.2025.100372_bb0970","article-title":"Systematic review of literature on the efficiency of using PRP in arthroscopic rotator cuff repair","volume":"113","author":"Samy","year":"2020","journal-title":"QJM Int. J. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb0975","first-page":"634","article-title":"Comparison of single and double centrifugation methods for preparation of Platelet-Rich Plasma (PRP)","volume":"39","author":"Saqlain","year":"2023","journal-title":"Pakistan J. Med. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb0980","doi-asserted-by":"crossref","DOI":"10.3390\/cells11060965","article-title":"Methodological flaws in meta-analyses of clinical studies on the management of knee osteoarthritis with stem cells: a systematic review","volume":"11","author":"Schmitz","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ijpx.2025.100372_bb0985","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1146\/annurev-pathmechdis-012419-032611","article-title":"Human organoids: tools for understanding biology and treating diseases","volume":"15","author":"Schutgens","year":"2020","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.ijpx.2025.100372_bb0990","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10815-021-02385-w","article-title":"Ovarian response to intraovarian platelet-rich plasma (PRP) administration: hypotheses and potential mechanisms of action","volume":"39","author":"Seckin","year":"2022","journal-title":"J. Assist. Reprod. Genet."},{"key":"10.1016\/j.ijpx.2025.100372_bb0995","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1083\/jcb.141.7.1659","article-title":"Fibroblast Growth Factor-2 (FGF-2) induces Vascular Endothelial Growth Factor (VEGF) expression in the endothelial cells of forming capillaries: an autocrine mechanism contributing to angiogenesis","volume":"141","author":"Seghezzi","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1000","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jcp.10371","article-title":"TNFalpha suppresses link protein and type II collagen expression in chondrocytes: role of MEK1\/2 and NF-kappaB signaling pathways","volume":"197","author":"S\u00e9guin","year":"2003","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1005","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/03008207.2024.2397657","article-title":"Exploring the applications of platelet-rich plasma in tissue engineering and regenerative medicine: evidence from goat and sheep experimental research","volume":"65","author":"Sharun","year":"2024","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb1010","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/ar4233","article-title":"Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo","volume":"15","author":"Shepard","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.ijpx.2025.100372_bb1015","doi-asserted-by":"crossref","first-page":"7493","DOI":"10.1074\/jbc.M108653200","article-title":"Regulation of osteoblast, chondrocyte, and osteoclast functions by Fibroblast Growth Factor (FGF)-18 in comparison with FGF-2 and FGF-10 *","volume":"277","author":"Shimoaka","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.ijpx.2025.100372_bb1020","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1038\/s41467-020-20763-3","article-title":"3D high-density microelectrode array with optical stimulation and drug delivery for investigating neural circuit dynamics","volume":"12","author":"Shin","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2025.100372_bb1025","doi-asserted-by":"crossref","DOI":"10.1088\/2516-1091\/ad1338","article-title":"Recent advances in platelet-rich plasma and its derivatives: therapeutic agents for tissue engineering and regenerative medicine","volume":"6","author":"Shome","year":"2024","journal-title":"Progr. Biomed. Eng."},{"key":"10.1016\/j.ijpx.2025.100372_bb1030","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/j.cellsig.2005.03.026","article-title":"Autocrine, paracrine and juxtacrine signaling by EGFR ligands","volume":"17","author":"Singh","year":"2005","journal-title":"Cell. Signal."},{"key":"10.1016\/j.ijpx.2025.100372_bb1035","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1097\/JSM.0000000000000063","article-title":"Comparing PRP injections with ESWT for athletes with chronic patellar tendinopathy","volume":"24","author":"Smith","year":"2014","journal-title":"Clin. J. Sport Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb1040","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12891-018-1990-1","article-title":"Nanotechnology in orthopedics: a clinically oriented review","volume":"19","author":"Smith","year":"2018","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.ijpx.2025.100372_bb1045","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202204791","article-title":"Puffball-inspired microrobotic systems with robust payload, strong protection, and targeted locomotion for on-demand drug delivery","volume":"34","author":"Song","year":"2022","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpx.2025.100372_bb1050","doi-asserted-by":"crossref","first-page":"eabm1421","DOI":"10.1126\/scirobotics.abm1421","article-title":"Light-driven carbon nitride microswimmers with propulsion in biological and ionic media and responsive on-demand drug delivery","volume":"7","author":"Sridhar","year":"2022","journal-title":"Sci. Robot."},{"key":"10.1016\/j.ijpx.2025.100372_bb1055","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.1016\/j.biomaterials.2009.03.054","article-title":"The relationship between the antimicrobial effect of catheter coatings containing silver nanoparticles and the coagulation of contacting blood","volume":"30","author":"Stevens","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2025.100372_bb1060","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119934","article-title":"Regenerative effect of platelet-rich plasma in the murine ischemic limbs","volume":"284","author":"Stilhano","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb1065","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1073\/pnas.152324099","article-title":"Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover","volume":"99","author":"Street","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpx.2025.100372_bb1070","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-020-00745-9","article-title":"Distribution of polymeric nanoparticles in the eye: implications in ocular disease therapy","volume":"19","author":"Swetledge","year":"2021","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1075","doi-asserted-by":"crossref","first-page":"5492","DOI":"10.3390\/ijms22115492","article-title":"The effect of platelet-rich plasma on the intra-articular microenvironment in knee osteoarthritis","volume":"22","author":"Szwedowski","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb1080","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1046\/j.1523-1755.1999.00796.x","article-title":"Vascular endothelial growth factor activates MAP kinase and enhances collagen synthesis in human mesangial cells","volume":"56","author":"T","year":"1999","journal-title":"Kidney Int."},{"key":"10.1016\/j.ijpx.2025.100372_bb1085","doi-asserted-by":"crossref","first-page":"733","DOI":"10.7150\/thno.17450","article-title":"Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt\/Bad\/Bcl-2 signal pathway","volume":"7","author":"Tao","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpx.2025.100372_bb1090","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1111\/j.1532-950X.2012.01016.x","article-title":"Activation of equine platelet-rich plasma: comparison of methods and characterization of equine autologous thrombin","volume":"41","author":"Textor","year":"2012","journal-title":"Vet. Surg."},{"key":"10.1016\/j.ijpx.2025.100372_bb1095","doi-asserted-by":"crossref","first-page":"4433","DOI":"10.1038\/s41467-018-06981-w","article-title":"Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery","volume":"9","author":"Than","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2025.100372_bb1100","doi-asserted-by":"crossref","first-page":"206","DOI":"10.12701\/jyms.2022.00290","article-title":"The use of platelet-rich plasma in management of musculoskeletal pain: a narrative review","volume":"39","author":"Thu","year":"2022","journal-title":"J. Yeungnam Med. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb1105","doi-asserted-by":"crossref","first-page":"1046438","DOI":"10.1155\/2017\/1046438","article-title":"Platelet-released growth factors modulate the secretion of cytokines in synoviocytes under inflammatory joint disease","volume":"2017","author":"Tohidnezhad","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijpx.2025.100372_bb1110","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10238-017-0449-2","article-title":"Platelet-rich plasma inhibits inflammatory factors and represses rheumatoid fibroblast-like synoviocytes in rheumatoid arthritis","volume":"17","author":"Tong","year":"2017","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb1115","doi-asserted-by":"crossref","first-page":"4082","DOI":"10.3892\/mmr.2017.7091","article-title":"Platelet-rich plasma exhibits beneficial effects for rheumatoid arthritis mice by suppressing inflammatory factors","volume":"16","author":"Tong","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.ijpx.2025.100372_bb1120","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41413-022-00226-9","article-title":"Current understanding of osteoarthritis pathogenesis and relevant new approaches","volume":"10","author":"Tong","year":"2022","journal-title":"Bone Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb1125","doi-asserted-by":"crossref","DOI":"10.3390\/cells11071080","article-title":"Role of platelets in osteoarthritis-updated systematic review and meta-analysis on the role of platelet-rich plasma in osteoarthritis","volume":"11","author":"Tram\u015b","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ijpx.2025.100372_bb1130","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/pmrj.12561","article-title":"Randomized, placebo-controlled analysis of the knee synovial environment following platelet-rich plasma treatment for knee osteoarthritis","volume":"13","author":"Tucker","year":"2021","journal-title":"PM&R"},{"key":"10.1016\/j.ijpx.2025.100372_bb1135","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102392","article-title":"An overview of autoantibodies in rheumatoid arthritis","volume":"110","author":"van Delft","year":"2020","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.ijpx.2025.100372_bb1140","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.injury.2020.12.005","article-title":"Effect of platelet-rich plasma on fracture healing","volume":"52","author":"Van Lieshout","year":"2021","journal-title":"Injury"},{"key":"10.1016\/j.ijpx.2025.100372_bb1145","article-title":"Objective assessment of chronic pain in horses using the Horse Chronic Pain Scale (HCPS): a scale-construction study","volume":"11","author":"van Loon","year":"2021","journal-title":"Animals (Basel)"},{"key":"10.1016\/j.ijpx.2025.100372_bb1150","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1155","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s41419-022-05089-w","article-title":"Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression","volume":"13","author":"Varela Eir\u00edn","year":"2022","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijpx.2025.100372_bb1160","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00281-017-0630-4","article-title":"Genetics of rheumatoid arthritis susceptibility, severity, and treatment response","volume":"39","author":"Viatte","year":"2017","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1165","first-page":"55","article-title":"Features of radiological and anatomical changes in bone of the hip joint due to injuries","volume":"7","author":"Volodymyr","year":"2015","journal-title":"Ortop. Travmatol. Protez."},{"key":"10.1016\/j.ijpx.2025.100372_bb1170","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.10.002","article-title":"Pro-inflammatory cytokines: the link between obesity and osteoarthritis","volume":"44","author":"Wang","year":"2018","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb1175","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00441-020-03319-1","article-title":"TGF-\u03b21-modified MSC-derived exosomal miR-135b attenuates cartilage injury via promoting M2 synovial macrophage polarization by targeting MAPK6","volume":"384","author":"Wang","year":"2021","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb1180","first-page":"725","article-title":"Structures and properties of chitosan-starch-sodium benzoate blend films","volume":"49","author":"Wang","year":"2003","journal-title":"J.-Wuhan Univ. Nat. Sci. Ed."},{"key":"10.1016\/j.ijpx.2025.100372_bb1185","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12951-022-01447-0","article-title":"Microvesicle-camouflaged biomimetic nanoparticles encapsulating a metal-organic framework for targeted rheumatoid arthritis therapy","volume":"20","author":"Wang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1190","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202370290","article-title":"Adipose mesenchymal stem cell derived exosomes promote keratinocytes and fibroblasts embedded in collagen\/platelet-rich plasma scaffold and accelerate wound healing","volume":"35","author":"Wang","year":"2023","journal-title":"Adv. Mater."},{"issue":"1","key":"10.1016\/j.ijpx.2025.100372_bb1195","article-title":"Polymeric nanoparticles (PNPs) for oral delivery of insulin","volume":"22","author":"Wang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1200","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1051\/ject\/2004363250","article-title":"Database review of possible factors influencing point-of-care platelet gel manufacture","volume":"36","author":"Waters","year":"2004","journal-title":"J Extra Corpor Technol"},{"key":"10.1016\/j.ijpx.2025.100372_bb1205","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abb3946","article-title":"Targeting cartilage EGFR pathway for osteoarthritis treatment","volume":"13","author":"Wei","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb1210","article-title":"Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management","volume":"19","author":"Wen","year":"2023","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ijpx.2025.100372_bb1215","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.1002\/art.34645","article-title":"Genetic inhibition of fibroblast growth factor receptor 1 in knee cartilage attenuates the degeneration of articular cartilage in adult mice","volume":"64","author":"Weng","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.ijpx.2025.100372_bb1220","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1002\/bip.21196","article-title":"Adhesion of pancreatic beta cells to biopolymer films","volume":"91","author":"Williams","year":"2009","journal-title":"Biopolymers"},{"key":"10.1016\/j.ijpx.2025.100372_bb1225","doi-asserted-by":"crossref","first-page":"eaax0613","DOI":"10.1126\/scirobotics.aax0613","article-title":"A microrobotic system guided by photoacoustic computed tomography for targeted navigation in intestines in vivo","volume":"4","author":"Wu","year":"2019","journal-title":"Sci. Robot."},{"key":"10.1016\/j.ijpx.2025.100372_bb1230","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.13123","article-title":"Platelet-rich plasma-derived extracellular vesicles: a superior alternative in regenerative medicine?","volume":"54","author":"Wu","year":"2021","journal-title":"Cell Prolif."},{"key":"10.1016\/j.ijpx.2025.100372_bb1235","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.996668","article-title":"Efficacy analysis of splint combined with platelet-rich plasma in the treatment of temporomandibular joint osteoarthritis","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1240","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s11926-019-0868-z","article-title":"Adipokines: new therapeutic target for osteoarthritis?","volume":"21","author":"Xie","year":"2019","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.ijpx.2025.100372_bb1245","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/s41392-020-00222-7","article-title":"FGF\/FGFR signaling in health and disease","volume":"5","author":"Xie","year":"2020","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ijpx.2025.100372_bb1250","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41584-020-0469-2","article-title":"Fibroblast growth factor signalling in osteoarthritis and cartilage repair","volume":"16","author":"Xie","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1255","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1172\/JCI81129","article-title":"Extracellular vesicle isolation and characterization: toward clinical application","volume":"126","author":"Xu","year":"2016","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.ijpx.2025.100372_bb1260","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1002\/term.2020","article-title":"Platelet-rich plasma activates tendon-derived stem cells to promote regeneration of Achilles tendon rupture in rats","volume":"11","author":"Xu","year":"2017","journal-title":"J. Tissue Eng. Regen. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb1265","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1080\/15384101.2021.1949839","article-title":"Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes","volume":"20","author":"Xu","year":"2021","journal-title":"Cell Cycle"},{"key":"10.1016\/j.ijpx.2025.100372_bb1270","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9674809","article-title":"[Retracted] Platelet-rich plasma-derived exosomal USP15 promotes cutaneous wound healing via deubiquitinating EIF4A1","volume":"2021","author":"Xu","year":"2021","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.ijpx.2025.100372_bb1275","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/rb\/rbz039","article-title":"Platelet-rich plasma combined with injectable hyaluronic acid hydrogel for porcine cartilage regeneration: a 6-month follow-up","volume":"7","author":"Yan","year":"2020","journal-title":"Regenerat. Biomater."},{"key":"10.1016\/j.ijpx.2025.100372_bb1280","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4252\/wjsc.v16.i2.191","article-title":"Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a","volume":"16","author":"Yang","year":"2024","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.ijpx.2025.100372_bb1285","doi-asserted-by":"crossref","first-page":"4490","DOI":"10.4049\/jimmunol.1601988","article-title":"CD40L-dependent pathway is active at various stages of rheumatoid arthritis disease progression","volume":"198","author":"Yanxia","year":"2017","journal-title":"J. Immunol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1290","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/s41551-018-0201-6","article-title":"Needle-shaped ultrathin piezoelectric microsystem for guided tissue targeting via mechanical sensing","volume":"2","author":"Yu","year":"2018","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijpx.2025.100372_bb1295","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202403890","article-title":"Injectable GelMA hydrogel microspheres with sustained release of platelet-rich plasma for the treatment of thin endometrium","volume":"20","author":"Yuan","year":"2024","journal-title":"Small"},{"key":"10.1016\/j.ijpx.2025.100372_bb1300","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/1075975","article-title":"Platelet-rich plasma as an autologous and proangiogenic cell delivery system","volume":"2017","author":"Zahn","year":"2017","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.ijpx.2025.100372_bb1305","article-title":"Research progress in the mechanism of effect of PRP in bone deficiency healing","volume":"2013","author":"Zhang","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.ijpx.2025.100372_bb1310","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1002\/stem.1771","article-title":"HucMSC-exosome mediated-wnt4 signaling is required for cutaneous wound healing","volume":"33","author":"Zhang","year":"2015","journal-title":"Stem Cells"},{"key":"10.1016\/j.ijpx.2025.100372_bb1315","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107813","article-title":"Exosomes derived from platelet-rich plasma mediate hyperglycemia-induced retinal endothelial injury via targeting the TLR4 signaling pathway","volume":"189","author":"Zhang","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb1320","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/ten.teb.2018.0309","article-title":"Platelet-rich plasma for the treatment of tissue infection: preparation and clinical evaluation","volume":"25","author":"Zhang","year":"2019","journal-title":"Tissue Eng. Part B Rev."},{"key":"10.1016\/j.ijpx.2025.100372_bb1325","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2020.107973","article-title":"Exosomes derived from platelet-rich plasma activate YAP and promote the fibrogenic activity of M\u00fcller cells via the PI3K\/Akt pathway","volume":"193","author":"Zhang","year":"2020","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.ijpx.2025.100372_bb1330","article-title":"Development of polymeric nanoparticles for blood-brain barrier transfer-strategies and challenges","volume":"8","author":"Zhang","year":"2021","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb1335","first-page":"733","article-title":"Exosomes derived from platelet-rich plasma administration in site mediate cartilage protection in subtalar osteoarthritis","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1340","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1186\/s12951-022-01671-8","article-title":"Scalable and high-throughput production of an injectable platelet-rich plasma (PRP)\/cell-laden microcarrier\/hydrogel composite system for hair follicle tissue engineering","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2025.100372_bb1345","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/s00109-017-1516-6","article-title":"Downregulation of miR-221-3p contributes to IL-1\u03b2-induced cartilage degradation by directly targeting the SDF1\/CXCR4 signaling pathway","volume":"95","author":"Zheng","year":"2017","journal-title":"J. Mol. Med. (Berl)"},{"key":"10.1016\/j.ijpx.2025.100372_bb1350","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.7150\/ijms.51060","article-title":"Injectable gelatin microspheres loaded with platelet rich plasma improve wound healing by regulating early inflammation","volume":"18","author":"Zhou","year":"2021","journal-title":"Int. J. Med. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb1355","doi-asserted-by":"crossref","first-page":"7472","DOI":"10.1111\/jcmm.16779","article-title":"Recombinant platelet-derived growth factor-BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivo","volume":"25","author":"Zhu","year":"2021","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.ijpx.2025.100372_bb1360","article-title":"Application progress of modified chitosan and its composite biomaterials for bone tissue engineering","volume":"23","author":"Zhu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2025.100372_bb1365","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25163731","article-title":"Polymeric nanoparticles: production, characterization, toxicology and ecotoxicology","volume":"25","author":"Zieli\u0144ska","year":"2020","journal-title":"Molecules"}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672500057X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672500057X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:45:25Z","timestamp":1765932325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259015672500057X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":273,"alternative-id":["S259015672500057X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2025.100372","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2025.100372","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100372"}}