{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:01:46Z","timestamp":1785211306527,"version":"3.55.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T00:00:00Z","timestamp":1776297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007065","name":"University of Salerno","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.ijpx.2026.100547","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T06:57:27Z","timestamp":1776409047000},"page":"100547","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Development of hyaluronic acid-based nanocomposite eye drops: A synergistic platform for enhanced ocular delivery of acetazolamide"],"prefix":"10.1016","volume":"11","author":[{"given":"Giovanni","family":"Falcone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Lina","family":"Formica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamoudi Ghassan Awde","family":"Alfonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julieta","family":"Ribotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Ignacio","family":"Tartara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Amante","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita Patrizia","family":"Aquino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pasquale","family":"Del Gaudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago Daniel","family":"Palma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100547_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1208\/s12249-022-02459-7","article-title":"The development and evaluation of phase transition microemulsion for ocular delivery of acetazolamide for glaucoma treatment","volume":"24","author":"Abd El Wahab","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2026.100547_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.nanoso.2020.100630","article-title":"Development of hydroxyapatite reinforced alginate\u2013chitosan based printable biomaterial-ink","volume":"25","author":"Adhikari","year":"2021","journal-title":"Nano-Struct. Nano-Objects"},{"key":"10.1016\/j.ijpx.2026.100547_bb0015","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1208\/s12249-023-02516-9","article-title":"Ocular drug delivery: a comprehensive review","volume":"24","author":"Ahmed","year":"2023","journal-title":"AAPS PharmSciTech"},{"issue":"6","key":"10.1016\/j.ijpx.2026.100547_bb0020","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/tvst.8.6.2","article-title":"Physicochemical properties of hyaluronic acid\u2013based lubricant eye drops","volume":"8","author":"Aragona","year":"2019","journal-title":"Transl. Vis. Sci. Technol."},{"issue":"12","key":"10.1016\/j.ijpx.2026.100547_bb0025","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.3390\/pharmaceutics13122010","article-title":"Synergistic effect of acetazolamide-(2-hydroxy)propyl \u03b2-cyclodextrin in timolol liposomes for decreasing and prolonging intraocular pressure levels","volume":"13","author":"Arroyo-Garc\u00eda","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100547_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125440","article-title":"Enhanced in vivo performance of topical ocular acetazolamide nanocrystals: a novel approach for glaucoma treatment","volume":"674","author":"Awde Alfonso","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100547_bb0035","doi-asserted-by":"crossref","first-page":"2200211","DOI":"10.1002\/admi.202200211","article-title":"Recent advances in mucoadhesive interface materials, mucoadhesion characterization, and technologies","volume":"9","author":"Bayer","year":"2022","journal-title":"Adv. Mater. Interfaces"},{"key":"10.1016\/j.ijpx.2026.100547_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.122671","article-title":"A review of conventional and emerging technologies for hydrogels sterilization","volume":"634","author":"Bento C.","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100547_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105748","article-title":"Latanoprost-loaded phytantriol cubosomes for the treatment of glaucoma","volume":"160","author":"Bessone","year":"2021","journal-title":"Eur. J. Pharm. Sci."},{"issue":"7","key":"10.1016\/j.ijpx.2026.100547_bb0050","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.3390\/pharmaceutics14071479","article-title":"Hyaluronic acid: its versatile use in ocular drug delivery with a specific focus on hyaluronic Acid-based polyelectrolyte complexes","volume":"14","author":"Casey-Power","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100547_bb0055","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2019.05.034","article-title":"Hydrogel-based ocular drug delivery systems: emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations","volume":"306","author":"Cooper","year":"2019","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100547_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.msec.2020.111383","article-title":"Mucoadhesive and responsive nanogels as carriers for sustainable delivery of timolol for glaucoma therapy","volume":"118","author":"Cuggino","year":"2021","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijpx.2026.100547_bb0065","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1039\/C1SM06639K","article-title":"Gel-nanocomposites: Materials with promising applications","volume":"8","author":"Das","year":"2012","journal-title":"Soft Matter"},{"issue":"2","key":"10.1016\/j.ijpx.2026.100547_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15020683","article-title":"Development of triamcinolone acetonide nanocrystals for ocular administration","volume":"15","author":"Formica","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100547_bb0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S1529-1839(04)70035-4","article-title":"PH stability of ophthalmic solutions","volume":"75","author":"Garcia-Valldecabres","year":"2004","journal-title":"Optometry - J. Am. Optometric Assoc."},{"key":"10.1016\/j.ijpx.2026.100547_bb0080","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.jconrel.2017.01.014","article-title":"BCS class IV drugs: Highly notorious candidates for formulation development","volume":"248","author":"Ghadi","year":"2017","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100547_bb0085","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.msec.2015.02.048","article-title":"Crosslinked soy protein films and their application as ophthalmic drug delivery system","volume":"51","author":"Gonz\u00e1lez","year":"2015","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.ijpx.2026.100547_bb0090","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1080\/17512433.2021.1931123","article-title":"Oral acetazolamide for intraocular pressure lowering: Balancing efficacy and safety in ophthalmic practice","volume":"14","author":"Gulati","year":"2021","journal-title":"Expert. Rev. Clin. Pharmacol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117697","article-title":"Hyaluronan and its derivatives for ophthalmology: recent advances and future perspectives","volume":"259","author":"Huerta \u00c1ngeles","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100547_bb0100","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.colsurfb.2011.12.020","article-title":"Comparison of in vitro methods of measuring mucoadhesion: Ellipsometry, tensile strength and rheological measurements","volume":"92","author":"Ivarsson","year":"2012","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijpx.2026.100547_bb0105","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1002\/btm2.10122","article-title":"Nanocrystals: a perspective on translational research and clinical studies","volume":"4","author":"Jarvis","year":"2019","journal-title":"Bioeng. Transl. Med."},{"key":"10.1016\/j.ijpx.2026.100547_bb0110","first-page":"295","article-title":"Nanocrystal technology, drug delivery and clinical applications","volume":"3","author":"Junghanns","year":"2008","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100547_bb0115","doi-asserted-by":"crossref","DOI":"10.1167\/tvst.11.3.1","article-title":"Shear-Thinning and Temperature-Dependent viscosity relationships of contemporary ocular lubricants","volume":"11","author":"Kapadia","year":"2022","journal-title":"Transl. Vis. Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0120","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s10529-020-03035-4","article-title":"Preparation, purification, and characterization of low-molecular-weight hyaluronic acid","volume":"43","author":"Karami","year":"2021","journal-title":"Biotechnol. Lett."},{"key":"10.1016\/j.ijpx.2026.100547_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123793","article-title":"Development of direct compression acetazolamide tablet with improved bioavailability in healthy human volunteers enabled by cocrystallization with p-aminobenzoic acid","volume":"652","author":"Kumari","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100547_bb0130","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s11094-024-03255-2","article-title":"Features of the thermal degradation of sodium hyaluronates with different molecular weights","volume":"58","author":"Lagutina","year":"2024","journal-title":"Pharm. Chem. J."},{"issue":"15","key":"10.1016\/j.ijpx.2026.100547_bb0135","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.3390\/molecules28155931","article-title":"Diffusion-limited processes in hydrogels with chosen applications from drug delivery to electronic components","volume":"28","author":"Lavrentev","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ijpx.2026.100547_bb0140","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/s12951-023-01992-2","article-title":"Nanotechnology-based ocular drug delivery systems: recent advances and future prospects","volume":"21","author":"Li","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0234690","article-title":"Intraocular and intracranial pressure in glaucoma patients taking acetazolamide","volume":"15","author":"Loiselle","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ijpx.2026.100547_bb0150","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0168-3659(97)00138-7","article-title":"A rheological examination of the mucoadhesive\/mucus interaction: the effect of mucoadhesive type and concentration","volume":"50","author":"Madsen","year":"1998","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100547_bb0155","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.drudis.2018.01.016","article-title":"Pharmaceutical nanocrystals: production by wet milling and applications","volume":"23","author":"Malamatari","year":"2018","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ijpx.2026.100547_bb0160","first-page":"338","article-title":"RP-HPLC method development and validation for the estimation of acetazolamide in bulk drug and formulations with forced degradation studies","volume":"8","author":"Manchanda","year":"2016","journal-title":"Pharm. Lett."},{"key":"10.1016\/j.ijpx.2026.100547_bb0165","doi-asserted-by":"crossref","first-page":"4132","DOI":"10.1021\/acs.jpcb.2c00771","article-title":"Relationship between gel mesh and particle size in determining nanoparticle diffusion in hydrogel nanocomposites","volume":"126","author":"Moncure","year":"2022","journal-title":"J. Phys. Chem. B"},{"key":"10.1016\/j.ijpx.2026.100547_bb0170","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jddst.2018.05.020","article-title":"Preparation and characterization of solid dispersions of celecoxib obtained by spray-drying ethanolic suspensions containing PVP-K30 or isomalt","volume":"46","author":"Motallae","year":"2018","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0175","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s12553-019-00381-w","article-title":"Application of nanoparticles in ocular drug delivery systems","volume":"10","author":"Omerovi\u0107","year":"2020","journal-title":"Heal. Technol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119501","article-title":"Ricobendazole nanocrystals obtained by media milling and spray drying: pharmacokinetic comparison with the micronized form of the drug","volume":"585","author":"Paredes","year":"2020","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100547_bb0185","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jconrel.2014.03.030","article-title":"Engineered nanocrystal technology: In-vivo fate, targeting and applications in drug delivery","volume":"183","author":"Pawar","year":"2014","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100547_bb0190","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.carbpol.2012.08.011","article-title":"Sulfated chitosan as tear substitute with no antimicrobial activity","volume":"91","author":"Pires","year":"2013","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100547_bb0195","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1515\/secm-2017-0161","article-title":"A review on nanocomposite hydrogels and their biomedical applications","volume":"26","author":"Rafieian","year":"2019","journal-title":"Sci. Eng. Compos. Mater."},{"key":"10.1016\/j.ijpx.2026.100547_bb0200","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.saa.2018.10.020","article-title":"FTIR and TG analyses coupled with factor analysis in a compatibility study of acetazolamide with excipients","volume":"208","author":"Rojek","year":"2019","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.ijpx.2026.100547_bb0205","doi-asserted-by":"crossref","first-page":"14982","DOI":"10.1039\/D5TB01575H","article-title":"Hydrogel-based ocular drug delivery systems","volume":"13","author":"Sabbagh","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijpx.2026.100547_bb0210","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.carbpol.2016.07.106","article-title":"Optimization of hyaluronan-based eye drop formulations","volume":"153","author":"Salzillo","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100547_bb0215","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12886-021-02079-y","article-title":"Impact of dorzolamide, benzalkonium-preserved dorzolamide and benzalkonium-preserved brinzolamide on selected biomarkers of oxidative stress in the tear film","volume":"21","author":"Sedlak","year":"2021","journal-title":"BMC Ophthalmol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpet.2025.103738","article-title":"Recent advances and future challenges in nanosystems for ocular drug delivery","volume":"392","author":"Shahror","year":"2025","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.ijpx.2026.100547_bb0225","first-page":"399","article-title":"Nanocrystal for ocular drug delivery: Hope or hype","volume":"6","author":"Sharma","year":"2016","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ijpx.2026.100547_bb0230","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3109\/03639045.2013.814061","article-title":"Development of acetazolamide-loaded, pH-triggered polymeric nanoparticulate in situ gel for sustained ocular delivery: in vitro. Ex vivo evaluation and pharmacodynamic study","volume":"40","author":"Singh","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"10.1016\/j.ijpx.2026.100547_bb0235","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jtos.2022.09.001","article-title":"Redefining ocular drug delivery","volume":"26","author":"Song","year":"2022","journal-title":"Ocul. Surf."},{"key":"10.1016\/j.ijpx.2026.100547_bb0240","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1007\/s00289-024-05595-1","article-title":"Synthesis and physical\u2013chemical characterization of chitosan grafted with hyaluronic acid as potential application in biomaterials","volume":"82","author":"de Souza","year":"2025","journal-title":"Polym. Bull."},{"key":"10.1016\/j.ijpx.2026.100547_bb0245","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.2147\/DDDT.S570027","article-title":"Spray drying for pharmaceutical raw materials: a systematic review on enhancing bioavailability and stability","author":"Swm","year":"2025","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.ijpx.2026.100547_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.124902","article-title":"Carbohydrate polymer-based bioadhesive formulations and their potentials for the treatment of ocular diseases: a review","volume":"242","author":"Tang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0255","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.ijpharm.2010.05.031","article-title":"Synergistic interaction between TS-polysaccharide and hyaluronic acid: Implications in the formulation of eye drops","volume":"395","author":"Uccello-Barretta","year":"2010","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100547_bb0260","series-title":"Osmolality and Osmolarity\/Physical Tests Le Tran","author":"US-Pharmacopeia44-NF39","year":"2021"},{"issue":"22","key":"10.1016\/j.ijpx.2026.100547_bb0265","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222212368","article-title":"Nanotechnology for topical drug delivery to the anterior segment of the eye","volume":"22","author":"Vaneev","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2026.100547_bb0270","article-title":"From bench to bedside: Hydrogel platforms bridging anti-adhesion barriers, tissue regeneration, and personalized postoperative recovery","volume":"4","author":"Wang","year":"2025","journal-title":"MedComm \u2013 Biomater. Appl."},{"key":"10.1016\/j.ijpx.2026.100547_bb0275","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1021\/acs.nanolett.4c06501","article-title":"Nanoparticle loading in swollen polymer gels: an unexpected thermodynamic twist","volume":"25","author":"Waugaman","year":"2025","journal-title":"Nano Lett."},{"key":"10.1016\/j.ijpx.2026.100547_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.117800","article-title":"Multifunctional nanocomposite eye drops of cyclodextrin complex@layered double hydroxides for relay drug delivery to the posterior segment of the eye","volume":"260","author":"Xu","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100547_bb0285","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jddst.2017.06.012","article-title":"Comparison of different in vitro mucoadhesion testing methods for hydrogels","volume":"40","author":"Yan","year":"2017","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100547_bb0290","doi-asserted-by":"crossref","first-page":"915","DOI":"10.7150\/thno.103266","article-title":"Advances in adhesive hydrogels applied for ophthalmology: an overview focused on the treatment","volume":"15","author":"Yan","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpx.2026.100547_bb0295","doi-asserted-by":"crossref","first-page":"367","DOI":"10.2147\/IJN.S494224","article-title":"Strategies to enhance nanocrystal formulations for overcoming physiological barriers across diverse routes of administration","author":"Yanamadala","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100547_bb0300","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1039\/D4SM01522C","article-title":"Mechano-diffusion of particles in stretchable hydrogels","volume":"21","author":"Ye","year":"2025","journal-title":"Soft Matter"},{"key":"10.1016\/j.ijpx.2026.100547_bb0305","doi-asserted-by":"crossref","first-page":"2100088","DOI":"10.1002\/adtp.202100088","article-title":"Improved treatment on ocular inflammation with rationally designed thermoresponsive nanocomposite formulation","volume":"4","author":"Zhang","year":"2021","journal-title":"Adv. Ther."},{"key":"10.1016\/j.ijpx.2026.100547_bb0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2021.118006","article-title":"Hyaluronic acid in ocular drug delivery","volume":"264","author":"Zhang","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100547_bb0315","doi-asserted-by":"crossref","DOI":"10.1097\/OPX.0b013e3181824dc4","article-title":"Effect of viscosity on tear drainage and ocular residence time","volume":"85","author":"Zhu","year":"2008","journal-title":"Optom. Vis. Sci."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726000678?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726000678?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T03:44:27Z","timestamp":1785210267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156726000678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":63,"alternative-id":["S2590156726000678"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100547","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of hyaluronic acid-based nanocomposite eye drops: A synergistic platform for enhanced ocular delivery of acetazolamide","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100547","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100547"}}