{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:40:45Z","timestamp":1793032845880,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:00:00Z","timestamp":1785888000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100632","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:42:06Z","timestamp":1786322526000},"page":"100632","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bile acid triggered release of daunorubicin from silica nanoparticle-stabilized antibubbles"],"prefix":"10.1016","volume":"12","author":[{"given":"Rabia","family":"Zia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemarije","family":"van der Vorst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert T.","family":"Poortinga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akmal","family":"Nazir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelus F.","family":"van Nostrum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100632_bb0005","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/j.ijbiomac.2019.01.142","article-title":"Daunorubicin oral bioavailability enhancement by surface coated natural biodegradable macromolecule chitosan based polymeric nanoparticles","volume":"128","author":"Ahmad","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0010","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/0378-5173(86)90215-2","article-title":"Aspects of the degradation kinetics of daunorubicin in aqueous solution","volume":"31","author":"Beijnen","year":"1986","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100632_bb0015","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.ijpharm.2011.11.035","article-title":"Lipomer of doxorubicin hydrochloride for enhanced oral bioavailability","volume":"423","author":"Benival","year":"2012","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100632_bb0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1634\/theoncologist.6-suppl_4-12","article-title":"Answering patients\u2019 needs: Oral Alternatives to Intravenous Therapy","volume":"6","author":"Borner","year":"2001","journal-title":"Oncologist"},{"key":"10.1016\/j.ijpx.2026.100632_bb0025","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.colsurfa.2009.01.031","article-title":"Pickering emulsions with bare silica","volume":"343","author":"Frelichowska","year":"2009","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.ijpx.2026.100632_bb0030","first-page":"1111","article-title":"Oral treatment of metastatic breast cancer (MBC) with capecitabine (X): what influences the decision-making process?","volume":"25","author":"Gornas","year":"2007"},{"key":"10.1016\/j.ijpx.2026.100632_bb0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0065-2164(08)70081-9","article-title":"Antitumor Anthracyclines Produced by Streptomyces peucetius","volume":"32","author":"Grein","year":"1987","journal-title":"Adv. Appl. Microbiol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0040","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.biomaterials.2014.10.059","article-title":"Layer-by-layer assembled milk protein coated magnetic nanoparticle enabled oral drug delivery with high stability in stomach and enzyme-responsive release in small intestine","volume":"39","author":"Huang","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2026.100632_bb0045","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jcis.2018.02.076","article-title":"Self-assembled and pH-sensitive mixed micelles as an intracellular doxorubicin delivery system","volume":"523","author":"Jafarzadeh-Holagh","year":"2018","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0050","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jcis.2011.09.073","article-title":"Investigation into the potential ability of Pickering emulsions (food-grade particles) to enhance the oxidative stability of oil-in-water emulsions","volume":"366","author":"Kargar","year":"2012","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0055","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1039\/c4ra00195h","article-title":"The development of chitosan based microcapsules as delivery vehicles for orally administered daunorubicin","volume":"4","author":"Lam","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.ijpx.2026.100632_bb0060","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.cocis.2014.07.003","article-title":"Pickering stabilization of foams and emulsions with particles of biological origin","volume":"19","author":"Lam","year":"2014","journal-title":"Curr. Opin. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1200\/JCO.1997.15.1.110","article-title":"Patient preferences for oral versus intravenous palliative chemotherapy","volume":"15","author":"Liu","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0070","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.microc.2009.03.005","article-title":"Rapid analysis of anthracycline antibiotics doxorubicin and daunorubicin by microchip capillary electrophoresis","volume":"92","author":"Lu","year":"2009","journal-title":"Microchem. J."},{"key":"10.1016\/j.ijpx.2026.100632_bb0075","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/0731-7085(86)80057-7","article-title":"Degradation of doxorubicin and daunorubicin in human and rabbit biological fluids","volume":"4","author":"Maniez-Devos","year":"1986","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.ijpx.2026.100632_bb0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.drudis.2012.08.004","article-title":"Oral delivery of anticancer drugs I: general considerations","volume":"18","author":"Mazzaferro","year":"2013","journal-title":"Drug Discov. Today"},{"key":"10.1016\/j.ijpx.2026.100632_bb0085","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.addr.2012.11.005","article-title":"Pharmaceutical nanotechnology for oral delivery of anticancer drugs","volume":"65","author":"Mei","year":"2013","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"4","key":"10.1016\/j.ijpx.2026.100632_bb0090","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/s40262-015-0242-x","article-title":"Oral bioavailability: issues and solutions via nanoformulations","volume":"54","author":"Pathak","year":"2015","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.ijpx.2026.100632_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/803789","article-title":"The Influence of pH and Temperature on the Stability of N-[(Piperidine)methylene]daunorubicin Hydrochloride and a Comparison of the Stability of Daunorubicin and its four New Amidine Derivatives in Aqueous Solutions","volume":"2014","author":"Piekarski","year":"2014","journal-title":"Scientific World Journal"},{"key":"10.1016\/j.ijpx.2026.100632_bb0100","doi-asserted-by":"crossref","first-page":"2490","DOI":"10.1039\/D2TB02670H","article-title":"Interaction of polyelectrolyte-shell cubosomes with serum albumin for triggering drug release in gastrointestinal cancer","volume":"11","author":"Pimenta","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.ijpx.2026.100632_bb0105","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.colsurfa.2012.11.040","article-title":"Micron-sized antibubbles with tunable stability","volume":"419","author":"Poortinga","year":"2013","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.ijpx.2026.100632_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125309","article-title":"Microbubble-encapsulation of actives for controlled release and its application to the taste-masking of acetaminophen","volume":"672","author":"Poortinga","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100632_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2024.121780","article-title":"Use of novel taurine-chitosan mediated liposomes for enhancing the oral absorption of doxorubicin via the TAUT transporter","volume":"329","author":"Qin","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100632_bb0120","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.jpba.2013.05.007","article-title":"A stability-indicating, ion-pairing, reversed-phase liquid chromatography method for studies of daunorubicin degradation in i.v. infusion fluids","volume":"83","author":"Respaud","year":"2013","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100632_bb0125","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.3390\/molecules28062504","article-title":"Pickering emulsions based in inorganic solid particles: from product development to food applications","volume":"28","author":"Ribeiro","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.ijpx.2026.100632_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1208\/s12248-025-01016-x","article-title":"Gastrointestinal Bile salt concentrations in healthy adults under fasted and fed conditions: a systematic review and meta-analysis for mechanistic physiologically-based pharmacokinetic (PBPK) modelling","volume":"27","author":"Santos","year":"2025","journal-title":"AAPS J."},{"key":"10.1016\/j.ijpx.2026.100632_bb0135","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat. Methods"},{"issue":"11","key":"10.1016\/j.ijpx.2026.100632_bb0140","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.3390\/molecules27113401","article-title":"The role of bile acids in the human body and in the development of diseases","volume":"27","author":"Shulpekova","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.ijpx.2026.100632_bb0145","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.2147\/IJN.S164518","article-title":"Advancements in the oral delivery of docetaxel: challenges, current state-of-the-art and future trends","volume":"13","author":"Sohail","year":"2018","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100632_bb0150","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1166\/jbn.2016.2227","article-title":"Sodium dodecyl sulfate-modified doxorubicin-loaded chitosan-lipid nanocarrier with multi polysaccharide-lecithin nanoarchitecture for augmented bioavailability and stability of oral administration in vitro and in vivo","volume":"12","author":"Su","year":"2016","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.122427","article-title":"Permeation enhancers loaded bilosomes for improved intestinal absorption and cytotoxic activity of doxorubicin","volume":"630","author":"Sultan","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100632_bb0160","series-title":"Cancer Immunotherapy","first-page":"101","article-title":"Cytotoxic Chemotherapy in Clinical Treatment of Cancer","author":"Thirumaran","year":"2007"},{"key":"10.1016\/j.ijpx.2026.100632_bb0165","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.foodres.2012.03.007","article-title":"Effect of emulsifier type against the action of bile salts at oil-water interfaces","volume":"48","author":"Torcello-G\u00f3mez","year":"2012","journal-title":"Food Res. Int."},{"key":"10.1016\/j.ijpx.2026.100632_bb0170","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1080\/21691401.2019.1581791","article-title":"Development and evaluation of doxorubicin self nanoemulsifying drug delivery system with Nigella Sativa oil against human hepatocellular carcinoma","volume":"47","author":"Usmani","year":"2019","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0175","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1002\/jobm.201200302","article-title":"Regulation of daunorubicin biosynthesis in Streptomyces peucetius - feed forward and feedback transcriptional control","volume":"53","author":"Vasanthakumar","year":"2013","journal-title":"J. Basic Microbiol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0180","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jcis.2010.05.089","article-title":"Interfacial displacement of nanoparticles by surfactant molecules in emulsions","volume":"349","author":"Vashisth","year":"2010","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0185","doi-asserted-by":"crossref","DOI":"10.1103\/PhysRevLett.96.178301","article-title":"Dynamics of surfactant-driven fracture of particle rafts","volume":"96","author":"Vella","year":"2006","journal-title":"Phys. Rev. Lett."},{"key":"10.1016\/j.ijpx.2026.100632_bb0190","first-page":"203","article-title":"Synthesis and antitumor efficacy of daunorubicin-loaded magnetic nanoparticles","volume":"6","author":"Wang","year":"2011","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100632_bb0195","doi-asserted-by":"crossref","first-page":"4633","DOI":"10.1002\/smll.201600877","article-title":"Recent studies of pickering emulsions: particles make the difference","volume":"12","author":"Wu","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.ijpx.2026.100632_bb0200","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1021\/acsabm.9b01119","article-title":"Preparation, characterization, and release behavior of doxorubicin hydrochloride from dual cross-linked chitosan\/alginate hydrogel beads","volume":"3","author":"Wu","year":"2020","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.ijpx.2026.100632_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.133063","article-title":"Hyaluronic acid nanoparticles for targeted oral delivery of doxorubicin: lymphatic transport and CD44 engagement","volume":"273","author":"Wu","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2026.100632_bb0210","series-title":"Construction of Pickering Double Emulsions Based on Xanthan Gum \/ Lysozyme Nanoparticles: Structure , Stability , and Co-Encapsulation of Epigallocatechin Gallate and \u03b2 -Carotene","author":"Yin","year":"2025"},{"key":"10.1016\/j.ijpx.2026.100632_bb0215","doi-asserted-by":"crossref","first-page":"11845","DOI":"10.1039\/D1SC02596A","article-title":"Conversion of bile salts from inferior emulsifier to efficient smart emulsifier assisted by negatively charged nanoparticles at low concentrations","volume":"12","author":"Zhang","year":"2021","journal-title":"Chem. Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2022.102688","article-title":"Advances in antibubble formation and potential applications","volume":"305","author":"Zia","year":"2022","journal-title":"Adv. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2023.09.007","article-title":"Preparation of acid-responsive antibubbles from CaCO3-based Pickering emulsions","author":"Zia","year":"2023","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.ijpx.2026.100632_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2024.134935","article-title":"Influence of emulsification conditions on the preparation of nanoparticle-stabilized antibubbles: high-shear homogenization versus premix membrane emulsification","volume":"701","author":"Zia","year":"2024","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:12:22Z","timestamp":1793031142000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156726001520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S2590156726001520"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100632","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bile acid triggered release of daunorubicin from silica nanoparticle-stabilized antibubbles","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100632","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100632"}}