{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:56Z","timestamp":1793032916707,"version":"4.5.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T00:00:00Z","timestamp":1786406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008559","name":"Tarim University","doi-asserted-by":"publisher","award":["TDZKBS202527"],"award-info":[{"award-number":["TDZKBS202527"]}],"id":[{"id":"10.13039\/501100008559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008559","name":"Tarim University","doi-asserted-by":"publisher","award":["TDZKJQ202603"],"award-info":[{"award-number":["TDZKJQ202603"]}],"id":[{"id":"10.13039\/501100008559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100637","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T23:33:05Z","timestamp":1786577585000},"page":"100637","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Triple-layered nanogel for targeted and sustained delivery of florfenicol against bacterial enteritis"],"prefix":"10.1016","volume":"12","author":[{"given":"Tianhui","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingwang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yidan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aizhi","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samah Attia","family":"Algharib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Usman","family":"Ghani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuge","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanhe","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.ijpx.2026.100637_bb0005","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/vms3.825","article-title":"Antimicrobial drug resistance against Escherichia coli and its harmful effect on animal health","volume":"8","author":"Arbab","year":"2022","journal-title":"Vet. Med. Sci."},{"issue":"5","key":"10.1016\/j.ijpx.2026.100637_bb0010","first-page":"267","article-title":"Molecular serotyping of Shiga toxin-producing Escherichia coli (STEC) of animal origin in Iran reveals the presence of important non-O157 seropathotypes","volume":"14","author":"Askari Badouei","year":"2023","journal-title":"Vet. Res. Forum"},{"issue":"39","key":"10.1016\/j.ijpx.2026.100637_bb0015","doi-asserted-by":"crossref","first-page":"33523","DOI":"10.1021\/acsami.8b10064","article-title":"Ultratough, self-healing, and tissue-adhesive hydrogel for wound dressing","volume":"10","author":"Chen","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"1","key":"10.1016\/j.ijpx.2026.100637_bb0020","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2431645","article-title":"Comparison of Crohn\u2019s disease-associated adherent-invasive Escherichia coli (AIEC) from France and Hong Kong: results from the Pacific study","volume":"16","author":"Chevarin","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.ijpx.2026.100637_bb0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jconrel.2022.05.056","article-title":"Preparation and application of pH-responsive drug delivery systems","volume":"348","author":"Ding","year":"2022","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ijpx.2026.100637_bb0030","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1177\/10820132221125104","article-title":"Prevalence and molecular characterization of Shiga toxin-producing Escherichia coli in animal source foods and green leafy vegetables","volume":"30","author":"G\u00f6kmen","year":"2024","journal-title":"Food Sci. Technol. Int."},{"key":"10.1016\/j.ijpx.2026.100637_bb0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ijbiomac.2021.02.216","article-title":"Chitosan-based nanocarriers for encapsulation and delivery of curcumin: a review","volume":"179","author":"Hu","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100637_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/biom14010086","article-title":"Exploring PLGA-OH-CATH30 microspheres for oral therapy of Escherichia coli-induced enteritis","volume":"14","author":"Jiao","year":"2024","journal-title":"Biomolecules"},{"issue":"12","key":"10.1016\/j.ijpx.2026.100637_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics12121728","article-title":"In vitro microevolution and co-selection assessment of florfenicol impact on Escherichia coli resistance development","volume":"12","author":"Kerek","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.ijpx.2026.100637_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2021.102475","article-title":"Current progress and prospects of organic nanoparticles against bacterial biofilm","volume":"294","author":"Li","year":"2021","journal-title":"Adv. Colloid Interf. Sci."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100637_bb0055","article-title":"Population structure and antibiotic resistance of swine extraintestinal pathogenic Escherichia coli from China","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"issue":"4","key":"10.1016\/j.ijpx.2026.100637_bb0060","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1021\/acsnano.1c00204","article-title":"Dual-Dynamic-Bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.ijpx.2026.100637_bb0065","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/s41551-025-01354-3","article-title":"Enhancing phage therapy by coating single bacteriophage-infected bacteria with polymer to preserve phage vitality","volume":"9","author":"Lin","year":"2025","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijpx.2026.100637_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124499","article-title":"Florfenicol core-shell composite nanogels as oral administration for efficient treatment of bacterial enteritis","volume":"662","author":"Luo","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100637_bb0075","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3390\/gels11060380","article-title":"Nanogel dressing with targeted glucose reduction and pH\/hyaluronidase dual-responsive release for Synergetic therapy of diabetic bacterial wounds","volume":"11","author":"Luo","year":"2025","journal-title":"Gels"},{"key":"10.1016\/j.ijpx.2026.100637_bb0080","doi-asserted-by":"crossref","first-page":"541","DOI":"10.2147\/IJN.S484536","article-title":"Manipulated slow release of florfenicol hydrogels for effective treatment of anti-intestinal bacterial infections","volume":"20","author":"Luo","year":"2025","journal-title":"Int. J. Nanomedicine"},{"issue":"32","key":"10.1016\/j.ijpx.2026.100637_bb0085","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202503056","article-title":"Mannosylated MOF encapsulated in Lactobacillus biofilm for dual-targeting intervention against mammalian Escherichia coli infections","volume":"37","author":"Ma","year":"2025","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpx.2026.100637_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2020.117414","article-title":"Chitosan as a machine for biomolecule delivery: a review","volume":"256","author":"Mohammadi","year":"2021","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.ijpx.2026.100637_bb0095","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.2147\/IDR.S398951","article-title":"Phenotypic characterization and antibiograms of extended-spectrum beta-lactamase-producing Escherichia coli isolated at the human-animal-environment interface using a one health approach among households in Wakiso District, Uganda","volume":"16","author":"Muleme","year":"2023","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.ijpx.2026.100637_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120606","article-title":"Development of sodium carboxymethyl cellulose based polymeric microparticles for in situ hydrogel wound dressing formation","volume":"602","author":"Pagano","year":"2021","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.ijpx.2026.100637_bb0105","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1038\/s41564-021-00870-7","article-title":"Characterization of antimicrobial-resistant Gram-negative bacteria that cause neonatal sepsis in seven low- and middle-income countries","volume":"6","author":"Sands","year":"2021","journal-title":"Nat. Microbiol."},{"issue":"2","key":"10.1016\/j.ijpx.2026.100637_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/gels7020044","article-title":"Ionotropic gelation fronts in sodium carboxymethyl cellulose for hydrogel particle formation","volume":"7","author":"Sharratt","year":"2021","journal-title":"Gels"},{"issue":"18","key":"10.1016\/j.ijpx.2026.100637_bb0115","doi-asserted-by":"crossref","first-page":"21272","DOI":"10.1021\/acsami.1c02882","article-title":"Antibiofouling ultrathin Poly(amidoxime) membrane for enhanced U(VI) recovery from wastewater and seawater","volume":"13","author":"Sun","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.ijpx.2026.100637_bb0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.chemosphere.2016.04.072","article-title":"Prediction of joint algal toxicity of nano-CeO2\/nano-TiO2 and florfenicol: independent action surpasses concentration addition","volume":"156","author":"Wang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.ijpx.2026.100637_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2021.121249","article-title":"Infection microenvironment-related antibacterial nanotherapeutic strategies","volume":"280","author":"Wang","year":"2022","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.ijpx.2026.100637_bb0130","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1186\/s12866-025-04172-4","article-title":"Co-resistance and plasmid-mediated co-dissemination of florfenicol and azithromycin resistance in non-O157 Shiga toxin-producing Escherichia coli from cattle in Xinjiang, China","volume":"25","author":"Wang","year":"2025","journal-title":"BMC Microbiol."},{"issue":"28","key":"10.1016\/j.ijpx.2026.100637_bb0135","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adg9116","article-title":"Targeting and arginine-driven synergizing photodynamic therapy with nutritional immunotherapy nanosystems for combating MRSA biofilms","volume":"9","author":"Zhang","year":"2023","journal-title":"Sci. Adv."},{"issue":"12","key":"10.1016\/j.ijpx.2026.100637_bb0140","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1038\/s41564-024-01862-z","article-title":"Enteric bacterial infection stimulates remodelling of bile metabolites to promote intestinal homeostasis","volume":"9","author":"Zhang","year":"2024","journal-title":"Nat. Microbiol."},{"issue":"2","key":"10.1016\/j.ijpx.2026.100637_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.psj.2023.103373","article-title":"Effects of chitooligosaccharide on the in vitro antibacterial activity against avian Escherichia coli and the pharmacokinetics of florfenicol in healthy chickens","volume":"103","author":"Zhang","year":"2024","journal-title":"Poult. Sci."},{"issue":"36","key":"10.1016\/j.ijpx.2026.100637_bb0150","article-title":"A targeting singlet oxygen battery for multidrug-resistant bacterial deep-tissue infections","volume":"62","author":"Zhu","year":"2023","journal-title":"Angew. Chem. Int. Ed. Eng."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672600157X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672600157X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:15:04Z","timestamp":1793031304000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259015672600157X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":30,"alternative-id":["S259015672600157X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100637","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Triple-layered nanogel for targeted and sustained delivery of florfenicol against bacterial enteritis","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100637","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100637"}}