{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:40:54Z","timestamp":1793032854023,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014538","name":"Lembaga Pengelola Dana Pendidikan","doi-asserted-by":"publisher","award":["00517\/BPPT\/BPI.06\/9\/2024"],"award-info":[{"award-number":["00517\/BPPT\/BPI.06\/9\/2024"]}],"id":[{"id":"10.13039\/501100014538","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100640","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T16:04:42Z","timestamp":1786723482000},"page":"100640","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Impact of adsorption-based solidification on the pharmaceutical performance and antidyslipidemic efficacy of simvastatin\u2013ezetimibe SNEDDS"],"prefix":"10.1016","volume":"12","author":[{"given":"Sani Ega","family":"Priani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iyan","family":"Sopyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anis Yohana","family":"Chaerunisaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gofarana","family":"Wilar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100640_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16060763","article-title":"Enhancing oral bioavailability of simvastatin using uncoated and polymer-coated solid lipid nanoparticles","volume":"16","author":"Abd-Elghany","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0010","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s12035-022-03089-7","article-title":"Formulation and development of curcumin\u2013piperine-loaded S-SNEDDS for the treatment of Alzheimer\u2019s disease","volume":"60","author":"Ahmad","year":"2023","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0015","article-title":"Combined curcumin and lansoprazole-loaded bioactive solid self-nanoemulsifying drug delivery systems (Bio-ssnedds)","volume":"14","author":"Alshadidi","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125656","article-title":"Exploring mesoporous silica microparticles in pharmaceutical sciences: drug delivery and therapeutic insights","author":"Anas Al Tahan","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100640_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14112433","article-title":"Amidated pluronic decorated muco-penetrating self-nano emulsifying drug delivery system (SNEDDS) for improved anti-Salmonella typhi potential","volume":"14","author":"Arshad","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14061258","article-title":"Co-amorphous formation of simvastatin-ezetimibe: enhanced physical stability, bioavailability and cholesterol-lowering effects in LDLr\u2212\/\u2212mice","volume":"14","author":"Bahetibieke","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.mayocp.2025.01.018","article-title":"Impact of lipid-lowering combination therapy with statins and ezetimibe vs statin monotherapy on the reduction of cardiovascular outcomes: a meta-analysis","volume":"100","author":"Banach","year":"2025","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.ijpx.2026.100640_bb0040","doi-asserted-by":"crossref","DOI":"10.2147\/DDDT.S377686","article-title":"Development and evaluation of self-emulsifying drug-delivery system\u2013based tablets for simvastatin, a BCS class II drug","volume":"17","author":"Bashir","year":"2023","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ijpx.2026.100640_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16020163","article-title":"Effect of drug loading in mesoporous silica on amorphous stability and performance","volume":"16","author":"Bavnh\u00f8j","year":"2024","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.xphs.2020.10.020","article-title":"Capsaicin loaded solid SNEDDS for enhanced bioavailability and anticancer activity: in-vitro, in-silico, and in-vivo characterization","volume":"110","author":"Bhagwat","year":"2021","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijpx.2026.100640_bb0055","doi-asserted-by":"crossref","DOI":"10.5530\/jyp.2020.12s.40","article-title":"Nano co-crystal engineering technique to enhance the solubility of ezetimibe","volume":"12","author":"Bhandari","year":"2020","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.ijpx.2026.100640_bb0060","article-title":"Studies of the formation and stability of ezetimibe-cyclodextrin inclusion complexes","volume":"23","author":"Biernacka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2026.100640_bb0065","doi-asserted-by":"crossref","DOI":"10.1080\/10717544.2023.2288801","article-title":"Quality by design aided self-nano emulsifying drug delivery systems development for the oral delivery of benidipine: improvement of biopharmaceutical performance","volume":"31","author":"Buddhadev","year":"2024","journal-title":"Drug Deliv."},{"key":"10.1016\/j.ijpx.2026.100640_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12121194","article-title":"Self-nano-emulsifying drug-delivery systems: from the development to the current applications and challenges in oral drug delivery","author":"Buya","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13091388","article-title":"Quality-by-design-based development of a voxelotor self-nanoemulsifying drug-delivery system with improved biopharmaceutical attributes","volume":"13","author":"Buya","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2022.103117","article-title":"Designing and development of omega-3 fatty acid based self-nanoemulsifying drug delivery system (SNEDDS) of docetaxel with enhanced biopharmaceutical attributes for management of breast cancer","volume":"68","author":"Chaudhuri","year":"2022","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0085","doi-asserted-by":"crossref","DOI":"10.2174\/0113816128296705240327065131","article-title":"A comprehensive guide to the development, evaluation, and future prospects of self-nanoemulsifying drug delivery systems for poorly water-soluble drugs","volume":"30","author":"Chauhan","year":"2024","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.ijpx.2026.100640_bb0090","doi-asserted-by":"crossref","DOI":"10.1208\/s12249-024-03032-0","article-title":"Valsartan loaded solid self-nanoemulsifying delivery system to enhance oral absorption and bioavailability","volume":"26","author":"Chen","year":"2025","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2026.100640_bb0095","doi-asserted-by":"crossref","DOI":"10.1517\/17425247.2015.999038","article-title":"Self-nano-emulsifying drug delivery systems: an update of the biopharmaceutical aspects","author":"Cherniakov","year":"2015","journal-title":"Expert Opin. Drug Deliv."},{"key":"10.1016\/j.ijpx.2026.100640_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.apt.2022.103716","article-title":"Development and exploration on flowability of solid self-nanoemulsifying drug delivery system of morin hydrate","volume":"33","author":"Dangre","year":"2022","journal-title":"Adv. Powder Technol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0105","doi-asserted-by":"crossref","DOI":"10.1007\/s13346-021-01071-9","article-title":"Lipid-based emulsion drug delivery systems \u2014 a comprehensive review","author":"Dhaval","year":"2022","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.ijpx.2026.100640_bb0110","article-title":"Ezetimibe-loaded nanostructured lipid carrier for oral delivery: response surface methodology; in vitro characterization and assessing the antihyperlipidemic effect in rats","author":"Elkhayat","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.ijpx.2026.100640_bb0115","doi-asserted-by":"crossref","DOI":"10.1007\/s11883-023-01142-x","article-title":"Fixed combination for the treatment of dyslipidaemia","author":"Ferri","year":"2023","journal-title":"Curr. Atheroscler. Rep."},{"key":"10.1016\/j.ijpx.2026.100640_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsps.2021.04.024","article-title":"Design and characterization of propolis extract loaded self-nano emulsifying drug delivery system as immunostimulant","volume":"29","author":"Fitria","year":"2021","journal-title":"Saudi Pharm. J."},{"key":"10.1016\/j.ijpx.2026.100640_bb0125","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ejpb.2023.10.013","article-title":"Oral self-nanoemulsifying drug delivery systems for enhancing bioavailability and anticancer potential of fosfestrol: in vitro and in vivo characterization","volume":"193","author":"Galatage","year":"2023","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijpx.2026.100640_bb0130","article-title":"Palbociclib-letrozole loaded solid self-nano emulsifying drug delivery system for oral treatment of breast cancer: In-vitro and In-vivo characterization","volume":"104","author":"Galatage","year":"2025","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0135","article-title":"Design and evaluation of combined atorvastatin and ezetimibe optimized self- nano emulsifying drug delivery system","volume":"60","author":"Gardouh","year":"2020","journal-title":"J. Drug Deliv. Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.partic.2023.12.006","article-title":"Optimization of variables and assessment of in-vitro and in-vivo antihyperlipidemic activity of Eudragit RS nanoparticles containing simvastatin","volume":"90","author":"Gidwani","year":"2024","journal-title":"Particuology"},{"key":"10.1016\/j.ijpx.2026.100640_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14050912","article-title":"Preformulation studies of ezetimibe-simvastatin solid dispersions in the development of fixed-dose combinations","volume":"14","author":"G\u00f3rniak","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2018.11.002","article-title":"2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA guideline on the management of blood cholesterol: executive summary","volume":"73","author":"Grundy","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0155","doi-asserted-by":"crossref","DOI":"10.3390\/ph17040500","article-title":"Solid self-nanoemulsifying drug delivery systems of furosemide: in vivo proof of concept for enhanced predictable therapeutic response","volume":"17","author":"Gul","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ijpx.2026.100640_bb0160","doi-asserted-by":"crossref","first-page":"22584","DOI":"10.1038\/s41598-024-71980-5","article-title":"Impact of oil type on the development and oral bioavailability of self-nanoemulsifying drug delivery systems containing simvastatin","volume":"14","author":"Hamdy","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2026.100640_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-49277-w","article-title":"Developing a model to predict the early risk of hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL): a translational study","volume":"13","author":"Hernandez-Baixauli","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2026.100640_bb0170","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics12101510","article-title":"Development of bedaquiline-loaded SNEDDS using quality by design (QbD) approach to improve biopharmaceutical attributes for the management of multidrug-resistant tuberculosis (MDR-TB)","volume":"12","author":"Jahan","year":"2023","journal-title":"Antibiotics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0175","article-title":"Integrative nanoparticulate strategies with SEDDS for controlled drug release: from lipid platforms to smart delivery systems","author":"Jin","year":"2025","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ijpx.2026.100640_bb0180","doi-asserted-by":"crossref","DOI":"10.1208\/s12249-023-02725-2","article-title":"A quality by design approach for developing SNEDDS loaded with vemurafenib for enhanced oral bioavailability","volume":"25","author":"Jvus","year":"2024","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2026.100640_bb0185","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1055\/a-1332-2037","article-title":"Optimization and evaluation of self-nanoemulsifying drug delivery system for enhanced bioavailability of plumbagin","volume":"88","author":"Kamble","year":"2022","journal-title":"Planta Med."},{"key":"10.1016\/j.ijpx.2026.100640_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25071703","article-title":"Bioactive self-nanoemulsifying drug delivery systems (Bio-SNEDDS) for combined oral delivery of curcumin and piperine","volume":"25","author":"Kazi","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.ijpx.2026.100640_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113361","article-title":"Atorvastatin-loaded pro-nanolipospheres with ameliorated oral bioavailability and antidyslipidemic activity","volume":"227","author":"Khafagy","year":"2023","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijpx.2026.100640_bb0200","doi-asserted-by":"crossref","DOI":"10.1007\/s40005-021-00543-x","article-title":"Pharmaceutical application and development of fixed-dose combination: dosage form review","author":"Kim","year":"2021","journal-title":"J. Pharm. Investig."},{"key":"10.1016\/j.ijpx.2026.100640_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/S0140-6736(22)00916-3","article-title":"Long-term efficacy and safety of moderate-intensity statin with ezetimibe combination therapy versus high-intensity statin monotherapy in patients with atherosclerotic cardiovascular disease (RACING): a randomised, open-label, non-inferiority trial","volume":"400","author":"Kim","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2026.100640_bb0210","article-title":"Surfactant\u2013particle engineering hybrids: emerging strategies for enhancing solubility and oral bioavailability of poorly water-soluble drugs","author":"Kim","year":"2026","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0215","doi-asserted-by":"crossref","DOI":"10.3390\/ph12010040","article-title":"Physical stability and viscoelastic properties of co-amorphous ezetimibe\/simvastatin system","volume":"12","author":"Knapik-Kowalczuk","year":"2019","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ijpx.2026.100640_bb0220","article-title":"Investigation of magnesium aluminometasilicate (Neusilin US2) based surface solid dispersion of sorafenib tosylate using QbD approach: in vitro and in vivo pharmacokinetic study","volume":"12","author":"Kumar Panda","year":"2024","journal-title":"ADMET DMPK"},{"key":"10.1016\/j.ijpx.2026.100640_bb0225","first-page":"36","article-title":"Improving lovastatin absorption using supersaturated-self nanoemulsifying drug delivery system (SNEDDS)","volume":"15","author":"Lestari","year":"2025","journal-title":"Int. J. Drug Deliv. Technol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0230","article-title":"Global trends in the epidemiology and management of dyslipidemia","author":"Liu","year":"2022","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.ijpx.2026.100640_bb0235","doi-asserted-by":"crossref","DOI":"10.1208\/s12249-020-01687-z","article-title":"Understanding concomitant physical and chemical transformations of simvastatin during dry ball milling","volume":"21","author":"Modhave","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2026.100640_bb0240","doi-asserted-by":"crossref","first-page":"27724","DOI":"10.1038\/s41598-024-73760-7","article-title":"Development and characterization of a self-nano emulsifying drug delivery system (SNEDDS) for Ornidazole to improve solubility and oral bioavailability of BCS class II drugs","volume":"14","author":"Mohite","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2026.100640_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/ph14111089","article-title":"In vitro evaluation of a solid supersaturated self nanoemulsifying drug delivery system (Super-snedds) of aprepitant for enhanced solubility","volume":"14","author":"Nazl\u0131","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ijpx.2026.100640_bb0250","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12040365","article-title":"Current status of supersaturable self-emulsifying drug delivery systems","author":"Park","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0255","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14081694","article-title":"Development of alectinib-suspended SNEDDS for enhanced solubility and dissolution","volume":"14","author":"Park","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0260","doi-asserted-by":"crossref","DOI":"10.3390\/cells11111795","article-title":"Poloxamer 407 induces hypertriglyceridemia but decreases atherosclerosis in Ldlr\u2212\/\u2212 mice","volume":"11","author":"Peng","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.ijpx.2026.100640_bb0265","doi-asserted-by":"crossref","DOI":"10.2147\/DDDT.S550340","article-title":"Formulation strategies for ezetimibe and its combinations: advancing biopharmaceutical and therapeutic potential","author":"Priani","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ijpx.2026.100640_bb0270","doi-asserted-by":"crossref","DOI":"10.1155\/jnt\/8346300","article-title":"QbD-based development of self-nanoemulsifying drug delivery system for codelivery of simvastatin and ezetimibe with enhanced in vitro dissolution","volume":"2025","author":"Priani","year":"2025","journal-title":"J. Nanotechnol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.onano.2025.100252","article-title":"Recent progress in supersaturation-based SNEDDS: formulation, mechanism, and biopharmaceutical performance","author":"Priani","year":"2025","journal-title":"OpenNano"},{"key":"10.1016\/j.ijpx.2026.100640_bb0280","doi-asserted-by":"crossref","DOI":"10.2147\/DDDT.S577016","article-title":"Solidification of SNEDDS using mesoporous carriers (2020\u20132025): a review of design, biopharmaceutical enhancement, and therapeutic impact","author":"Priani","year":"2025","journal-title":"Drug Des. Dev. Ther."},{"key":"10.1016\/j.ijpx.2026.100640_bb0285","doi-asserted-by":"crossref","DOI":"10.3390\/ph15091135","article-title":"Preparation of solid self-nanoemulsifying drug delivery systems (S-SNEDDS) by co-extrusion of liquid SNEDDS and polymeric carriers\u2014a new and promising formulation approach to improve the solubility of poorly water-soluble drugs","volume":"15","author":"Schmied","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.ijpx.2026.100640_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13050627","article-title":"Combined self-nanoemulsifying and solid dispersion systems showed enhanced cinnarizine release in hypochlorhydria\/achlorhydria dissolution model","volume":"13","author":"Shahba","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0295","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14071486","article-title":"Solid self-nano emulsifying nanoplatform loaded with tamoxifen and resveratrol for treatment of breast cancer","volume":"14","author":"Shrivastava","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125659","article-title":"Ellagic acid-loaded chitosan nanoparticles as an approach for mitigating oxidative stress and liver damage in Poloxamer-407-induced hyperlipidemia in mice: development and optimization through 3 level full factorial design","volume":"677","author":"Sobhy","year":"2025","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100640_bb0305","doi-asserted-by":"crossref","DOI":"10.56499\/jppres23.1898_12.6.1079","article-title":"Multicomponent crystals: solubility enhancement of simvastatin using arginine and glycine coformers","volume":"12","author":"Sopyan","year":"2024","journal-title":"J. Pharm. Pharmacogn. Res."},{"key":"10.1016\/j.ijpx.2026.100640_bb0310","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9883352","article-title":"Current management guidelines on hyperlipidemia: the silent killer","volume":"2021","author":"Su","year":"2021","journal-title":"J. Lipids"},{"key":"10.1016\/j.ijpx.2026.100640_bb0315","doi-asserted-by":"crossref","DOI":"10.1186\/s40360-023-00649-y","article-title":"Pharmacokinetics and bioequivalence of Ezetimibe tablet versus Ezetrol\u00ae:an open-label, randomized, two-sequence crossover study in healthy Chinese subjects","volume":"24","author":"Sun","year":"2023","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0320","doi-asserted-by":"crossref","DOI":"10.31083\/j.fbl2812349","article-title":"Unlocking the potential: synergistic effects of solid SNEDDS and lyophilized solid dispersion to enhance stability attributes","volume":"28","author":"Tashish","year":"2023","journal-title":"Front. Biosci. Landmark"},{"key":"10.1016\/j.ijpx.2026.100640_bb0325","doi-asserted-by":"crossref","DOI":"10.4103\/ijp.IJP_133_19","article-title":"Fixed-dose combinations: an essential for rational preparation","author":"Thangaraju","year":"2021","journal-title":"Indian J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100640_bb0330","doi-asserted-by":"crossref","DOI":"10.2147\/IJN.S308790","article-title":"Formulation and evaluation of Linum usitatissimum mucilage-based nanoparticles for effective delivery of ezetimibe","volume":"16","author":"Tulain","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100640_bb0335","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17010063","article-title":"Self-emulsifying drug delivery systems (SEDDS): transition from liquid to solid\u2014a comprehensive review of formulation, characterization, applications, and future trends","author":"Uttreja","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100640_bb0340","article-title":"Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances","volume":"20","author":"Verma","year":"2022","journal-title":"Curr. Drug Deliv."},{"key":"10.1016\/j.ijpx.2026.100640_bb0345","doi-asserted-by":"crossref","DOI":"10.1002\/jps.23970","article-title":"Lipid-based formulations solidified via adsorption onto the mesoporous carrier neusilin\u00ae US2: effect of drug type and formulation composition on in vitro pharmaceutical performance","volume":"103","author":"Williams","year":"2014","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.ijpx.2026.100640_bb0350","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.123.031615","article-title":"Upfront combination of statin and ezetimibe for patients with acute coronary syndrome: time for a new approach?","author":"Ya\u2019qoub","year":"2023","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.ijpx.2026.100640_bb0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123219","article-title":"Development and pharmacokinetic evaluation of Neusilin\u00ae US2-based S-SNEDDS tablets for bosentan: fasted and fed states bioavailability, IVIS\u00ae real-time biodistribution, and ex-vivo imaging","volume":"643","author":"Yilmaz Usta","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100640_bb0360","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.106330","article-title":"Synthesis and evaluation of transdermal rosuvastatin-loaded ultradeformable vesicles: restoring the serum lipid profile in poloxamer 407-caused hyperlipidemia","volume":"102","author":"Younas","year":"2024","journal-title":"J. Drug Delivery Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100640_bb0365","doi-asserted-by":"crossref","DOI":"10.3390\/polym14051055","article-title":"Formulation of self-nanoemulsifying drug delivery system of cephalexin: physiochemical characterization and antibacterial evaluation","volume":"14","author":"Zafar","year":"2022","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.ijpx.2026.100640_bb0370","article-title":"An update on oral drug delivery via intestinal lymphatic transport","author":"Zhang","year":"2021","journal-title":"Acta Pharm. Sin. B"}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672600160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672600160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:14:30Z","timestamp":1793031270000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259015672600160X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":74,"alternative-id":["S259015672600160X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100640","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of adsorption-based solidification on the pharmaceutical performance and antidyslipidemic efficacy of simvastatin\u2013ezetimibe SNEDDS","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100640","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100640"}}