{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:07Z","timestamp":1793032867917,"version":"4.5.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T00:00:00Z","timestamp":1786752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001858","name":"Sweden's Innovation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007633","name":"Swedish Foundation for Strategic Environmental Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100641","type":"journal-article","created":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T22:00:07Z","timestamp":1786917607000},"page":"100641","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Self-assembly of sodium caprate in simulated intestinal fluids and with a therapeutic peptide: A small-angle neutron scattering study"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2328-5838","authenticated-orcid":false,"given":"Shahina","family":"Akter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3942-5730","authenticated-orcid":false,"given":"L. Magnus","family":"Bergstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0895-1180","authenticated-orcid":false,"given":"Per","family":"Hansson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Kohlbrecher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Doutch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9556-2695","authenticated-orcid":false,"given":"Shakhawath","family":"Hossain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8418-4956","authenticated-orcid":false,"given":"Per","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100641_bb0005","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.softx.2015.06.001","article-title":"GROMACS: high performance molecular simulations through multi-level parallelism from laptops to supercomputers","volume":"1-2","author":"Abraham","year":"2015","journal-title":"SoftwareX"},{"issue":"22","key":"10.1016\/j.ijpx.2026.100641_bb0010","doi-asserted-by":"crossref","first-page":"13514","DOI":"10.1039\/D6CP00414H","article-title":"Aggregation behavior of sodium caprate under different pH, concentration, and intestinal fluid conditions: a coarse-grained molecular dynamics study comparing Martini 2 and Martini 3","volume":"28","author":"Akter","year":"2026","journal-title":"Phys. Chem. Chem. Phys."},{"issue":"7","key":"10.1016\/j.ijpx.2026.100641_bb0015","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1007\/s13346-025-01978-7","article-title":"An effort to enhance the clinical translatability of caprate-based tablet formulations in gastric peptide delivery","volume":"16","author":"Bardonnet","year":"2026","journal-title":"Drug Deliv. Transl. Res."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0020","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.xphs.2020.10.066","article-title":"In vitro and in Vivo evaluation of 3D printed capsules with pressure triggered release mechanism for oral peptide delivery","volume":"110","author":"Berg","year":"2021","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1021\/acs.molpharmaceut.1c00724","article-title":"Impact of intestinal concentration and colloidal structure on the permeation-enhancing efficiency of sodium caprate in the rat","volume":"19","author":"Berg","year":"2022","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0030","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/s41421-022-00405-2","article-title":"Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues","volume":"8","author":"Bo","year":"2022","journal-title":"Cell Discov."},{"key":"10.1016\/j.ijpx.2026.100641_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jcis.2025.139373","article-title":"Structural determination of self-assembled aggregates formed by a therapeutic cyclical peptide and an ionic surfactant in aqueous solution","volume":"704","author":"Brunzell","year":"2026","journal-title":"J. Colloid Interface Sci."},{"issue":"467","key":"10.1016\/j.ijpx.2026.100641_bb0040","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aar7047","article-title":"Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist","volume":"10","author":"Buckley","year":"2018","journal-title":"Sci. Transl. Med."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0045","doi-asserted-by":"crossref","DOI":"10.1063\/1.2408420","article-title":"Canonical sampling through velocity rescaling","volume":"126","author":"Bussi","year":"2007","journal-title":"J. Chem. Phys."},{"issue":"14","key":"10.1016\/j.ijpx.2026.100641_bb0050","doi-asserted-by":"crossref","first-page":"3658","DOI":"10.1021\/jp066500h","article-title":"Self-aggregation of Ionic C10 surfactants having different headgroups with special reference to the behavior of decyltrimethylammonium bromide in different salt environments: a calorimetric study with energetic analysis","volume":"111","author":"Chakraborty","year":"2007","journal-title":"J. Phys. Chem. B"},{"issue":"48","key":"10.1016\/j.ijpx.2026.100641_bb0055","doi-asserted-by":"crossref","first-page":"10869","DOI":"10.1021\/acs.jpcb.7b08622","article-title":"Characterization of solubilizing nanoaggregates present in different versions of simulated intestinal fluid","volume":"121","author":"Clulow","year":"2017","journal-title":"J. Phys. Chem. B"},{"issue":"8","key":"10.1016\/j.ijpx.2026.100641_bb0060","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/jssc.200800567","article-title":"Evaluation of indole-based probes for high-throughput screening of drug binding to human serum albumin: analysis by high-performance affinity chromatography","volume":"32","author":"Conrad","year":"2009","journal-title":"J. Sep. Sci."},{"key":"10.1016\/j.ijpx.2026.100641_bb0065","article-title":"Decanoate-induced permeation enhancement: distinct membrane effects of micellar and vesicular colloids","volume":"5","author":"Cunha","year":"2026","journal-title":"Pharmacol. Res. Rep."},{"key":"10.1016\/j.ijpx.2026.100641_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2026.127237","article-title":"Impact of dosage form on the pharmacokinetics of octreotide after oral administration with permeation enhancers","author":"Fredholt","year":"2026","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100641_bb0075","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1007\/BF01421709","article-title":"Determination of micelle structure and charge by neutron small-angle scattering","volume":"261","author":"Hayter","year":"1983","journal-title":"Colloid Polym. Sci."},{"issue":"3\u20134","key":"10.1016\/j.ijpx.2026.100641_bb0080","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1017\/S0033583508004721","article-title":"Interactions of surfactants with lipid membranes","volume":"41","author":"Heerklotz","year":"2008","journal-title":"Q. Rev. Biophys."},{"issue":"11","key":"10.1016\/j.ijpx.2026.100641_bb0085","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1107\/S0907444910017658","article-title":"Small-angle neutron scattering and contrast variation: a powerful combination for studying biological structures","volume":"66","author":"Heller","year":"2010","journal-title":"Acta Crystallogr. Sect. D"},{"issue":"2","key":"10.1016\/j.ijpx.2026.100641_bb0090","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1208\/s12249-018-1289-4","article-title":"Aggregation Behavior of Medium Chain Fatty Acids Studied by Coarse-Grained Molecular Dynamics simulation","volume":"20","author":"Hossain","year":"2019","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2026.100641_bb0095","doi-asserted-by":"crossref","first-page":"4226","DOI":"10.1021\/acs.molpharmaceut.0c00668","article-title":"Influence of bile composition on membrane incorporation of transient permeability enhancers","volume":"17","author":"Hossain","year":"2020","journal-title":"Mol. Pharm."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/pr10010029","article-title":"Explicit-pH coarse-grained molecular dynamics simulations enable insights into restructuring of intestinal colloidal aggregates with permeation enhancers","volume":"10","author":"Hossain","year":"2022","journal-title":"Processes"},{"issue":"47","key":"10.1016\/j.ijpx.2026.100641_bb0105","doi-asserted-by":"crossref","first-page":"19180","DOI":"10.1039\/D3NR05571J","article-title":"Revealing the interaction between peptide drugs and permeation enhancers in the presence of intestinal bile salts","volume":"15","author":"Hossain","year":"2023","journal-title":"Nanoscale"},{"issue":"2","key":"10.1016\/j.ijpx.2026.100641_bb0110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/BF02767918","article-title":"Thermodynamic and aggregation behavior of mixed micellar systems of sodium decanoate and ethoxylated alcohols in water at 25\u00b0C","volume":"26","author":"Huang","year":"1997","journal-title":"J. Solut. Chem."},{"key":"10.1016\/j.ijpx.2026.100641_bb0115","unstructured":"Instrument, S.-I.S.A.N.S. n.d."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100641_bb0120","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1021\/la020672y","article-title":"Effect of premicellar aggregation on the pKa of fatty acid soap solutions","volume":"19","author":"Kanicky","year":"2003","journal-title":"Langmuir"},{"issue":"19","key":"10.1016\/j.ijpx.2026.100641_bb0125","doi-asserted-by":"crossref","first-page":"11864","DOI":"10.1039\/D4NR04508D","article-title":"More than a delivery system: the evolving role of lipid-based nanoparticles","volume":"17","author":"Karmaker","year":"2025","journal-title":"Nanoscale"},{"key":"10.1016\/j.ijpx.2026.100641_bb0130","series-title":"\u201cHahn-Meitner-Institut, 14109 Berlin\u201d, The new \u2018BerSANS-PC\u2019 Software for Reduction and Treatment of Small Angle Neutron Scattering Data","author":"Keiderling, U. and G.S","year":"2002"},{"issue":"7","key":"10.1016\/j.ijpx.2026.100641_bb0135","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1002\/jps.24470","article-title":"Fasted-state simulated intestinal fluid \u201cFaSSIF-C\u201d, a cholesterol containing intestinal model medium for in vitro drug delivery development","volume":"104","author":"Khoshakhlagh","year":"2015","journal-title":"J. Pharm. Sci."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0140","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1021\/acs.molpharmaceut.1c00689","article-title":"In silico-based experiments on mechanistic interactions between several intestinal permeation enhancers with a lipid bilayer model","volume":"19","author":"Kneiszl","year":"2022","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijpx.2026.100641_bb0145","series-title":"Martinize2 and vermouth: unified framework for topology generation","author":"Kroon","year":"2025"},{"key":"10.1016\/j.ijpx.2026.100641_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.sbi.2022.102375","article-title":"Small-angle neutron scattering contrast variation studies of biological complexes: challenges and triumphs","volume":"74","author":"Krueger","year":"2022","journal-title":"Curr. Opin. Struct. Biol."},{"key":"10.1016\/j.ijpx.2026.100641_bb0155","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.addr.2009.09.006","article-title":"Safety and Efficacy of Sodium Caprate in Promoting Oral Drug Absorption: from in Vitro to the Clinic","volume":"61","author":"Maher","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpx.2026.100641_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2023.115086","article-title":"Safety of surfactant excipients in oral drug formulations","volume":"202","author":"Maher","year":"2023","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"10","key":"10.1016\/j.ijpx.2026.100641_bb0165","doi-asserted-by":"crossref","DOI":"10.5650\/jos1996.45.1087","article-title":"Small-angle neutron scattering analysis of self-assembly in surfactant systems","volume":"45","author":"Matsuoka","year":"1996","journal-title":"J. Jpn. Oil Chem. Soc."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0170","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0927-7757(02)00336-9","article-title":"Thermodynamic and kinetic stability. Properties of micelles and vesicles formed by the decanoic acid\/decanoate system","volume":"213","author":"Morigaki","year":"2003","journal-title":"Colloids Surf. A Physicochem. Eng. Aspects"},{"key":"10.1016\/j.ijpx.2026.100641_bb0175","series-title":"Amphiphiles: Molecular Assembly and Applications","first-page":"1","article-title":"Amphiphilic Surfactants and Amphiphilic Polymers: Principles of Molecular Assembly","author":"Nagarajan","year":"2011"},{"issue":"14","key":"10.1016\/j.ijpx.2026.100641_bb0180","doi-asserted-by":"crossref","first-page":"6210","DOI":"10.1021\/la047028z","article-title":"From decanoate micelles to decanoic acid\/dodecylbenzenesulfonate vesicles","volume":"21","author":"Namani","year":"2005","journal-title":"Langmuir"},{"issue":"12","key":"10.1016\/j.ijpx.2026.100641_bb0185","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.1063\/1.328693","article-title":"Polymorphic transitions in single crystals: a new molecular dynamics method","volume":"52","author":"Parrinello","year":"1981","journal-title":"J. Appl. Phys."},{"key":"10.1016\/j.ijpx.2026.100641_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfa.2021.127531","article-title":"Unveiling the microstructures of micelles from polyoxyethylene alkyl ether-based multi-responsive nonionic amphiphile","volume":"630","author":"Patel","year":"2021","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"10.1016\/j.ijpx.2026.100641_bb0195","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0001-8686(97)00312-6","article-title":"Analysis of small-angle scattering data from colloids and polymer solutions: modeling and least-squares fitting","volume":"70","author":"Pedersen","year":"1997","journal-title":"Adv. Colloid Interf. Sci."},{"issue":"3","key":"10.1016\/j.ijpx.2026.100641_bb0200","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/j.1600-0889.2008.00352.x","article-title":"Surfactant partitioning in cloud droplet activation: a study of C8, C10, C12 and C14 normal fatty acid sodium salts","volume":"60","author":"Prisle","year":"2008","journal-title":"Tellus Ser. B Chem. Phys. Meteorol."},{"key":"10.1016\/j.ijpx.2026.100641_bb0205","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.jcis.2017.03.109","article-title":"Characterization of colloidal structures during intestinal lipolysis using small-angle neutron scattering","volume":"499","author":"Rezhdo","year":"2017","journal-title":"J. Colloid Interface Sci."},{"issue":"10","key":"10.1016\/j.ijpx.2026.100641_bb0210","doi-asserted-by":"crossref","first-page":"3484","DOI":"10.1021\/acs.molpharmaceut.6b00496","article-title":"An in-depth view into human intestinal fluid colloids: intersubject variability in relation to composition","volume":"13","author":"Riethorst","year":"2016","journal-title":"Mol. Pharm."},{"issue":"12","key":"10.1016\/j.ijpx.2026.100641_bb0215","doi-asserted-by":"crossref","first-page":"9378","DOI":"10.1021\/la100373r","article-title":"Experimental and theoretical approach to the sodium decanoate\u2212dodecanoate mixed surfactant system in aqueous solution","volume":"26","author":"Rodr\u00edguez-Pulido","year":"2010","journal-title":"Langmuir"},{"issue":"1","key":"10.1016\/j.ijpx.2026.100641_bb0220","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0021-9797(71)90240-2","article-title":"The CMC-decreasing effects of some added alcohols on the aqueous sodium dodecyl sulfate solutions","volume":"36","author":"Shirahama","year":"1971","journal-title":"J. Colloid Interface Sci."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100641_bb0225","doi-asserted-by":"crossref","first-page":"4219","DOI":"10.1529\/biophysj.105.065342","article-title":"Interactions between charged polypeptides and nonionic surfactants","volume":"89","author":"Sj\u00f6gren","year":"2005","journal-title":"Biophys. J."},{"issue":"4","key":"10.1016\/j.ijpx.2026.100641_bb0230","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41592-021-01098-3","article-title":"Martini 3: a general purpose force field for coarse-grained molecular dynamics","volume":"18","author":"Souza","year":"2021","journal-title":"Nat. Methods"},{"issue":"2","key":"10.1016\/j.ijpx.2026.100641_bb0235","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11020078","article-title":"Intestinal permeation enhancers for oral delivery of macromolecules: a comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C(10))","volume":"11","author":"Twarog","year":"2019","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100641_bb0240","unstructured":"Uppsala, C.-E.; n.d. Available from: https:\/\/www.uu.se\/en\/department\/cell-and-molecular-biology\/research\/infrastructures\/cryo-em."},{"key":"10.1016\/j.ijpx.2026.100641_bb0245","first-page":"804","article-title":"The new SANS instrument at the Swiss spallation source SINQ in International Union of Crystallography","author":"Wagner","year":"2000","journal-title":"J. Appl. Crystallogr.: Great Britain"},{"key":"10.1016\/j.ijpx.2026.100641_bb0250","unstructured":"ZOOM diffractometer at the ISSI neutron source. n.d. Available from: https:\/\/www.isis.stfc.ac.uk\/instruments\/zoom\/."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:13:27Z","timestamp":1793031207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156726001611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":50,"alternative-id":["S2590156726001611"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100641","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-assembly of sodium caprate in simulated intestinal fluids and with a therapeutic peptide: A small-angle neutron scattering study","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100641","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100641"}}