{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:41:48Z","timestamp":1793032908430,"version":"4.5.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,16]],"date-time":"2026-08-16T00:00:00Z","timestamp":1786838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003815","name":"Huaqiao University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2024J08094"],"award-info":[{"award-number":["2024J08094"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Fujian Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2025J01234"],"award-info":[{"award-number":["2025J01234"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504646"],"award-info":[{"award-number":["82504646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100642","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:52:33Z","timestamp":1787068353000},"page":"100642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Imaging-guided COX-2 inhibition synergizes with photodynamic immunogenic cell death to potentiate checkpoint blockade in colon cancer"],"prefix":"10.1016","volume":"12","author":[{"given":"Lina","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoliang","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiying","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boxin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianquan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100642_bb0005","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2020-001926","article-title":"Targeting immunogenic cancer cell death by photodynamic therapy: past, present and future","volume":"9","author":"Alzeibak","year":"2021","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ijpx.2026.100642_bb0010","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.3390\/biomedicines10112940","article-title":"How the tumor micromilieu modulates the recruitment and activation of colorectal cancer-infiltrating lymphocytes","volume":"10","author":"Atreya","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.ijpx.2026.100642_bb0015","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.ijpx.2026.100642_bb0020","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202512540","article-title":"Self-assembled carrier-free nanomedicines potentiate chemo-photothermal immunotherapy by overcoming prostaglandin E2-mediated immunosuppression","volume":"22","author":"Deng","year":"2026","journal-title":"Small"},{"key":"10.1016\/j.ijpx.2026.100642_bb0025","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s11095-022-03424-6","article-title":"TPGS decorated liposomes as multifunctional nano-delivery systems","volume":"40","author":"Farooq","year":"2022","journal-title":"Pharm. Res."},{"key":"10.1016\/j.ijpx.2026.100642_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117220","article-title":"Self-delivery nanodrug to manipulate tumor microenvironment for boosting photodynamic cancer immunotherapy","volume":"178","author":"Feng","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.ijpx.2026.100642_bb0035","article-title":"A self-amplifying photodynamic biomedicine for cascade immune activation against triple-negative breast cancer","volume":"21","author":"Feng","year":"2025","journal-title":"Small"},{"key":"10.1016\/j.ijpx.2026.100642_bb0040","doi-asserted-by":"crossref","first-page":"5354","DOI":"10.1039\/D3MH00717K","article-title":"Dynamic light scattering and transmission electron microscopy in drug delivery: a roadmap for correct characterization of nanoparticles and interpretation of results","volume":"10","author":"Filippov","year":"2023","journal-title":"Mater. Horiz."},{"key":"10.1016\/j.ijpx.2026.100642_bb0045","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/s41573-024-00920-9","article-title":"Targeting immunogenic cell stress and death for cancer therapy","volume":"23","author":"Galluzzi","year":"2024","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.ijpx.2026.100642_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.111403","article-title":"Activity-dependent COX-2 proteolysis modulates aerobic respiration and proliferation in a prostaglandin-independent manner","volume":"27","author":"Hartal-Benishay","year":"2024","journal-title":"iScience"},{"key":"10.1016\/j.ijpx.2026.100642_bb0055","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s11671-024-04118-1","article-title":"Comprehensive insights into mechanism of nanotoxicity, assessment methods and regulatory challenges of nanomedicines","volume":"19","author":"Havelikar","year":"2024","journal-title":"Discov. Nano"},{"key":"10.1016\/j.ijpx.2026.100642_bb0060","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41571-024-00859-1","article-title":"Dendritic cells as orchestrators of anticancer immunity and immunotherapy","volume":"21","author":"Heras-Murillo","year":"2024","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0065","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1186\/s12951-024-02525-1","article-title":"A combination of a TLR7\/8 agonist and an epigenetic inhibitor suppresses triple-negative breast cancer through triggering anti-tumor immune","volume":"22","author":"Jiang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217511","article-title":"Synergistic enhancement of radio-immunotherapy efficacy by IL-15 via macrophage activation and memory T cell response","volume":"613","author":"Jin","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpx.2026.100642_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.106932","article-title":"Glycyrrhizic acid facilitates anti-tumor immunity by attenuating Tregs and MDSCs: An immunotherapeutic approach","volume":"88","author":"Juin","year":"2020","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0080","doi-asserted-by":"crossref","first-page":"1691392","DOI":"10.3389\/fphar.2025.1691392","article-title":"Celecoxib in oncology: targeting the COX-2\/PGE(2) axis to reprogram the tumor immune microenvironment and enhance multimodal therapy","volume":"16","author":"Kuang","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0085","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1186\/s13046-025-03582-6","article-title":"COX-2\/PGE(2) axis blockade with celecoxib enhances anti-PD-1 efficacy by activating natural killer cells for residual hepatocellular carcinoma after radiofrequency ablation","volume":"44","author":"Lei","year":"2025","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.ijpx.2026.100642_bb0090","article-title":"Immunogenic cell death activates the tumor immune microenvironment to boost the immunotherapy efficiency","volume":"9","author":"Li","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.ijpx.2026.100642_bb0095","article-title":"Human serum albumin based nanodrug delivery systems: recent advances and future perspective","volume":"15","author":"Li","year":"2023","journal-title":"Polymers"},{"key":"10.1016\/j.ijpx.2026.100642_bb0100","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40824-023-00360-3","article-title":"Albumin-binding photosensitizer capable of targeting glioma via the SPARC pathway","volume":"27","author":"Li","year":"2023","journal-title":"Biomater. Res."},{"key":"10.1016\/j.ijpx.2026.100642_bb0105","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1039\/D1CS01079D","article-title":"New guidelines and definitions for type I photodynamic therapy","volume":"54","author":"Li","year":"2025","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.ijpx.2026.100642_bb0110","doi-asserted-by":"crossref","first-page":"29341","DOI":"10.1021\/acsnano.5c06115","article-title":"Synergizing ferroptosis suppressor protein 1 gene silencing and photodynamic therapy based on photosensitive lipid nanoparticles for colon cancer immunotherapy","volume":"19","author":"Liu","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100642_bb0115","doi-asserted-by":"crossref","first-page":"188447","DOI":"10.1016\/j.bbcan.2020.188447","article-title":"Immunotherapy efficacy on mismatch repair-deficient colorectal cancer: From bench to bedside","volume":"1874","author":"Lizardo","year":"2020","journal-title":"Biochimica Et Biophysica Acta Rev. Cancer"},{"key":"10.1016\/j.ijpx.2026.100642_bb0120","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/s13287-023-03342-3","article-title":"TNF-\u03b1\/IL-1\u03b2-licensed hADSCs alleviate cholestatic liver injury and fibrosis in mice via COX-2\/PGE2 pathway","volume":"14","author":"Luan","year":"2023","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.ijpx.2026.100642_bb0125","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2424251122","article-title":"Prostaglandin E(2)-EP2\/EP4 signaling induces the tumor-infiltrating Treg phenotype for tumor growth","volume":"122","author":"Matsuura","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.ijpx.2026.100642_bb0130","doi-asserted-by":"crossref","first-page":"1635747","DOI":"10.3389\/fbioe.2025.1635747","article-title":"Reprogramming the tumor-immune landscape via nanomaterial-induced immunogenic cell death: a mini review","volume":"13","author":"Meng","year":"2025","journal-title":"Front Bioeng. Biotechnol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0135","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1080\/17425247.2022.2134341","article-title":"Current trends in the use of human serum albumin for drug delivery in cancer","volume":"19","author":"Paul","year":"2022","journal-title":"Expert Opinion On Drug Delivery"},{"key":"10.1016\/j.ijpx.2026.100642_bb0140","doi-asserted-by":"crossref","first-page":"9464","DOI":"10.1038\/s41467-024-53706-3","article-title":"Prostaglandin E(2)-EP2\/EP4 signaling induces immunosuppression in human cancer by impairing bioenergetics and ribosome biogenesis in immune cells","volume":"15","author":"Punyawatthananukool","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2026.100642_bb0145","doi-asserted-by":"crossref","first-page":"6945","DOI":"10.2147\/IJN.S467876","article-title":"Albumin Nanoparticle-Based Drug Delivery Systems","volume":"19","author":"Qu","year":"2024","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100642_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512204","article-title":"Photodynamic therapy for colorectal cancer: an update and a look to the future","volume":"24","author":"Rodrigues","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2026.100642_bb0155","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1186\/s12967-024-05457-4","article-title":"Extracellular vesicles at the crossroad between cancer progression and immunotherapy: focus on dendritic cells","volume":"22","author":"Schioppa","year":"2024","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.ijpx.2026.100642_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2023.123449","article-title":"Profiling in-vitro release of verteporfin from VISUDYNE\u00ae liposomal formulation and investigating verteporfin binding to human serum albumin","volume":"646","author":"Siriwardane","year":"2023","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100642_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116735","article-title":"Salvia mitiorrhiza Bunge aqueous extract attenuates infiltration of tumor-associated macrophages and potentiates anti-PD-L1 immunotherapy in colorectal cancer through modulating Cox2\/PGE2 cascade","volume":"316","author":"Song","year":"2023","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0170","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/acs.molpharmaceut.1c00046","article-title":"The Uniqueness of Albumin as a Carrier in Nanodrug Delivery","volume":"18","author":"Spada","year":"2021","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.ijpx.2026.100642_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110914","article-title":"PGE2-EP2\/EP4 signaling elicits immunosuppression by driving the mregDC-Treg axis in inflammatory tumor microenvironment","volume":"39","author":"Thumkeo","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.ijpx.2026.100642_bb0180","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1016\/j.ccell.2025.09.004","article-title":"Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H\/dMMR colon cancer: A randomized phase 1b study","volume":"43","author":"Wang","year":"2025","journal-title":"Cancer Cell"},{"key":"10.1016\/j.ijpx.2026.100642_bb0185","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s13045-022-01294-4","article-title":"Exploring immunotherapy in colorectal cancer","volume":"15","author":"Weng","year":"2022","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0190","article-title":"Engineered T cells stimulate dendritic cell recruitment and antigen spreading for potent anti-tumor immunity","volume":"6","author":"Xiao","year":"2025","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.ijpx.2026.100642_bb0195","doi-asserted-by":"crossref","first-page":"2931","DOI":"10.1016\/j.ymthe.2021.05.017","article-title":"Photodynamic therapy synergizes with PD-L1 checkpoint blockade for immunotherapy of CRC by multifunctional nanoparticles","volume":"29","author":"Yuan","year":"2021","journal-title":"Mol. Ther."},{"key":"10.1016\/j.ijpx.2026.100642_bb0200","doi-asserted-by":"crossref","first-page":"16204","DOI":"10.1021\/acsnano.4c15765","article-title":"Cancer nanovaccines: mechanisms, design principles, and clinical translation","volume":"19","author":"Zaccariotto","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100642_bb0205","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1186\/s12951-024-02598-y","article-title":"Dual depletion of myeloid-derived suppressor cells and tumor cells with self-assembled gemcitabine-celecoxib nano-twin drug for cancer chemoimmunotherapy","volume":"22","author":"Zhang","year":"2024","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0210","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1186\/s12876-025-03948-2","article-title":"Global burden of colon and rectal cancer and attributable risk factors in 204 countries and territories from 1990 to 2021","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Gastroenterol."},{"key":"10.1016\/j.ijpx.2026.100642_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2022.215816","article-title":"Colorectal cancer immunotherapy-Recent progress and future directions","volume":"545","author":"Zhao","year":"2022","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpx.2026.100642_bb0220","doi-asserted-by":"crossref","first-page":"8221","DOI":"10.2147\/IJN.S514659","article-title":"Advancements in Nano-Delivery Systems for Photodynamic and Photothermal Therapy to Induce Immunogenic Cell Death in Tumor Immunotherapy","volume":"20","author":"Zhao","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100642_bb0225","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2023-008054","article-title":"Mitochondria-targeted photodynamic therapy triggers GSDME-mediated pyroptosis and sensitizes anti-PD-1 therapy in colorectal cancer","volume":"12","author":"Zhou","year":"2024","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ijpx.2026.100642_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2024.217079","article-title":"Emerging role of immunogenic cell death in cancer immunotherapy: Advancing next-generation CAR-T cell immunotherapy by combination","volume":"598","author":"Zhou","year":"2024","journal-title":"Cancer Lett."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:14:47Z","timestamp":1793031287000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156726001623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":46,"alternative-id":["S2590156726001623"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100642","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging-guided COX-2 inhibition synergizes with photodynamic immunogenic cell death to potentiate checkpoint blockade in colon cancer","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100642","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100642"}}