{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:40:09Z","timestamp":1793032809427,"version":"4.5.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017585","name":"First Hospital of Jilin University","doi-asserted-by":"publisher","award":["JDYY-TRP-2025003"],"award-info":[{"award-number":["JDYY-TRP-2025003"]}],"id":[{"id":"10.13039\/501100017585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["YDZJ202401650ZYTS"],"award-info":[{"award-number":["YDZJ202401650ZYTS"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100661","type":"journal-article","created":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T15:00:36Z","timestamp":1788706836000},"page":"100661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["KAT6A inhibitor-loaded and anti-PD-L1-coated manganese metal\u2013organic framework nanoplatform for enhanced colorectal cancer immunotherapy via cGAS-STING activation"],"prefix":"10.1016","volume":"12","author":[{"given":"Helei","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongyang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqiao","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100661_bb0005","article-title":"Tumor microenvironment-activated nanocomposite for self-amplifying chemodynamic\/starvation therapy enhanced IDO-blockade tumor immunotherapy","volume":"10","author":"Bian","year":"2023","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ijpx.2026.100661_bb0010","article-title":"Biocompatible injectable glycyrrhizic acid-based growth factor hydrogel for synergistic endometrial regeneration","volume":"35","author":"Cai","year":"2025","journal-title":"Mater. Today Bio"},{"key":"10.1016\/j.ijpx.2026.100661_bb0015","doi-asserted-by":"crossref","first-page":"23746","DOI":"10.1021\/acsnano.3c07555","article-title":"Biomimetic macrophage membrane-camouflaged nanoparticles induce ferroptosis by promoting mitochondrial damage in glioblastoma","volume":"17","author":"Cao","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100661_bb0020","article-title":"Hierarchical small molecule inhibition of MYST acetyltransferases","volume":"17","author":"Chen","year":"2026","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2026.100661_bb0025","doi-asserted-by":"crossref","DOI":"10.1136\/egastro-2024-100106","article-title":"Immunotherapy against colorectal cancer via delivery of anti-PD-L1 nanobody mRNA","volume":"3","author":"Chu","year":"2025","journal-title":"eGastroenterology"},{"key":"10.1016\/j.ijpx.2026.100661_bb0030","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/s41586-024-08257-4","article-title":"Cancer cells impair monocyte-mediated T cell stimulation to evade immunity","volume":"637","author":"Elewaut","year":"2025","journal-title":"Nature"},{"key":"10.1016\/j.ijpx.2026.100661_bb0035","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1158\/0008-5472.CAN-25-0079","article-title":"Tumor-associated macrophages produce PGE2 to promote CD8+ T-cell exhaustion and drive resistance to PD-L1 blockade in microsatellite-stable colorectal cancer","volume":"86","author":"Fumet","year":"2026","journal-title":"Cancer Res."},{"key":"10.1016\/j.ijpx.2026.100661_bb0040","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/s41586-024-07121-9","article-title":"Anti-TIGIT antibody improves PD-L1 blockade through myeloid and T(reg) cells","volume":"627","author":"Guan","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.ijpx.2026.100661_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.217946","article-title":"Inhibition of KAT6A enhances immunotherapy efficacy in colorectal cancer by activating interferon response","volume":"631","author":"Han","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpx.2026.100661_bb0050","doi-asserted-by":"crossref","first-page":"3849","DOI":"10.1016\/j.cell.2026.06.001","article-title":"The cGAS-STING pathway: Mechanism and medical implications","volume":"189","author":"Hooftman","year":"2026","journal-title":"Cell"},{"key":"10.1016\/j.ijpx.2026.100661_bb0055","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1038\/s41467-023-40345-3","article-title":"A bimetallic nanoplatform for STING activation and CRISPR\/Cas mediated depletion of the methionine transporter in cancer cells restores anti-tumor immune responses","volume":"14","author":"Huang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2026.100661_bb0060","article-title":"CD8(+) T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy","volume":"4","author":"Huseni","year":"2023","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.ijpx.2026.100661_bb0065","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.actbio.2025.02.035","article-title":"Subcutaneous liposomal delivery improves monoclonal antibody pharmacokinetics in vivo","volume":"195","author":"Karimi","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpx.2026.100661_bb0070","doi-asserted-by":"crossref","first-page":"7226","DOI":"10.1038\/s41467-024-51411-9","article-title":"Innate immune responses against mRNA vaccine promote cellular immunity through IFN-\u03b2 at the injection site","volume":"15","author":"Kim","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2026.100661_bb0075","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1038\/s41565-022-01134-z","article-title":"Cancer immunotherapy based on image-guided STING activation by nucleotide nanocomplex-decorated ultrasound microbubbles","volume":"17","author":"Li","year":"2022","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0080","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1007\/s00262-023-03520-5","article-title":"PD-1 and PD-L1 inhibitors in cold colorectal cancer: challenges and strategies","volume":"72","author":"Lin","year":"2023","journal-title":"Cancer Immunol. Immunother."},{"key":"10.1016\/j.ijpx.2026.100661_bb0085","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/s12951-023-01835-0","article-title":"Medicinal plant-derived mtDNA via nanovesicles induces the cGAS-STING pathway to remold tumor-associated macrophages for tumor regression","volume":"21","author":"Liu","year":"2023","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0090","doi-asserted-by":"crossref","first-page":"31077","DOI":"10.1021\/acsnano.5c09460","article-title":"Reprogramming macrophage via an antigen phagocytosis-presentation nanoenhancer for improved cancer immunotherapy","volume":"19","author":"Liu","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100661_bb0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1038\/s41551-025-01447-z","article-title":"Nanobody-based bispecific antibody engagers targeting CTLA-4 or PD-L1 for cancer immunotherapy","volume":"10","author":"Liu","year":"2026","journal-title":"Nat. Biomed. Eng."},{"key":"10.1016\/j.ijpx.2026.100661_bb0100","article-title":"KAT6A deficiency impairs cognitive functions through suppressing RSPO2\/Wnt signaling in hippocampal CA3","volume":"10","author":"Liu","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.ijpx.2026.100661_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2025.115003","article-title":"Biomimetic anlotinib-loaded FePc-silicate nanoparticles for sonodynamic and immunotherapy in non-small cell lung cancer via dual PD-L1 modulation","volume":"256","author":"Liu","year":"2025","journal-title":"Colloids Surf. B: Biointerfaces"},{"key":"10.1016\/j.ijpx.2026.100661_bb0110","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2022-005769","article-title":"Activated NK cells reprogram MDSCs via NKG2D-NKG2DL and IFN-\u03b3 to modulate antitumor T-cell response after cryo-thermal therapy","volume":"10","author":"Peng","year":"2022","journal-title":"J. Immunother. Cancer"},{"key":"10.1016\/j.ijpx.2026.100661_bb0115","doi-asserted-by":"crossref","first-page":"26858","DOI":"10.1021\/acsnano.4c08117","article-title":"Spatiotemporal delivery of dual nanobodies by engineered probiotics to reverse tumor immunosuppression via targeting tumor-derived exosomes","volume":"18","author":"Qin","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100661_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.126811","article-title":"Design and evaluation of \u03b1-helix-based peptide inhibitors for blocking PD-1\/PD-L1 interaction","volume":"253","author":"Rui","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0125","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jconrel.2022.12.004","article-title":"Targeted CuFe(2)O(4) hybrid nanoradiosensitizers for synchronous chemoradiotherapy","volume":"353","author":"Salehiabar","year":"2023","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100661_bb0130","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.chembiol.2023.07.005","article-title":"Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A\/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer","volume":"30","author":"Sharma","year":"2023","journal-title":"Cell Chem. Biol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0135","doi-asserted-by":"crossref","first-page":"3807","DOI":"10.1016\/j.molcel.2025.08.030","article-title":"Activation and regulation of cGAS-STING signaling in cancer cells","volume":"85","author":"Shim","year":"2025","journal-title":"Mol. Cell"},{"key":"10.1016\/j.ijpx.2026.100661_bb0140","doi-asserted-by":"crossref","first-page":"2070","DOI":"10.1136\/gutjnl-2025-335412","article-title":"Current and emerging concepts for systemic treatment of metastatic colorectal cancer","volume":"74","author":"Steup","year":"2025","journal-title":"Gut"},{"key":"10.1016\/j.ijpx.2026.100661_bb0145","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1038\/s41565-021-00962-9","article-title":"Amplifying STING activation by cyclic dinucleotide-manganese particles for local and systemic cancer metalloimmunotherapy","volume":"16","author":"Sun","year":"2021","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156671","article-title":"Diosmin alleviates colitis by inhibiting PANoptosis of intestinal epithelial cells and regulating gut microbiota and metabolites","volume":"141","author":"Tan","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijpx.2026.100661_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2024.10.019","article-title":"Dual impacts of serine\/glycine-free diet in enhancing antitumor immunity and promoting evasion via PD-L1 lactylation","volume":"36","author":"Tong","year":"2024","journal-title":"Cell Metab."},{"key":"10.1016\/j.ijpx.2026.100661_bb0160","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1038\/s41467-023-38601-7","article-title":"Gas therapy potentiates aggregation-induced emission luminogen-based photoimmunotherapy of poorly immunogenic tumors through cGAS-STING pathway activation","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.ijpx.2026.100661_bb0165","article-title":"Emerging cGAS-STING agonist-based nanotherapeutics: mechanistic insights and applications in cancer combination therapy","volume":"12","author":"Wang","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ijpx.2026.100661_bb0170","article-title":"ST6GAL1-mediated sialylation stabilizes PD-L1 and drives immunosuppressive tumor microenvironment in colorectal cancer","volume":"12","author":"Xu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ijpx.2026.100661_bb0175","doi-asserted-by":"crossref","first-page":"494","DOI":"10.4103\/jcrt.jcrt_2113_24","article-title":"Proteomics analysis explored the changes in the tumor microenvironment of CT26 tumor-bearing mice after microwave ablation","volume":"21","author":"Xue","year":"2025","journal-title":"J. Cancer Res. Ther."},{"key":"10.1016\/j.ijpx.2026.100661_bb0180","article-title":"ATP-responsive manganese-based bacterial materials synergistically activate the cGAS-STING pathway for tumor immunotherapy","volume":"36","author":"Yang","year":"2024","journal-title":"Adv. Mater."},{"key":"10.1016\/j.ijpx.2026.100661_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2025.218060","article-title":"Cancer-associated fibroblast secreted DKK1 promotes the immunosuppressive tumor microenvironment and colorectal cancer resistance to chemotherapy","volume":"634","author":"Yin","year":"2025","journal-title":"Cancer Lett."},{"key":"10.1016\/j.ijpx.2026.100661_bb0190","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41565-025-02071-3","article-title":"Nanorobots hold PD-L1 and break membrane of colorectal cancer cells for immunotherapy","volume":"21","author":"Ying","year":"2026","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0195","article-title":"The role of CAF-derived vitronectin in promoting colorectal cancer progression and immunosuppression","volume":"12","author":"Yu","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"key":"10.1016\/j.ijpx.2026.100661_bb0200","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.1021\/acsnano.4c12237","article-title":"Activating the cGAS-STING Pathway by Manganese-based Nanoparticles combined with Platinum-based Nanoparticles for Enhanced Ovarian Cancer Immunotherapy","volume":"19","author":"Zhang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100661_bb0205","article-title":"Emerging strategies in colorectal cancer immunotherapy: enhancing efficacy and survival","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.ijpx.2026.100661_bb0210","doi-asserted-by":"crossref","first-page":"15905","DOI":"10.1021\/acsnano.3c03962","article-title":"Manganese-based immunostimulatory metal-organic framework activates the cGAS-STING pathway for cancer metalloimmunotherapy","volume":"17","author":"Zheng","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.ijpx.2026.100661_bb0215","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.actbio.2025.04.040","article-title":"Mitochondria-targeted manganese-based mesoporous silica nanoplatforms trigger cGAS-STING activation and sensitize anti PD-L1 therapy in triple-negative breast cancer","volume":"199","author":"Zhong","year":"2025","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpx.2026.100661_bb0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2026.115564","article-title":"\"Self\" signal-suppressed metal-organic framework (MOF) nanodrug for enhanced immunotherapy of melanoma via CD47 blockade","volume":"262","author":"Zhu","year":"2026","journal-title":"Colloids Surf. B: Biointerfaces"}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001817?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001817?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:07:09Z","timestamp":1793030829000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156726001817"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":44,"alternative-id":["S2590156726001817"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100661","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KAT6A inhibitor-loaded and anti-PD-L1-coated manganese metal\u2013organic framework nanoplatform for enhanced colorectal cancer immunotherapy via cGAS-STING activation","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100661"}}