{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:40:48Z","timestamp":1793032848209,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002573","name":"Yonsei University","doi-asserted-by":"publisher","award":["2024-22-0543"],"award-info":[{"award-number":["2024-22-0543"]}],"id":[{"id":"10.13039\/501100002573","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","award":["RS-2025-16071710"],"award-info":[{"award-number":["RS-2025-16071710"]}],"id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100668","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:38:46Z","timestamp":1790264326000},"page":"100668","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lipid matrix composition-tuned nanoparticles for enhanced topical retinol delivery and anti-photoaging efficacy"],"prefix":"10.1016","volume":"12","author":[{"given":"Hae Kyung","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Yong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunghyeon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaelin","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minyoung","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Yeon","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyeon","family":"Bok","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hoon","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100668_bb0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.cis.2025.103667","article-title":"Fusogenic lipid nanocarriers: Nature-inspired design for advanced drug delivery systems","volume":"346","author":"Balenzano","year":"2025","journal-title":"Adv. Colloid Interf. Sci."},{"key":"10.1016\/j.ijpx.2026.100668_bb0010","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.jconrel.2016.06.017","article-title":"DLS and zeta potential\u2013what they are and what they are not?","volume":"235","author":"Bhattacharjee","year":"2016","journal-title":"J. Control. Release"},{"issue":"6","key":"10.1016\/j.ijpx.2026.100668_bb0015","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1088\/0034-4885\/62\/6\/203","article-title":"Emulsions: Basic principles","volume":"62","author":"Bibette","year":"1999","journal-title":"Rep. Prog. Phys."},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2026.100668_bb0020","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ijpharm.2012.06.052","article-title":"Proteins, polysaccharides, and their complexes used as stabilizers for emulsions: Alternatives to synthetic surfactants in the pharmaceutical field?","volume":"436","author":"Bouyer","year":"2012","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.ijpx.2026.100668_bb0025","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1021\/acsami.6b00821","article-title":"Transport mechanisms of solid lipid nanoparticles across Caco-2 cell monolayers and their related cytotoxicology","volume":"8","author":"Chai","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"issue":"29","key":"10.1016\/j.ijpx.2026.100668_bb0030","doi-asserted-by":"crossref","first-page":"18367","DOI":"10.1021\/acsomega.0c02102","article-title":"Characterization of retinol stabilized in phosphatidylcholine vesicles with and without antioxidants","volume":"5","author":"Chmykh","year":"2020","journal-title":"ACS Omega"},{"key":"10.1016\/j.ijpx.2026.100668_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.120178","article-title":"Hyaluronic acid hydrolysis using vacuum ultraviolet TiO2 photocatalysis combined with an oxygen nanobubble system","volume":"299","author":"Cho","year":"2023","journal-title":"Carbohydr. Polym."},{"issue":"3","key":"10.1016\/j.ijpx.2026.100668_bb0040","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1021\/ar200113c","article-title":"Nanoparticle \u03b6-potentials","volume":"45","author":"Doane","year":"2012","journal-title":"Acc. Chem. Res."},{"issue":"9","key":"10.1016\/j.ijpx.2026.100668_bb0045","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1096\/fasebj.10.9.8801161","article-title":"Molecular mechanisms of retinoid actions in skin","volume":"10","author":"Fisher","year":"1996","journal-title":"The FASEB J."},{"issue":"20","key":"10.1016\/j.ijpx.2026.100668_bb0050","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1056\/NEJM199711133372003","article-title":"Pathophysiology of premature skin aging induced by ultraviolet light","volume":"337","author":"Fisher","year":"1997","journal-title":"N. Engl. J. Med."},{"issue":"2","key":"10.1016\/j.ijpx.2026.100668_bb0055","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1046\/j.0022-202x.2001.01432.x","article-title":"Ultraviolet irradiation increases matrix metalloproteinase-8 protein in human skin in vivo","volume":"117","author":"Fisher","year":"2001","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.ijpx.2026.100668_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.123825","article-title":"Emollients in dermatological creams: Early evaluation for tailoring formulation and therapeutic performance","volume":"653","author":"Franco-Gil","year":"2024","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0065","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ejpb.2016.07.026","article-title":"Nanostructured lipid carriers for the topical delivery of tretinoin","volume":"108","author":"Ghate","year":"2016","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0070","article-title":"Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: Evaluation of antioxidant potential for dermal applications","volume":"1841\u20131850","author":"Gokce","year":"2012","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100668_bb0075","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tifs.2016.03.001","article-title":"Microencapsulation of vitamin a: A review","volume":"51","author":"Gon\u00e7alves","year":"2016","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100668_bb0080","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ejpb.2018.10.017","article-title":"Solid lipid nanoparticles and nanostructured lipid carriers: A review emphasizing on particle structure and drug release","volume":"133","author":"Gordillo-Galeano","year":"2018","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0085","article-title":"In vitro release behavior of SLN, NLC, and NE: An explanation based on the particle structure and carried molecule location","volume":"76","author":"Gordillo-Galeano","year":"2022","journal-title":"J. Drug Deliv. Sci. Technol."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100668_bb0090","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12951-015-0107-3","article-title":"Nanostructured lipid carriers for percutaneous administration of alkaloids isolated from Aconitum sinomontanum","volume":"13","author":"Guo","year":"2015","journal-title":"J. Nanobiotechnol."},{"issue":"38","key":"10.1016\/j.ijpx.2026.100668_bb0095","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202203070","article-title":"Probing the effect of rigidity on the cellular uptake of core-shell nanoparticles: Stiffness effects are size dependent","volume":"18","author":"Gurnani","year":"2022","journal-title":"Small"},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2026.100668_bb0100","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.ijpharm.2018.06.012","article-title":"Strat-M\u00ae synthetic membrane: Permeability comparison to human cadaver skin","volume":"547","author":"Haq","year":"2018","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.lwt.2022.113474","article-title":"Digestion stability of curcumin-loaded nanostructured lipid carrier","volume":"162","author":"Hyun","year":"2022","journal-title":"LWT"},{"key":"10.1016\/j.ijpx.2026.100668_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113692","article-title":"Evaluating the effects of surfactant types on the properties and stability of oil-in-water Rhodiola rosea nanoemulsion","volume":"234","author":"Iskandar","year":"2024","journal-title":"Colloids Surf. B: Biointerfaces"},{"issue":"7","key":"10.1016\/j.ijpx.2026.100668_bb0115","doi-asserted-by":"crossref","first-page":"9958","DOI":"10.1021\/acsanm.2c02214","article-title":"Dependence of the core\u2013shell structure on the lipid composition of nanostructured lipid carriers: Implications for drug carrier design","volume":"5","author":"Izza","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"issue":"7","key":"10.1016\/j.ijpx.2026.100668_bb0120","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1021\/acs.molpharmaceut.4c00392","article-title":"On the structure, stability, and cell uptake of nanostructured lipid carriers for drug delivery","volume":"21","author":"Jeitler","year":"2024","journal-title":"Mol. Pharm."},{"issue":"2","key":"10.1016\/j.ijpx.2026.100668_bb0125","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jconrel.2003.11.012","article-title":"Investigations on the structure of solid lipid nanoparticles (SLN) and oil-loaded solid lipid nanoparticles by photon correlation spectroscopy, field-flow fractionation and transmission electron microscopy","volume":"95","author":"Jores","year":"2004","journal-title":"J. Control. Release"},{"issue":"132","key":"10.1016\/j.ijpx.2026.100668_bb0130","article-title":"Nanostructured lipid carrier (NLC) based gel of celecoxib","volume":"346","author":"Joshi","year":"2008","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0135","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.tifs.2017.07.017","article-title":"Formulation and application of a new generation of lipid nano-carriers for food bioactive ingredients","volume":"68","author":"Katouzian","year":"2017","journal-title":"Trends Food Sci. Technol."},{"key":"10.1016\/j.ijpx.2026.100668_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119736","article-title":"Optimization of phytic acid-crosslinked chitosan microspheres for oral insulin delivery using response surface methodology","volume":"588","author":"Kim","year":"2020","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100668_bb0145","article-title":"Plant derived extract loaded nanostructured lipid carriers with enhanced oral delivery for the treatment of acute inflammation","volume":"15","author":"Lee","year":"2025","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.ijpx.2026.100668_bb0150","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1111\/ijfs.15588","article-title":"Influence of different solid lipids on the properties of a novel nanostructured lipid carrier containing Antarctic krill oil","volume":"57","author":"Lin","year":"2022","journal-title":"Int. J. Food Sci. Technol."},{"issue":"8","key":"10.1016\/j.ijpx.2026.100668_bb0155","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/nrm2216","article-title":"Pathways of clathrin-independent endocytosis","volume":"8","author":"Mayor","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.ijpx.2026.100668_bb0160","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.addr.2012.09.021","article-title":"Solid lipid nanoparticles: Production, characterization and applications","volume":"64","author":"Mehnert","year":"2012","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"12","key":"10.1016\/j.ijpx.2026.100668_bb0165","doi-asserted-by":"crossref","first-page":"5351","DOI":"10.1007\/s12325-022-02319-7","article-title":"Use of retinoids in topical antiaging treatments: A focused review of clinical evidence for conventional and nanoformulations","volume":"39","author":"Milosheska","year":"2022","journal-title":"Adv. Ther."},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2026.100668_bb0170","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ijpharm.2011.05.008","article-title":"Lipid nanocarriers for dermal delivery of lutein: Preparation, characterization, stability and performance","volume":"414","author":"Mitri","year":"2011","journal-title":"Int. J. Pharm."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100668_bb0175","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0939-6411(00)00087-4","article-title":"Solid lipid nanoparticles (SLN) for controlled drug delivery \u2013 A review of the state of the art","volume":"50","author":"M\u00fcller","year":"2000","journal-title":"Eur. J. Pharm. Biopharm."},{"issue":"Suppl. 1","key":"10.1016\/j.ijpx.2026.100668_bb0180","doi-asserted-by":"crossref","first-page":"S131","DOI":"10.1016\/S0169-409X(02)00118-7","article-title":"Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) in cosmetic and dermatological preparations","volume":"54","author":"M\u00fcller","year":"2002","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100668_bb0185","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.addr.2007.04.012","article-title":"Nanostructured lipid carriers (NLC) in cosmetic dermal products","volume":"59","author":"M\u00fcller","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100668_bb0190","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/s42255-022-00591-z","article-title":"Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo","volume":"4","author":"Murphy","year":"2022","journal-title":"Nat. Metab."},{"key":"10.1016\/j.ijpx.2026.100668_bb0195","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejps.2018.10.003","article-title":"Nanostructured lipid carriers versus solid lipid nanoparticles for the potential treatment of pulmonary hypertension via nebulization","volume":"125","author":"Nafee","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2026.100668_bb0200","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.ijpharm.2008.10.004","article-title":"Anion effects on electrostatic charging of sterically stabilized, water insoluble drug particles","volume":"368","author":"Owen","year":"2009","journal-title":"Int. J. Pharm."},{"issue":"5\u20136","key":"10.1016\/j.ijpx.2026.100668_bb0205","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/S0891-5849(98)00266-4","article-title":"Antioxidant potentials of vitamin a and carotenoids and their relevance to heart disease","volume":"26","author":"Palace","year":"1999","journal-title":"Free Radic. Biol. Med."},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2026.100668_bb0210","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijpharm.2008.10.003","article-title":"Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products","volume":"366","author":"Pardeike","year":"2009","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0215","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.foodchem.2018.01.071","article-title":"Improvement of curcuminoid bioaccessibility from turmeric by a nanostructured lipid carrier system","volume":"251","author":"Park","year":"2018","journal-title":"Food Chem."},{"issue":"11","key":"10.1016\/j.ijpx.2026.100668_bb0220","first-page":"1261","article-title":"Transdermal drug delivery. Nat","volume":"26","author":"Prausnitz","year":"2008","journal-title":"Biotech"},{"issue":"1\u20132","key":"10.1016\/j.ijpx.2026.100668_bb0225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0378-5173(97)00368-2","article-title":"Formulation and evaluation of o\/w emulsions using experimental design","volume":"163","author":"Prinderre","year":"1998","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.ijpx.2026.100668_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124409","article-title":"Multilayered collagen\u2013lipid hybrid nanovesicles for retinol stabilization and efficient skin delivery","volume":"661","author":"Rahman","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"4","key":"10.1016\/j.ijpx.2026.100668_bb0235","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1159\/000534136","article-title":"The skin barrier and moisturization: Function, disruption, and mechanisms of repair","volume":"36","author":"Rajkumar","year":"2023","journal-title":"Skin Pharmacol. Physiol."},{"issue":"6","key":"10.1016\/j.ijpx.2026.100668_bb0240","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.addr.2007.04.006","article-title":"Lipid nanoparticles for improved topical application of drugs for skin diseases","volume":"59","author":"Sch\u00e4fer-Korting","year":"2007","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.ijpx.2026.100668_bb0245","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jconrel.2018.03.023","article-title":"Encapsulation and controlled release of retinol from silicone particles for topical delivery","volume":"273","author":"Shields","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100668_bb0250","article-title":"Formulation and characterization of phytostanol ester solid lipid nanoparticles for the management of hypercholesterolemia: An ex vivo study","volume":"1977\u20131992","author":"Shrestha","year":"2021","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100668_bb0255","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s12551-016-0218-6","article-title":"Dynamic light scattering: A practical guide and applications in biomedical sciences","volume":"8","author":"Stetefeld","year":"2016","journal-title":"Biophys. Rev."},{"issue":"7","key":"10.1016\/j.ijpx.2026.100668_bb0260","doi-asserted-by":"crossref","first-page":"2350","DOI":"10.1111\/jocd.13852","article-title":"Retinoid stability and degradation kinetics in commercial cosmetic products","volume":"20","author":"Temova Raku\u0161a","year":"2021","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.ijpx.2026.100668_bb0265","article-title":"Preparation and characterization of nimodipine-loaded nanostructured lipid systems for enhanced solubility and bioavailability","volume":"119\u2013133","author":"Teng","year":"2019","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100668_bb0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.carbpol.2022.119401","article-title":"Chitosan-coated nanostructured lipid carriers for transdermal delivery of tetrahydrocurcumin for breast cancer therapy","volume":"288","author":"Truong","year":"2022","journal-title":"Carbohydr. Polym."},{"issue":"1","key":"10.1016\/j.ijpx.2026.100668_bb0275","article-title":"Retinol semisolid preparations in cosmetics: Transcutaneous permeation mechanism and behaviour","volume":"14","author":"Wang","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.ijpx.2026.100668_bb0280","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1208\/s12249-021-02108-5","article-title":"Primaquine loaded solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), and nanoemulsion (NE): Effect of lipid matrix and surfactant on drug entrapment, in vitro release, and ex vivo hemolysis","volume":"22","author":"Wu","year":"2021","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.ijpx.2026.100668_bb0285","article-title":"Advances in emulsion stability: A review on mechanisms, role of emulsifiers, and applications in food","volume":"102792","author":"Xiao","year":"2025","journal-title":"Food Chem."},{"key":"10.1016\/j.ijpx.2026.100668_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125711","article-title":"A new insight into the influence of pH on the adsorption at oil-water interface and emulsion stability of egg yolk protein","volume":"246","author":"Yang","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2026.100668_bb0295","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jconrel.2023.10.021","article-title":"Mucoadhesive chitosan microcapsules for controlled gastrointestinal delivery and oral bioavailability enhancement of low molecular weight peptides","volume":"365","author":"Yang","year":"2024","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.ijpx.2026.100668_bb0300","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1186\/s12951-025-03407-w","article-title":"Enhanced therapeutic effects of all-trans retinoic acid nanostructured lipid carrier composite gel drug delivery system for alopecia areata","volume":"23","author":"Zheng","year":"2025","journal-title":"J. Nanobiotechnol."},{"issue":"10","key":"10.1016\/j.ijpx.2026.100668_bb0305","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1111\/jocd.16415","article-title":"Topical retinoids: Novel derivatives, nano lipid-based carriers, and combinations to improve chemical instability and skin irritation","volume":"23","author":"Zhong","year":"2024","journal-title":"J. Cosmet. Dermatol."}],"updated-by":[{"DOI":"10.1016\/j.ijpx.2026.100686","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000}}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672600188X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S259015672600188X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:05:30Z","timestamp":1793030730000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S259015672600188X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":61,"alternative-id":["S259015672600188X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100668","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lipid matrix composition-tuned nanoparticles for enhanced topical retinol delivery and anti-photoaging efficacy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100668","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100668"}}