{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:40:29Z","timestamp":1793032829988,"version":"4.5.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003787","name":"Hebei Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003787","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Pharmaceutics: X"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.ijpx.2026.100674","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:12:58Z","timestamp":1790349178000},"page":"100674","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Lactoferrin-modified MSC-derived extracellular vesicles facilitate BBB penetration and enhance gastrodin-induced neuroprotection in Parkinson's disease: involvement of mitophagy"],"prefix":"10.1016","volume":"12","author":[{"given":"Zi-Yu","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-Jie","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Jiao","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bai-He","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Li","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Zhen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Wei","family":"Sang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-tong","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-qin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheng-Jun","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Xu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijpx.2026.100674_bb0005","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.ijbiomac.2020.11.107","article-title":"Lactoferrin coated or conjugated nanomaterials as an active targeting approach in nanomedicine","volume":"167","author":"Agwa","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119326","article-title":"Targeting receptor-ligand chemistry for drug delivery across blood-brain barrier in brain diseases","volume":"274","author":"Anthony","year":"2021","journal-title":"Life Sci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics10040218","article-title":"Exosomes and exosome-inspired vesicles for targeted drug delivery","volume":"10","author":"Antimisiaris","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100674_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124407","article-title":"Transport of extracellular vesicles across the blood-brain barrier: brain pharmacokinetics and effects of inflammation","volume":"21","author":"Banks","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0025","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051772","article-title":"PINK1\/Parkin mediated mitophagy, Ca(2+) signalling, and ER-mitochondria contacts in Parkinson\u2019s disease","volume":"21","author":"Barazzuol","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(23)01419-8","article-title":"The epidemiology of Parkinson's disease","volume":"403","author":"Ben-Shlomo","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2026.100674_bb0035","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1016\/S0140-6736(21)00218-X","article-title":"Parkinson\u2019s disease","volume":"397","author":"Bloem","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.ijpx.2026.100674_bb0040","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41419-020-2473-5","article-title":"Exosomes derived from mesenchymal stem cells repair a Parkinson\u2019s disease model by inducing autophagy","volume":"11","author":"Chen","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.ijpx.2026.100674_bb0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/2045-8118-10-33","article-title":"Comparative study of four immortalized human brain capillary endothelial cell lines, hCMEC\/D3, hBMEC, TY10, and BB19, and optimization of culture conditions, for an in vitro blood-brain barrier model for drug permeability studies","volume":"10","author":"Eigenmann","year":"2013","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.ijpx.2026.100674_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13010122","article-title":"Unlocking the power of exosomes for crossing biological barriers in drug delivery","volume":"13","author":"Elliott","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.ijpx.2026.100674_bb0055","series-title":"Parkinson's Disease: Pathogenesis and Clinical Aspects","article-title":"Principles and practice of movement disorders","author":"Fahn","year":"2018"},{"key":"10.1016\/j.ijpx.2026.100674_bb0060","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.actbio.2021.03.018","article-title":"Berberine-loaded M2 macrophage-derived exosomes for spinal cord injury therapy","volume":"126","author":"Gao","year":"2021","journal-title":"Acta Biomater."},{"key":"10.1016\/j.ijpx.2026.100674_bb0065","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12987-026-00812-7","article-title":"Transport pathways across the blood-brain barrier for waste clearance and drug delivery","volume":"23","author":"Gr\u00f6bner","year":"2026","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.ijpx.2026.100674_bb0070","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2022.949724","article-title":"Safety and biodistribution of exosomes derived from human induced pluripotent stem cells","volume":"10","author":"Gu","year":"2022","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0075","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1080\/15548627.2022.2139080","article-title":"PINK1-PRKN mediated mitophagy: differences between in vitro and in vivo models","volume":"19","author":"Han","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.ijpx.2026.100674_bb0080","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1166\/jbn.2021.3041","article-title":"Functional exosome-mediated delivery of triptolide endowed with targeting properties as chemotherapy carriers for ovarian carcinoma","volume":"17","author":"He","year":"2021","journal-title":"J. Biomed. Nanotechnol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0085","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.1039\/D1FO00847A","article-title":"Gastrodin extends the lifespan and protects against neurodegeneration in the Drosophila PINK1 model of Parkinson\u2019s disease","volume":"12","author":"He","year":"2021","journal-title":"Food Funct."},{"key":"10.1016\/j.ijpx.2026.100674_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/s13287-022-03050-4","article-title":"The potential use of mesenchymal stem cells and their exosomes in Parkinson\u2019s disease treatment","volume":"13","author":"Heris","year":"2022","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.ijpx.2026.100674_bb0095","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/jgm.1361","article-title":"Neuroprotection in a 6-hydroxydopamine-lesioned Parkinson model using lactoferrin-modified nanoparticles","volume":"11","author":"Huang","year":"2009","journal-title":"J. Gene Med."},{"key":"10.1016\/j.ijpx.2026.100674_bb0100","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1177\/1073858421990001","article-title":"The two faces of exosomes in Parkinson\u2019s disease: from pathology to therapy","volume":"28","author":"Izco","year":"2022","journal-title":"Neuroscientist"},{"key":"10.1016\/j.ijpx.2026.100674_bb0105","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","article-title":"Protocol for the MPTP mouse model of Parkinson\u2019s disease","volume":"2","author":"Jackson-Lewis","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.ijpx.2026.100674_bb0110","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nano.2015.10.012","article-title":"Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells","volume":"12","author":"Kim","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100674_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2021.105730","article-title":"A single low-energy shockwave pulse opens blood-cerebrospinal fluid barriers and facilitates gastrodin delivery to alleviate epilepsy","volume":"78","author":"Kung","year":"2021","journal-title":"Ultrason. Sonochem."},{"key":"10.1016\/j.ijpx.2026.100674_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12175","article-title":"Tissue-derived extracellular vesicles in cancers and non-cancer diseases: present and future","volume":"10","author":"Li","year":"2021","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.ijpx.2026.100674_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114813","article-title":"Exosomes derived from human umbilical cord mesenchymal stem cells attenuate senescence of peritoneal mesothelial cells by inhibiting oxidative stress","volume":"158","author":"Li","year":"2025","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0130","doi-asserted-by":"crossref","first-page":"3183","DOI":"10.7150\/thno.52570","article-title":"Engineering exosomes for targeted drug delivery","volume":"11","author":"Liang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.ijpx.2026.100674_bb0135","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00401-018-1815-1","article-title":"Functional morphology of the blood-brain barrier in health and disease","volume":"135","author":"Liebner","year":"2018","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0140","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/nbt.2247","article-title":"Derivation of blood-brain barrier endothelial cells from human pluripotent stem cells","volume":"30","author":"Lippmann","year":"2012","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0145","article-title":"Tianma Gouteng Yin, a traditional Chinese medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson\u2019s disease","volume":"5","author":"Liu","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.ijpx.2026.100674_bb0150","article-title":"A review on central nervous system effects of gastrodin","volume":"9","author":"Liu","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0155","doi-asserted-by":"crossref","first-page":"20704","DOI":"10.3390\/ijms160920704","article-title":"Mitochondria: a therapeutic target for Parkinson\u2019s disease?","volume":"16","author":"Luo","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0160","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.tibs.2020.11.007","article-title":"Mitochondrial dysfunction and mitophagy in Parkinson\u2019s disease: from mechanism to therapy","volume":"46","author":"Malpartida","year":"2021","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0165","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1007\/s12035-020-01926-1","article-title":"The role of mitochondria in neurodegenerative diseases: the lesson from Alzheimer\u2019s disease and Parkinson\u2019s disease","volume":"57","author":"Monzio Compagnoni","year":"2020","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0170","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.neuron.2014.12.007","article-title":"The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson's disease","volume":"85","author":"Pickrell","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.ijpx.2026.100674_bb0175","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jconrel.2018.08.035","article-title":"Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson\u2019s disease","volume":"287","author":"Qu","year":"2018","journal-title":"J. Control. Release"},{"key":"10.1016\/j.ijpx.2026.100674_bb0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121949","article-title":"Exosomes based strategies for brain drug delivery","volume":"293","author":"Rehman","year":"2023","journal-title":"Biomaterials"},{"key":"10.1016\/j.ijpx.2026.100674_bb0185","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41593-022-01221-3","article-title":"Microglia ferroptosis is regulated by SEC24B and contributes to neurodegeneration","volume":"26","author":"Ryan","year":"2023","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0190","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1007\/s40199-019-00280-5","article-title":"Paclitaxel incorporated exosomes derived from glioblastoma cells: comparative study of two loading techniques","volume":"27","author":"Salarpour","year":"2019","journal-title":"Daru"},{"issue":"2","key":"10.1016\/j.ijpx.2026.100674_bb0195","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/jnc.15699","article-title":"Neurochemical, histological, and behavioral profiling of the acute, sub-acute, and chronic MPTP mouse model of Parkinson\u2019s disease","volume":"164","author":"Santoro","year":"2023","journal-title":"J. Neurochem."},{"key":"10.1016\/j.ijpx.2026.100674_bb0200","doi-asserted-by":"crossref","first-page":"7923","DOI":"10.2147\/IJN.S444582","article-title":"Engineered exosome for drug delivery: recent development and clinical applications","volume":"18","author":"Tian","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100674_bb0205","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson's disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2014.08.004","article-title":"Gastrodin prevents motor deficits and oxidative stress in the MPTP mouse model of Parkinson\u2019s disease: Involvement of ERK1\/2\u2013Nrf2 signaling pathway","volume":"114","author":"Wang","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0215","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/ptr.5538","article-title":"Protective effects of gastrodin against autophagy-mediated astrocyte death","volume":"30","author":"Wang","year":"2016","journal-title":"Phytother. Res."},{"key":"10.1016\/j.ijpx.2026.100674_bb0220","article-title":"Focused ultrasound promotes the delivery of gastrodin and enhances the protective effect on dopaminergic neurons in a mouse model of Parkinson\u2019s disease","volume":"16","author":"Wang","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.ijpx.2026.100674_bb0225","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41392-023-01503-7","article-title":"The mitophagy pathway and its implications in human diseases","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.ijpx.2026.100674_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155518","article-title":"Gastrodin regulates the TLR4\/TRAF6\/NF-\u03baB pathway to reduce neuroinflammation and microglial activation in an AD model","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijpx.2026.100674_bb0235","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12404","article-title":"Minimal information for studies of extracellular vesicles (MISEV2023): from basic to advanced approaches","volume":"13","author":"Welsh","year":"2024","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.ijpx.2026.100674_bb0240","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.26316","article-title":"Extracellular vesicle in vivo biodistribution is determined by cell source, route of administration and targeting","volume":"4","author":"Wiklander","year":"2015","journal-title":"J. Extracell. Vesicles"},{"key":"10.1016\/j.ijpx.2026.100674_bb0245","doi-asserted-by":"crossref","DOI":"10.3390\/cells12101416","article-title":"Current strategies for exosome cargo loading and targeting delivery","volume":"12","author":"Zeng","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.ijpx.2026.100674_bb0250","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.2147\/IJN.S409588","article-title":"Advances in therapeutic applications of extracellular vesicles","volume":"18","author":"Zhang","year":"2023","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100674_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.113012","article-title":"Gastrodin against oxidative stress-inflammation crosstalk via inhibiting mtDNA\/TLR9 and JAK2\/STAT3 signaling to ameliorate ischemic stroke injury","volume":"141","author":"Zhang","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.ijpx.2026.100674_bb0260","doi-asserted-by":"crossref","first-page":"12117","DOI":"10.2147\/IJN.S550390","article-title":"Biological nanotherapeutics derived from human umbilical cord mesenchymal stem cells: mechanisms and translational potential in multisystem therapies for regeneration and oncology","volume":"20","author":"Zhang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.ijpx.2026.100674_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155819","article-title":"Gastrodin relieves Parkinson's disease-related motor deficits by facilitating the MEK-dependent VMAT2 to maintain dopamine homeostasis","volume":"132","author":"Zhao","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.ijpx.2026.100674_bb0270","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s13287-023-03409-1","article-title":"Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury","volume":"14","author":"Zhong","year":"2023","journal-title":"Stem Cell Res. Ther."}],"container-title":["International Journal of Pharmaceutics: X"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001945?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590156726001945?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:07:24Z","timestamp":1793030844000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590156726001945"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":54,"alternative-id":["S2590156726001945"],"URL":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100674","relation":{},"ISSN":["2590-1567"],"issn-type":[{"value":"2590-1567","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactoferrin-modified MSC-derived extracellular vesicles facilitate BBB penetration and enhance gastrodin-induced neuroprotection in Parkinson's disease: involvement of mitophagy","name":"articletitle","label":"Article Title"},{"value":"International Journal of Pharmaceutics: X","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijpx.2026.100674","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"100674"}}