{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T05:03:52Z","timestamp":1771650232624,"version":"3.50.1"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T00:00:00Z","timestamp":1648598400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJID Regions"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.ijregi.2022.03.025","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T21:57:38Z","timestamp":1648850258000},"page":"143-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Hepatic and gastrointestinal manifestations in patients with COVID-19 and relationship with disease severity: a single-centre experience"],"prefix":"10.1016","volume":"3","author":[{"given":"Hadiel","family":"Kaiyasah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Fardan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oghowan","family":"Bashir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mawada","family":"Hussein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-481X","authenticated-orcid":false,"given":"Hamzeh","family":"Alsubbah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laila Al","family":"Dabal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijregi.2022.03.025_bib0001","doi-asserted-by":"crossref","first-page":"E941","DOI":"10.3390\/jcm9040941","article-title":"Novel coronavirus infection (COVID-19) in humans: a scoping review and meta-analysis","volume":"9","author":"Borges do Nascimento","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0002","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.3390\/jcm9061733","article-title":"A cohort of patients with COVID-19 in a major teaching hospital in Europe","volume":"9","author":"Borobia","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0003","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.3748\/wjg.v26.i19.2323","article-title":"Gastrointestinal and hepatic manifestations of COVID-19: a comprehensive review","volume":"26","author":"Cha","year":"2020","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0004","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1053\/j.gastro.2020.03.065","article-title":"Gastrointestinal manifestations of SARS-CoV-2 infection and virus load in fecal samples from the Hong Kong cohort and systematic review and meta-analysis","volume":"159","author":"Cheung","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0005","doi-asserted-by":"crossref","first-page":"1708","DOI":"10.1056\/NEJMoa2002032","article-title":"China Medical Treatment Expert Group for COVID-19. Clinical characteristics of coronavirus disease 2019 in China","volume":"382","author":"Guan","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0006","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1093\/cid\/ciaa330","article-title":"Self-reported olfactory and taste disorders in SARS-CoV-2 patients: a cross-sectional study","volume":"71","author":"Giacomelli","year":"2020","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0007","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1053\/j.gastro.2020.05.010","article-title":"Gastrointestinal and hepatic manifestations of 2019 novel coronavirus disease in a large cohort of infected patients from New York: clinical implications","volume":"159","author":"Hajifathalian","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0008","doi-asserted-by":"crossref","first-page":"916","DOI":"10.14309\/ajg.0000000000000664","article-title":"Digestive symptoms in COVID-19 patients with mild disease severity: clinical presentation, stool viral RNA testing, and outcomes","volume":"115","author":"Han","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0009","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0140-6736(20)30183-5","article-title":"Clinical features of patients infected with 2019 novel coronavirus in Wuhan","volume":"395","author":"Huang","year":"2020","journal-title":"China. Lancet."},{"key":"10.1016\/j.ijregi.2022.03.025_bib23","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1186\/s12879-021-06605-7","article-title":"COVID-19: a fatal case of acute liver failure associated with SARS-CoV-2 infection in pre-existing liver cirrhosis","volume":"21","author":"Ihlow","year":"2021","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0010","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1136\/gutjnl-2020-320832","article-title":"Diarrhoea may be underestimated: a missing link in 2019 novel coronavirus","volume":"69","author":"Liang","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0011","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/S2468-1253(20)30126-6","article-title":"Manifestations and prognosis of gastrointestinal and liver involvement in patients with COVID- 19: a systematic review and meta-analysis","volume":"5","author":"Mao","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0012","doi-asserted-by":"crossref","first-page":"e22818","DOI":"10.1097\/MD.0000000000022818","article-title":"COVID-19 presenting as fulminant hepatic failure: a case report","volume":"99","author":"Melquist","year":"2020","journal-title":"Medicine"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0013","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s10735-020-09915-3","article-title":"COVID-19 and multiorgan failure: a narrative review on potential mechanisms","volume":"51","author":"Mokhtari","year":"2020","journal-title":"J Mol Histol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0014","doi-asserted-by":"crossref","first-page":"766","DOI":"10.14309\/ajg.0000000000000620","article-title":"Clinical characteristics of COVID-19 patients with digestive symptoms in Hubei, China: a descriptive, cross-sectional, multicenter study","volume":"115","author":"Pan","year":"2020","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0016","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgast-2020-000571","article-title":"Gastroenterological and hepatic manifestations of patients with COVID-19, prevalence, mortality by country, and intensive care admission rate: systematic review and meta-analysis","volume":"8","author":"Shehab","year":"2021","journal-title":"BMJ Open Gastroenterol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0017","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/apt.15731","article-title":"Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission","volume":"51","author":"Tian","year":"2020","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"10.1016\/j.ijregi.2022.03.025_bib21","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jinf.2020.06.067","article-title":"SARS-CoV-2 detection, viral load and infectivity over the course of an infection","volume":"81","author":"Walsh","year":"2020","journal-title":"The Journal of infection"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0018","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1111\/jgh.15047","article-title":"COVID-19 and the digestive system","volume":"35","author":"Wong","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0019","doi-asserted-by":"crossref","DOI":"10.1016\/j.cpcardiol.2020.100618","article-title":"COVID-19 and multiorgan response","volume":"45","author":"Zaim","year":"2020","journal-title":"Curr Probl Cardiol"},{"key":"10.1016\/j.ijregi.2022.03.025_bib0020","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1053\/j.gastro.2020.03.020","article-title":"Effect of gastrointestinal symptoms in patients with COVID-19","volume":"158","author":"Zhou","year":"2020","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijregi.2022.03.025_bib22","doi-asserted-by":"crossref","unstructured":"Orandi, Babak John; Li, Geling; Dhall, Deepti; Bajpai, Prachi, Chapleau, Jayme Elizabeth; Gutierrez Sanchez, Luz Helena. Acute Liver Failure in a Healthy Young Female With COVID-19. JPGN Reports: (2021) Volume 2 - Issue 3","DOI":"10.1097\/PG9.0000000000000108"}],"container-title":["IJID Regions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707622000534?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707622000534?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T12:28:36Z","timestamp":1757420916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772707622000534"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":22,"alternative-id":["S2772707622000534"],"URL":"https:\/\/doi.org\/10.1016\/j.ijregi.2022.03.025","relation":{},"ISSN":["2772-7076"],"issn-type":[{"value":"2772-7076","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hepatic and gastrointestinal manifestations in patients with COVID-19 and relationship with disease severity: a single-centre experience","name":"articletitle","label":"Article Title"},{"value":"IJID Regions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijregi.2022.03.025","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}