{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:07:25Z","timestamp":1778936845278,"version":"3.51.4"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,2]],"date-time":"2024-01-02T00:00:00Z","timestamp":1704153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP23K09618"],"award-info":[{"award-number":["JP23K09618"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["3429"],"award-info":[{"award-number":["3429"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJID Regions"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.ijregi.2024.01.002","type":"journal-article","created":{"date-parts":[[2024,1,3]],"date-time":"2024-01-03T19:07:09Z","timestamp":1704308829000},"page":"162-167","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Epidemiology and patterns of empiric antimicrobial therapy practice in patients with community-onset sepsis using data from a Japanese nationwide medical claims database\u2014the Japan Sepsis Alliance (JaSA) study group"],"prefix":"10.1016","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8343-5151","authenticated-orcid":false,"given":"Toshikazu","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Iriyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2824-2162","authenticated-orcid":false,"given":"Taro","family":"Imaeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8548-3707","authenticated-orcid":false,"given":"Akira","family":"Komori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Oami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuerxun","family":"Aizimu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nozomi","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Yamao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Nakagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Ogura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Umemura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asako","family":"Matsushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyohide","family":"Fushimi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9113-6151","authenticated-orcid":false,"given":"Nobuaki","family":"Shime","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4480-556X","authenticated-orcid":false,"given":"Taka-aki","family":"Nakada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijregi.2024.01.002_bib0001","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2020.106184","article-title":"Systematic review of the impact of appropriate versus inappropriate initial antibiotic therapy on outcomes of patients with severe bacterial infections","volume":"56","author":"Bassetti","year":"2020","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0003","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.je.2016.09.009","article-title":"Validity of diagnoses, procedures, and laboratory data in Japanese administrative data","volume":"27","author":"Yamana","year":"2017","journal-title":"J Epidemiol"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0004","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1186\/s13054-021-03762-8","article-title":"Trends in the incidence and outcome of sepsis using data from a Japanese nationwide medical claims database-the Japan Sepsis Alliance (JaSA) study group","volume":"25","author":"Imaeda","year":"2021","journal-title":"Crit Care"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0005","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1097\/CCM.0b013e3181eb3ccd","article-title":"Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: a propensity-matched analysis","volume":"38","author":"Kumar","year":"2010","journal-title":"Crit Care Med"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0006","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s40560-021-00555-7","article-title":"The Japanese clinical practice guidelines for management of sepsis and septic shock 2020 (J-SSCG 2020)","volume":"9","author":"Egi","year":"2021","journal-title":"J Intensive Care"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0007","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1001\/jama.2020.2717","article-title":"Prevalence and outcomes of infection among patients in intensive care units in 2017","volume":"323","author":"Vincent","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0008","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1093\/infdis\/jiaa221","article-title":"Considerations for empiric Antimicrobial Therapy in sepsis and septic shock in an era of antimicrobial resistance","volume":"222","author":"Strich","year":"2020","journal-title":"J Infect Dis"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0009","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1001\/jama.2018.12179","article-title":"Antibiotics for sepsis-finding the equilibrium","volume":"320","author":"Klompas","year":"2018","journal-title":"JAMA"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0010","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1056\/NEJMoa1914433","article-title":"Multidrug-resistant bacterial infections in U.S. hospitalized patients, 2012\u20132017","volume":"382","author":"Jernigan","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0011","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1007\/s00134-020-06151-x","article-title":"Incidence and mortality of hospital- and ICU-treated sepsis: results from an updated and expanded systematic review and meta-analysis","volume":"46","author":"Fleischmann-Struzek","year":"2020","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0012","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.1001\/jama.2012.5833","article-title":"Effect of empirical treatment with moxifloxacin and meropenem vs meropenem on sepsis-related organ dysfunction in patients with severe sepsis: a randomized trial","volume":"307","author":"Brunkhorst","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0013","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jinf.2016.11.013","article-title":"Empirical mono- versus combination antibiotic therapy in adult intensive care patients with severe sepsis - A systematic review with meta-analysis and trial sequential analysis","volume":"74","author":"Sj\u00f6vall","year":"2017","journal-title":"J Infect"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0014","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1370\/afm.1993","article-title":"Prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis","volume":"14","author":"Marchello","year":"2016","journal-title":"Ann Fam Med"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0015","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1164\/rccm.201908-1581ST","article-title":"Diagnosis and treatment of adults with community-acquired pneumonia. An official clinical practice guideline of the American Thoracic Society and Infectious Diseases Society of America","volume":"200","author":"Metlay","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0016","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s13054-018-2186-7","article-title":"Characteristics, management, and in-hospital mortality among patients with severe sepsis in intensive care units in Japan: the FORECAST study","volume":"22","author":"Abe","year":"2018","journal-title":"Crit Care"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0017","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0263936","article-title":"Hour-1 bundle adherence was associated with reduction of in-hospital mortality among patients with sepsis in Japan","volume":"17","author":"Umemura","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0018","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1186\/s13054-019-2644-x","article-title":"Implementation of earlier antibiotic administration in patients with severe sepsis and septic shock in Japan: a descriptive analysis of a prospective observational study","volume":"23","author":"Abe","year":"2019","journal-title":"Crit Care"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0019","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/jama.2016.0288","article-title":"Assessment of clinical criteria for sepsis: for the third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Seymour","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0020","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S1473-3099(20)30477-1","article-title":"Inappropriate empirical antibiotic therapy for bloodstream infections based on discordant in-vitro susceptibilities: a retrospective cohort analysis of prevalence, predictors, and mortality risk in US hospitals","volume":"21","author":"Kadri","year":"2021","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0021","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0227752","article-title":"Incidence, trends, and outcomes of infection sites among hospitalizations of sepsis: a nationwide study","volume":"15","author":"Chou","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0022","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s40560-019-0383-3","article-title":"Variations in infection sites and mortality rates among patients in intensive care units with severe sepsis and septic shock in Japan","volume":"7","author":"Abe","year":"2019","journal-title":"J Intensive Care"},{"key":"10.1016\/j.ijregi.2024.01.002_bib0023","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13054-019-2475-9","article-title":"In-hospital mortality associated with the misdiagnosis or unidentified site of infection at admission","volume":"23","author":"Abe","year":"2019","journal-title":"Crit Care"}],"container-title":["IJID Regions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707624000018?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707624000018?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T12:13:34Z","timestamp":1778933614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772707624000018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":23,"alternative-id":["S2772707624000018"],"URL":"https:\/\/doi.org\/10.1016\/j.ijregi.2024.01.002","relation":{},"ISSN":["2772-7076"],"issn-type":[{"value":"2772-7076","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiology and patterns of empiric antimicrobial therapy practice in patients with community-onset sepsis using data from a Japanese nationwide medical claims database\u2014the Japan Sepsis Alliance (JaSA) study group","name":"articletitle","label":"Article Title"},{"value":"IJID Regions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijregi.2024.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}]}}