{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:23:27Z","timestamp":1793413407860,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,9]],"date-time":"2025-03-09T00:00:00Z","timestamp":1741478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004423","name":"World Health Organization","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004423","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006736","name":"Orebro University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006736","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJID Regions"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.ijregi.2025.100624","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T12:29:34Z","timestamp":1741696174000},"page":"100624","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["High susceptibility to the novel antimicrobial zoliflodacin among Neisseria gonorrhoeae isolates in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021-2024"],"prefix":"10.1016","volume":"15","author":[{"given":"Susanne","family":"Jacobsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thitima","family":"Cherdtrakulkiat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Golparian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lon Say","family":"Heng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irving","family":"Hoffman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Manuel C.","family":"Jamoralin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Kakooza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossaphorn","family":"Kittiyaowamarn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Kyambadde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pham Thi","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Venessa","family":"Maseko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6542-8193","authenticated-orcid":false,"given":"Mitch","family":"Matoga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Etienne","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thuy Thi Phan","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vichea","family":"Ouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Schr\u00f6der","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivi","family":"Setiawaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia B.","family":"Sia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verawati","family":"Sulaiman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mot","family":"Virak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thi Thuy","family":"Van","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Maatouk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teodora","family":"Wi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1710-2081","authenticated-orcid":false,"given":"Magnus","family":"Unemo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijregi.2025.100624_bib0001","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1128\/CMR.00010-14","article-title":"Antimicrobial resistance in Neisseria gonorrhoeae in the 21st century: past, evolution, and future","volume":"27","author":"Unemo","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijregi.2025.100624_bib0002","doi-asserted-by":"crossref","first-page":"e627","DOI":"10.1016\/S2666-5247(21)00171-3","article-title":"WHO global antimicrobial resistance surveillance for Neisseria gonorrhoeae 2017\u201318: a retrospective observational study","volume":"2","author":"Unemo","year":"2021","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.ijregi.2025.100624_bib0003","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/s41579-024-01023-3","article-title":"Antimicrobial treatment and resistance in sexually transmitted bacterial infections","volume":"22","author":"Jensen","year":"2024","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.ijregi.2025.100624_bib0004","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s13073-021-00858-2","article-title":"A community-driven resource for genomic epidemiology and antimicrobial resistance prediction of Neisseria gonorrhoeae at Pathogenwatch","volume":"13","author":"S\u00e1nchez-Bus\u00f3","year":"2021","journal-title":"Genome Med"},{"key":"10.1016\/j.ijregi.2025.100624_bib0005","doi-asserted-by":"crossref","first-page":"e478","DOI":"10.1016\/S2666-5247(23)00370-1","article-title":"Antimicrobial-resistant Neisseria gonorrhoeae in Europe in 2020 compared with in 2013 and 2018: a retrospective genomic surveillance study","volume":"5","author":"Golparian","year":"2024","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.ijregi.2025.100624_bib0006","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/IM9.0000000000000113","article-title":"Global transmission of the penA allele 60.001\u2013containing high-level ceftriaxone-resistant gonococcal FC428 clone and antimicrobial therapy of associated cases: a review","volume":"5","author":"van der Veen","year":"2023","journal-title":"Infect Microbe Dis"},{"key":"10.1016\/j.ijregi.2025.100624_bib0007","doi-asserted-by":"crossref","DOI":"10.1093\/jacamr\/dlae053","article-title":"High prevalence of ceftriaxone-resistant and XDR Neisseria gonorrhoeae in several cities of Cambodia, 2022\u201323: WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP)","volume":"6","author":"Ouk","year":"2024","journal-title":"JAC Antimicrob Resist"},{"key":"10.1016\/j.ijregi.2025.100624_bib0008","article-title":"The WHO Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) identifies high levels of ceftriaxone resistance across Vietnam, 2023","volume":"48","author":"Lan","year":"2024","journal-title":"Lancet Reg Health West Pac"},{"key":"10.1016\/j.ijregi.2025.100624_bib0009","doi-asserted-by":"crossref","first-page":"255","DOI":"10.15585\/mmwr.mm7312a2","article-title":"Ceftriaxone-resistant gonorrhea - China, 2022","volume":"73","author":"Zhu","year":"2024","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.ijregi.2025.100624_bib0010","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.3201\/eid3007.240354","article-title":"World Health Organization Enhanced Gonococcal Antimicrobial Surveillance Programme, Cambodia, 2023","volume":"30","author":"Ouk","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.ijregi.2025.100624_bib0011","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2018.23.27.1800323","article-title":"Gonorrhoea treatment failure caused by a Neisseria gonorrhoeae strain with combined ceftriaxone and high-level azithromycin resistance, England, February 2018","volume":"23","author":"Eyre","year":"2018","journal-title":"Euro Surveill"},{"key":"10.1016\/j.ijregi.2025.100624_bib0012","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2019.24.8.1900118","article-title":"Genetic relatedness of ceftriaxone-resistant and high-level azithromycin resistant Neisseria gonorrhoeae cases, United Kingdom and Australia, February to April 2018","volume":"24","author":"Jennison","year":"2019","journal-title":"Euro Surveill"},{"key":"10.1016\/j.ijregi.2025.100624_bib0013","doi-asserted-by":"crossref","DOI":"10.1128\/mra.00744-22","article-title":"Complete reference genome sequence of the extensively drug-resistant strain Neisseria gonorrhoeae AT159, with ceftriaxone resistance and high-level azithromycin resistance, using nanopore Q20+ chemistry and Illumina sequencing","volume":"11","author":"Golparian","year":"2022","journal-title":"Microbiol Resour Announc"},{"key":"10.1016\/j.ijregi.2025.100624_bib0014","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2022.27.24.2200455","article-title":"Extensively drug-resistant (XDR) Neisseria gonorrhoeae causing possible gonorrhoea treatment failure with ceftriaxone plus azithromycin in Austria, April 2022","volume":"27","author":"Pleininger","year":"2022","journal-title":"Euro Surveill"},{"key":"10.1016\/j.ijregi.2025.100624_bib0015","series-title":"Global action plan to control the spread and impact of antimicrobial resistance in Neisseria gonorrhoeae","year":"2012"},{"key":"10.1016\/j.ijregi.2025.100624_bib0016","series-title":"Response plan to control and manage the threat of multi- and extensively drug-resistant gonorrhoea in Europe \u20132019 update","year":"2019"},{"key":"10.1016\/j.ijregi.2025.100624_bib0017","series-title":"Cephalosporin-resistant Neisseria gonorrhoeae public health response plan","year":"2012"},{"key":"10.1016\/j.ijregi.2025.100624_bib0018","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1021\/acsinfecdis.0c00021","article-title":"Zoliflodacin: an oral spiropyrimidinetrione antibiotic for the treatment of Neisseria gonorrheae, including multi-drug-resistant isolates","volume":"6","author":"Bradford","year":"2020","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.ijregi.2025.100624_bib0019","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/jac\/dkab024","article-title":"High susceptibility to zoliflodacin and conserved target (GyrB) for zoliflodacin among 1209 consecutive clinical Neisseria gonorrhoeae isolates from 25 European countries, 2018","volume":"76","author":"Unemo","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijregi.2025.100624_bib0020","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1128\/AAC.04456-14","article-title":"Characterization of the novel DNA gyrase inhibitor AZD0914: low resistance potential and lack of cross-resistance in Neisseria gonorrhoeae","volume":"59","author":"Alm","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijregi.2025.100624_bib0021","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.3389\/fmicb.2015.01377","article-title":"Genetic resistance determinants, in vitro time-kill curve analysis and pharmacodynamic functions for the novel topoisomerase II inhibitor ETX0914 (AZD0914) in Neisseria gonorrhoeae","volume":"6","author":"Foerster","year":"2015","journal-title":"Front Microbiol"},{"key":"10.1016\/j.ijregi.2025.100624_bib0022","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.682135","article-title":"Pharmacodynamic evaluation of dosing, bacterial kill, and resistance suppression for zoliflodacin against Neisseria gonorrhoeae in a dynamic hollow fiber infection model","volume":"12","author":"Jacobsson","year":"2021","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ijregi.2025.100624_bib0023","article-title":"Pharmacodynamic evaluation of zoliflodacin treatment of Neisseria gonorrhoeae strains with amino acid substitutions in the zoliflodacin target GyrB using a dynamic hollow fiber infection model","volume":"13","author":"Jacobsson","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ijregi.2025.100624_bib0024","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1291885","article-title":"Pharmacodynamics of zoliflodacin plus doxycycline combination therapy against Neisseria gonorrhoeae in a gonococcal hollow-fiber infection model","volume":"14","author":"Jacobsson","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.ijregi.2025.100624_bib0025","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/jac\/dkac366","article-title":"GyrB in silico mining in 27\u200a151 global gonococcal genomes from 1928\u20132021 combined with zoliflodacin in vitro testing of 71 international gonococcal isolates with different GyrB, ParC and ParE substitutions confirms high susceptibility","volume":"78","author":"Golparian","year":"2022","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijregi.2025.100624_bib0026","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002344","article-title":"Antimicrobial resistance in Neisseria gonorrhoeae: global surveillance and a call for international collaborative action","volume":"14","author":"Wi","year":"2017","journal-title":"PLoS Med"},{"key":"10.1016\/j.ijregi.2025.100624_bib0027","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1071\/SH19023","article-title":"World Health Organization Global Gonococcal Antimicrobial Surveillance Program (WHO GASP): review of new data and evidence to inform international collaborative actions and research efforts","volume":"16","author":"Unemo","year":"2019","journal-title":"Sex Health"},{"key":"10.1016\/j.ijregi.2025.100624_bib0028","doi-asserted-by":"crossref","first-page":"dlad139","DOI":"10.1093\/jacamr\/dlad139","article-title":"Neisseria gonorrhoeae antimicrobial susceptibility trends in Bangkok, Thailand, 2015\u201321: Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP)","volume":"5","author":"Kittiyaowamarn","year":"2023","journal-title":"JAC Antimicrob Resist"},{"key":"10.1016\/j.ijregi.2025.100624_bib0029","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1093\/jac\/dkae176","article-title":"The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization","volume":"79","author":"Unemo","year":"2024","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.ijregi.2025.100624_bib0030","doi-asserted-by":"crossref","first-page":"5585","DOI":"10.1128\/AAC.03090-14","article-title":"High in vitro activity of the novel spiropyrimidinetrione AZD0914, a DNA gyrase inhibitor, against multidrug-resistant Neisseria gonorrhoeae isolates suggests a new effective option for oral treatment of gonorrhea","volume":"58","author":"Jacobsson","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijregi.2025.100624_bib0031","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01479-19","article-title":"High in vitro susceptibility to the first-in-class spiropyrimidinetrione zoliflodacin among consecutive clinical Neisseria gonorrhoeae isolates from Thailand (2018) and South Africa (2015\u20132017)","volume":"63","author":"Jacobsson","year":"2019","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.ijregi.2025.100624_bib0032","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s44263-024-00087-w","article-title":"Recommendations for the optimal introduction of novel antibiotics to treat uncomplicated gonorrhoea in the face of increasing antimicrobial resistance: a case study with zoliflodacin","volume":"2","author":"Pascual","year":"2024","journal-title":"BMC Glob Public Health"}],"container-title":["IJID Regions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707625000591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707625000591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T00:13:14Z","timestamp":1762647194000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772707625000591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"alternative-id":["S2772707625000591"],"URL":"https:\/\/doi.org\/10.1016\/j.ijregi.2025.100624","relation":{},"ISSN":["2772-7076"],"issn-type":[{"value":"2772-7076","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High susceptibility to the novel antimicrobial zoliflodacin among Neisseria gonorrhoeae isolates in eight WHO Enhanced Gonococcal Antimicrobial Surveillance Programme countries in three WHO regions, 2021-2024","name":"articletitle","label":"Article Title"},{"value":"IJID Regions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijregi.2025.100624","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"100624"}}