{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:25:35Z","timestamp":1792027535796,"version":"4.4.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009697","name":"Hashemite University","doi-asserted-by":"publisher","award":["19\/4\/2022\/2023"],"award-info":[{"award-number":["19\/4\/2022\/2023"]}],"id":[{"id":"10.13039\/501100009697","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["IJID Regions"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.ijregi.2025.100756","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T06:57:19Z","timestamp":1757573839000},"page":"100756","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Bacterial prevalence and inflammatory changes in positive blood culture in community-acquired neonatal sepsis in Jordan"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9973-3663","authenticated-orcid":false,"given":"Abedulrhman S.","family":"Abdelfattah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamzeh","family":"Al-Momani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ala'a","family":"Al-ma'aiteh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamara","family":"Kufoof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amjad","family":"Tarawneh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Alhroob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossam","family":"AlNoaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein Abu","family":"Qaoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazan","family":"Alshra\u2019ah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara","family":"Alhazaimeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahaf","family":"Alshorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"AlMshagba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Alkhaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruba","family":"Alfuqaha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamadrasoul","family":"Alrashaideh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijregi.2025.100756_bib0001","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1136\/archdischild-2020-320217","article-title":"Global incidence and mortality of neonatal sepsis: a systematic review and meta-analysis","volume":"106","author":"Fleischmann","year":"2021","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ijregi.2025.100756_bib0002","first-page":"154","article-title":"Aetiology of community-acquired neonatal sepsis in low and middle income countries","volume":"1","author":"Waters","year":"2011","journal-title":"J Glob Health"},{"key":"10.1016\/j.ijregi.2025.100756_bib0003","doi-asserted-by":"crossref","first-page":"136","DOI":"10.36346\/sarjams.2023.v05i06.004","article-title":"Neonatal sepsis: insight into incidence, classification, risk factors, causative organisms, pathophysiology, prognosis, clinical manifestations, complications, systemic examination, and treatment","volume":"5","author":"Al Bakoush","year":"2023","journal-title":"South Asian Res J App Med Sci"},{"key":"10.1016\/j.ijregi.2025.100756_bib0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Earlyonset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.ijregi.2025.100756_bib0005","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.891572","article-title":"Quality assessment of clinical practice guidelines for neonatal sepsis using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument: a systematic review of neonatal guidelines","volume":"10","author":"Amer","year":"2022","journal-title":"Front Pediatr"},{"key":"10.1016\/j.ijregi.2025.100756_bib0006","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/tropej\/fmu079","article-title":"Challenges in the diagnosis and management of neonatal sepsis","volume":"61","author":"Zea-Vera","year":"2015","journal-title":"J Trop Pediatr"},{"key":"10.1016\/j.ijregi.2025.100756_bib0007","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0215683","article-title":"Risk factors of neonatal sepsis in India: a systematic review and meta-analysis","volume":"14","author":"Murthy","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.ijregi.2025.100756_bib0008","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1186\/s12879-023-08887-5","article-title":"Clinical effects of bacteremia in sepsis patients with community-acquired pneumonia","volume":"23","author":"Kim","year":"2023","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.ijregi.2025.100756_bib0009","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1097\/PEC.0000000000001539","article-title":"Hypothermia: a sign of sepsis in young infants in the emergency department?","volume":"37","author":"Kasmire","year":"2021","journal-title":"Pediatr Emerg Care"},{"key":"10.1016\/j.ijregi.2025.100756_bib0010","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jped.2019.10.004","article-title":"The challenges of neonatal sepsis management","volume":"96","author":"Procianoy","year":"2020","journal-title":"J Pediatr (Rio J)"},{"key":"10.1016\/j.ijregi.2025.100756_bib0011","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3390\/antibiotics12081233","article-title":"Biomarkers of neonatal sepsis: where we are and where we are going","volume":"12","author":"Boscarino","year":"2023","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.ijregi.2025.100756_bib0012","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/j.1442-200X.2008.02767.x","article-title":"Clinical features of neonatal sepsis caused by resistant Gram-negative bacteria","volume":"51","author":"Khassawneh","year":"2009","journal-title":"Pediatr Int"},{"key":"10.1016\/j.ijregi.2025.100756_bib0013","first-page":"1","article-title":"Neonatal sepsis in Jordan: bacterial isolates and antibiotic susceptibility patterns","volume":"36","author":"Younis","year":"2011","journal-title":"Rawal Med J"},{"key":"10.1016\/j.ijregi.2025.100756_bib0014","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pedneo.2017.06.001","article-title":"Clinical characteristics and epidemiology of sepsis in the neonatal intensive care unit in the era of multidrug-resistant organisms: a retrospective review","volume":"59","author":"Yusef","year":"2018","journal-title":"Pediatr Neonatol"},{"key":"10.1016\/j.ijregi.2025.100756_bib0015","series-title":"WHO Calls for Global Action on Sepsis\u2014cause of 1 in 5 deaths Worldwide","year":"2020"},{"key":"10.1016\/j.ijregi.2025.100756_bib0016","series-title":"Study of aerobic bacterial profile of bloodstream infections and antibiotic susceptibility pattern of the isolates","author":"Nagabhushan","year":"2013"},{"key":"10.1016\/j.ijregi.2025.100756_bib0017","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.PCC.0000149131.72248.E6","article-title":"International pediatric sepsis consensus conference: definitions for sepsis and organ dysfunction in pediatrics","volume":"6","author":"Goldstein","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.ijregi.2025.100756_bib0018","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.jpeds.2018.05.048","article-title":"Neonatal sepsis of early onset, and hospital-acquired and community-acquired late onset: a prospective population-based cohort study","volume":"201","author":"Giannoni","year":"2018","journal-title":"J Pediatr"},{"key":"10.1016\/j.ijregi.2025.100756_bib0019","series-title":"Infectious diseases of the fetus and newborn","year":"2011"},{"key":"10.1016\/j.ijregi.2025.100756_bib0020","doi-asserted-by":"crossref","first-page":"209","DOI":"10.2174\/1874285801812010209","article-title":"Diagnostic significance of white blood cell count and C-reactive protein in neonatal sepsis; Asella Referral Hospital, South East Ethiopia","volume":"12","author":"Sorsa","year":"2018","journal-title":"Open Microbiol J"},{"key":"10.1016\/j.ijregi.2025.100756_bib0021","series-title":"Principles and practice of pediatric infectious diseases","first-page":"1400","article-title":"Laboratory manifestations of infectious diseases","author":"Long","year":"2012"},{"key":"10.1016\/j.ijregi.2025.100756_bib0022","doi-asserted-by":"crossref","first-page":"186","DOI":"10.29074\/ascls.30.3.186","article-title":"A methodical approach to interpreting the white blood cell parameters of the complete blood count","volume":"30","author":"Doig","year":"2017","journal-title":"Clin Lab Sci"},{"key":"10.1016\/j.ijregi.2025.100756_bib0023","first-page":"640","article-title":"Early markers of late-onset sepsis in premature neonates: clinical, hematological, and cytokine profile","volume":"23","author":"Gonzalez","year":"2003","journal-title":"J Perinatol"},{"key":"10.1016\/j.ijregi.2025.100756_bib0024","doi-asserted-by":"crossref","first-page":"94","DOI":"10.25082\/TCPP.2021.01.006","article-title":"Neonatal sepsis: a review of the literature","volume":"3","author":"Nyenga","year":"2021","journal-title":"Theory Clin Pract Pediatr"},{"key":"10.1016\/j.ijregi.2025.100756_bib0025","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1136\/archdischild-2012-302033","article-title":"Community-acquired neonatal and infant sepsis in developing countries: efficacy of WHO\u2019s currently recommended antibiotics\u2014systematic review and meta-analysis","volume":"98","author":"Downie","year":"2013","journal-title":"Arch Dis Child"},{"key":"10.1016\/j.ijregi.2025.100756_bib0026","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1097\/INF.0b013e3181958769","article-title":"Pathogens associated with sepsis in newborns and young infants in developing countries","volume":"28","author":"Zaidi","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"10.1016\/j.ijregi.2025.100756_bib0027","first-page":"1385","article-title":"Early onset of neonatal sepsis: analysis of the risk factors and the bacterial isolates by using the BacT alert system","volume":"5","author":"Bhat","year":"2011","journal-title":"J Clin Diagn Res"},{"key":"10.1016\/j.ijregi.2025.100756_bib0028","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3389\/fimmu.2018.00754","article-title":"Role of C-reactive protein at sites of inflammation and infection","volume":"9","author":"Sproston","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.ijregi.2025.100756_bib0029","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/S0140-6736(17)31002-4","article-title":"Neonatal sepsis","volume":"390","author":"Shane","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.ijregi.2025.100756_bib0030","doi-asserted-by":"crossref","first-page":"5123","DOI":"10.2147\/JIR.S334642","article-title":"Clinical value of C-reactive protein\/platelet ratio in neonatal sepsis: a cross-sectional study","volume":"14","author":"Li","year":"2021","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.ijregi.2025.100756_bib0031","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1542\/peds.2010-0935","article-title":"Interpreting complete blood counts soon after birth in newborns at risk for sepsis","volume":"126","author":"Newman","year":"2010","journal-title":"Pediatrics"},{"key":"10.1016\/j.ijregi.2025.100756_bib0032","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1080\/14767058.2017.1322060","article-title":"Biomarkers for diagnosis of neonatal sepsis: a literature review","volume":"31","author":"Sharma","year":"2018","journal-title":"J Matern Fetal Neonatal Med"},{"key":"10.1016\/j.ijregi.2025.100756_bib0033","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1373\/49.1.60","article-title":"C-reactive protein, interleukin-6, and procalcitonin in the immediate postnatal period: influence of illness severity, risk status, antenatal and perinatal complications, and infection","volume":"49","author":"Chiesa","year":"2003","journal-title":"Clin Chem"},{"key":"10.1016\/j.ijregi.2025.100756_bib0034","first-page":"1001","article-title":"Utility of sepsis screen in the early diagnosis of neonatal sepsis","volume":"4","author":"Bhale","year":"2016","journal-title":"Indian J Neonatal Med Res"},{"key":"10.1016\/j.ijregi.2025.100756_bib0035","first-page":"429","article-title":"Performance of the hematological scoring system for early diagnosis of neonatal sepsis in a neonatal intensive care unit of a developing country","volume":"3","author":"Derbala","year":"2017","journal-title":"Infect Dis Trop Med"},{"key":"10.1016\/j.ijregi.2025.100756_bib0036","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4103\/jcn.JCN_158_15","article-title":"Role of hematological scoring system in diagnosis of neonatal sepsis","volume":"6","author":"Bhalodia","year":"2017","journal-title":"J Clin Neonatol"},{"key":"10.1016\/j.ijregi.2025.100756_bib0037","doi-asserted-by":"crossref","first-page":"60","DOI":"10.4236\/ojped.2016.61011","article-title":"Clinical features and haematological indices of neonatal septicaemia in poor resource settings","volume":"6","author":"Pius","year":"2016","journal-title":"Open J Pediatr"},{"key":"10.1016\/j.ijregi.2025.100756_bib0038","first-page":"409","article-title":"Early diagnosis and evaluation of neonatal septicemia by hematological scoring system","volume":"6","author":"Shah","year":"2019","journal-title":"Int J Med Sci Public Health"},{"key":"10.1016\/j.ijregi.2025.100756_bib0039","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2431-14-248","article-title":"Utility of qualitative C-reactive protein assay and white blood cell counts in the diagnosis of neonatal septicaemia at Bugando Medical Centre, Tanzania","volume":"14","author":"Chacha","year":"2014","journal-title":"BMC Pediatr"}],"container-title":["IJID Regions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707625001912?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772707625001912?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:24:13Z","timestamp":1770899053000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772707625001912"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":39,"alternative-id":["S2772707625001912"],"URL":"https:\/\/doi.org\/10.1016\/j.ijregi.2025.100756","relation":{},"ISSN":["2772-7076"],"issn-type":[{"value":"2772-7076","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacterial prevalence and inflammatory changes in positive blood culture in community-acquired neonatal sepsis in Jordan","name":"articletitle","label":"Article Title"},{"value":"IJID Regions","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ijregi.2025.100756","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.","name":"copyright","label":"Copyright"}],"article-number":"100756"}}