{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T02:20:18Z","timestamp":1777602018275,"version":"3.51.4"},"reference-count":29,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,3,1]],"date-time":"2004-03-01T00:00:00Z","timestamp":1078099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2004,3]]},"DOI":"10.1016\/j.ijrobp.2003.08.008","type":"journal-article","created":{"date-parts":[[2004,2,28]],"date-time":"2004-02-28T10:31:19Z","timestamp":1077964279000},"page":"1072-1082","source":"Crossref","is-referenced-by-count":72,"title":["Impact of volume and location of irradiated rectum wall on rectal blood loss after radiotherapy of prostate cancer"],"prefix":"10.1016","volume":"58","author":[{"given":"Peter C.M","family":"Koper","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wilma D","family":"Heemsbergen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mischa S","family":"Hoogeman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter P","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guus A.M","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arendjan J","family":"Wijnmaalen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marjolein van","family":"Os","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liesebeth J","family":"Boersma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joos V","family":"Lebesque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Levendag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2003.08.008_BIB1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0360-3016(99)00443-5","article-title":"Preliminary report of toxicity following 3D radiation therapy for prostate cancer on 3DOG\/RTOG 9406","volume":"46","author":"Michalski","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB2","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1200\/JCO.2000.18.23.3904","article-title":"Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer","volume":"18","author":"Pollack","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB3","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0167-8140(99)00100-0","article-title":"Clinical experience with intensity modulated radiation therapy (IMRT) in prostate cancer","volume":"55","author":"Zelefsky","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0360-3016(99)00560-X","article-title":"Late rectal toxicity after conformal radiotherapy of prostate cancer (I)","volume":"47","author":"Skwarchuk","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB5","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0360-3016(02)02829-8","article-title":"Prostate cancer radiation dose response","volume":"53","author":"Pollack","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0360-3016(91)90172-Z","article-title":"Fitting of normal tissue tolerance data to an analytic function","volume":"21","author":"Burman","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB7","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0360-3016(91)90173-2","article-title":"Histogram reduction method for calculating complication probabilities for three-dimensional treatment planning evaluations","volume":"21","author":"Kutcher","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0360-3016(98)00406-4","article-title":"Acute morbidity reduction using 3DCRT for prostate carcinoma","volume":"43","author":"Koper","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB9","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/S1278-3218(98)80104-2","article-title":"Derni\u00e8res recommandations de l\u2019ICRU par la prescription, l\u2019engistrement et le compte rendu de la Radioth\u00e9rapie externe. [Last ICRU recommendations for the prescription, recording and reporting of external bean therapy]","volume":"2","author":"Chavaudra","year":"1998","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB10","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S1278-3218(01)00117-2","article-title":"[Definition of volumes in external radiotherapy: ICRU reports 50 and 62]","volume":"5","author":"Chavaudra","year":"2001","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB11","first-page":"1","article-title":"Dosimetry of high-energy photon beams based on standards of absorbed dose to water","volume":"vol. 1","year":"2001","journal-title":"J ICRU"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0360-3016(95)02395-X","article-title":"High-precision prostate cancer irradiation by clinical application of an offline patient setup verification procedure, using portal imaging","volume":"35","author":"Bel","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB13","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/S0360-3016(99)00280-1","article-title":"Comparison of prostate cancer treatment in two institutions","volume":"45","author":"Rasch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB14","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0360-3016(99)00270-9","article-title":"Dose-wall histograms and normalized dose-surface histograms for the rectum","volume":"45","author":"Meijer","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB15","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/0360-3016(91)90732-J","article-title":"Long-term treatment sequelae following external beam irradiation for adenocarcinoma of the prostate","volume":"21","author":"Lawton","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(02)00147-0","article-title":"Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer","volume":"64","author":"Fiorino","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB17","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/S0360-3016(02)03742-2","article-title":"Late rectal toxicity","volume":"54","author":"Huang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB18","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0360-3016(00)01496-6","article-title":"Correlations between dose-surface histograms and the incidence of long-term rectal bleeding following conformal or conventional radiotherapy treatment of prostate cancer","volume":"49","author":"Fenwick","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB19","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0360-3016(98)00037-6","article-title":"Estimation of the incidence of late bladder and rectum complications after high-dose (70-78 GY) conformal radiotherapy for prostate cancer, using dose-volume histograms","volume":"41","author":"Boersma","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB20","series-title":"Modelling survival data in medical research","first-page":"243","author":"Collett","year":"1994"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB21","doi-asserted-by":"crossref","unstructured":"Hoogeman MS, van Herk M, de Bois J, et al. Quantification of local rectal wall displacements by virtual rectum unfolding. Radiother Oncol. In press","DOI":"10.1016\/j.radonc.2003.11.015"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB22","series-title":"Regression modeling strategies. With applications to linear models, logistic regression and survival analysis","first-page":"20","author":"Harrell","year":"2001"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB23","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0360-3016(00)01414-0","article-title":"Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms","volume":"49","author":"Jackson","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB24","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0360-3016(00)00700-8","article-title":"Complications from radiotherapy dose escalation in prostate cancer","volume":"48","author":"Storey","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 2","key":"10.1016\/j.ijrobp.2003.08.008_BIB25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/BF03038898","article-title":"Three dimensional conformal photon radiotherapy at a moderate dose level of 66 Gy for prostate carcinoma","volume":"175","author":"Wachter","year":"1999","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-8140(01)00281-X","article-title":"Rectal sequelae after conformal radiotherapy of prostate cancer","volume":"59","author":"Wachter","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB27","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1118\/1.1287050","article-title":"A new three-dimensional dose distribution reduction scheme for tubular organs","volume":"27","author":"Zhou","year":"2000","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB28","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1016\/S0167-8140(02)82526-9","article-title":"Correlation of 3D dose distribution and rectal complications after prostate treatment","volume":"64","author":"Hoogeman","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2003.08.008_BIB29","doi-asserted-by":"crossref","first-page":"S52","DOI":"10.1016\/S0167-8140(01)80781-7","article-title":"Biological dose surface maps","volume":"61","author":"Sanchez-Nieto","year":"2001","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301603017644?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301603017644?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,14]],"date-time":"2019-02-14T22:59:03Z","timestamp":1550185143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301603017644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,3]]}},"alternative-id":["S0360301603017644"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2003.08.008","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3]]}}}