{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:27:50Z","timestamp":1778628470109,"version":"3.51.4"},"reference-count":49,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.ijrobp.2004.04.021","type":"journal-article","created":{"date-parts":[[2004,10,5]],"date-time":"2004-10-05T11:09:06Z","timestamp":1096974546000},"page":"715-721","source":"Crossref","is-referenced-by-count":73,"title":["Incidence of internal mammary node metastases after a sentinel lymph node technique in breast cancer and its implication in the radiotherapy plan"],"prefix":"10.1016","volume":"60","author":[{"given":"Blanca","family":"Farr\u00fas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergi","family":"Vidal-Sicart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn","family":"Velasco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel","family":"Zan\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro L.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gorane","family":"Santamar\u00eda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Albanell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Biete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2004.04.021_BIB1","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1007\/BF02523652","article-title":"Should internal mammary nodes be sampled in the sentinel lymph node era?","volume":"7","author":"Sugg","year":"2000","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB2","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1097\/00000658-198312000-00002","article-title":"Risk of internal mammary lymph node metastases and its relevance on prognosis of breast cancer patients","volume":"198","author":"Veronesi","year":"1983","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02966683","article-title":"The role of internal mammary lymph node metastases in the management of breast cancer","volume":"5","author":"Noguchi","year":"1998","journal-title":"Breast Ca"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB4","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/S0959-8049(99)00133-1","article-title":"The dissection of internal mammary nodes does not improve the survival of breast cancer patients. 30-year results of a randomised trial","volume":"35","author":"Veronesi","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB5","doi-asserted-by":"crossref","unstructured":"Overgaard M, Hansen PS, Overgaaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med 1997;337:949\u2013955","DOI":"10.1056\/NEJM199710023371401"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB6","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1016\/S0140-6736(98)09201-0","article-title":"Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen","volume":"353","author":"Overgaard","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB7","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1056\/NEJM199710023371402","article-title":"Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer","volume":"337","author":"Ragaz","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB8","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0360-3016(00)00526-5","article-title":"Internal mammary node irradiation neither decreases distant metastases nor improves survival in stage I and II breast cancer","volume":"47","author":"Fowble","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB9","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1056\/NEJM199810013391401","article-title":"The sentinel node in breast cancer","volume":"339","author":"Krag","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB10","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00000658-200107000-00012","article-title":"Halsted revisited","volume":"234","author":"Van der Ent","year":"2001","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB11","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1056\/NEJMoa022152","article-title":"Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy and lumpectomy plus irradiation for the treatment of invasive breast cancer","volume":"347","author":"Fisher","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB12","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa020989","article-title":"Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer","volume":"347","author":"Veronesi","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB13","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1093\/jnci\/92.14.1143","article-title":"Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy","volume":"92","author":"Van Dongen","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1093\/jnci\/djh013","article-title":"Breast-conserving surgery with or without radiotherapy","volume":"96","author":"Vinh-Hung","year":"2004","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/1097-0142(197901)43:1<137::AID-CNCR2820430121>3.0.CO;2-#","article-title":"Computerized body tomography in breast cancer. Internal mammary nodes and radiation treatment planning","volume":"43","author":"Munzenrider","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB16","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00006231-200101000-00003","article-title":"Sentinel lymph node biopsy in breast cancer patients","volume":"22","author":"Mateos","year":"2001","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB17","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0212-6982(00)71895-7","article-title":"The sentinel node. Concepts and clinical applications in neoplasms of the breast and melanoma","volume":"19","author":"Fern\u00e1ndez","year":"2000","journal-title":"Rev Esp Med Nucl"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB18","unstructured":"Manuel Fraile (principal investigator). AATM 048\/13\/2000 \u201cLinfadenectom\u00eda axilar completa frente a observaci\u00f3n en pacientes con micromet\u00e1stasis en el ganglio centinela por neoplasia de mama. Ensayo cl\u00ednico multic\u00e9ntrico\u201d"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/cncr.10696","article-title":"Optimal use of sentinel lymph node biopsy versus axillary lymph node dissection in patients with breast carcinoma","volume":"95","author":"Wong","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0002-9610(01)00717-6","article-title":"Reliable lymphatic drainage to axillary sentinel lymph nodes regardless of tumor location within the breast","volume":"182","author":"Chao","year":"2001","journal-title":"Am J Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB21","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1053\/ejso.2000.0987","article-title":"False negative sentinel node procedure established through palpation of the biopsy wound","volume":"26","author":"Tanis","year":"2000","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB22","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1053\/ejso.1998.0594","article-title":"Sentinel node biopsy in 70 unselected patients with breast cancer","volume":"25","author":"Van der Ent","year":"1999","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB23","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S0002-9610(02)00956-X","article-title":"Clinical axillary recurrence in breast cancer patients after a negative sentinel node biopsy","volume":"184","author":"Chung","year":"2002","journal-title":"Am J Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1007\/s10434-001-0234-y","article-title":"Internal mammary lymph node drainage patterns in patients with breast cancer documented by breast lymphoscintigraphy","volume":"8","author":"Byrd","year":"2001","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB25","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1002\/1097-0142(19830515)51:10<1941::AID-CNCR2820511032>3.0.CO;2-T","article-title":"Radical mastectomy versus radical mastectomy plus internal mammary dissection. Ten year results of an international cooperative trial in breast cancer","volume":"51","author":"Lacour","year":"1983","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB26","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/00000658-198512000-00007","article-title":"Prognosis of breast cancer patients after mastectomy and dissection of internal mammary nodes","volume":"202","author":"Veronesi","year":"1985","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB27","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0360-3016(99)00481-2","article-title":"Should internal mammary lymph nodes in breast cancer be a target for the radiation oncologist?","volume":"46","author":"Freedman","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB28","first-page":"1198","article-title":"New simplified lymphoscintigraphic technique in patients with breast cancer","volume":"30","author":"Terui","year":"1989","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00000658-199409000-00015","article-title":"Lymphatic mapping and sentinel lymphadenectomy for breast cancer","volume":"220","author":"Giuliano","year":"1994","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB30","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1056\/NEJM199810013391401","article-title":"The sentinel node in breast cancer","volume":"339","author":"Krag","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB31","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1097\/00000658-199805000-00005","article-title":"Guidelines for sentinel node biopsy and lymphatic mapping of patients with breast cancer","volume":"227","author":"Cox","year":"1998","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB32","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1053\/ejso.1999.0655","article-title":"In search of the true sentinel node by different injection techniques in breast cancer patients","volume":"25","author":"Roumen","year":"1999","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s10434-999-0450-4","article-title":"Intradermal radiocolloid and intraparenchymal blue dye injection optimize sentinel node identification in breast cancer patients","volume":"6","author":"Linehan","year":"1999","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB34","first-page":"1500","article-title":"Evaluation of mammary lymphoscintigraphy by a single intratumoral injection for sentinel node identification","volume":"41","author":"Vald\u00e9s","year":"2000","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/cncr.11918","article-title":"Should decisions on internal mammary lymph node irradiation be based on current lymphoscintigraphy techniques for sentinel lymph node identification?","volume":"100","author":"Benda","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB36","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1245\/ASO.2003.02.015","article-title":"Should the hunt for internal mammary chain sentinel nodes begin? An evaluation of 150 breast cancer patients","volume":"10","author":"Estourgie","year":"2003","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB37","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/s10434-001-0833-7","article-title":"Utility of internal mammary lymph node removal when noted by intraoperative gamma probe detection","volume":"8","author":"Dupont","year":"2002","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB38","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1002\/1097-0142(19911101)68:9<1918::AID-CNCR2820680913>3.0.CO;2-L","article-title":"Reappraisal of internal mammary node metastases as a prognostic factor in patients with breast cancer","volume":"68","author":"Noguchi","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB39","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/S0002-9610(00)00365-2","article-title":"Sentinel node biopsy and internal mammary lymphatic mapping in breast cancer","volume":"179","author":"Johnson","year":"2000","journal-title":"Am J Surg"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB40","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1002\/1097-0142(19901201)66:11<2313::AID-CNCR2820661110>3.0.CO;2-M","article-title":"Can internal mammary chain treatment decrease the risk of death for patients with medial breast cancers and positive axillary lymph nodes","volume":"66","author":"Le","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB41","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/BF02303699","article-title":"Internal mammary node status","volume":"2","author":"Cody","year":"1995","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB42","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/1097-0142(19890101)63:1<188::AID-CNCR2820630130>3.0.CO;2-M","article-title":"A controlled trial of extended radical versus radical mastectomy. Ten-year results","volume":"63","author":"Meier","year":"1989","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB43","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1200\/JCO.1996.14.5.1558","article-title":"Conservative treatment versus mastectomy in early breast cancer","volume":"14","author":"Arriagada","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/1097-0142(197702)39:2<533::AID-CNCR2820390222>3.0.CO;2-V","article-title":"The influence of untreated internal mammary metastases upon the course of mammary cancer","volume":"39","author":"Donegan","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB45","doi-asserted-by":"crossref","first-page":"S277","DOI":"10.1016\/S0360-3016(97)85578-2","article-title":"Efficacy of loco-regional lymph nodes irradiation after mastectomy for breast cancer with biopsy proven parasternal lymph node metastases. A randomized study","volume":"36","author":"Yamashita","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB46","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1200\/JCO.1994.12.3.447","article-title":"Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy","volume":"12","author":"Cuzick","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB47","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1056\/NEJM199511303332202","article-title":"Effects of radiotherapy and surgery in early breast cancer","volume":"333","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB48","series-title":"Internal mammary and medial supraclavicular (IM-MS) lymph node chain irradiation in stage I-III breast cancer. A phase III randomised trial of the EORTC, protocol 22922\/10925, May 1996, revision May 1999","author":"Van den Bogaert","year":"1999"},{"key":"10.1016\/j.ijrobp.2004.04.021_BIB49","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1200\/JCO.1999.17.6.1720","article-title":"Sentinel lymph node biopsy with metastasis","volume":"17","author":"Reynolds","year":"1999","journal-title":"J Clin Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301604006558?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301604006558?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,2,3]],"date-time":"2019-02-03T01:54:56Z","timestamp":1549158896000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301604006558"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0360301604006558"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2004.04.021","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}