{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T04:05:07Z","timestamp":1792641907193,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.ijrobp.2004.07.714","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T18:31:07Z","timestamp":1110306667000},"page":"1045-1053","source":"Crossref","is-referenced-by-count":52,"title":["Concomitant radiation therapy and paclitaxel for unresectable locally advanced breast cancer: Results from two consecutive Phase I\/II trials"],"prefix":"10.1016","volume":"61","author":[{"given":"Johnny","family":"Kao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne D.","family":"Conzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora T.","family":"Jaskowiak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H.","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Recant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachana","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gini F.","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruth","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2004.07.714_bib1","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1097\/00000658-194311850-00008","article-title":"Carcinoma of the breast: Criteria of inoperability","volume":"118","author":"Haagensen","year":"1943","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib2","first-page":"190","article-title":"Cancer of the breast: Local and regional recurrence","volume":"5","author":"Donegan","year":"1967","journal-title":"Major Probl Clin Surg"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib3","first-page":"573","article-title":"Radical irradiation of advanced breast cancer","volume":"93","author":"Fletcher","year":"1965","journal-title":"Am J Roentgenol Radium Ther Nucl Med"},{"issue":"1 Suppl","key":"10.1016\/j.ijrobp.2004.07.714_bib4","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/cncr.2820741336","article-title":"Management of locally advanced carcinoma of the breastII. Inflammatory carcinoma","volume":"74","author":"Perez","year":"1994","journal-title":"Cancer"},{"issue":"1 Suppl","key":"10.1016\/j.ijrobp.2004.07.714_bib5","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/cncr.2820741335","article-title":"Management of locally advanced carcinoma of the breastI. Noninflammatory","volume":"74","author":"Perez","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s002800050664","article-title":"Combined-modality treatment of inflammatory breast carcinoma: Twenty years of experience at M","volume":"40","author":"Ueno","year":"1997","journal-title":"D. Anderson Cancer Center. Cancer Chemother Pharmacol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib7","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/S0360-3016(02)04201-3","article-title":"Ten-year outcome after combined modality therapy for inflammatory breast cancer","volume":"55","author":"Harris","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib8","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1056\/NEJM199605233342102","article-title":"The sequencing of chemotherapy and radiation therapy after conservative surgery for early-stage breast cancer","volume":"334","author":"Recht","year":"1996","journal-title":"N Engl J Med"},{"issue":"2 Suppl. 1","key":"10.1016\/j.ijrobp.2004.07.714_bib9","first-page":"34","article-title":"Concurrent paclitaxel and radiation therapy for breast cancer","volume":"9","author":"Formenti","year":"1999","journal-title":"Semin Radiat Oncol"},{"issue":"9208","key":"10.1016\/j.ijrobp.2004.07.714_bib10","first-page":"949","article-title":"Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: Three meta-analyses of updated individual data","volume":"355","author":"Pignon","year":"2000","journal-title":"MACH-NC Collaborative Group. Meta-Analysis of Chemotherapy on Head and Neck Cancer. Lancet"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib11","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1056\/NEJM199904153401509","article-title":"Improved treatment for cervical cancer\u2014concurrent chemotherapy and radiotherapy","volume":"340","author":"Thomas","year":"1999","journal-title":"N Engl J Med"},{"issue":"Suppl. 1","key":"10.1016\/j.ijrobp.2004.07.714_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0360-3016(00)80022-X","article-title":"Sequential vs. concurrent chemotherapy and radiation therapy for inoperable non-small cell lung cancer (NSCLC): Analysis of failures in a phase III study (RTOG 9410)","volume":"48","author":"Komaki","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 2","key":"10.1016\/j.ijrobp.2004.07.714_bib13","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0360-3016(02)03156-5","article-title":"Randomized study comparing adjuvant radiotherapy with concomitant chemotherapy versus sequential treatment after conservative surgery for patients with Stage I and II breast carcinoma","volume":"54","author":"Calais","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib14","series-title":"Diseases of the breast","first-page":"515","article-title":"Local management of invasive breast cancer","author":"Morrow","year":"2000"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib15","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1200\/JCO.1996.14.7.1982","volume":"14","author":"Fisher","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib16","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0360-3016(91)90782-Y","article-title":"Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy","volume":"21","author":"Lingos","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib17","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1148\/115.2.471","article-title":"Adriamycin cardiomyopathy: Enhanced cardiac damage in rabbits with combined drug and cardiac irradiation","volume":"115","author":"Eltringham","year":"1975","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib18","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/S0360-3016(97)00506-3","article-title":"Original p53 status predicts for pathological response in locally advanced breast cancer patients treated preoperatively with continuous infusion 5-fluorouracil and radiation therapy","volume":"39","author":"Formenti","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib19","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/jnci\/83.24.1797-a","article-title":"Phase II trial of taxol, an active drug in the treatment of metastatic breast cancer","volume":"83","author":"Holmes","year":"1991","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib20","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1200\/JCO.1999.17.11.3412","article-title":"Prospective evaluation of paclitaxel versus combination chemotherapy with fluorouracil, doxorubicin, and cyclophosphamide as neoadjuvant therapy in patients with operable breast cancer","volume":"17","author":"Buzdar","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib21","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1093\/jnci\/86.6.441","article-title":"In vitro studies of Taxol as a radiation sensitizer in human tumor cells","volume":"86","author":"Liebmann","year":"1994","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib22","first-page":"4191","article-title":"Effect of docetaxel on the therapeutic ratio of fractionated radiotherapy in vivo","volume":"5","author":"Mason","year":"1999","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib23","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1200\/JCO.2003.06.006","article-title":"Weekly carboplatin and paclitaxel followed by concomitant paclitaxel, fluorouracil, and hydroxyurea chemoradiotherapy: Curative and organ-preserving therapy for advanced head and neck cancer","volume":"21","author":"Vokes","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib24","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1200\/JCO.1999.17.1.74","article-title":"Vinorelbine and paclitaxel as first-line chemotherapy in metastatic breast cancer","volume":"17","author":"Romero Acuna","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0169-5002(01)00265-3","article-title":"Mechanism of the radiosensitization induced by vinorelbine in human non-small cell lung cancer cells","volume":"34","author":"Fukuoka","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib26","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0360-3016(83)90080-9","article-title":"Three-field technique for breast irradiation using tangential field corner blocks","volume":"9","author":"Siddon","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib27","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1200\/JCO.2003.06.132","article-title":"Preoperative twice-weekly paclitaxel with concurrent radiation therapy followed by surgery and postoperative doxorubicin-based chemotherapy in locally advanced breast cancer: A phase I\/II trial","volume":"21","author":"Formenti","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib28","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1093\/jnci\/93.23.1806","article-title":"Risk of pneumonitis in breast cancer patients treated with radiation therapy and combination chemotherapy with paclitaxel","volume":"93","author":"Taghian","year":"2001","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib29","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1046\/j.1524-4741.2002.08306.x","article-title":"Acute and subacute toxicity associated with concurrent adjuvant radiation therapy and paclitaxel in primary breast cancer therapy","volume":"8","author":"Hanna","year":"2002","journal-title":"Breast J"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib30","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1046\/j.1524-4741.2003.09203.x","article-title":"Breast-conserving therapy with adjuvant paclitaxel and radiation therapy: Feasibility of concurrent treatment","volume":"9","author":"Ellerbroek","year":"2003","journal-title":"Breast J"},{"issue":"2 Suppl","key":"10.1016\/j.ijrobp.2004.07.714_bib31","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1016\/S0360-3016(03)00829-0","article-title":"Clinically-relevant pneumonitis is not increased in breast cancer patients treated with sequential paclitaxel and radiation","volume":"57","author":"Yu","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib32","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/S0360-3016(00)00636-2","article-title":"Concurrent radiation therapy and paclitaxel or docetaxel chemotherapy in high-risk breast cancer","volume":"48","author":"Bellon","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib33","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/0360-3016(83)90330-9","article-title":"Pleural-based changes on chest X ray after irradiation for primary breast cancer: Correlation with findings on computerized tomography","volume":"9","author":"Srinivasan","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0360-3016(94)90238-0","article-title":"Time-dose relationship for local tumor control following alternate week concomitant radiation and chemotherapy of advanced head and neck cancer","volume":"29","author":"Wong","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib35","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0360-3016(00)00561-7","article-title":"Locoregional irradiation for inflammatory breast cancer: Effectiveness of dose escalation in decreasing recurrence","volume":"47","author":"Liao","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib36","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1016\/0959-8049(95)00199-S","article-title":"Locally advanced non-metastatic breast cancer: Analysis of prognostic factors in 125 homogeneously treated patients with a combined modality approach","volume":"31A","author":"Gardin","year":"1995","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib37","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/oxfordjournals.jncimonographs.a003469","article-title":"Preoperative chemotherapy in patients with operable breast cancer: Nine year results from National Surgical Adjuvant Breast and Bowel project B-18","volume":"30","author":"Wolmark","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib38","doi-asserted-by":"crossref","first-page":"4165","DOI":"10.1200\/JCO.2003.12.005","article-title":"The effect on tumor response of adding sequential preoperative docetaxel to preoperative doxorubicin and cyclophosphamide: Preliminary results from National Surgical Adjuvant Breast and Bowel Project Protocol B-27","volume":"21","author":"Bear","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/sj.bjc.6601616","article-title":"Phase II study of neoadjuvant paclitaxel and cisplatin for operable and locally advanced breast cancer: Analysis of 126 patients","volume":"90","author":"Ezzat","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib40","doi-asserted-by":"crossref","first-page":"3506","DOI":"10.1200\/JCO.2001.19.15.3506","article-title":"Dose-dense doxorubicin, docetaxel, and granulocyte colony-stimulating factor support with or without tamoxifen as preoperative therapy in patients with operable carcinoma of the breast: A randomized, controlled, open phase IIb study","volume":"19","author":"von Minckwitz","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib41","first-page":"35a","article-title":"Weekly paclitaxel followed by FAC as primary systemic chemotherapy of operable breast cancer improves pathologic complete remission rates when compared to every 3 week paclitaxel therapy followed by FAC: Final results of a prospective Phase III trial","volume":"21","author":"Green","year":"2002","journal-title":"Proc Am Soc Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib42","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1016\/S0360-3016(02)02878-X","article-title":"Locoregional treatment outcomes for inoperable anthracycline-resistant breast cancer","volume":"53","author":"Huang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib43","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1200\/JCO.1999.17.2.460","article-title":"Clinical course of breast cancer patients with complete pathologic primary tumor and axillary lymph node response to doxorubicin-based neoadjuvant chemotherapy","volume":"17","author":"Kuerer","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib44","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1200\/JCO.2003.02.018","article-title":"Trastuzumab and vinorelbine as first-line therapy for HER2-overexpressing metastatic breast cancer: Multicenter phase II trial with clinical outcomes, analysis of serum tumor markers as predictive factors, and cardiac surveillance algorithm","volume":"21","author":"Burstein","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib45","first-page":"1902","article-title":"Paclitaxel alone and in combination with radiation therapy as neo-adjuvant approach to locally advanced breast cancer (LABC): Clinical and pathological response","volume":"21","author":"Silvia","year":"2001","journal-title":"Proc Am Soc Clin Oncol"},{"issue":"Suppl. 1","key":"10.1016\/j.ijrobp.2004.07.714_bib46","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0360-3016(01)02180-0","article-title":"Clinical course of locally advanced breast cancer (LABC) patients with pathological response to concurrent 5-fluorouracil and radiation (FU\/RT)","volume":"51","author":"Formenti","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.07.714_bib47","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0360-3016(01)02655-4","article-title":"Low HER2\/neu gene expression is associated with pathological response to concurrent paclitaxel and radiation therapy in locally advanced breast cancer","volume":"52","author":"Formenti","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301604021200?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301604021200?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T03:52:40Z","timestamp":1548647560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301604021200"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0360301604021200"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2004.07.714","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}