{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T15:37:09Z","timestamp":1790609829742,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.ijrobp.2004.11.002","type":"journal-article","created":{"date-parts":[[2005,3,8]],"date-time":"2005-03-08T23:31:07Z","timestamp":1110324667000},"page":"672-679","source":"Crossref","is-referenced-by-count":201,"title":["Treatment outcomes and late complications of 849 patients with nasopharyngeal carcinoma treated with radiotherapy alone"],"prefix":"10.1016","volume":"62","author":[{"given":"Shyh-An","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeh","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Chung","family":"Lui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Jie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eng-Yen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2004.11.002_bib1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1097\/00000421-198808000-00002","article-title":"Excellent response to cisplatin-based chemotherapy in patients with recurrent or previously untreated advanced nasopharyngeal carcinoma","volume":"11","author":"Al Kourainy","year":"1988","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib2","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/(SICI)1097-0142(19980315)82:6<1003::AID-CNCR1>3.0.CO;2-F","article-title":"The role of chemotherapy in the management of nasopharyngeal carcinoma","volume":"82","author":"Chan","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib3","first-page":"1223","article-title":"Chemotherapy in advanced nasopharyngeal carcinoma","volume":"14","author":"Ali","year":"2000","journal-title":"Oncology"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib4","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0360-3016(98)00092-3","article-title":"Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy","volume":"41","author":"Cheng","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib5","series-title":"American Joint Committee on Cancer manual for staging of cancer","year":"1997"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib6","series-title":"Histological typing of upper respiratory tract tumors. No. 19","first-page":"32","article-title":"International histological classification of tumors","year":"1978"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib7","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1148\/radiology.147.3.6844608","article-title":"Computed tomography of the nasopharynx and related spaces","volume":"147","author":"Silver","year":"1983","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1053\/clon.2000.9199","article-title":"Parapharyngeal space involvement in nasopharyngeal cancer","volume":"12","author":"King","year":"2000","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib9","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib10","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/0360-3016(95)00059-8","article-title":"Late effects toxicity scoring","volume":"31","author":"Pavy","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib11","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto","year":"1977","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life tables","volume":"34","author":"Cox","year":"1972","journal-title":"J Royal Stat Soc"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib14","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/(SICI)1097-0142(19960715)78:2<202::AID-CNCR3>3.0.CO;2-N","article-title":"Prognostic value of parapharyngeal extension of nasopharyngeal carcinoma","volume":"78","author":"Chua","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0167-8140(92)90339-V","article-title":"Prognostic factors in nasopharyngeal carcinoma investigated by computer tomography\u2014an analysis of 659 patients","volume":"23","author":"Teo","year":"1992","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib16","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0360-3016(01)02708-0","article-title":"Prognostic influence of parapharyngeal space involvement in nasopharyngeal carcinoma","volume":"52","author":"Xiao","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib17","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/S0360-3016(01)01537-1","article-title":"Is the 1997 AJCC staging system for nasopharyngeal carcinoma prognostically useful for Chinese patient populations?","volume":"50","author":"Ma","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib18","series-title":"UICC Workshop on Nasopharyngeal Cancer","first-page":"77","article-title":"Staging and prognostic factors in NPC\u2014the Hong Kong experience","author":"Lee","year":"1998"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib19","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/hed.2880130406","article-title":"Prognostic value of parapharyngeal extension of nasopharyngeal carcinoma on local control and short-term survival","volume":"13","author":"Sham","year":"1991","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib20","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/0360-3016(94)90307-7","article-title":"A new staging system for nasopharyngeal carcinoma in China","volume":"30","author":"Min","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib21","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1002\/(SICI)1097-0142(19991115)86:10<1912::AID-CNCR6>3.0.CO;2-S","article-title":"Prognostic factors in 677 patients in Singapore with nondisseminated nasopharyngeal carcinoma","volume":"86","author":"Heng","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib22","series-title":"Radiation therapy for head and neck neoplasms","first-page":"257","article-title":"Carcinoma of the nasopharynx","author":"Wang","year":"1997"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib23","series-title":"Principles and practice of radiation oncology","first-page":"897","author":"Perez","year":"1998"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib24","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0360-3016(90)90014-B","article-title":"Nasopharyngeal carcinoma","volume":"19","author":"Sham","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib25","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0360-3016(92)90740-9","article-title":"Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976\u20131985","volume":"23","author":"Lee","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib26","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1259\/0007-1285-66-786-528","article-title":"Nasopharyngeal carcinoma","volume":"66","author":"Lee","year":"1993","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib27","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1016\/0360-3016(89)90950-4","article-title":"Management of local residual primary lesion of nasopharyngeal carcinoma (NPC)","volume":"16","author":"Yan","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib28","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0360-3016(89)90318-0","article-title":"Radiation therapy of nasopharyngeal carcinoma","volume":"16","author":"Zhang","year":"1989","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib29","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0936-6555(96)80040-9","article-title":"A retrospective study of the role of intracavitary brachytherapy and prognostic factors determining local tumour control after primary radical radiotherapy in 903 non-disseminated nasopharyngeal carcinoma patients","volume":"8","author":"Teo","year":"1996","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib30","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1200\/JCO.1998.16.6.2213","article-title":"Fractionated high-dose-rate brachytherapy in primary carcinoma of the nasopharynx","volume":"16","author":"Levendag","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0167-8140(00)00248-6","article-title":"Improved local control for early T-stage nasopharyngeal carcinoma","volume":"57","author":"Teo","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib32","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1259\/0007-1285-63-745-51","article-title":"Prognostic factors of nasopharyngeal carcinoma","volume":"63","author":"Sham","year":"1990","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib33","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0360-3016(96)00416-6","article-title":"The role of brachytherapy in early-stage nasopharyngeal carcinoma","volume":"36","author":"Chang","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib34","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0360-3016(01)01818-1","article-title":"Adjuvant high-dose-rate brachytherapy after external beam radiotherapy in nasopharyngeal carcinoma","volume":"52","author":"Ozyar","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib35","doi-asserted-by":"crossref","first-page":"63","DOI":"10.14219\/jada.archive.1991.0098","article-title":"How much saliva is enough? Normal function defined","volume":"122","author":"Ship","year":"1991","journal-title":"J Am Dent Assoc"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib36","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/0360-3016(82)90166-3","article-title":"Long-term effects of radiotherapy on taste and salivary function in man","volume":"8","author":"Mossman","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib37","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0360-3016(94)90104-X","article-title":"Quality of life in patients treated for head and neck cancer","volume":"28","author":"Bjordal","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib38","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1200\/JCO.2000.18.19.3339","article-title":"Phase III randomized trial of amifostine as a radioprotector in head and neck cancer","volume":"18","author":"Brizel","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0167-8140(00)00235-8","article-title":"Has the outlook improved for amifostine as a clinical radioprotector?","volume":"57","author":"Lindegaard","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib40","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0964-1955(95)00085-2","article-title":"Acupuncture treatment of patients with radiation-induced xerostomia","volume":"32B","author":"Blom","year":"1996","journal-title":"Eur J Cancer Part B, Oral Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib41","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1056\/NEJM199308053290603","article-title":"Oral pilocarpine for post-irradiation xerostomia in patients with head and neck cancer","volume":"329","author":"Johnson","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib42","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0167-8140(03)00023-9","article-title":"Prevention of radiation induced xerostomia by surgical transfer of submandibular salivary gland into the submental space","volume":"66","author":"Jha","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.11.002_bib43","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0167-8140(01)00449-2","article-title":"Intensity-modulated radiation therapy reduces late salivary toxicity without compromising tumor control in patients with oropharyngeal carcinoma","volume":"61","author":"Chao","year":"2001","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301604028329?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301604028329?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T10:51:06Z","timestamp":1735210266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301604028329"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S0360301604028329"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2004.11.002","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}