{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T22:58:49Z","timestamp":1782255529933,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.ijrobp.2004.12.049","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T07:02:36Z","timestamp":1121670156000},"page":"1451-1457","source":"Crossref","is-referenced-by-count":47,"title":["Expressions of Ku70 and DNA-PKcs as prognostic indicators of local control in nasopharyngeal carcinoma"],"prefix":"10.1016","volume":"62","author":[{"given":"Sang-wook","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung-Ja","family":"Cho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-hong","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Yoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soon Yuhl","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong-Jae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Bae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Do","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seong Soo","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Kyung","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsil","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2004.12.049_bib1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1259\/0007-1285-63-745-51","article-title":"Prognostic factors of nasopharyngeal carcinoma","volume":"63","author":"Sham","year":"1990","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0360-3016(92)90740-9","article-title":"Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976\u20131985; overall survival and patterns of failure","volume":"23","author":"Lee","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib3","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1259\/0007-1285-66-786-528","article-title":"Nasopharyngeal carcinoma","volume":"66","author":"Lee","year":"1993","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib4","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0936-6555(94)80056-1","article-title":"Patterns of early treatment failure in non-metastatic nasopharyngeal carcinoma","volume":"6","author":"Yu","year":"1994","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib5","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0360-3016(95)00157-T","article-title":"Prognostic value of tumor regression during radiotherapy for head and neck cancer","volume":"33","author":"Jaulerry","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib6","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1002\/(SICI)1097-0142(19990401)85:7<1446::AID-CNCR4>3.0.CO;2-3","article-title":"The time course of histologic remission after treatment of patients with nasopharyngeal carcinoma","volume":"85","author":"Kwong","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib7","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0968-0004(93)90144-C","article-title":"DNA damage and the DNA-activated protein kinase","volume":"18","author":"Anderson","year":"1993","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib8","doi-asserted-by":"crossref","first-page":"24763","DOI":"10.1074\/jbc.272.40.24763","article-title":"Binding of Ku and c-Abl at the kinase homology region of DNA-dependent protein kinase catalytic subunit","volume":"272","author":"Jin","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0921-8777(99)00006-3","article-title":"Ku, a DNA repair protein with multiple cellular functions?","volume":"434","author":"Featherstone","year":"1999","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1172\/JCI110295","article-title":"Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies from patients with polymyositis-scleroderma overlap","volume":"68","author":"Mimori","year":"1981","journal-title":"J Clin Invest"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0921-8777(97)00009-8","article-title":"DNA-PK","volume":"384","author":"Jeggo","year":"1997","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0300-9084(99)80044-3","article-title":"Regulation of the DNA-dependent protein kinase (DNA-PK) activity in eukaryotic cells","volume":"81","author":"Muller","year":"1999","journal-title":"Biochimie"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib13","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/13755","article-title":"The kudos of non-homologous end-joining","volume":"23","author":"Lustig","year":"1999","journal-title":"Nat Genet"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0959-437X(97)80116-5","article-title":"Tying loose ends","volume":"7","author":"Lieber","year":"1997","journal-title":"Curr Opin Genet Dev"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib15","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1054\/bjoc.2000.1510","article-title":"Expression of Ku70 correlates with survival in carcinoma of the cervix","volume":"83","author":"Wilson","year":"2000","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib16","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1002\/hed.10199","article-title":"Expression of Ku86 confers favorable outcome of tonsillar carcinoma treated with radiotherapy","volume":"25","author":"Friesland","year":"2003","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib17","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1002\/cncr.10807","article-title":"The expression pattern of Ku correlates with tumor radiosensitivity and disease free survival in patients with rectal carcinoma","volume":"95","author":"Komuro","year":"2002","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib18","doi-asserted-by":"crossref","first-page":"e80","DOI":"10.1097\/01.COC.0000077938.48974.59","article-title":"Expression of Ku80 in cervical cancer correlates with response to radiotherapy and survival","volume":"26","author":"Yoko","year":"2003","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib19","first-page":"1073","article-title":"DNA-dependent protein kinase activity correlates with Ku70 expression and radiation sensitivity in esophageal cell lines","volume":"6","author":"Zhao","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0959-8049(98)00289-5","article-title":"DNA-dependent protein kinase content and activity in lung carcinoma cell lines","volume":"35","author":"Sirzen","year":"1999","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0360-3016(98)00362-9","article-title":"DNA double-strand break repair, DNA-PK, and DNA ligases in two human squamous carcinoma cell lines with different radiosensitivity","volume":"43","author":"Polischouk","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1038\/sj.bjc.6690166","article-title":"Ku70\/80 gene expression and DNA-dependent protein kinase (DNA-PK) activity do not correlate with double-strand break (dsb) repair capacity and cellular radiosensitivity in normal human fibroblasts","volume":"79","author":"Kasten","year":"1999","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib23","series-title":"AJCC cancer staging manual","first-page":"31","author":"Fleming","year":"1997"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.humpath.2003.08.014","article-title":"Application of new in situ hybridization probes for Ku70 and Ku80 in tissue microarrays of paraffin-embedded malignant melanomas","volume":"35","author":"Korabiowska","year":"2004","journal-title":"Hum Pathol"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib25","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0360-3016(99)00268-0","article-title":"The immunohistochemical expression of DNA-PK and Ku (p70\/p80) in head and neck cancers","volume":"45","author":"Bjork-Eriksson","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.dnarep.2003.09.004","article-title":"End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4","volume":"3","author":"van Heemst","year":"2004","journal-title":"DNA Repair"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib27","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/0360-3016(83)90428-5","article-title":"Regional stage IV carcinoma of the nasopharynx treated by aggressive radiotherapy","volume":"9","author":"Cooper","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/00000421-198608000-00002","article-title":"Cancer of the nasopharynx in British Columbia","volume":"9","author":"Flores","year":"1986","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib29","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/hed.2880120105","article-title":"Analysis of prognostic factors and proposal of a new classification for nasopharyngeal cancer","volume":"12","author":"Grandi","year":"1990","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib30","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0360-3016(92)90740-9","article-title":"Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976\u20131985","volume":"23","author":"Lee","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.049_bib31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0360-3016(92)90741-Y","article-title":"Carcinoma of the nasopharynx","volume":"23","author":"Perez","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030160403161X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030160403161X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T17:08:13Z","timestamp":1551892093000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030160403161X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S036030160403161X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2004.12.049","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}