{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:10:07Z","timestamp":1792001407452,"version":"4.4.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,8,1]],"date-time":"2005-08-01T00:00:00Z","timestamp":1122854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2005,8]]},"DOI":"10.1016\/j.ijrobp.2004.12.052","type":"journal-article","created":{"date-parts":[[2005,4,2]],"date-time":"2005-04-02T12:15:01Z","timestamp":1112444101000},"page":"1297-1308","source":"Crossref","is-referenced-by-count":211,"title":["Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy"],"prefix":"10.1016","volume":"62","author":[{"given":"Carlos","family":"Vargas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry L.","family":"Kestin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inga","family":"Grills","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald S.","family":"Brabbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Lockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary S.","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Vicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2004.12.052_bib1","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0360-3016(93)90978-5","article-title":"Late rectal bleeding following combined X-ray and proton high dose irradiation for patients with stages T3-T4 prostate carcinoma","volume":"26","author":"Benk","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib2","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0360-3016(98)00037-6","article-title":"Estimation of the incidence of late bladder and rectum complications after high-dose (70\u201378 GY) conformal radiotherapy for prostate cancer, using dose-volume histograms","volume":"41","author":"Boersma","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(02)00147-0","article-title":"Relationships between DVHs and late rectal bleeding after radiotherapy for prostate cancer","volume":"64","author":"Fiorino","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib4","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/S0360-3016(02)03742-2","article-title":"Late rectal toxicity","volume":"54","author":"Huang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib5","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0360-3016(00)01414-0","article-title":"Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms","volume":"49","author":"Jackson","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib6","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1097\/00130404-200201000-00011","article-title":"Dose\/volume relationship of late rectal bleeding after external beam radiotherapy for localized prostate cancer","volume":"8","author":"Kupelian","year":"2002","journal-title":"Cancer J"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0360-3016(99)00560-X","article-title":"Late rectal toxicity after conformal radiotherapy of prostate cancer (I)","volume":"47","author":"Skwarchuk","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-8140(01)00281-X","article-title":"Rectal sequelae after conformal radiotherapy of prostate cancer","volume":"59","author":"Wachter","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1053\/srao.2001.23481","article-title":"Partial irradiation of the rectum","volume":"11","author":"Jackson","year":"2001","journal-title":"Semin Radiat Oncol"},{"issue":"Suppl","key":"10.1016\/j.ijrobp.2004.12.052_bib10","doi-asserted-by":"crossref","first-page":"S151","DOI":"10.1016\/S0360-3016(03)00922-2","article-title":"Toxicity following 3D radiation therapy for prostate cancer on RTOG 9406 dose level V","volume":"57","author":"Michalski","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib11","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1053\/srao.2002.31378","article-title":"Trade-off to low-grade toxicity with conformal radiation therapy for prostate cancer on Radiation Therapy Oncology Group 9406","volume":"12","author":"Michalski","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib12","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0360-3016(03)00072-5","article-title":"Preliminary evaluation of low-grade toxicity with conformal radiation therapy for prostate cancer on RTOG 9406 dose levels I and II","volume":"56","author":"Michalski","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0360-3016(95)02103-5","article-title":"Conventional vs. conformal radiotherapy for prostate cancer","volume":"34","author":"Pollack","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib14","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1200\/JCO.2000.18.23.3904","article-title":"Preliminary results of a randomized radiotherapy dose-escalation study comparing 70 Gy with 78 Gy for prostate cancer","volume":"18","author":"Pollack","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib15","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0360-3016(02)02829-8","article-title":"Prostate cancer radiation dose response","volume":"53","author":"Pollack","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib16","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s00345-003-0356-x","article-title":"Radiation therapy dose escalation for prostate cancer","volume":"21","author":"Pollack","year":"2003","journal-title":"World J Urol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib17","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/S0360-3016(02)03006-7","article-title":"Interim report of toxicity from 3D conformal radiation therapy (3D-CRT) for prostate cancer on 3DOG\/RTOG 9406, level III (79.2 Gy)","volume":"54","author":"Ryu","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0360-3016(00)00700-8","article-title":"Complications from radiotherapy dose escalation in prostate cancer","volume":"48","author":"Storey","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib19","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0360-3016(01)01552-8","article-title":"Improvement in dose escalation using the process of adaptive radiotherapy combined with three-dimensional conformal or intensity-modulated beams for prostate cancer","volume":"50","author":"Martinez","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib20","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0360-3016(00)00608-8","article-title":"An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer","volume":"48","author":"Yan","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib21","series-title":"AJCC cancer staging handbook, 5th ed","first-page":"203","article-title":"Prostate","year":"1998"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib22","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0360-3016(91)90172-Z","article-title":"Fitting of normal tissue tolerance data to an analytic function","volume":"21","author":"Burman","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1118\/1.598063","article-title":"Reporting and analyzing dose distributions","volume":"24","author":"Niemierko","year":"1997","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life-tables","volume":"34","author":"Cox","year":"1972","journal-title":"J R Stat Soc B"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib26","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0360-3016(02)02931-0","article-title":"Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis","volume":"54","author":"O\u2019Brien","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0167-8140(97)00146-1","article-title":"A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis","volume":"45","author":"O\u2019Brien","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib28","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/S0360-3016(01)02591-3","article-title":"Relationship between acute and late normal tissue injury after postoperative radiotherapy in endometrial cancer","volume":"52","author":"Jereczek-Fossa","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib29","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0360-3016(94)00382-U","article-title":"Measurement of prostate movement over the course of routine radiotherapy using implanted markers","volume":"31","author":"Balter","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.radonc.2003.08.003","article-title":"Finding dose-volume constraints to reduce late rectal toxicity following 3D-conformal radiotherapy (3D-CRT) of prostate cancer","volume":"69","author":"Greco","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib31","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S0360-3016(96)00366-5","article-title":"Conformal irradiation of the prostate","volume":"36","author":"Hartford","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib32","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0360-3016(96)00008-9","article-title":"A method of incorporating organ motion uncertainties into three-dimensional conformal treatment plans","volume":"35","author":"Mageras","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0360-3016(97)00221-6","article-title":"Variation in prostate position quantitation and implications for three-dimensional conformal treatment planning","volume":"38","author":"Melian","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib34","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1016\/0360-3016(95)00225-1","article-title":"Evaluation of changes in the size and location of the prostate, seminal vesicles, bladder, and rectum during a course of external beam radiation therapy","volume":"33","author":"Roeske","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib35","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1016\/0360-3016(95)00116-6","article-title":"Quantification of organ motion during conformal radiotherapy of the prostate by three dimensional image registration","volume":"33","author":"van Herk","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib36","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0360-3016(00)00469-7","article-title":"Prostate position late in the course of external beam therapy","volume":"47","author":"Zellars","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib37","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/S1053-4296(03)70007-1","article-title":"Hormones and radiation therapy in locally advanced adenocarcinoma of the prostate","volume":"13","author":"Lawton","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib38","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/sj.bjc.6600266","article-title":"Adjuvant androgen deprivation impacts late rectal toxicity after conformal radiotherapy of prostate carcinoma","volume":"86","author":"Sanguineti","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib39","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S0090-4295(97)00168-4","article-title":"Neoadjuvant androgen ablation prior to radiotherapy for prostate cancer","volume":"49","author":"Zelefsky","year":"1997","journal-title":"Urology"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib40","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/S0360-3016(99)00270-9","article-title":"Dose-wall histograms and normalized dose-surface histograms for the rectum","volume":"45","author":"Meijer","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib41","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0167-8140(01)00469-8","article-title":"Rectum contouring variability in patients treated for prostate cancer","volume":"63","author":"Fiorino","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib42","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0360-3016(01)02599-8","article-title":"The influence of interpatient and intrapatient rectum variation on external beam treatment of prostate cancer","volume":"51","author":"Yan","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib43","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/S0360-3016(03)00749-1","article-title":"Influence of rectal volume changes during radiotherapy for prostate cancer","volume":"57","author":"Miralbell","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib44","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0022-5347(05)65855-7","article-title":"High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer","volume":"166","author":"Zelefsky","year":"2001","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib45","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0360-3016(02)02857-2","article-title":"High-dose intensity modulated radiation therapy for prostate cancer","volume":"53","author":"Zelefsky","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl","key":"10.1016\/j.ijrobp.2004.12.052_bib46","doi-asserted-by":"crossref","first-page":"S276","DOI":"10.1016\/S0360-3016(03)01123-4","article-title":"Hypofractionated IMRT boost for prostate carcinoma with on-line targeting of the prostate gland","volume":"57","author":"Cheung","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib47","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/S0360-3016(00)01474-7","article-title":"Intensity modulated radiation therapy (IMRT) following prostatectomy","volume":"49","author":"Teh","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2004.12.052_bib48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0360-3016(00)01428-0","article-title":"Intensity-modulated radiation therapy (IMRT) for prostate cancer with the use of a rectal balloon for prostate immobilization","volume":"49","author":"Teh","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301605000076?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301605000076?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T07:51:46Z","timestamp":1735545106000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301605000076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["S0360301605000076"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2004.12.052","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}