{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:21:58Z","timestamp":1791199318888,"version":"4.1.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2006,10,1]],"date-time":"2006-10-01T00:00:00Z","timestamp":1159660800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2006,10]]},"DOI":"10.1016\/j.ijrobp.2006.05.070","type":"journal-article","created":{"date-parts":[[2006,9,10]],"date-time":"2006-09-10T11:09:41Z","timestamp":1157886581000},"page":"365-371","source":"Crossref","is-referenced-by-count":33,"title":["The impact of lobular carcinoma in situ in association with invasive breast cancer on the rate of local recurrence in patients with early-stage breast cancer treated with breast-conserving therapy"],"prefix":"10.1016","volume":"66","author":[{"given":"Shruti","family":"Jolly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry L.","family":"Kestin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal S.","family":"Goldstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A.","family":"Vicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2006.05.070_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0167-8140(89)90165-5","article-title":"Ten-year results of a randomized trial comparing a conservative treatment to mastectomy in early breast cancer","volume":"14","author":"Sarrazin","year":"1989","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib2","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1056\/NEJMoa020989","article-title":"Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer","volume":"347","author":"Veronesi","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib3","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1056\/NEJMoa020128","article-title":"Twenty-five-year follow-up of a randomized trial comparing radical mastectomy, total mastectomy, and total mastectomy followed by irradiation","volume":"347","author":"Fisher","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib4","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1056\/NEJM199504063321402","article-title":"Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer","volume":"332","author":"Jacobson","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib5","first-page":"15","article-title":"Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 trial","volume":"11","author":"van Dongen","year":"1992","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib6","first-page":"19","article-title":"Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life-table analysis","volume":"11","author":"Blichert-Toft","year":"1992","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib7","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/(SICI)1097-0142(19961101)78:9<1921::AID-CNCR12>3.0.CO;2-#","article-title":"Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy","volume":"78","author":"Gage","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1309\/8941VDAJMKY2GCLX","article-title":"Factors associated with ipsilateral breast failure and distant metastases in patients with invasive breast carcinoma treated with breast-conserving therapy: A clinicopathologic study of 607 neoplasms from 583 patients","volume":"120","author":"Goldstein","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib9","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1002\/1097-0142(19900415)65:8<1867::AID-CNCR2820650833>3.0.CO;2-I","article-title":"Risk factors for breast recurrence in premenopausal and postmenopausal patients with ductal cancers treated by conservation therapy","volume":"65","author":"Kurtz","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib10","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1200\/JCO.1992.10.3.474","article-title":"Identification of patients who are at high risk for locoregional breast cancer recurrence after conservative surgery and radiotherapy: A review article for surgeons, pathologists, and radiation and medical oncologists","volume":"10","author":"Clarke","year":"1992","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0360-3016(85)90372-4","article-title":"Analysis of local-regional relapses in patients with early breast cancers treated by excision and radiotherapy: Experience of the Institut Gustave-Roussy","volume":"11","author":"Clarke","year":"1985","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1200\/JCO.1994.12.5.888","article-title":"Relationship of patient age to pathologic features of the tumor and prognosis for patients with stage I or II breast cancer","volume":"12","author":"Nixon","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1097\/00000658-199109000-00002","article-title":"The optimal extent of resection for patients with stages I or II breast cancer treated with conservative surgery and radiotherapy","volume":"214","author":"Vicini","year":"1991","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib14","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1200\/JCO.2000.18.2.296","article-title":"Impact of young age on outcome in patients with ductal carcinoma-in-situ treated with breast-conserving therapy","volume":"18","author":"Vicini","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib15","series-title":"Les tumeurs du sein","author":"Cornil","year":"1908"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib16","series-title":"Neoplastic diseases","first-page":"562","author":"Ewing","year":"1928"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib17","first-page":"491","article-title":"Lobular carcinoma in situ: A rare form of mammary carcinoma","author":"Foote","year":"1941","journal-title":"Am J Pathol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib18","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/path.1700520202","article-title":"The evolution of carcinoma of the mamma","volume":"52","author":"Muir","year":"1941","journal-title":"J Pathol Bacteriol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib19","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00000658-196608000-00018","article-title":"Lobular carcinoma of the female breast: Report of 73 cases","volume":"164","author":"Newman","year":"1966","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib20","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00000658-196304000-00015","article-title":"In situ lobular carcinoma of the breast: Report of 26 women with 32 cancers","volume":"157","author":"Newman","year":"1963","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/jama.1967.03130020028006","article-title":"In situ lobular carcinoma: A prospective follow-up study indicating cumulative patient risks","volume":"201","author":"McDivitt","year":"1967","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib22","first-page":"1280","article-title":"Lobular carcinoma in situ of the breast","volume":"126","author":"Lewison","year":"1968","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib23","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/1097-0142(196911)24:5<1081::AID-CNCR2820240534>3.0.CO;2-D","article-title":"Lobular carcinoma in situ: Long term follow-up","volume":"24","author":"Hutter","year":"1969","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib24","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/1097-0142(196904)23:4<826::AID-CNCR2820230417>3.0.CO;2-P","article-title":"Clinical and pathologic correlation with mammographic findings in lobular carcinoma in situ","volume":"23","author":"Hutter","year":"1969","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib25","first-page":"193","article-title":"Lobular carcinoma in situ (lobular neoplasia) of the breast: A symposium","volume":"15","author":"Andersen","year":"1980","journal-title":"Pathol Annu"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib26","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1002\/1097-0142(197706)39:6<2597::AID-CNCR2820390644>3.0.CO;2-E","article-title":"Lobular carcinoma in situ of the breast: An approach to rational treatment","volume":"39","author":"Andersen","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib27","first-page":"655","article-title":"Lobular carcinoma in situ of the breast with ductal involvement: Frequency and possible influence on prognosis","volume":"82","author":"Andersen","year":"1974","journal-title":"Acta Pathol Microbiol Scand [A]"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib28","first-page":"519","article-title":"Lobular carcinoma in situ: A long-term follow-up in 52 cases","volume":"82","author":"Andersen","year":"1974","journal-title":"Acta Pathol Microbiol Scand [A]"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1002\/1097-0142(197301)31:1<105::AID-CNCR2820310114>3.0.CO;2-K","article-title":"Lobular carcinoma in situ: Incidence and treatment","volume":"31","author":"Giordano","year":"1973","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib30","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1002\/1097-0142(197409)34:3<554::AID-CNCR2820340313>3.0.CO;2-7","article-title":"Lobular carcinoma in situ of the breast: Long-term followup","volume":"34","author":"Wheeler","year":"1974","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib31","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00000478-197809000-00001","article-title":"Lobular carcinoma in situ of the breast: Detailed analysis of 99 patients with average follow-up of 24 years","volume":"2","author":"Rosen","year":"1978","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1002\/1097-0142(197808)42:2<737::AID-CNCR2820420247>3.0.CO;2-T","article-title":"Lobular neoplasia (so-called lobular carcinoma in situ) of the breast","volume":"42","author":"Haagensen","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib33","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1046\/j.1524-4741.1999.00002.x","article-title":"Lobular carcinoma in situ of the breast","volume":"5","author":"Frykberg","year":"1999","journal-title":"Breast J"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0360-3016(97)00573-7","article-title":"Lobular carcinoma in situ as a component of breast cancer: The long-term outcome in patients treated with breast-conservation therapy","volume":"40","author":"Moran","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib35","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1002\/(SICI)1097-0142(20000301)88:5<1072::AID-CNCR18>3.0.CO;2-D","article-title":"The relation between the presence and extent of lobular carcinoma in situ and the risk of local recurrence for patients with infiltrating carcinoma of the breast treated with conservative surgery and radiation therapy","volume":"88","author":"Abner","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib36","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1002\/1097-0142(20010515)91:10<1862::AID-CNCR1207>3.0.CO;2-#","article-title":"Lobular carcinoma in situ increases the risk of local recurrence in selected patients with stages I and II breast carcinoma treated with conservative surgery and radiation","volume":"91","author":"Sasson","year":"2001","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib37","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1002\/cncr.11883","article-title":"Pathologic findings from the National Surgical Adjuvant Breast and Bowel Project: Twelve-year observations concerning lobular carcinoma in situ","volume":"100","author":"Fisher","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib38","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/cncr.21555","article-title":"Is lobular carcinoma in situ as a component of breast carcinoma a risk factor for local failure after breast-conserving therapy?","volume":"106","author":"Ben David","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib39","series-title":"Diagnostic histopathology of the breast","first-page":"129","author":"Page","year":"1987"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib40","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/0360-3016(85)90241-X","article-title":"Breast relapse following primary radiation therapy for early breast cancer","volume":"11","author":"Recht","year":"1985","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib41","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0360-3016(91)90772-V","article-title":"The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer","volume":"21","author":"Solin","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib42","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/S0360-3016(99)00112-1","article-title":"Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy","volume":"44","author":"Freedman","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib43","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1093\/jnci\/90.18.1371","article-title":"Tamoxifen for prevention of breast cancer: Report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study","volume":"90","author":"Fisher","year":"1998","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib44","series-title":"Advanced therapy of breast disease","first-page":"269","article-title":"Clinical management of lobular carcinoma in situ","author":"Anderson","year":"2004"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib45","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00000658-199701000-00008","article-title":"Risk of contralateral breast cancer among women with carcinoma in situ of the breast","volume":"225","author":"Habel","year":"1997","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2006.05.070_bib46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0140-6736(03)12230-1","article-title":"Atypical lobular hyperplasia as a unilateral predictor of breast cancer risk: A retrospective cohort study","volume":"361","author":"Page","year":"2003","journal-title":"Lancet"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301606009680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301606009680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,13]],"date-time":"2019-01-13T11:21:57Z","timestamp":1547378517000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301606009680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["S0360301606009680"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2006.05.070","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2006,10]]}}}