{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T16:43:40Z","timestamp":1793033020571,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2006,11,1]],"date-time":"2006-11-01T00:00:00Z","timestamp":1162339200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2006,11]]},"DOI":"10.1016\/j.ijrobp.2006.06.015","type":"journal-article","created":{"date-parts":[[2006,10,27]],"date-time":"2006-10-27T12:12:37Z","timestamp":1161951157000},"page":"1152-1158","source":"Crossref","is-referenced-by-count":185,"title":["Feasibility and efficacy of high-dose three-dimensional-conformal radiotherapy in cirrhotic patients with small-size hepatocellular carcinoma non-eligible for curative therapies\u2014mature results of the French Phase II RTF-1 trial"],"prefix":"10.1016","volume":"66","author":[{"given":"Fran\u00e7oise","family":"Mornex","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Girard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Beziat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul","family":"Kubas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustapha","family":"Khodri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trepo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Merle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2006.06.015_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1056\/NEJM199903113401001","article-title":"Rising incidence of hepatocellular carcinoma in the United States","volume":"340","author":"El-Serag","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1056\/NEJM199603143341104","article-title":"Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis","volume":"334","author":"Mazzaferro","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib3","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00000658-199304000-00009","article-title":"Liver resection for hepatocellular carcinoma","volume":"217","author":"Nagasue","year":"1993","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/S1470-2045(04)01567-0","article-title":"Radiofrequency ablation of liver tumors: Systematic review","volume":"5","author":"Decadt","year":"2004","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib5","first-page":"194","article-title":"The effect of percutaneous ethanol injection therapy on small solitary hepatocellular carcinoma is comparable to that of hepatectomy","volume":"89","author":"Kotoh","year":"1994","journal-title":"Am J Gastroenterol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib6","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1056\/NEJM199505113321903","article-title":"Comparison of lipidol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma","volume":"332","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib7","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0140-6736(98)01259-8","article-title":"Tamoxifen in treatment of hepatocellular carcinoma: A randomised controlled trial","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib8","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/0360-3016(89)90530-0","article-title":"194 hepatocellular cancers treated by radiation and chemotherapy combinations: Toxicity and response","volume":"17","author":"Stillwagon","year":"1989","journal-title":"I J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib9","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0360-3016(92)90651-W","article-title":"The use of 3-D dose volume analysis to predict radiation hepatitis","volume":"23","author":"Lawrence","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib10","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0360-3016(90)90031-E","article-title":"An application of dose volume histograms to the treatment of intrahepatic malignancies with radiation therapy","volume":"19","author":"Lawrence","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib11","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1016\/S0360-3016(01)02653-0","article-title":"The reproducibility of organ position using active breathing control (ABC) during liver radiotherapy","volume":"51","author":"Dawson","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib12","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1200\/JCO.1993.11.7.1286","article-title":"Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy","volume":"11","author":"Robertson","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib13","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1046\/j.1440-1746.1999.01994.x","article-title":"A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma","volume":"14","author":"Cheng","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib14","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.canrad.2005.09.007","article-title":"[Tolerance and efficacy of conformal radiotherapy for hepatocellular carcinoma in cirrhotic patients Results of the French RTF 1 phase II trial]","volume":"9","author":"Mornex","year":"2005","journal-title":"Cancer Radiother"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib15","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0167-8140(91)90065-O","article-title":"Technical considerations in the use of 3-D beam arrangements in the abdomen","volume":"22","author":"Ten Haken","year":"1991","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib16","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1016\/j.ijrobp.2003.08.025","article-title":"Alterations in normal liver doses due to organ motion","volume":"57","author":"Rosu","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib17","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/S0360-3016(97)00550-6","article-title":"A Phase I trial of hepatic arterial bromodeoxyuridine and conformal radiation therapy for patients with primary hepatobiliary cancers or colorectal liver metastases","volume":"39","author":"Robertson","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib18","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1200\/JCO.1998.16.6.2246","article-title":"Treatment of intrahepatic cancers with radiation doses based on a normal tissue complication probability model","volume":"16","author":"McGinn","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib19","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1055\/s-2007-1007122","article-title":"Prognosis of hepatocellular carcinoma: The BCLC staging classification","volume":"19","author":"Llovet","year":"1999","journal-title":"Semin Liver Dis"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib20","series-title":"Evaluation of chemotherapeutic agents","first-page":"191","article-title":"The clinical evaluation of chemotherapeutic agents","author":"Karnofsky","year":"1949"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib21","series-title":"The Liver and Portal Hypertension","first-page":"50","article-title":"Surgery and portal hypertension","author":"Child","year":"1964"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib22","unstructured":"World Health Organisation. WHO handbook for reporting results of cancer treatment. World Health Organization Offset Publication, No. 48, 1979. Geneva, Switzerland."},{"key":"10.1016\/j.ijrobp.2006.06.015_bib23","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0168-8278(01)00130-1","article-title":"Conclusions of the Barcelona-2000 EASL conference","volume":"35","author":"Bruix","year":"2001","journal-title":"J Hepatol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0360-3016(99)00559-3","article-title":"Common toxicity criteria: Version 2.0","volume":"47","author":"Trotti","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib25","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/0360-3016(95)90159-0","article-title":"LENT SOMA scales for all anatomic sites","volume":"31","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Non-parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib27","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0360-3016(96)00528-7","article-title":"Long-term results of hepatic artery fluorodeoxyuridine and conformal radiation therapy for primary hepatobiliary cancers","volume":"37","author":"Robertson","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib28","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1200\/JCO.2000.18.11.2210","article-title":"Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies","volume":"18","author":"Dawson","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib29","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/S0360-3016(02)02846-8","article-title":"Analysis of radiation-induced liver disease using the Lyman NTCP model","volume":"53","author":"Dawson","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib30","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.semradonc.2005.04.005","article-title":"Partial volume tolerance of the liver to radiation","volume":"15","author":"Dawson","year":"2005","journal-title":"Sem Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0360-3016(91)90069-G","article-title":"Treatment of cancers involving the liver and porta hepatis with external beam irradiation and intraarterial hepatic fluorodeoxyuridine","volume":"20","author":"Lawrence","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib32","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1093\/jjco\/hyh089","article-title":"Three-dimensional conformal radiation therapy for unresectable hepatocellular carcinoma patients who had failed with or were unsuited for transcatheter arterial chemoembolization","volume":"34","author":"Liu","year":"2004","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib33","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0360-3016(02)02864-X","article-title":"Dose-response relationship in local radiotherapy for hepatocellular carcinoma","volume":"54","author":"Park","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib34","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1053\/j.gastro.2004.09.003","article-title":"Radiofrequency ablation improves prognosis compared with ethanol injection for hepatocellular carcinoma < or = 4 cm","volume":"127","author":"Lin","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib35","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/S0360-3016(02)02915-2","article-title":"Radiation-induced liver disease after three-dimensional conformal radiotherapy for patients with hepatocellular carcinoma: Dosimetric analysis and implication","volume":"54","author":"Cheng","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib36","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0360-3016(03)00091-9","article-title":"Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease","volume":"56","author":"Cheng","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib37","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.ijrobp.2004.05.048","article-title":"Biologic susceptibility of hepatocellular carcinoma patients treated with radiotherapy to radiation-induced liver disease","volume":"60","author":"Cheng","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib38","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.ijrobp.2003.12.030","article-title":"Daily ultrasound-based image-guided targeting for radiotherapy of upper abdominal malignancies","volume":"59","author":"Fuss","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib39","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0360-3016(03)00434-6","article-title":"Prospective trial of combined transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for portal vein tumor thrombus in patients with unresectable hepatocellular carcinoma","volume":"57","author":"Yamada","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.06.015_bib40","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijrobp.2005.11.043","article-title":"Repeated proton beam therapy for hepatocellular carcinoma","volume":"65","author":"Hashimoto","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030160601042X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030160601042X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,11]],"date-time":"2019-01-11T17:20:32Z","timestamp":1547227232000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030160601042X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["S036030160601042X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2006.06.015","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2006,11]]}}}