{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:59:12Z","timestamp":1791104352547,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.ijrobp.2006.09.034","type":"journal-article","created":{"date-parts":[[2006,12,9]],"date-time":"2006-12-09T12:15:14Z","timestamp":1165666514000},"page":"799-811","source":"Crossref","is-referenced-by-count":94,"title":["Reduced late rectal mucosal changes after prostate three-dimensional conformal radiotherapy with endorectal balloon as observed in repeated endoscopy"],"prefix":"10.1016","volume":"67","author":[{"given":"Emile N.J.Th.","family":"van Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3n","family":"Kristinsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00eblle E.P.","family":"Philippens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk J.","family":"de Jong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette P.","family":"van der Vight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes H.A.M.","family":"Kaanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Leer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andries G.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2006.09.034_bib1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.ijrobp.2005.10.002","article-title":"Localized volume effects for late rectal and anal toxicity after radiotherapy for prostate cancer","volume":"64","author":"Peeters","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib2","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1016\/j.ijrobp.2005.05.054","article-title":"Hypofractionated intensity-modulated radiotherapy (70 Gy at 2.5 Gy per fraction) for localized prostate cancer: Long-term outcomes","volume":"63","author":"Kupelian","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib3","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1016\/S0360-3016(02)03245-5","article-title":"Late rectal toxicity: Dose-volume effects of conformal radiotherapy for prostate cancer","volume":"54","author":"Huang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib4","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0360-3016(00)00700-8","article-title":"Complications from radiotherapy dose escalation in prostate cancer: Preliminary results of a randomized trial","volume":"48","author":"Storey","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib5","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.ijrobp.2005.10.029","article-title":"Cluster model analysis of late rectal bleeding after IMRT of prostate cancer: A case-control study","volume":"64","author":"Tucker","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib6","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1016\/j.ijrobp.2004.07.712","article-title":"Comparison of rectal dose-wall histogram versus dose-volume histogram for modeling the incidence of late rectal bleeding after radiotherapy","volume":"60","author":"Tucker","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib7","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0360-3016(00)01414-0","article-title":"Late rectal bleeding after conformal radiotherapy of prostate cancer. II. Volume effects and dose-volume histograms","volume":"49","author":"Jackson","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib8","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0360-3016(99)00560-X","article-title":"Late rectal toxicity after conformal radiotherapy of prostate cancer (I): Multivariate analysis and dose-response","volume":"47","author":"Skwarchuk","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.urology.2005.10.008","article-title":"A prospective evaluation of rectal bleeding after dose-escalated three-dimensional conformal radiation therapy using an intrarectal balloon for prostate gland localization and immobilization","volume":"67","author":"D\u2019Amico","year":"2006","journal-title":"Urology"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib10","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.coc.0000195099.26957.63","article-title":"Tolerance of endorectal balloon in 396 patients treated with intensity-modulated radiation therapy (IMRT) for prostate cancer","volume":"29","author":"Bastasch","year":"2006","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib11","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.ijrobp.2005.11.001","article-title":"Patient tolerance of rectal balloons in conformal radiation treatment of prostate cancer","volume":"64","author":"Ronson","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.meddos.2004.10.005","article-title":"Rectal wall sparing by dosimetric effect of rectal balloon used during intensity-modulated radiation therapy (IMRT) for prostate cancer","volume":"30","author":"Teh","year":"2005","journal-title":"Med Dosim"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib13","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.ijrobp.2004.10.003","article-title":"Acute gastrointestinal, genitourinary, and dermatological toxicity during dose-escalated 3D-conformal radiation therapy (3DCRT) using an intrarectal balloon for prostate gland localization and immobilization","volume":"62","author":"Woel","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib14","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ijrobp.2005.05.010","article-title":"Rectal wall sparing effect of three different endorectal balloons in 3D conformal and IMRT prostate radiotherapy","volume":"63","author":"van Lin","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib15","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0167-8140(03)00056-2","article-title":"Rectal dose sparing with a balloon catheter and ultrasound localization in conformal radiation therapy for prostate cancer","volume":"67","author":"Patel","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib16","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0360-3016(01)01821-1","article-title":"The influence of a rectal balloon tube as internal immobilization device on variations of volumes and dose-volume histograms during treatment course of conformal radiotherapy for prostate cancer","volume":"52","author":"Wachter","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/S0360-3016(00)01428-0","article-title":"Intensity-modulated radiation therapy (IMRT) for prostate cancer with the use of a rectal balloon for prostate immobilization: Acute toxicity and dose-volume analysis","volume":"49","author":"Teh","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(01)00378-4","article-title":"Radiation injury of the rectum","volume":"60","author":"O\u2019Brien","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib19","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0360-3016(03)01445-7","article-title":"Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer","volume":"58","author":"O\u2019Brien","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib20","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-8140(99)00173-5","article-title":"Endoscopic scoring of late rectal mucosal damage after conformal radiotherapy for prostatic carcinoma","volume":"54","author":"Wachter","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.ijrobp.2004.09.042","article-title":"The effect of an endorectal balloon and off-line correction on the interfraction systematic and random prostate position variations: A comparative study","volume":"61","author":"van Lin","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib22","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1016\/S0360-3016(01)02663-3","article-title":"A practical method to achieve prostate gland immobilization and target verification for daily treatment","volume":"51","author":"D\u2019Amico","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib23","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S0360-3016(01)02585-8","article-title":"Optimization of intensity-modulated radiotherapy plans based on the equivalent uniform dose","volume":"52","author":"Wu","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib24","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0167-8140(99)00027-4","article-title":"Is there more than one late radiation proctitis syndrome?","volume":"51","author":"Denham","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.ijrobp.2005.12.046","article-title":"IMRT boost dose planning on dominant intraprostatic lesions: Gold marker-based three-dimensional fusion of CT with dynamic contrast-enhanced and 1H-spectroscopic MRI","volume":"65","author":"van Lin","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib26","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/j.ijrobp.2004.12.087","article-title":"Gastrointestinal symptoms after pelvic radiotherapy: Role for the gastroenterologist?","volume":"62","author":"Andreyev","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib27","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.1002\/(SICI)1097-0142(19990601)85:11<2460::AID-CNCR23>3.0.CO;2-N","article-title":"Long term tolerance of high dose three-dimensional conformal radiotherapy in patients with localized prostate carcinoma","volume":"85","author":"Zelefsky","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib28","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0360-3016(97)00301-5","article-title":"Rectal bleeding after conformal 3D treatment of prostate cancer: Time to occurrence, response to treatment and duration of morbidity","volume":"39","author":"Teshima","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.ijrobp.2004.10.021","article-title":"Long-term androgen deprivation increases Grade 2 and higher late morbidity in prostate cancer patients treated with three-dimensional conformal radiation therapy","volume":"62","author":"Feigenberg","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib30","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1148\/radiology.195.3.7753997","article-title":"Proctitis after conventional external radiation therapy for prostate cancer: Importance of minimizing posterior rectal dose","volume":"195","author":"Cho","year":"1995","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2006.09.034_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0360-3016(96)00064-8","article-title":"Lateral rectal shielding reduces late rectal morbidity following high dose three-dimensional conformal radiation therapy for clinically localized prostate cancer: Further evidence for a significant dose effect","volume":"35","author":"Lee","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301606031233?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301606031233?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T23:55:35Z","timestamp":1547164535000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301606031233"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0360301606031233"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2006.09.034","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}