{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T22:56:23Z","timestamp":1791068183914,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1016\/j.ijrobp.2006.09.035","type":"journal-article","created":{"date-parts":[[2006,12,16]],"date-time":"2006-12-16T12:14:37Z","timestamp":1166271277000},"page":"651-659","source":"Crossref","is-referenced-by-count":64,"title":["Changes in salivary gland function after radiotherapy of head and neck tumors measured by quantitative pertechnetate scintigraphy: Comparison of intensity-modulated radiotherapy and conventional radiation therapy with and without Amifostine"],"prefix":"10.1016","volume":"67","author":[{"given":"Marc W.","family":"M\u00fcnter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Hoffner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holger","family":"Hof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus K.","family":"Herfarth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Haberkorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Rudat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"Karger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2006.09.035_bib1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0360-3016(99)00128-5","article-title":"Quality of life in patients cured from a carcinoma of the head-and-neck by radiotherapy: The importance of the target volume","volume":"45","author":"Huguenin","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib2","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.tripleo.2004.04.009","article-title":"Double-blind randomized, placebo-controlled study of pilocarpine to salvage salivary gland function during radiotherapy of patients with head-and-neck cancer","volume":"98","author":"Gornitsky","year":"2004","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib3","first-page":"397","article-title":"[Prospective double-blind study of prophylaxis of radioxerostomia with Coumarin\/Troxerutine in patients with head-and-neck cancer]","volume":"175","author":"Grotz","year":"1999","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib4","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1200\/JCO.2000.18.19.3339","article-title":"Phase III randomized trial of amifostine as a radioprotector in head-and-neck cancer","volume":"18","author":"Brizel","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1053\/srao.2002.31359","article-title":"Protection of salivary function by intensity-modulated radiation therapy in patients with head-and-neck cancer","volume":"12","author":"Chao","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S0360-3016(00)01441-3","article-title":"A prospective study of salivary function sparing in patients with head-and-neck cancers receiving intensity-modulated or three-dimensional radiation therapy: Initial results","volume":"49","author":"Chao","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib7","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/S0360-3016(01)01512-7","article-title":"Xerostomia and its predictors following parotid-sparing irradiation of head-and-neck cancer","volume":"50","author":"Eisbruch","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0360-3016(03)01437-8","article-title":"Evaluation of salivary gland function after treatment of head-and-neck tumors with intensity-modulated radiotherapy by quantitative pertechnetate scintigraphy","volume":"58","author":"Munter","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib9","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1007\/s00066-002-0987-7","article-title":"Inverse treatment planning and stereotactic intensity-modulated radiation therapy (IMRT) of the tumor and lymph node levels for nasopharyngeal carcinomas","volume":"178","author":"Munter","year":"2002","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib10","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1080\/095530097143112","article-title":"Muscarinic receptor stimulation increases tolerance of rat salivary gland function to radiation damage","volume":"72","author":"Coppes","year":"1997","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib11","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2307\/3579045","article-title":"The role of secretory granules in radiation-induced dysfunction of rat salivary glands","volume":"141","author":"Peter","year":"1995","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib12","doi-asserted-by":"crossref","first-page":"259","DOI":"10.2307\/3577837","article-title":"A functional and chemical study of radiation effects on rat parotid and submandibular\/sublingual glands","volume":"124","author":"Vissink","year":"1990","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib13","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0167-8140(02)00129-9","article-title":"Comparison of radiosensitivity of rat parotid and submandibular glands after different radiation schedules","volume":"63","author":"Coppes","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib14","unstructured":"StatSoft I. STATISTICA f\u00fcr Windows (Software-System f\u00fcr Datenanalyse) Version 6. www.statsoft.com. 2004"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib15","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/PL00002356","article-title":"Determination of tolerance dose uncertainties and optimal design of dose response experiments with small animal numbers","volume":"177","author":"Karger","year":"2001","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib16","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijrobp.2005.07.966","article-title":"Influence of intravenous Amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and-neck cancer: 2-Year follow-up of a prospective, randomized, phase III trial","volume":"63","author":"Wasserman","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib17","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.ijrobp.2005.08.005","article-title":"Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: A randomized placebo-controlled phase III study","volume":"64","author":"Buentzel","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib18","first-page":"34","article-title":"Pharmacokinetics of amifostine: Effects of dose and method of administration","volume":"26","author":"Shaw","year":"1999","journal-title":"Semin Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib19","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00066-003-1016-1","article-title":"Randomized phase III trial of postoperative radiochemotherapy +\/\u2212 amifostine in head-and-neck cancer","volume":"179","author":"Vacha","year":"2003","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib20","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0360-3016(01)02683-9","article-title":"Prophylactic use of amifostine to prevent radiochemotherapy-induced mucositis and xerostomia in head-and-neck cancer","volume":"52","author":"Antonadou","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib21","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.ijrobp.2003.09.021","article-title":"Scintigraphic assessment of early and late parotid gland function after radiotherapy for head-and-neck cancer: A prospective study of dose-volume response relationships","volume":"58","author":"Roesink","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-0714.1992.tb00982.x","article-title":"Salivary gland 99mTc-scintigraphy: A grading scale and correlation with major salivary gland flow rates","volume":"21","author":"Kohn","year":"1992","journal-title":"J Oral Pathol Med"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib23","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1007\/s00066-005-1366-y","article-title":"[Quantitative and qualitative investigations of salivary gland function in dependence on irradiation dose and volume for reduction of xerostomia in patients with head-and-neck cancer]","volume":"181","author":"Kuhnt","year":"2005","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib24","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.radonc.2003.10.005","article-title":"Serious adverse effects of amifostine during radiotherapy in head-and-neck cancer patients","volume":"70","author":"Rades","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib25","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1002\/cncr.20552","article-title":"Intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: A prospective study on disease control and preservation of salivary function","volume":"101","author":"Kwong","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijrobp.2003.08.004","article-title":"Intensity-modulated radiation therapy for oropharyngeal carcinoma: Impact of tumor volume","volume":"59","author":"Chao","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijrobp.2005.03.057","article-title":"Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: Update of the Memorial Sloan-Kettering experience","volume":"64","author":"Wolden","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.radonc.2004.11.004","article-title":"Intensity modulated radiotherapy for head-and-neck cancer: Evidence for preserved salivary gland function","volume":"74","author":"Saarilahti","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib29","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head-and-neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2006.09.035_bib30","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.radonc.2006.02.017","article-title":"Sparing of the submandibular glands by intensity modulated radiotherapy in the treatment of head-and-neck cancer","volume":"78","author":"Saarilahti","year":"2006","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301606031294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301606031294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T02:10:07Z","timestamp":1555985407000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301606031294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3]]}},"alternative-id":["S0360301606031294"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2006.09.035","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}