{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T20:55:38Z","timestamp":1792097738077,"version":"4.4.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.ijrobp.2007.01.053","type":"journal-article","created":{"date-parts":[[2007,3,31]],"date-time":"2007-03-31T07:19:10Z","timestamp":1175325550000},"page":"1110-1120","source":"Crossref","is-referenced-by-count":458,"title":["Risk, Outcomes, and Costs of Radiation-Induced Oral Mucositis Among Patients With Head-and-Neck Malignancies"],"prefix":"10.1016","volume":"68","author":[{"given":"Linda S.","family":"Elting","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine D.","family":"Cooksley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam S.","family":"Garden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2007.01.053_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0360-3016(99)00558-1","article-title":"Toxicity in head and neck cancer: A review of trends and issues","volume":"47","author":"Trotti","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib2","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s11912-005-0039-4","article-title":"Intensity-modulated radiotherapy: Is xerostomia still prevalent?","volume":"7","author":"Chambers","year":"2005","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib3","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1200\/JCO.1999.17.3.1020","article-title":"Quality of life and performance in advanced head and neck cancer patients on concomitant chemoradiotherapy: A prospective examination","volume":"17","author":"List","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib4","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1001\/archotol.130.4.401","article-title":"Clinical predictors of quality of life in patients with head and neck cancer","volume":"130","author":"Terrell","year":"2004","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s11912-006-0049-x","article-title":"How to reduce radiation-related toxicity in patients with cancer of the head and neck","volume":"8","author":"Garden","year":"2006","journal-title":"Curr Oncol Rep"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.ijrobp.2006.08.078","article-title":"Disease-control rates following intensity-modulated radiation therapy for small primary oropharyngeal carcinoma","volume":"67","author":"Garden","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib7","series-title":"Common toxicity criteria, V2.0","article-title":"Cancer Therapy Evaluation Program","year":"1999"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib8","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/0360-3016(90)90341-G","article-title":"Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx","volume":"19","author":"Ang","year":"1990","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib9","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0360-3016(00)00663-5","article-title":"A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003","volume":"48","author":"Fu","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib10","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib11","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/0360-3016(95)00093-E","article-title":"Split-course accelerated therapy in head and neck cancer: An analysis of toxicity","volume":"32","author":"Delaney","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib12","first-page":"680","article-title":"Oral complications of cancer therapy","volume":"16","author":"Sonis","year":"2002","journal-title":"Oncology (Williston Park, NY)"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cncr.21622","article-title":"Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma","volume":"106","author":"Vera-Llonch","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib14","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1002\/cncr.20162","article-title":"Perspectives on cancer therapy-induced mucosal injury: Pathogenesis, measurement, epidemiology, and consequences for patients","volume":"100","author":"Sonis","year":"2004","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0347(199901)21:1<1::AID-HED1>3.0.CO;2-4","article-title":"Quality of life and oral function following radiotherapy for head and neck cancer","volume":"21","author":"Epstein","year":"1999","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib16","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00002820-200212000-00010","article-title":"Complications of radiation therapy for head and neck cancers","volume":"25","author":"Rose-Ped","year":"2002","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib17","doi-asserted-by":"crossref","first-page":"5186","DOI":"10.1200\/JCO.2005.02.8340","article-title":"Palifermin reduces patient-reported mouth and throat soreness and improves patient functioning in the hematopoietic stem-cell transplantation setting","volume":"24","author":"Stiff","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib18","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/clinids\/14.6.1201","article-title":"Septicemia and shock syndrome due to viridans streptococci: A case-control study of predisposing factors","volume":"14","author":"Elting","year":"1992","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib19","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q","article-title":"The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies","volume":"82","author":"Ruescher","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib20","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1056\/NEJMoa040125","article-title":"Palifermin for oral mucositis after intensive therapy for hematologic cancers","volume":"351","author":"Spielberger","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00520-006-0019-8","article-title":"Symptom clusters in cancer patients","volume":"14","author":"Chen","year":"2006","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib22","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1002\/cncr.11382","article-title":"Are the symptoms of cancer and cancer treatment due to a shared biologic mechanism?","volume":"97","author":"Cleeland","year":"2003","journal-title":"Cancer"},{"issue":"Suppl. 1","key":"10.1016\/j.ijrobp.2007.01.053_bib23","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1016\/S0889-1591(02)00077-6","article-title":"Cytokine-induced sickness behavior","volume":"17","author":"Kelley","year":"2003","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib24","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1007\/s00520-005-0899-z","article-title":"Symptom clustering in advanced cancer","volume":"14","author":"Walsh","year":"2006","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib25","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0149-7634(88)80004-6","article-title":"Biological basis of the behavior of sick animals","volume":"12","author":"Hart","year":"1988","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib26","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1007\/s00520-006-0058-1","article-title":"New thoughts on the pathobiology of regimen-related mucosal injury","volume":"14","author":"Anthony","year":"2006","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib27","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/oxfordjournals.jncimonographs.a003440","article-title":"Mucositis in head and neck cancer: Economic and quality-of-life outcomes","volume":"29","author":"Peterman","year":"2001","journal-title":"J Natl Cancer Inst Monogr"},{"key":"10.1016\/j.ijrobp.2007.01.053_bib28","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1002\/cncr.11671","article-title":"The burdens of cancer therapy","volume":"98","author":"Elting","year":"2003","journal-title":"Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301607002477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301607002477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T08:21:09Z","timestamp":1546935669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301607002477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0360301607002477"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2007.01.053","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}