{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:45:44Z","timestamp":1785577544536,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.ijrobp.2007.03.059","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T08:49:58Z","timestamp":1180082998000},"page":"1238-1250","source":"Crossref","is-referenced-by-count":83,"title":["Optimized Dose Coverage of Regional Lymph Nodes in Breast Cancer: The Role of Intensity-Modulated Radiotherapy"],"prefix":"10.1016","volume":"68","author":[{"given":"Nesrin","family":"Dogan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie","family":"Cuttino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Bump","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas W.","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2007.03.059_bib1","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM198503143121102","article-title":"Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation","volume":"312","author":"Fisher","year":"1985","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib2","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.ijrobp.2005.05.044","article-title":"Clinical investigation: Regional nodal failure patterns in breast cancer patients treated with mastectomy without radiotherapy","volume":"63","author":"Strom","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0360-3016(97)00001-1","article-title":"Long-term follow-up of axillary node-positive breast cancer patients receiving adjuvant systemic therapy alone: Patterns of recurrence","volume":"38","author":"Fisher","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib4","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1001\/archsurg.1991.01410280027002","article-title":"Local-regional breast cancer recurrence following mastectomy","volume":"126","author":"Crowe","year":"1991","journal-title":"Arch Surg"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib5","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0360-3016(00)00633-7","article-title":"Internal mammary node coverage: An investigation of presently accepted techniques","volume":"48","author":"Arthur","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib6","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1016\/S0360-3016(01)02760-2","article-title":"Postmastectomy radiotherapy of the chest wall: Dosimetric comparison of common techniques","volume":"52","author":"Pierce","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib7","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/0167-8140(93)90150-7","article-title":"Matching of electron and photon beams with a multi-leaf collimator","volume":"29","author":"Karlsson","year":"1993","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0167-8140(97)00176-X","article-title":"Radiotherapy of breast cancer after breast-conserving surgery: An improved technique using mixed electron-photon beams with a multileaf collimator","volume":"46","author":"Jansson","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0167-8140(02)00266-9","article-title":"Node-positive left-sided breast cancer patients after breast-conserving surgery: Potential outcomes of radiotherapy modalities and techniques","volume":"65","author":"Johansson","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib10","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0167-8140(00)00152-3","article-title":"Cardiac and lung complication probabilities after breast cancer irradiation","volume":"55","author":"Hurkmans","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib11","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0360-3016(94)90584-3","article-title":"To treat or not to treat the internal mammary nodes: A possible compromise","volume":"29","author":"Marks","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0360-3016(02)04163-9","article-title":"Breast radiotherapy with inclusion of internal mammary nodes: A comparison of techniques with three-dimensional planning","volume":"55","author":"Severin","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib13","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/S0360-3016(00)00504-6","article-title":"An improved technique for breast cancer irradiation including the locoregional lymph nodes","volume":"47","author":"Hurkmans","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0167-8140(01)00472-8","article-title":"Intensity modulated versus non-intensity modulated radiotherapy in the treatment of the left breast and upper internal mammary lymph node chain: A comparative planning study","volume":"62","author":"Cho","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib15","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1016\/j.ijrobp.2005.04.027","article-title":"Comparison of normal tissue dose with three-dimensional conformal techniques for breast cancer irradiation including the internal mammary nodes","volume":"63","author":"van der Laan","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib16","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0360-3016(03)00183-4","article-title":"Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapy","volume":"56","author":"Krueger","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0360-3016(02)04210-4","article-title":"Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes","volume":"55","author":"Lomax","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/153303460400300108","article-title":"Inversely planned intensity modulated radiotherapy of the breast including the internal mammary chain: A plan comparison study","volume":"3","author":"Thilmann","year":"2004","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib19","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0360-3016(02)04143-3","article-title":"Significant reductions in heart and lung doses using deep inspiration breath hold with active breathing control and intensity-modulated radiation therapy for patients treated with locoregional breast irradiation","volume":"55","author":"Remouchamps","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib20","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/S0360-3016(03)00010-5","article-title":"Initial clinical experience with moderate deep-inspiration breath hold using an active breathing control device in the treatment of patients with left-sided breast cancer using external beam radiation therapy","volume":"56","author":"Remouchamps","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib21","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1016\/S0360-3016(02)03746-X","article-title":"Optimizing breast cancer treatment efficacy with intensity-modulated radiotherapy","volume":"54","author":"Vicini","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib22","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0167-8140(00)00263-2","article-title":"The delivery of intensity modulated radiotherapy to the breast using multiple static fields","volume":"57","author":"Evans","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0958-3947(02)00089-4","article-title":"Intensity-modulated radiotherapy of the female breast","volume":"27","author":"Thilmann","year":"2002","journal-title":"Med Dosim"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib24","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1053\/srao.2002.32468","article-title":"Clinical aspects of intensity-modulated radiotherapy in the treatment of breast cancer","volume":"12","author":"Krueger","year":"2002","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-8140(00)00189-4","article-title":"Breast-conserving radiation therapy using combined electron and intensity-modulated radiotherapy technique","volume":"56","author":"Li","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1148\/radiol.2212010247","article-title":"Definition of the supraclavicular and infraclavicular nodes: Implications for three-dimensional CT-based conformal radiation therapy","volume":"221","author":"Madu","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0167-8140(00)00260-7","article-title":"Set-up verification using portal imaging: Review of current clinical practice","volume":"58","author":"Hurkmans","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib28","series-title":"Pinnacle3 white paper no. 4535 983 02479","article-title":"P3IMRT: Inverse planning optimization","author":"Rehbinder","year":"2003"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib29","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1118\/1.595774","article-title":"A convolution method of calculating dose for 15-MV x rays","volume":"12","author":"Mackie","year":"1985","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib30","series-title":"Philips Pinnacle manual release 7.4","first-page":"4-15","article-title":"Pinnacle physics instructions for use","year":"2004"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib31","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1016\/S0360-3016(99)00344-2","article-title":"A comparison of different intensity modulated treatment techniques for tangential breast irradiation","volume":"45","author":"Chang","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib32","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/0360-3016(92)90895-O","article-title":"Long-term radiation complications following conservative surgery (CS) and radiation therapy (RT) in patients with early stage breast cancer","volume":"23","author":"Pierce","year":"1992","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib33","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/095530000138466","article-title":"Radiation-induced pulmonary injury: Symptomatic versus subclinical endpoints","volume":"76","author":"Marks","year":"2000","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib34","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.radonc.2005.08.004","article-title":"IMRT for breast: A planning study","volume":"76","author":"Fogliata","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib35","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1016\/j.ijrobp.2004.10.033","article-title":"Hybrid IMRT plans\u2014Concurrently treating conventional and IMRT beams for improved breast irradiation and reduced planning time","volume":"61","author":"Mayo","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib36","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0360-3016(99)00132-7","article-title":"Intensity-modulated tangential beam irradiation of the intact breast","volume":"44","author":"Hong","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib37","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0167-8140(01)00374-7","article-title":"Cardiac avoidance in breast radiotherapy: A comparison of simple shielding techniques with intensity-modulated radiotherapy","volume":"60","author":"Landau","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib38","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1259\/bjr\/11764177","article-title":"Irradiation of the heart during tangential breast treatment: A study within the START trial","volume":"77","author":"Venables","year":"2004","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0167-8140(99)00026-2","article-title":"Ischemic heart disease after mantlefield irradiation for Hodgkin\u2019s disease in long-term follow-up","volume":"51","author":"Reinders","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib40","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1088\/0031-9155\/46\/5\/309","article-title":"A simulation of the effects of set-up error and changes in breast volume on conventional and intensity-modulated treatments in breast radiotherapy","volume":"46","author":"Hector","year":"2001","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0167-8140(01)00309-7","article-title":"The dosimetric consequences of inter-fractional patient movement on three classes of intensity-modulated delivery techniques in breast radiotherapy","volume":"59","author":"Hector","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.03.059_bib42","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0167-8140(99)00167-X","article-title":"The dosimetric consequences of inter-fractional patient movement on conventional and intensity-modulated breast radiotherapy treatments","volume":"54","author":"Hector","year":"2000","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301607006633?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301607006633?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T23:20:53Z","timestamp":1546816853000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301607006633"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":42,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0360301607006633"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2007.03.059","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]}}}