{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:45:56Z","timestamp":1793123156996,"version":"4.5.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.ijrobp.2007.12.048","type":"journal-article","created":{"date-parts":[[2008,3,15]],"date-time":"2008-03-15T10:58:19Z","timestamp":1205578699000},"page":"134-143.e15","source":"Crossref","is-referenced-by-count":211,"title":["Hyperbaric Oxygen Treatment of Chronic Refractory Radiation Proctitis: A Randomized and Controlled Double-Blind Crossover Trial With Long-Term Follow-Up"],"prefix":"10.1016","volume":"72","clinical-trial-number":[{"clinical-trial-number":"isrctn85456814","registry":"10.18810\/isrctn"},{"clinical-trial-number":"nct00134628","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Richard E.","family":"Clarke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. M. Catalina","family":"Tenorio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Hussey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akin S.","family":"Toklu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Lindsie","family":"Cone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose G.","family":"Hinojosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir P.","family":"Desai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Dominguez Parra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvia D.","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret B.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2007.12.048_bib1","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S0305-7372(03)00068-9","article-title":"Modern management of locally advanced cervical carcinoma","volume":"29","author":"Duenas-Gonzalez","year":"2003","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0167-8140(01)00378-4","article-title":"Radiation injury of the rectum","volume":"60","author":"O'Brien","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s10350-004-6530-4","article-title":"Management of late complications of pelvic radiation in the rectum and anus","volume":"46","author":"Johnston","year":"2003","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0360-3016(03)01445-7","article-title":"Spontaneous improvement in late rectal mucosal changes after radiotherapy for prostate cancer","volume":"58","author":"O'Brien","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0360-3016(03)01395-6","article-title":"Rectal bleeding and its management after irradiation for uterine cervical cancer","volume":"58","author":"Chun","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0360-3016(97)00560-9","article-title":"The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinoma: Evidence suggestive of consequential late effect (CQLE)","volume":"40","author":"Wang","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib7","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0360-3016(83)90298-5","article-title":"Analysis of the severe complications of irradiation of carcinoma of the cervix: Whole pelvis irradiation and intracavitary radium","volume":"9","author":"Hamberger","year":"1983","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib8","first-page":"40","article-title":"The natural history of radiation-induced proctosigmoiditis: An analysis of 88 patients","volume":"205","author":"Gilinsky","year":"1983","journal-title":"Q J Med New Series LII"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib9","first-page":"801","article-title":"Late progress of radiation-induced proctitis","volume":"156","author":"Fischer","year":"1990","journal-title":"Acta Chir Scand"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib10","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1046\/j.1365-2168.1998.00821.x","article-title":"Quality of life in patients undergoing treatment for chronic radiation-induced rectal bleeding","volume":"85","author":"Dent","year":"1998","journal-title":"Br J Surg"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib11","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1046\/j.1365-2036.2003.01760.x","article-title":"How patients manage gastrointestinal symptoms after pelvic radiotherapy","volume":"18","author":"Gammi","year":"2003","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib12","first-page":"521","article-title":"The management of late radiation-induced rectal injury after treatment of carcinoma of the uterus","volume":"164","author":"Allen-Mersh","year":"1987","journal-title":"Surg Gynecol Obstet"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib13","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1136\/gut.2004.062596","article-title":"Gastrointestinal complications of pelvic radiotherapy: Are they of any importance?","volume":"54","author":"Andreyev","year":"2005","journal-title":"Gut"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib14","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/0360-3016(95)00118-I","article-title":"Time course and incidence of late complications in patients treated with radiation therapy for FIGO stage IB carcinoma of the uterine cervix","volume":"32","author":"Eifel","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib15","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/sj.bjc.6600360","article-title":"Systematic review for non-surgical interventions for the management of late radiation proctitis","volume":"87","author":"Denton","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib16","first-page":"4","article-title":"A systematic review of the literature reporting the application of hyperbaric oxygen prevention and treatment of delayed radiation injuries: An evidence based approach","volume":"29","author":"Feldmeier","year":"2002","journal-title":"Undersea Hyperb Med"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0278-2391(83)80005-6","article-title":"A new concept in the treatment of osteoradionecrosis","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib18","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD005005","article-title":"Hyperbaric oxygen therapy for late radiation tissue injury (Protocol)","author":"Bennett","year":"2004","journal-title":"The Cochrane Database of Systematic Reviews"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib19","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0360-3016(95)00057-6","article-title":"Overview: Late effects of normal tissues (LENT) scoring system","volume":"31","author":"Rubin","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib20","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0090-4295(00)00858-X","article-title":"Development and validation of the Expanded Prostate Cancer Index Composite (EPIC) for comprehensive assessment of health-related quality of life in men with prostate cancer","volume":"56","author":"Wei","year":"2000","journal-title":"Urology"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib21","unstructured":"Anderson B, Shelton DL. Axial length in hyperoxic myopia. Presented at the Ninth International Symposium on Underwater and Hyperbaric Physiology Undersea and Hyperbaric Medical Society, Bethesda, MD, 1987. p. 607\u2013611."},{"key":"10.1016\/j.ijrobp.2007.12.048_bib22","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1046\/j.1365-2036.2001.01075.x","article-title":"Review article: Current therapeutic options for radiation proctopathy","volume":"15","author":"Hong","year":"2001","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib23","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/cncr.11595","article-title":"Late genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapy","volume":"98","author":"Albert","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib24","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1445-2197.1996.tb00717.x","article-title":"The development of a treatment protocol for patients with chronic radiation-induced rectal bleeding","volume":"66","author":"Chapuis","year":"1996","journal-title":"Aust NZ J Surg"},{"issue":"Suppl. III","key":"10.1016\/j.ijrobp.2007.12.048_bib25","first-page":"85","article-title":"Clinical and pathological manifestations: Therapy and prophylaxis of acute and late injurious effects of radiation on the rectal mucosa","volume":"174","author":"Zimmermann","year":"1998","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib26","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1136\/gut.25.5.448","article-title":"Microvascular studies in human radiation bowel disease","volume":"25","author":"Carr","year":"1984","journal-title":"Gut"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib27","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1148\/radiographics.17.6.9397458","article-title":"Imaging features of radiation-induced changes in the abdomen","volume":"17","author":"Capps","year":"1997","journal-title":"Radiographics"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/BF01318212","article-title":"Severe hemorrhagic radiation proctitis advancing to gradual cessation with hyperbaric oxygen","volume":"36","author":"Charneau","year":"1991","journal-title":"Dig Dis Sci"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib29","first-page":"1426","article-title":"Hyperbaric oxygen treatment of mandibular osteomyelitis: Report of three cases","volume":"87","author":"Mainous","year":"1973","journal-title":"JADA"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib30","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0278-2391(83)90294-X","article-title":"Osteoradionecrosis: A new chapter of its pathophysiology","volume":"41","author":"Marx","year":"1983","journal-title":"J Oral Maxillofac Surg"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib31","unstructured":"Bouachour G, Ronceray J, Bouali AB, et al. Hyperbaric oxygen in the treatment of radiation induced proctitis: A report on 8 cases. Proceedings of the Tenth International Congress on Hyperbaric Medicine, Amsterdam, 1990. p. 158\u2013163."},{"key":"10.1016\/j.ijrobp.2007.12.048_bib32","doi-asserted-by":"crossref","first-page":"A11","DOI":"10.7326\/ACPJC-2002-136-2-A11","article-title":"Clinical expertise in the era of evidence-based medicine and patient choice (Editorial)","volume":"136","author":"Haynes","year":"2002","journal-title":"ACP J Club"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib33","series-title":"Hyperbaric medicine practice","first-page":"665","article-title":"Radiation injury to tissue","author":"Marx","year":"2004"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4172\/plastic-surgery.1000174","article-title":"Cost effectiveness analysis of hyperbaric therapy in osteoradionecrosis","volume":"5","author":"Dempsey","year":"1997","journal-title":"Can J Plast Surg"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib35","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/BF02050634","article-title":"Therapeutic experience of hyperbaric oxygenation in radiation colitis","volume":"36","author":"Nakada","year":"1993","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0140-6736(05)66143-0","article-title":"Hyperbaric oxygen therapy in a woman who declined colostomy","volume":"348","author":"Hamour","year":"1996","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib37","first-page":"205","article-title":"Hyperbaric oxygen an adjunctive treatment for delayed radiation injuries of the abdomen and pelvis","volume":"23","author":"Feldmeier","year":"1996","journal-title":"Undersea Hyperbaric Med"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib38","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0360-3016(97)00017-5","article-title":"Hyperbaric oxygen treatment for radiation proctitis","volume":"38","author":"Woo","year":"1997","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib39","first-page":"181","article-title":"Chronic radiation proctitis treated with hyperbaric oxygen","volume":"24","author":"Warren","year":"1997","journal-title":"Undersea Hyperb Med"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib40","unstructured":"Ugheoke EA, Norris T, Sharma VK, et al. Radiation proctitis (RTP): Is there a role for hyperbaric oxygen (HBO) therapy? Proceedings of the American College of Gastroenterology 63rd Annual Scientific Meeting, October 12\u201314, 1998, Boston, MA."},{"key":"10.1016\/j.ijrobp.2007.12.048_bib41","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/BF03038628","article-title":"Treatment of radiation proctitis with hyperbaric oxygen: What is the optimal number of HBO treatments?","volume":"174","author":"Carl","year":"1998","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib42","first-page":"1053","article-title":"The role of hyperbaric oxygen therapy in radiation-induced digestive disorders: 36 cases","volume":"28","author":"Gouello","year":"1999","journal-title":"Presse Med"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib43","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1046\/j.1464-410x.2000.00404.x","article-title":"The treatment of chronic radiation proctitis with hyperbaric oxygen in patients with prostate cancer","volume":"85","author":"Kitta","year":"2000","journal-title":"BJU Int"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib44","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1007\/BF02236641","article-title":"Use of hyperbaric oxygen chamber in the management of radiation-related complications of the anorectal region","volume":"43","author":"Bem","year":"2000","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib45","unstructured":"Roque F, Saraiva A, Simao G, et al. Hyperbaric oxygen therapy for late radio-induced intestinal lesions. Proceedings of the European Society for Therapeutic Radiology and Consensus Conference, Lisbon, Portugal, 2001. p. 105\u2013121."},{"key":"10.1016\/j.ijrobp.2007.12.048_bib46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0167-8140(01)00430-3","article-title":"Hyperbaric oxygen\u2014An effective tool to treat radiation morbidity in prostate cancer","volume":"61","author":"Mayer","year":"2001","journal-title":"Radiother Oncol"},{"issue":"Suppl.","key":"10.1016\/j.ijrobp.2007.12.048_bib47","first-page":"19","article-title":"Hyperbaric oxygen therapy for chronic radiation proctitis (CRP) [Abstract]","volume":"29","author":"Boyle","year":"2002","journal-title":"Undersea Hyperb Med"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib48","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.radonc.2005.11.004","article-title":"Treatment of radiation proctitis with hyperbaric oxygen","volume":"78","author":"Jones","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib49","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0022-5347(06)00491-5","article-title":"Hyperbaric oxygen therapy for radiation induced proctopathy in men treated for prostate cancer","volume":"176","author":"Dall'Era","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib50","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1111\/j.1525-1438.2006.00388.x","article-title":"Hyperbaric oxygen therapy for delayed radiation injuries in gynecological cancers","volume":"16","author":"Fink","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib51","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/01.coc.0000236004.95384.5b","article-title":"Treatment of refractory radiation-induced hemorrhagic proctitis with hyperbaric oxygen therapy","volume":"29","author":"Girnius","year":"2006","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib52","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.urolonc.2006.02.002","article-title":"Treatment of a radiation-induced rectal ulcer with hyperbaric oxygen therapy in a man with prostate cancer","volume":"24","author":"Nakabayashi","year":"2006","journal-title":"Urol Oncol Semin Orig Invest"},{"key":"10.1016\/j.ijrobp.2007.12.048_bib53","first-page":"35","article-title":"Treatment of gastrointestinal radiation injury with hyperbaric oxygen","volume":"34","author":"Marshall","year":"2007","journal-title":"Undersea Hyperb Med"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608000424?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608000424?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,16]],"date-time":"2023-05-16T22:30:18Z","timestamp":1684276218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301608000424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S0360301608000424"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2007.12.048","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}