{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:38:43Z","timestamp":1773297523470,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.ijrobp.2008.01.029","type":"journal-article","created":{"date-parts":[[2008,4,19]],"date-time":"2008-04-19T13:28:29Z","timestamp":1208611709000},"page":"808-813","source":"Crossref","is-referenced-by-count":26,"title":["Influence of Multiple Genetic Polymorphisms on Genitourinary Morbidity After Carbon Ion Radiotherapy for Prostate Cancer"],"prefix":"10.1016","volume":"72","author":[{"given":"Tomo","family":"Suga","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Iwakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Tsuji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisei","family":"Oda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Noda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Otsuka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-Ichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Etsu","family":"Mizoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirohiko","family":"Tsujii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Imai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2008.01.029_bib1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","article-title":"Cancer statistics, 2006","volume":"56","author":"Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0959-8049(97)10044-2","article-title":"Particle beam therapy (hadrontherapy): Basis for interest and clinical experience","volume":"34","author":"Orecchia","year":"1998","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib3","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0360-3016(03)01439-1","article-title":"Evaluation of therapeutic potential of heavy ion therapy for patients with locally advanced prostate cancer","volume":"58","author":"Nikoghosyan","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib4","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ijrobp.2005.04.022","article-title":"Hypofractionated radiotherapy with carbon ion beams for prostate cancer","volume":"63","author":"Tsuji","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib5","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.ijrobp.2006.06.056","article-title":"Risk factors of late rectal bleeding after carbon ion therapy for prostate cancer","volume":"66","author":"Ishikawa","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib6","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/pros.10328","article-title":"Phase I\/II clinical trials of carbon ion therapy for prostate cancer","volume":"58","author":"Akakura","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0167-8140(02)00154-8","article-title":"Does variability in normal tissue reactions after radiotherapy have a genetic basis\u2014Where and how to look for it?","volume":"64","author":"Andreassen","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.radonc.2003.09.010","article-title":"Prediction of normal tissue radiosensitivity from polymorphisms in candidate genes","volume":"69","author":"Andreassen","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.ijrobp.2004.09.031","article-title":"ATM sequence variants are predictive of adverse radiotherapy response among patients treated for prostate cancer","volume":"61","author":"Cesaretti","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib10","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.ijrobp.2007.05.023","article-title":"TGFB1 Single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy","volume":"70","author":"Peters","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib11","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1158\/1078-0432.CCR-05-2703","article-title":"Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer","volume":"12","author":"Damaraju","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib12","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijrobp.2007.06.021","article-title":"Haplotype-based analysis of genes associated with risk of adverse skin reactions after radiotherapy in breast cancer patients","volume":"69","author":"Suga","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib13","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ijrobp.2005.12.048","article-title":"Gene expression profile changes correlating with radioresistance in human cell lines","volume":"65","author":"Ishikawa","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib14","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1269\/jrr.46.43","article-title":"Potential in a single cancer cell to produce heterogeneous morphology, radiosensitivity and gene expression","volume":"46","author":"Ban","year":"2005","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib15","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1269\/jrr.44.7","article-title":"Different radiation susceptibility among five strains of mice detected by a skin reaction","volume":"44","author":"Iwakawa","year":"2003","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib16","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1269\/jrr.45.515","article-title":"Fractionated irradiation augments inter-strain variation of skin reactions among three strains of mice","volume":"45","author":"Ohta","year":"2004","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib17","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1269\/jrr.45.423","article-title":"Strain dependent differences in a histological study of CD44 and collagen fibers with an expression analysis of inflammatory response-related genes in irradiated murine lung","volume":"45","author":"Iwakawa","year":"2004","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib18","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.cdp.2005.06.005","article-title":"Inter-strain variance in late phase of erythematous reaction or leg contracture after local irradiation among three strains of mice","volume":"29","author":"Noda","year":"2005","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0167-8140(95)90055-1","article-title":"LENT-SOMA tables","volume":"35","year":"1995","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib20","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1006\/abio.1997.2177","article-title":"Characterization of PicoGreen reagent and development of a fluorescence-based solution assay for double-stranded DNA quantitation","volume":"249","author":"Singer","year":"1997","journal-title":"Anal Biochem"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib21","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib22","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2325\/jbcs.13.300","article-title":"Analysis of non-genetic risk factors for adverse skin reactions to radiotherapy among 284 breast cancer patients","volume":"13","author":"Iwakawa","year":"2006","journal-title":"Breast Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib23","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.187.3.277","article-title":"A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes","volume":"187","author":"Shichijo","year":"1998","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/(SICI)1097-0215(19990105)80:1<64::AID-IJC13>3.0.CO;2-7","article-title":"Expression of the SART-1 tumor rejection antigen in breast cancer","volume":"80","author":"Kawamoto","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib25","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1093\/emboj\/20.10.2553","article-title":"The 65 and 110 kDa SR-related proteins of the U4\/U6.U5 tri-snRNP are essential for the assembly of mature spliceosomes","volume":"20","author":"Makarova","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib26","first-page":"599","article-title":"An immediate early human gene encodes an Id-like helix-loop-helix protein and is regulated by protein kinase C activation in diverse cell types","volume":"8","author":"Deed","year":"1993","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib27","doi-asserted-by":"crossref","first-page":"5047","DOI":"10.1016\/S0021-9258(18)83697-3","article-title":"Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen","volume":"264","author":"Reeves","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib28","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.1016\/S0021-9258(19)84898-6","article-title":"Cloning and characterization of a cDNA that encodes a 70-kDa novel human thyroid autoantigen","volume":"264","author":"Chan","year":"1989","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib29","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1002\/j.1460-2075.1994.tb06826.x","article-title":"Human DNA helicase II: A novel DNA unwinding enzyme identified as the Ku autoantigen","volume":"13","author":"Tuteja","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib30","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.1073\/pnas.94.15.8076","article-title":"Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination","volume":"94","author":"Gu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib31","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0304-3835(01)00390-1","article-title":"The novel ependymin related gene UCC1 is highly expressed in colorectal tumor cells","volume":"165","author":"Nimmrich","year":"2001","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib32","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0378-1119(02)00434-1","article-title":"MERP1: a mammalian ependymin-related protein gene differentially expressed in hematopoietic cells","volume":"286","author":"Gregorio-King","year":"2002","journal-title":"Gene"},{"key":"10.1016\/j.ijrobp.2008.01.029_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/306151a0","article-title":"Cloned h\u00fc phenylalanine hydroxylase gene allows prenatal diagnosis and carrier detection of classical phenylketonuria","volume":"306","author":"Woo","year":"1983","journal-title":"Nature"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608001818?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608001818?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T15:34:12Z","timestamp":1631115252000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301608001818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0360301608001818"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2008.01.029","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}