{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:52:04Z","timestamp":1790949124364,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.ijrobp.2008.01.051","type":"journal-article","created":{"date-parts":[[2008,4,21]],"date-time":"2008-04-21T20:33:06Z","timestamp":1208809986000},"page":"678-686","source":"Crossref","is-referenced-by-count":289,"title":["Gemcitabine Chemotherapy and Single-Fraction Stereotactic Body Radiotherapy for Locally Advanced Pancreatic Cancer"],"prefix":"10.1016","volume":"72","author":[{"given":"Devin","family":"Schellenberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karyn A.","family":"Goodman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James M.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Fisher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Quon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry S.","family":"Desser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Norton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert C.","family":"Koong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2008.01.051_bib1","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3322\/canjclin.56.2.106","article-title":"Cancer statistics, 2006","volume":"56","author":"Jemal","year":"2006","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1072-7515(99)00075-7","article-title":"Pancreatic cancer: A report of treatment and survival trends for 100,313 patients diagnosed from 1985\u20131995, using the National Cancer Database","volume":"189","author":"Sener","year":"1999","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.ijrobp.2003.11.019","article-title":"Intensity-modulated radiotherapy (IMRT) and concurrent capecitabine for pancreatic cancer","volume":"59","author":"Ben-Josef","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib4","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/j.ijrobp.2006.10.015","article-title":"Concurrent gemcitabine and radiotherapy with and without neoadjuvant gemcitabine for locally advanced unresectable or resected pancreatic cancer: A phase I-II study","volume":"67","author":"Brade","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib5","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0360-3016(94)90159-7","article-title":"Evaluation of external-beam radiation therapy plus 5-fluorouracil (5-FU) versus external-beam radiation therapy plus hycanthone (HYC) in confined, unresectable pancreatic cancer","volume":"28","author":"Earle","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.radonc.2004.12.022","article-title":"Phase-II study on stereotactic radiotherapy of locally advanced pancreatic carcinoma","volume":"76","author":"Hoyer","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib7","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/S0360-3016(03)00435-8","article-title":"Concurrent chemoradiotherapy treatment of locally advanced pancreatic cancer: Gemcitabine versus 5-fluorouracil, a randomized controlled study","volume":"57","author":"Li","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib8","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/sj.bjc.6602001","article-title":"Phase II study of radiotherapy combined with gemcitabine for locally advanced pancreatic cancer","volume":"91","author":"Okusaka","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib9","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S0360-3016(02)02980-2","article-title":"Phase I study of weekly gemcitabine as a radiation sensitizer for unresectable pancreatic cancer","volume":"54","author":"Poggi","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/01.coc.0000046300.88847.BF","article-title":"Phase II study of external irradiation and weekly paclitaxel for nonmetastatic, unresectable pancreatic cancer: RTOG 98-12","volume":"27","author":"Rich","year":"2004","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib11","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S0360-3016(01)02806-1","article-title":"Length and quality of survival after external-beam radiotherapy with concurrent continuous 5-fluorouracil infusion for locally unresectable pancreatic cancer","volume":"53","author":"Shinchi","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib12","doi-asserted-by":"crossref","first-page":"4538","DOI":"10.1200\/JCO.2005.23.911","article-title":"Locally advanced pancreatic cancer","volume":"23","author":"Willett","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib13","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/jnci\/80.10.751","article-title":"Treatment of locally unresectable carcinoma of the pancreas: Comparison of combined-modality therapy (chemotherapy plus radiotherapy) to chemotherapy alone","volume":"80","author":"Gastrointestinal Tumor Study Group","year":"1988","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib14","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/1097-0142(19811015)48:8<1705::AID-CNCR2820480803>3.0.CO;2-4","article-title":"Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil), and high dose radiation + 5-fluorouracil","volume":"48","author":"Moertel","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib15","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1634\/theoncologist.11-6-612","article-title":"Locally advanced pancreatic cancer: Current therapeutic approach","volume":"11","author":"Cardenes","year":"2006","journal-title":"Oncologist"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib16","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1097\/00006676-200404000-00016","article-title":"Intraoperative radiation therapy for pancreatic adenocarcinoma: The Komagome Hospital experience","volume":"28","author":"Okamoto","year":"2004","journal-title":"Pancreas"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1097\/01.sla.0000152016.40331.bb","article-title":"Long-term results of intraoperative electron beam irradiation (IOERT) for patients with unresectable pancreatic cancer","volume":"241","author":"Willett","year":"2005","journal-title":"Ann Surg"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1385\/IJGC:30:3:123","article-title":"Phase I study of concomitant gemcitabine and IMRT for patients with unresectable adenocarcinoma of the pancreatic head","volume":"30","author":"Crane","year":"2001","journal-title":"Int J Gastrointest Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib19","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1200\/JCO.2005.03.6780","article-title":"Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer","volume":"24","author":"Crane","year":"2006","journal-title":"J Clin Oncol"},{"issue":"18S","key":"10.1016\/j.ijrobp.2008.01.051_bib20","doi-asserted-by":"crossref","first-page":"4508","DOI":"10.1200\/jco.2007.25.18_suppl.4508","volume":"25","author":"Kindler","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib21","doi-asserted-by":"crossref","first-page":"3946","DOI":"10.1200\/JCO.2005.05.1490","article-title":"Randomized phase III trial of gemcitabine plus cisplatin compared with gemcitabine alone in advanced pancreatic cancer","volume":"24","author":"Heinemann","year":"2006","journal-title":"J Clin Oncol"},{"issue":"18S","key":"10.1016\/j.ijrobp.2008.01.051_bib22","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.1200\/jco.2007.25.18_suppl.lba4509","article-title":"Phase III study of gemcitabine [G] plus cetuximab [C] versus gemcitabine in patients [pts] with locally advanced or metastatic pancreatic adenocarcinoma [PC]: SWOG S0205 study. Presented at 2007 ASCO Annual Meeting","volume":"25","author":"Philip","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib23","unstructured":"ECOG-4201. Phase III randomised study of gemcitabine with or without radiotherapy in patients with locally advanced, unresectable pancreatic cancer. Accessed at: http:\/\/www.rtog.org\/studysummary\/062007reports\/ECOG4201.pdf"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD002093.pub2","article-title":"Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer","volume":"3","author":"Yip","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib25","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.ijrobp.2005.07.002","article-title":"Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced pancreatic cancer","volume":"63","author":"Koong","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib26","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.ijrobp.2003.11.004","article-title":"Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer","volume":"58","author":"Koong","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib27","unstructured":"National Cancer Institute. Common Terminology Criteria for Adverse Events, version 3.0. 2006. http:\/\/ctep.cancer.gov\/forms\/CTCAEv3.pdf"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib28","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.ijrobp.2006.12.053","article-title":"Full-dose gemcitabine and concurrent radiotherapy for unresectable pancreatic cancer","volume":"68","author":"Murphy","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib29","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1016\/S0959-8049(02)00076-X","article-title":"Gemcitabine-radiotherapy in patients with locally advanced pancreatic cancer","volume":"38","author":"de Lange","year":"2002","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib30","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1385\/IJGC:34:2-3:107","article-title":"Cancer and leukemia group B (CALGB) 89805: Phase II chemoradiation trial using gemcitabine in patients with locoregional adenocarcinoma of the pancreas","volume":"34","author":"Blackstock","year":"2003","journal-title":"Int J Gastrointest Cancer"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib31","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1002\/jso.10159","article-title":"Phase II study of gemcitabine combined with radiation therapy in patients with localized, unresectable pancreatic cancer","volume":"81","author":"Epelbaum","year":"2002","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib32","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1159\/000086993","article-title":"Phase II trial of primary radiation therapy and concurrent chemotherapy for patients with locally advanced pancreatic cancer","volume":"68","author":"Magnino","year":"2005","journal-title":"Oncology"},{"issue":"Suppl.","key":"10.1016\/j.ijrobp.2008.01.051_bib33","doi-asserted-by":"crossref","first-page":"S284","DOI":"10.1016\/j.ijrobp.2006.07.537","article-title":"Tolerability of standard fractionation vs. hypofractionation in chemoradiotherapy of pancreatic cancer","volume":"66","author":"Symon","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/01.coc.0000145290.06582.c3","article-title":"Radiation dose considerations in the palliative treatment of locally advanced adenocarcinoma of the pancreas","volume":"28","author":"Wong","year":"2005","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib35","doi-asserted-by":"crossref","first-page":"4202","DOI":"10.1200\/JCO.2001.19.22.4202","article-title":"Phase I trial of radiation dose escalation with concurrent weekly full-dose gemcitabine in patients with advanced pancreatic cancer","volume":"19","author":"McGinn","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib36","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1200\/JCO.2005.05.3934","article-title":"Perioperative CA19-9 levels can predict stage and survival in patients with resectable pancreatic adenocarcinoma","volume":"24","author":"Ferrone","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.01.051_bib37","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/sj.bjc.6601263","article-title":"Prognostic value of CA 19-9 levels in patients with inoperable adenocarcinoma of the pancreas treated with gemcitabine","volume":"89","author":"Ziske","year":"2003","journal-title":"Br J Cancer"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608002277?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608002277?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T16:17:34Z","timestamp":1588609054000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301608002277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0360301608002277"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2008.01.051","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}