{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:08:06Z","timestamp":1785881286919,"version":"3.56.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2008,10]]},"DOI":"10.1016\/j.ijrobp.2008.05.065","type":"journal-article","created":{"date-parts":[[2008,9,14]],"date-time":"2008-09-14T09:56:13Z","timestamp":1221386173000},"page":"589-596","source":"Crossref","is-referenced-by-count":130,"title":["Intensity-Modulated Proton Therapy Versus Helical Tomotherapy in Nasopharynx Cancer: Planning Comparison and NTCP Evaluation"],"prefix":"10.1016","volume":"72","author":[{"given":"Lamberto","family":"Widesott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Pierelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Fiorino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Dell'Oca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Broggi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Mauro","family":"Cattaneo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Di Muzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferruccio","family":"Fazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Calandrino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2008.05.065_bib1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0360-3016(91)90171-Y","article-title":"Tolerance of normal tissue to therapeutic irradiation","volume":"21","author":"Emami","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib2","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib3","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1016\/j.ijrobp.2003.09.021","article-title":"Scintigraphic assessment of early and late parotid gland function after radiotherapy for head and neck cancer: A prospective study of dose\u2013volume response relationship","volume":"58","author":"Roesink","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib4","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0167-8140(02)00404-8","article-title":"Mucositis incidence, severity and associated outcomes in patients with head and neck cancer receiving radiotherapy with or without chemotherapy: A systematic literature review","volume":"66","author":"Trotti","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.ijrobp.2006.05.060","article-title":"Is there a \u201cmucosa-sparing\u201d benefit of IMRT for head-and-neck cancer?","volume":"66","author":"Sanguineti","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib6","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ijrobp.2007.01.010","article-title":"Dosimetric predictors of laryngeal edema","volume":"68","author":"Sanguineti","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib7","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/j.ijrobp.2007.02.049","article-title":"Intensity-modulated radiotherapy of head and neck cancer aiming to reduce dysphagia: Early dose\u2013effect relationships for the swallowing structures","volume":"68","author":"Feng","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.radonc.2006.02.009","article-title":"Significant improvement in normal tissue sparing and target coverage for head and neck cancer by means of helical tomotherapy","volume":"78","author":"Fiorino","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib9","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.radonc.2006.01.005","article-title":"Comparison of LINAC based fractionated stereotactic radiotherapy and tomotherapy treatment plans for skull-based tumors","volume":"78","author":"Soisson","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib10","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.radonc.2007.11.003","article-title":"Dose painting with IMPT, helical tomotherapy and IMXT: A dosimetric comparison","volume":"86","author":"Thorwarth","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib11","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0360-3016(99)00438-1","article-title":"Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers","volume":"46","author":"Mohan","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib12","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00066-007-1698-x","article-title":"Simultaneous integrated boost (SIB) for nasopharynx cancer with helical tomotherapy","volume":"183","author":"Fiorino","year":"2007","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib13","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1118\/1.1779371","article-title":"Treatment planning and verification of proton therapy using spot scanning: Initial experiences","volume":"31","author":"Lomax","year":"2004","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.radonc.2006.07.025","article-title":"Intensity modulated photon and proton therapy for the treatment of head and neck tumors","volume":"80","author":"Steneker","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.ijrobp.2006.08.053","article-title":"Spot-scanning proton therapy for malignant soft tissue tumors in childhood: First experiences at the Paul Scherrer Institute","volume":"67","author":"Timmermann","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib16","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.radonc.2003.09.011","article-title":"CT-based delineation of lymph node levels and related CTVs in the node-negative neck: DAHANCA, EORTC, GORTEC, NCIC, RTOG consensus guidelines","volume":"69","author":"Gr\u00e9goire","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib17","unstructured":"RTOG H-0022. Phase I\/II study of conformal and intensity modulated irradiation for oropharyngeal cancer. Available at: http:\/\/www.rtog.org\/members\/protocols\/h0022\/h0022.pdf. Accessed January, 2008."},{"key":"10.1016\/j.ijrobp.2008.05.065_bib18","doi-asserted-by":"crossref","first-page":"R427","DOI":"10.1088\/0031-9155\/51\/13\/R24","article-title":"History of tomotherapy","volume":"51","author":"Mackie","year":"2006","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib19","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1118\/1.597154","article-title":"Investigation of the convolution method for polyenergetic spectra","volume":"20","author":"Papanikolaou","year":"1993","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib20","series-title":"13th International conference on the use of computers in radiation therapy","first-page":"46","article-title":"Hyperion: a planning tool","author":"Alber","year":"2000"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib21","doi-asserted-by":"crossref","first-page":"5089","DOI":"10.1088\/0031-9155\/50\/21\/010","article-title":"A pencil beam algorithm for intensity modulated proton therapy derived from Monte-Carlo simulations","volume":"50","author":"Soukup","year":"2005","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib22","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1088\/0031-9155\/44\/2\/014","article-title":"An objective function for radiation treatment optimization based on local biological measures","volume":"44","author":"Alber","year":"1999","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib23","doi-asserted-by":"crossref","first-page":"13","DOI":"10.2307\/3576626","article-title":"Complication probabilities as assessed from dose\u2013volume histograms","volume":"104","author":"Lyman","year":"1985","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib24","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0360-3016(91)90172-Z","article-title":"Fitting of normal tissue tolerance data to an analytic function","volume":"21","author":"Burman","year":"1991","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib25","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0360-3016(01)01717-5","article-title":"Quantitative dose\u2013volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region","volume":"51","author":"Roesink","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib26","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijrobp.2006.09.021","article-title":"The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy","volume":"67","author":"Li","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. 1","key":"10.1016\/j.ijrobp.2008.05.065_bib27","first-page":"S158","article-title":"NTCP modeling of subacute\/late laryngeal edema scored by fiberoptic examination: Evidence of a large volume effect","volume":"84","author":"Rancati","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib28","unstructured":"Gianolini S, Henggeler D. www.vodca.ch. 2008. Accessed February, 2008."},{"key":"10.1016\/j.ijrobp.2008.05.065_bib29","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0958-3947(00)00031-5","article-title":"BIOPLAN: Software for the biological evaluation of radiotherapy treatment plans","volume":"25","author":"Sanchez-Nieto","year":"2000","journal-title":"Med Dosim"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-8140(02)00308-0","article-title":"Intensity modulation in radiotherapy: Photons versus protons in the paranasal sinus","volume":"66","author":"Lomax","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib31","doi-asserted-by":"crossref","first-page":"6497","DOI":"10.1088\/0031-9155\/52\/21\/011","article-title":"On the making of sharp longitudinal dose profiles with helical tomotherapy","volume":"52","author":"Kissick","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib32","doi-asserted-by":"crossref","first-page":"S517","DOI":"10.1016\/j.ijrobp.2004.07.466","article-title":"Is it feasible to spare part of the mucosa with IMRT and does it matter","volume":"60","author":"Sanguineti","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib33","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0167-8140(99)00079-1","article-title":"Risk assessment of radiation-induced malignancies based on whole-body equivalent dose estimates for IMRT treatment in the head and neck region","volume":"53","author":"Verellen","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib34","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00066-006-1534-8","article-title":"The impact of IMRT and proton radiotherapy on secondary cancer incidence","volume":"182","author":"Schneider","year":"2006","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib35","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.radonc.2007.11.019","article-title":"Estimation of risk of radiation-induced carcinogenesis in adolescents with nasopharyngeal cancer treated using sliding window IMRT","volume":"86","author":"Sharma","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1120\/jacmp.v7i3.2212","article-title":"Out-of-field dosimetry measurements for a helical tomotherapy system","volume":"7","author":"Ramsey","year":"2006","journal-title":"J Appl Clin Med Phys"},{"issue":"Suppl. 2","key":"10.1016\/j.ijrobp.2008.05.065_bib37","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/S0167-8140(05)81383-0","article-title":"Integral and leakage dose in IMRT: A comparison between tomotherapy and conventional LINAC","volume":"76","author":"Calandrino","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib38","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1088\/0031-9155\/52\/10\/009","article-title":"Accounting for range uncertainties in the optimization of intensity modulated proton therapy","volume":"52","author":"Unkelbach","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib39","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1088\/0031-9155\/53\/6\/013","article-title":"Worst case optimization: A method to account for uncertainties in the optimization of intensity modulated proton therapy","volume":"53","author":"Pflugfelder","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib40","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.ijrobp.2007.10.057","article-title":"Magical protons?","volume":"70","author":"Goitein","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.05.065_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1078\/0939-3889-00194","article-title":"The PSI gantry 2: A second generation proton scanning gantry","volume":"14","author":"Pedroni","year":"2004","journal-title":"Z Med Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608024711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608024711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,25]],"date-time":"2018-12-25T18:58:58Z","timestamp":1545764338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301608024711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,10]]}},"alternative-id":["S0360301608024711"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2008.05.065","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}