{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:49:33Z","timestamp":1791038973583,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.ijrobp.2008.06.1956","type":"journal-article","created":{"date-parts":[[2008,10,28]],"date-time":"2008-10-28T08:06:38Z","timestamp":1225181198000},"page":"1313-1318","source":"Crossref","is-referenced-by-count":44,"title":["Outcome Prediction After Surgery and Chemoradiation of Squamous Cell Carcinoma in the Oral Cavity, Oropharynx, and Hypopharynx: Use of Baseline Perfusion CT Microcirculatory Parameters vs. Tumor Volume"],"prefix":"10.1016","volume":"73","author":[{"given":"Sotirios","family":"Bisdas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun A.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharma K.","family":"Anand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordana","family":"Glavina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terry","family":"Day","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoran","family":"Rumboldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2008.06.1956_bib1","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1002\/cncr.23206","article-title":"Adjuvant radiotherapy improves overall survival for patients with lymph node-positive head and neck squamous cell carcinoma","volume":"112","author":"Lavaf","year":"2008","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib2","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1016\/0360-3016(79)90977-5","article-title":"Squamous cell carcinoma of the head and neck: combined therapy: Surgery and postoperative irradiation","volume":"5","author":"Million","year":"1979","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib3","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/hed.20465","article-title":"Postoperative chemoradiotherapy for advanced squamous cell carcinoma of the head and neck: A systematic review with meta-analysis","volume":"29","author":"Winquist","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib4","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/hed.20488","article-title":"Usefulness of MRI volumetric evaluation in patients with squamous cell cancer of the head and neck treated with neoadjuvant chemotherapy","volume":"29","author":"Baghi","year":"2007","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib5","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1148\/radiol.2322031001","article-title":"Supraglottic carcinoma treated with curative radiation therapy: Identification of prognostic groups with MR imaging","volume":"232","author":"Ljumanovic","year":"2004","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0167-8140(03)00024-0","article-title":"Quantitative tissue perfusion measurements in head and neck carcinoma patients before and during radiation therapy with a non-invasive MR imaging spin-labeling technique","volume":"67","author":"Schmitt","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib7","first-page":"328","article-title":"Can pretreatment CT perfusion predict response of advanced squamous cell carcinoma of the upper aerodigestive tract treated with induction chemotherapy?","volume":"28","author":"Zima","year":"2007","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib8","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0360-3016(03)00764-8","article-title":"Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head-and-neck cancer after radiotherapy","volume":"57","author":"Hermans","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib9","first-page":"101","article-title":"Correlation between initial and early follow-up CT perfusion parameters with endoscopic tumor response in patients with advanced squamous cell carcinomas of the oropharynx treated with organ-preservation therapy","volume":"27","author":"Gandhi","year":"2006","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib10","doi-asserted-by":"crossref","first-page":"329","DOI":"10.2214\/ajr.138.2.329","article-title":"Volume determinations using computed tomography","volume":"138","author":"Breiman","year":"1982","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib11","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1002\/hep.1840070628","article-title":"Multivariate survival analysis using Cox's regression model","volume":"7","author":"Christensen","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1477-7525-2-70","article-title":"The use of bootstrap methods for analysing health-related quality of life outcomes (particularly the SF-36)","volume":"2","author":"Walters","year":"2004","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib13","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1200\/JCO.1999.17.2.631","article-title":"Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma","volume":"17","author":"Mancuso","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib14","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1016\/S0360-3016(99)00039-5","article-title":"Value of computed tomography as outcome predictor of supraglottic squamous cell carcinoma treated by definitive radiation therapy","volume":"44","author":"Hermans","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib15","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1055\/s-2003-36610","article-title":"[Prognostic value of pretreatment CT regarding local control in oropharyngeal cancer after primary surgical resection]","volume":"175","author":"Keberle","year":"2003","journal-title":"Rofo"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib16","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1007\/s00066-003-1017-0","article-title":"Usefulness of tumor volumetry as a prognostic factor of survival in head and neck cancer","volume":"179","author":"Kurek","year":"2003","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib17","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0360-3016(00)01559-5","article-title":"The relation of CT-determined tumor parameters and local and regional outcome of tonsillar cancer after definitive radiation treatment","volume":"50","author":"Hermans","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0347(200001)22:1<1::AID-HED1>3.0.CO;2-6","article-title":"The impact of primary tumor volume on local control for oropharyngeal squamous cell carcinoma treated with radiotherapy","volume":"22","author":"Nathu","year":"2000","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib19","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijrobp.2007.09.058","article-title":"Adjuvant radiotherapy and survival for patients with node-positive head and neck cancer: an analysis by primary site and nodal stage","volume":"71","author":"Kao","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib20","first-page":"1178","article-title":"Perfusion CT for head and neck tumors: Pilot study","volume":"26","author":"Rumboldt","year":"2005","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/01.rli.0000252496.74242.0b","article-title":"Quantitative measurements of perfusion and permeability of oropharyngeal and oral cavity cancer, recurrent disease, and associated lymph nodes using first-pass contrast-enhanced computed tomography studies","volume":"42","author":"Bisdas","year":"2007","journal-title":"Invest Radiol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib22","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0167-8140(99)00132-2","article-title":"Tumoural perfusion as measured by dynamic computed tomography in head and neck carcinoma","volume":"53","author":"Hermans","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1080\/09553008514552581","article-title":"Experimental chemotherapy and concepts related to the cell cycle","volume":"49","author":"Tannock","year":"1986","journal-title":"Int J Radiat Biol Relat Stud Phys Chem Med"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib24","first-page":"8912","article-title":"The extent and severity of vascular leakage as evidence of tumor aggressiveness in high-grade gliomas","volume":"66","author":"Cao","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib25","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.oraloncology.2004.08.001","article-title":"Prognostic relevance of CD105+ microvessel density in HNSCC patient outcome","volume":"41","author":"Martone","year":"2005","journal-title":"Oral Oncol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib26","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/COC.0b013e3180342fd4","article-title":"Microvessel density > or =60 does not predict for outcome after radiation treatment for locally advanced head and neck squamous cell carcinoma: Results of a correlative study from the Radiation Therapy Oncology Group (RTOG) 90-03 Trial","volume":"30","author":"Calvin","year":"2007","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib27","first-page":"172","article-title":"Expression of vascular permeability factor\/vascular endothelial growth factor by melanoma cells increases tumor growth, angiogenesis, and experimental metastasis","volume":"56","author":"Claffey","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2008.06.1956_bib28","doi-asserted-by":"crossref","first-page":"6181","DOI":"10.1088\/0031-9155\/52\/20\/007","article-title":"Dynamic contrast-enhanced CT of head and neck tumors: Perfusion measurements using a distributed-parameter tracer kinetic model. Initial results and comparison with deconvolution-based analysis","volume":"52","author":"Bisdas","year":"2007","journal-title":"Phys Med Biol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608031842?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608031842?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T21:26:50Z","timestamp":1545686810000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301608031842"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0360301608031842"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2008.06.1956","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]}}}