{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:21:14Z","timestamp":1781169674782,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,1,1]],"date-time":"2009-01-01T00:00:00Z","timestamp":1230768000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2009,1]]},"DOI":"10.1016\/j.ijrobp.2008.07.008","type":"journal-article","created":{"date-parts":[[2008,9,20]],"date-time":"2008-09-20T08:49:35Z","timestamp":1221900575000},"page":"148-153","source":"Crossref","is-referenced-by-count":125,"title":["Concurrent Chemoradiotherapy in Resected Extrahepatic Cholangiocarcinoma"],"prefix":"10.1016","volume":"73","author":[{"given":"John W.","family":"Nelson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Paiman","family":"Ghafoori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher G.","family":"Willett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas S.","family":"Tyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore N.","family":"Pappas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan M.","family":"Clary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert I.","family":"Hurwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna C.","family":"Bendell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael A.","family":"Morse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert W.","family":"Clough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian G.","family":"Czito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2008.07.008_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1159\/000077991","article-title":"A review and update on cholangiocarcinoma","volume":"66","author":"Olnes","year":"2004","journal-title":"Oncology"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib2","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1002\/1098-2388(200009)19:2<156::AID-SSU8>3.0.CO;2-#","article-title":"Cholangiocarcinoma of the extrahepatic bile ducts","volume":"19","author":"Jarnagin","year":"2000","journal-title":"Semin Surg Oncol"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib3","first-page":"939","article-title":"Cancers of the gallbladder and biliary ducts","volume":"16","author":"Yee","year":"2002","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib4","first-page":"1049","article-title":"Gallbladder and biliary tract carcinoma: A comprehensive update, part 2","volume":"18","author":"Daines","year":"2004","journal-title":"Oncology (Williston Park)"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib5","series-title":"Intraoperative irradiation: Techniques and results","first-page":"223","article-title":"Biliary tract IORT","author":"Todoroki","year":"1999"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib6","series-title":"Textbook of radiation oncology","first-page":"659","article-title":"Hepatobiliary carcinomas","author":"Schoenthaler","year":"1998"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib7","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/cncr.11699","article-title":"Patterns of initial disease recurrence after resection of gallbladder carcinoma and hilar cholangiocarcinoma: Implications for adjuvant therapeutic strategies","volume":"98","author":"Jarnagin","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib8","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2307\/2281868","article-title":"Non-parametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib9","unstructured":"National Cancer Institute Common Toxicity Criteria, version 3. Available from: http:\/\/www.fda.gov\/cdet\/cancer\/toxicityframe.htm; Accessed January 2008."},{"key":"10.1016\/j.ijrobp.2008.07.008_bib10","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/0360-3016(77)90186-9","article-title":"The role of radiation therapy in cancer of the extra-hepatic biliary system: An analysis of thirteen patients and a review of the literature of the effectiveness of surgery, chemotherapy and radiotherapy","volume":"2","author":"Kopelson","year":"1977","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib11","series-title":"Cancer: Principles and practice of oncology","first-page":"741","article-title":"Cancer of the hepatobiliary system","author":"Cady","year":"1985"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib12","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0360-3016(81)90118-8","article-title":"Patterns of failure after curative surgery for extra-hepatic biliary tract carcinoma: Implications for adjuvant therapy","volume":"7","author":"Kopelson","year":"1981","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib13","first-page":"1612","article-title":"Patterns and relevant factors of tumor recurrence for extrahepatic bile duct carcinoma after radical resection","volume":"51","author":"Park","year":"2004","journal-title":"Hepatogastrointerology"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib14","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1007\/s00261-002-0048-9","article-title":"CT analysis of postoperative tumor recurrence patterns in periampullary cancer","volume":"28","author":"Kim","year":"2003","journal-title":"Abdom Imaging"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib15","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.gassur.2004.08.006","article-title":"Recurrent disease after microscopically radical (R0) resection of periampullary adenocarcinoma in patients without adjuvant therapy","volume":"8","author":"de Castro","year":"2004","journal-title":"J Gastrointest Surg"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib16","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1001\/archsurg.1985.01390320023003","article-title":"Pancreatic cancer: Adjuvant combined radiation and chemotherapy following curative resection","volume":"120","author":"Kalser","year":"1985","journal-title":"Arch Surg"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib17","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/S0140-6736(69)92326-5","article-title":"Combined 5-fluorouracil and supervoltage radiation therapy of locally unresectable gastrointestinal cancer","volume":"2","author":"Moertel","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib18","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/1097-0142(19811015)48:8<1705::AID-CNCR2820480803>3.0.CO;2-4","article-title":"Therapy of locally unresectable pancreatic carcinoma: A randomized comparison of high-dose (6000 rads) radiation alone, moderate dose radiation (4000 rads + 5-fluorouracil) and high-dose radiation plus 5-fluorouracil","volume":"48","author":"Moertel","year":"1981","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.ijrobp.2006.11.048","article-title":"Adjuvant concurrent chemoradiation for adenocarcinoma of the distal common bile duct","volume":"68","author":"Hughes","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib20","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/S0360-3016(02)02952-8","article-title":"The role of postoperative radiotherapy in the management of extrahepatic bile duct cancer","volume":"54","author":"Kim","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib21","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1200\/JCO.1997.15.3.928","article-title":"Preoperative and postoperative chemoradiation strategies in patients treated with pancreaticoduodectomy for adenocarcinoma of the pancreas","volume":"15","author":"Spitz","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib22","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0002-9610(97)00203-1","article-title":"Neoadjuvant chemoradiation enhances margin-negative resection rates for extrahepatic cholangiocarcinoma","volume":"174","author":"McMasters","year":"1997","journal-title":"Am J Surg"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib23","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1245\/ASO.2006.02.003","article-title":"Effect of neoadjuvant chemoradiation on operative mortality and morbidity for pancreaticoduodenectomy","volume":"13","author":"Cheng","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib24","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMoa040694","article-title":"Preoperative versus postoperative chemoradiotherapy for rectal cancer","volume":"351","author":"Sauer","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib25","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ejso.2005.02.021","article-title":"Surgery for hilar cholangiocarcinoma: A 10 year experience of a tertiary referral centre in the UK","volume":"31","author":"Silva","year":"2005","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2008.07.008_bib26","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1097\/01.tp.0000253551.43583.d1","article-title":"Predictors of disease recurrence following neoadjuvant chemoradiotherapy and liver transplantation for unresectable perihilar cholangiocarcinoma","volume":"82","author":"Heimbach","year":"2006","journal-title":"Transplantation"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608030368?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301608030368?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T03:51:29Z","timestamp":1557805889000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301608030368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,1]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["S0360301608030368"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2008.07.008","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,1]]}}}