{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T06:13:06Z","timestamp":1791180786442,"version":"4.1.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.ijrobp.2009.01.012","type":"journal-article","created":{"date-parts":[[2009,4,10]],"date-time":"2009-04-10T08:22:22Z","timestamp":1239351742000},"page":"200-209","source":"Crossref","is-referenced-by-count":69,"title":["Different Mechanisms of Cell Death in Radiosensitive and Radioresistant P53 Mutated Head and Neck Squamous Cell Carcinoma Cell Lines Exposed to Carbon Ions and X-Rays"],"prefix":"10.1016","volume":"74","author":[{"given":"Mira","family":"Maalouf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gersende","family":"Alphonse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Colliaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Beuve","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selena","family":"Trajkovic-Bodennec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscillia","family":"Battiston-Montagne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Testard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chapet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel","family":"Bajard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisela","family":"Taucher-Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Rodriguez-Lafrasse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.01.012_bib1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.critrevonc.2004.04.005","article-title":"Clinical and research validity of hadrontherapy with ion beams","volume":"5","author":"Orecchia","year":"2004","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib2","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0360-3016(95)02112-4","article-title":"Measurement of intracellular DNA-double-strand-break induction and rejoining along the track of carbon and neon particle beams in water","volume":"34","author":"Heilmann","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib3","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1080\/095530099139232","article-title":"RBE for carbon track-segment irradiation in cell lines of differing repair capacity","volume":"75","author":"Weyrather","year":"1999","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ijrobp.2004.05.062","article-title":"High-LET radiation enhanced apoptosis but not necrosis regardless of p53-status","volume":"60","author":"Takahashi","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib5","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1269\/jrr.06081","article-title":"Cell cycle checkpoint and apoptosis induction in glioblastoma cells and fibroblasts irradiated with carbon beam","volume":"48","author":"Tsuboi","year":"2007","journal-title":"J Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1667\/RR3280","article-title":"Induction of accelerated senescence by \u03b3 radiation in human solid tumor-derived cell lines expressing wild-type TP53","volume":"163","author":"Mirzayans","year":"2005","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib7","doi-asserted-by":"crossref","first-page":"5501S","DOI":"10.1158\/1078-0432.CCR-07-0980","article-title":"Cell cycle disturbances and mitotic catastrophes in HeLa Hep2 cells following 2.5 to 10 Gy of ionizing radiation","volume":"13","author":"Eriksson","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1475-2867-1-1","article-title":"Mitotic catastrophe: A mechanism of survival? A review","volume":"1","author":"Erenpeisa","year":"2001","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib9","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1200\/JCO.2006.09.7816","article-title":"Particle radiation therapy using proton and heavier ion beams","volume":"25","author":"Schulz-Ertner","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ijrobp.2004.02.067","article-title":"Dose escalation study of carbon ion radiotherapy for locally advanced head-and-neck cancer","volume":"60","author":"Mizoe","year":"2004","journal-title":"Int J Rad Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1080\/09553000210153943","article-title":"Ceramide induces activation of the mitochondrial\/caspases pathway in Jurkat and SCC61 cells sensitive to gamma-radiation but activation of this sequence is defective in radioresistant SQ20B cells","volume":"78","author":"Alphonse","year":"2002","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib12","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.ijrobp.2007.10.050","article-title":"Radiobiologic parameters and local effect model predictions for head-and-neck squamous cell carcinomas exposed to high linear energy transfer ions","volume":"71","author":"Beuve","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib13","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1038\/sj.onc.1207357","article-title":"Overcoming resistance to gamma-rays in squamous carcinoma cells by poly-drug elevation of ceramide levels","volume":"23","author":"Alphonse","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib14","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1242\/jcs.113.20.3613","article-title":"Senescence-associated-(beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells","volume":"113","author":"Kurz","year":"2000","journal-title":"J Cell Sci"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib15","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1038\/sj.onc.1207528","article-title":"Cell death by mitotic catastrophe: A molecular definition","volume":"23","author":"Castedo","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0360-3016(00)00568-X","article-title":"Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba carbon-ion beams","volume":"48","author":"Suzuki","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1080\/09553000500141215","article-title":"Dose and time-dependent apoptotic response in a human melanoma cell line exposed to accelerated boron ions at four different LET","volume":"81","author":"Meijer","year":"2005","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib18","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/S0167-8140(04)80031-8","article-title":"Radiation-induced cell cycle arrest: An overview of specific effects following high-LET exposure","volume":"73","author":"Fournier","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib19","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0361-090X(03)00063-1","article-title":"Comparative analysis of G2 arrest after irradiation with 75 keV carbon-ion beams and 137Cs gamma-rays in a human lymphoblastoid cell line","volume":"27","author":"Matsumura","year":"2003","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib20","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.ijrobp.2004.10.036","article-title":"Different G2\/M accumulation in M059J and M059K cells after exposure to DNA-double-strand-break-inducing agents","volume":"61","author":"Holgersson","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib21","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.lfs.2006.01.037","article-title":"Cell death induced in a human glioblastoma cell line by p(65)+Be neutrons combined with cisplatin","volume":"79","author":"Benzina","year":"2006","journal-title":"Life Sci"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib22","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/excr.2000.4875","article-title":"Is beta-galactosidase staining a marker of senescence in vitro and in vivo?","volume":"257","author":"Severino","year":"2000","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib23","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1080\/09553000310001596995","article-title":"Low and high LET radiation-induced apoptosis in M059J and M059K cells","volume":"79","author":"Holgersson","year":"2003","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.01.012_bib24","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.ijrobp.2007.08.061","article-title":"Protective role of Hsp27 protein against gamma radiation-induced apoptosis and radiosensitization effects of Hsp27 gene silencing in different human tumor cells","volume":"70","author":"Aloy","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609000868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609000868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T03:02:46Z","timestamp":1633316566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609000868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0360301609000868"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.01.012","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}