{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:02:27Z","timestamp":1791860547792,"version":"4.3.4"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.ijrobp.2009.02.062","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T19:34:37Z","timestamp":1247859277000},"page":"685-697","source":"Crossref","is-referenced-by-count":142,"title":["Postoperative Proton Radiotherapy for Localized and Locoregional Breast Cancer: Potential for Clinically Relevant Improvements?"],"prefix":"10.1016","volume":"76","author":[{"given":"Carmen","family":"Ares","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaka","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"MacArtain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Heuberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gudrun","family":"Goitein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guenther","family":"Gruber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerd","family":"Lutters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugen B.","family":"Hug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Bodis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony J.","family":"Lomax","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.02.062_bib1","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1016\/S0140-6736(05)67887-7","article-title":"Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: An overview of the randomised trials","volume":"366","author":"Clarke","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib2","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1016\/S0140-6736(00)02263-7","article-title":"Favourable and unfavourable effects on long-term survival of radiotherapy for early breast cancer: an overview of the randomised trials","volume":"355","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib3","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.amjsurg.2008.06.003","article-title":"Internal mammary sentinel node biopsy for breast cancer","volume":"196","author":"Avisar","year":"2008","journal-title":"Am J Surg"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib4","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0167-8140(88)90003-5","article-title":"Long-term effect of internal mammary chain treatment. Results of a multivariate analysis of 1195 patients with operable breast cancer and positive axillary nodes","volume":"11","author":"Arriagada","year":"1988","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0959-8049(05)80070-X","article-title":"Post-mastectomy megavoltage radiotherapy: The Oslo and Stockholm trials","volume":"28","author":"Auquier","year":"1992","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib6","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/0360-3016(90)90214-5","article-title":"Evaluation of radiotherapy in high-risk breast cancer patients: Report from the Danish Breast Cancer Cooperative Group (DBCG-82)","volume":"19","author":"Overgaard","year":"1990","journal-title":"Trial. Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib7","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1200\/JCO.1994.12.3.447","article-title":"Cause-specific mortality in long-term survivors of breast cancer who participated in trials of radiotherapy","volume":"12","author":"Cuzick","year":"1994","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib8","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/153303460400300108","article-title":"Inversely planned intensity modulated radiotherapy of the breast including the internal mammary chain: A plan comparison study","volume":"3","author":"Thilmann","year":"2004","journal-title":"Technol Cancer Res Treat"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib9","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0360-3016(03)00183-4","article-title":"Potential gains for irradiation of chest wall and regional nodes with intensity modulated radiotherapy","volume":"56","author":"Krueger","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.ijrobp.2005.11.023","article-title":"Body radiation exposure in breast cancer radiotherapy: impact of breast IMRT and virtual wedge compensation techniques","volume":"65","author":"Woo","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.radonc.2004.02.017","article-title":"Loco-regional comformal radiotherapy of the breast: Delineation of the regional lymph-node clinical target volumes in treatmetn position","volume":"71","author":"Dijkema","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib12","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1118\/1.1779371","article-title":"Treatment planning and verification of proton therapy using spot scanning. Initial experiences","volume":"31","author":"Lomax","year":"2004","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1088\/0031-9155\/44\/1\/014","article-title":"Intensity modulated methods for proton therapy","volume":"44","author":"Lomax","year":"1999","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib14","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1016\/S0360-3016(00)01531-5","article-title":"Cardiac perfusion changes in patients treated for breast cancer with radiation therapy and doxorubicin: preliminary results","volume":"49","author":"Hardenbergh","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/srao.2001.23482","article-title":"Partial irradiation of the lung","volume":"11","author":"Seppenwoolde","year":"2001","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib16","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.ijrobp.2006.07.1337","article-title":"Analysis of clinical and dosimetric factors associated with treatment-related pneumonitis in patients with non-small-cell lung cancer treated with concurrent chemotherapy and three-dimensional conformal radiotherapy","volume":"66","author":"Wang","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib17","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1088\/0031-9155\/53\/4\/014","article-title":"Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: The potential effects of calculational uncertainties","volume":"53","author":"Lomax","year":"2008","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1118\/1.598577","article-title":"A method for incorporating organ motion due to breathing into 3D dose calculations","volume":"26","author":"Lujan","year":"1999","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib19","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1259\/bjr\/98024704","article-title":"Breast movement during normal and deep breathing, respiratory training and set up error; implications for external beam partial breast irradiation","volume":"79","author":"Chopra","year":"2006","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib20","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.radonc.2006.12.008","article-title":"Randomised trial of standard 2D radiotherapy versus intensity modulated radiotherapy in patients prescribed breast radiotherapy","volume":"82","author":"Donovan","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib21","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1200\/JCO.2007.15.2488","article-title":"A multicenter randomized trial of breast intensity-modulated radiation therapy to reduce acute radiation dermatitis","volume":"26","author":"Pignol","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib22","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0360-3016(02)04210-4","article-title":"Potential role of intensity-modulated photons and protons in the treatment of the breast and regional nodes","volume":"55","author":"Lomax","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.meddos.2006.05.003","article-title":"Inverse-planned, dynamic, multi-beam, intensity-modulated radiation therapy (IMRT): A promising technique when target volume is the left breast and internal mammary lymph nodes","volume":"31","author":"Popescu","year":"2006","journal-title":"Med Dosim"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib24","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.ijrobp.2007.03.059","article-title":"Optimized dose coverage of regional lymph nodes in breast cancer: The role of intensity-modulated radiotherapy","volume":"68","author":"Dogan","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib25","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.ijrobp.2007.06.060","article-title":"Is multibeam IMRT better than standard treatment for patients with left-sided breast cancer?","volume":"69","author":"Beckham","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijrobp.2006.01.027","article-title":"Intensity-modulated radiation therapy, protons, and the risk of second cancers","volume":"65","author":"Hall","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib27","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/j.ijrobp.2007.08.046","article-title":"The effect of intensity-modulated radiotherapy on radiation induced second malignancies","volume":"70","author":"Ruben","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib28","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1080\/02841860510029879","article-title":"Clinical experience in breast irradiation with intensity modulated photon beams","volume":"44","author":"Cozzi","year":"2005","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib29","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.ijrobp.2008.02.053","article-title":"Long-term outcomes of IMRT for breast cancer: a single-institution cohort analysis","volume":"72","author":"MCDonald","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib30","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3816\/CBC.2003.n.024","article-title":"Symptomatic cardiac events following radiation therapy for left-sided breast cancer: Possible association with radiation therapy-induced changes in regional perfusion","volume":"4","author":"Yu","year":"2003","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib31","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.ijrobp.2006.06.025","article-title":"Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer","volume":"66","author":"Evans","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib32","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1200\/JCO.2001.19.5.1539","article-title":"Postmastectomy radiotherapy: Clinical practice guidelines of the American Society of Clinical Oncology","volume":"19","author":"Recht","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1080\/02841860600702068","article-title":"Long-term follow-up of the Stockholm randomized trials of postoperative radiation therapy versus adjuvant chemotherapy among \u2018high risk\u2019 pre- and postmenopausal breast cancer patients","volume":"45","author":"Rutqvist","year":"2006","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib34","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1002\/cncr.11655","article-title":"The incidence of lung carcinoma after surgery for breast carcinoma with and without postoperative radiotherapy. Results of National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trials B-04 and B-06","volume":"98","author":"Deutsch","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib35","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1200\/JCO.2007.11.9081","article-title":"Risk of new primary non breast cancers after breast cancer treatment: a Dutch population-based study","volume":"26","author":"Schaapveld","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib36","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1200\/JCO.2007.13.3033","article-title":"Effect of breast cancer radiotherapy and cigarette smoking on risk of second primary lung cancer","volume":"26","author":"Kaufman","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib37","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0748-7983(03)00010-6","article-title":"Breast cancer risk among the survivors of atomic bomb and patients exposed to therapeutic ionising radiation","volume":"29","author":"Carmichael","year":"2003","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib38","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1088\/0031-9155\/37\/1\/016","article-title":"Effects of respiratory motion on dose uniformity with a charged particle scanning method","volume":"37","author":"Phillips","year":"1992","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib39","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ijrobp.2005.03.048","article-title":"Relative biologic effectiveness determination in mouse intestine for scanning proton beam at Paul Scherrer Institute, Switzerland. Influence of motion","volume":"62","author":"Gueulette","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.062_bib40","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1088\/0031-9155\/47\/13\/302","article-title":"Effects of intra-fraction motion on IMRT dose delivery: statistical analysis and simulation","volume":"47","author":"Bortfeld","year":"2002","journal-title":"Phys Med Biol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609003654?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609003654?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T10:54:08Z","timestamp":1558436048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609003654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0360301609003654"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.02.062","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}