{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:42:58Z","timestamp":1778931778723,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.ijrobp.2009.02.072","type":"journal-article","created":{"date-parts":[[2009,6,28]],"date-time":"2009-06-28T08:12:23Z","timestamp":1246176743000},"page":"1106-1113","source":"Crossref","is-referenced-by-count":87,"title":["Variations in Target Volume Definition for Postoperative Radiotherapy in Stage III Non\u2013Small-Cell Lung Cancer: Analysis of an International Contouring Study"],"prefix":"10.1016","volume":"76","author":[{"given":"Femke O.B.","family":"Spoelstra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suresh","family":"Senan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecile","family":"Le P\u00e9choux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Ishikura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Casas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Price","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"De Ruysscher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"van S\u00f6rnsen de Koste","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.02.072_bib1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/bjc.1996.413","article-title":"The role of post-operative radiotherapy in non-small-cell lung cancer: A multicentre randomised trial in patients with pathologically staged T1-2, N1-2, M0 disease. Medical Research Council Lung Cancer Working Party","volume":"74","author":"Stephens","year":"1996","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib2","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1378\/chest.112.4.954","article-title":"Postoperative radiotherapy in radically resected non-small cell lung cancer","volume":"112","author":"Mayer","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib3","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0167-8140(01)00478-9","article-title":"Adjuvant radiotherapy in non-small cell lung cancer with pathological stage I: Definitive results of a phase III randomized trial","volume":"62","author":"Trodella","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib4","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0140-6736(98)06341-7","article-title":"Postoperative radiotherapy in non-small-cell lung cancer: Systematic review and meta-analysis of individual patient data from nine randomised controlled trials. PORT Meta-analysis Trialists Group","volume":"352","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib5","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1200\/JCO.2001.19.19.3912","article-title":"Risk of death from intercurrent disease is not excessively increased by modern postoperative radiotherapy for high-risk resected non-small-cell lung carcinoma","volume":"19","author":"Machtay","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib6","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.ijrobp.2007.02.028","article-title":"Estimating the magnitude and field-size dependence of radiotherapy-induced mortality and tumor control after postoperative radiotherapy for non-small-cell lung cancer: Calculations from clinical trials","volume":"68","author":"Miles","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib7","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.lungcan.2007.01.017","article-title":"Postoperative radiotherapy for non-small-cell lung cancer: Results of the 1999-2001 patterns of care study nationwide process survey in Japan","volume":"56","author":"Uno","year":"2007","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib8","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1200\/JCO.2005.04.6110","article-title":"Postoperative radiotherapy for stage II or III non-small-cell lung cancer using the surveillance, epidemiology, and end results database","volume":"24","author":"Lally","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib9","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ijrobp.2008.01.044","volume":"72","author":"Douillard","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib10","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1200\/JCO.2006.09.6263","article-title":"Need for a new trial to evaluate adjuvant postoperative radiotherapy in non-small-cell lung cancer patients with N2 mediastinal involvement","volume":"25","author":"Le P\u00e9choux","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib11","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1056\/NEJM200010263431703","article-title":"A randomized trial of postoperative adjuvant therapy in patients with completely resected stage II or IIIA non-small-cell lung cancer. Eastern Cooperative Oncology Group","volume":"343","author":"Keller","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0167-8140(01)00453-4","article-title":"Definition of gross tumor volume in lung cancer: Inter-observer variability","volume":"62","author":"van de Steene","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0167-8140(99)00143-7","article-title":"Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer","volume":"53","author":"Senan","year":"1999","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib14","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/S0360-3016(02)02783-9","article-title":"Measurement of lung tumor volumes using three-dimensional computer planning software","volume":"53","author":"Bowden","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0167-8140(01)00444-3","article-title":"Conformal radiotherapy for lung cancer: Different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists","volume":"62","author":"Giraud","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib16","doi-asserted-by":"crossref","first-page":"334339","DOI":"10.1016\/j.ijrobp.2005.02.016","article-title":"Use of\u00a0CD-ROM-based tool for analyzing contouring variations in involved-field radiotherapy for Stage III NSCLC","volume":"63","author":"van S\u00f6rnsen de Koste","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib17","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1378\/chest.111.6.1718","article-title":"Regional lymph node classification for lung cancer staging","volume":"111","author":"Mountain","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib18","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ijrobp.2004.12.060","article-title":"CT-based definition of thoracic lymph node stations: An atlas from the University of Michigan","volume":"63","author":"Chapet","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib19","series-title":"ICRU report 62: Prescribing, recording, and reporting photon beam therapy (Supplement to ICRU report 50)","year":"1999"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib20","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1200\/JCO.2006.05.8560","article-title":"Postoperative radiotherapy in non-small-cell lung cancer warrants further exploration in the era of adjuvant chemotherapy and conformal radiotherapy","volume":"24","author":"Bonner","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib21","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1056\/NEJMe058110","article-title":"Adjuvant chemotherapy for non-small-cell lung cancer: The smoke clears","volume":"352","author":"Pisters","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib22","doi-asserted-by":"crossref","first-page":"3552","DOI":"10.1200\/JCO.2007.13.9030","article-title":"Lung adjuvant cisplatin evaluation: A pooled analysis by the LACE Collaborative Group","volume":"26","author":"Pignon","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0169-5002(01)00207-0","article-title":"Overall survival and local recurrence of 406 completely resected stage IIIa-N2 non-small cell lung cancer patients: Questionnaire survey of the Japan Clinical Oncology Group to plan for clinical trials","volume":"34","author":"Ichinose","year":"2001","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib24","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1097\/00000421-200006000-00008","article-title":"Standard off-cord lung oblique fields do not include the entire mediastinum: A computed tomography simulator study","volume":"23","author":"DiBiase","year":"2000","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib25","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/01.coc.0000256691.27796.24","article-title":"A randomized study of involved-field irradiation versus elective nodal irradiation in combination with concurrent chemotherapy for inoperable stage III nonsmall cell lung cancer","volume":"30","author":"Yuan","year":"2007","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib26","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/S0360-3016(02)03028-6","article-title":"Can elective nodal irradiation be omitted in stage III non-small-cell lung cancer? Analysis of recurrences in a phase II study of induction chemotherapy and involved-field radiotherapy","volume":"54","author":"Senan","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0167-8140(02)00143-3","article-title":"Quality assurance of the EORTC trial 22911. A phase III study of post-operative external radiotherapy in pathological stage T3N0 prostatic carcinoma: The dummy run","volume":"64","author":"Davis","year":"2002","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0360-3016(03)00659-X","article-title":"The impact of contouring uncertainty on rectal 3D dose-volume data: Results of a dummy run in a multicenter trial (AIROPROS01-02)","volume":"57","author":"Foppiano","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib29","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0167-8140(00)00191-2","article-title":"Target volume definition in conformal radiotherapy for prostate cancer: Quality assurance in the MRC RT-01 trial","volume":"56","author":"Seddon","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib30","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0167-8140(00)00232-2","article-title":"Quality assurance in preoperative radiotherapy of rectal cancer: Evaluation of a pre-trial dummy-run","volume":"56","author":"Widder","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib31","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.radonc.2004.08.005","article-title":"Quality assurance of the 22961 EORTC trial. A phase III study of the optimal combination of hormonal adjuvant treatment by LHRH analogue and radiation therapy for the management of locally advanced prostate cancer: The dummy run","volume":"73","author":"Kouloulias","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib32","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.radonc.2003.09.009","article-title":"Quantitative assessment of inter-clinician variability of target volume delineation for medulloblastoma: Quality assurance for the SIOP PNET 4 trial protocol","volume":"69","author":"Coles","year":"2003","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib33","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s00066-003-0976-5","article-title":"The impact of gross tumor volume (GTV) and clinical target volume (CTV) definition on the total accuracy in radiotherapy theoretical aspects and practical experiences","volume":"179","author":"Weiss","year":"2003","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2009.02.072_bib34","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1016\/j.ijrobp.2006.10.029","article-title":"An evaluation of the variability of tumor-shape definition derived by experienced observers from CT images of supraglottic carcinomas (ACRIN protocol 6658)","volume":"67","author":"Cooper","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609004714?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609004714?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T03:51:59Z","timestamp":1558410719000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609004714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0360301609004714"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.02.072","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}