{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:05:15Z","timestamp":1761843915820},"reference-count":24,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,6,1]],"date-time":"2010-06-01T00:00:00Z","timestamp":1275350400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2010,6]]},"DOI":"10.1016\/j.ijrobp.2009.05.021","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T11:08:40Z","timestamp":1252062520000},"page":"438-446","source":"Crossref","is-referenced-by-count":17,"title":["Predicting the Effect of Accelerated Fractionation in Postoperative Radiotherapy for Head and Neck Cancer Based on Molecular Marker Profiles: Data From a Randomized Clinical Trial"],"prefix":"10.1016","volume":"77","author":[{"given":"Rafal","family":"Suwinski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Jaworska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Nikiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wozniak","family":"Grzegorz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Bankowska-Wozniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Majewski","family":"Wojciech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Skladowski","family":"Krzysztof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lange","family":"Dariusz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.05.021_bib1","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.radonc.2008.02.009","article-title":"Randomized clinical trial on 7-days-a-week postoperative radiotherapy for high-risk squamous cell head and neck cancer","volume":"87","author":"Suwinski","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib2","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0360-3016(01)01690-X","article-title":"Randomized trial addressing risk features and time factors of surgery plus radiotherapy in advanced head-and-neck cancer","volume":"51","author":"Ang","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/sj.bjc.6600119","article-title":"Accelerated hyperfractionation (AHF) compared to conventional fractionation (CF) in the postoperative radiotherapy of locally advanced head and neck cancer: Influence of proliferation","volume":"86","author":"Awwad","year":"2002","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib4","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.ijrobp.2004.07.682","article-title":"Accelerated versus conventional fractionated postoperative radiotherapy for advanced head and neck cancer: results of a multicenter phase III study","volume":"61","author":"Sanguineti","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib5","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0360-3016(93)90167-T","article-title":"Evaluation of the dose for postoperative radiation therapy of head and neck cancer: First report of a prospective randomized trial","volume":"26","author":"Peters","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib6","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/(SICI)1097-0347(199810)20:7<588::AID-HED2>3.0.CO;2-F","article-title":"Precisely defining high-risk operable head and neck tumors based on RTOG 85-03 and 88-24: Targets for postoperative radiochemotherapy?","volume":"20","author":"Cooper","year":"1998","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/S0360-3016(02)04469-3","article-title":"Time factor in postoperative radiotherapy: A multivariate locoregional control analysis in 868 patients","volume":"56","author":"Suwinski","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib8","first-page":"7350","article-title":"Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma","volume":"15","author":"Ang","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib9","doi-asserted-by":"crossref","first-page":"5560","DOI":"10.1200\/JCO.2005.06.411","article-title":"Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial","volume":"20","author":"Bentzen","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib10","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.radonc.2004.12.018","volume":"74","author":"Eriksen","year":"2005","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib11","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1080\/02841860510007396","article-title":"Overgaard J for the Danish Head and Neck Cancer study group (DAHANCA). The role of epidermal growth factor receptor and E-cadherin for the outcome of reduction in the overall treatment time of radiotherapy of supraglottic larynx squamous cell carcinoma","volume":"44","author":"Eriksen","year":"2005","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s001090000081","article-title":"Increased activity of nm23-H1 gene in squamous cell carcinoma of the head and neck is associated with advanced disease and poor prognosis","volume":"78","author":"Paveli\u0107","year":"2000","journal-title":"J Mol Med"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib13","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF02893945","article-title":"nm23-H1 expression in squamous cell carcinoma of the head and neck","volume":"2","author":"McDonald","year":"1996","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib14","doi-asserted-by":"crossref","first-page":"2186","DOI":"10.1038\/sj.bjc.6601808","article-title":"Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma","volume":"90","author":"Wang","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib15","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1002\/1097-0142(20001215)89:12<2637::AID-CNCR17>3.0.CO;2-B","article-title":"COX-2 is expressed in human pulmonary, colonic and mammary tumors","volume":"89","author":"Soslow","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib16","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1002\/hed.20178","article-title":"Prediction of poor survival by cyclooxygenase-2 in patients with T4 nasopharyngeal cancer treated by radiation therapy: Clinical and in vitro studies","volume":"27","author":"Chen","year":"2005","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib17","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/00949657808810249","article-title":"Sample size and power determination for stratified clinical trials","volume":"8","author":"Bernstein","year":"1978","journal-title":"J Stat Comp Simul"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib18","first-page":"1133","article-title":"Human papillomavirus accounts both for increased incidence and better prognosis in tonsillar cancer","volume":"28","author":"Dahlstrand","year":"2008","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib19","doi-asserted-by":"crossref","first-page":"3128","DOI":"10.1200\/JCO.2007.12.7662","article-title":"EGFR, p16, HPV Titer, Bcl-xL and p-53, sex, and smoking as indicators of response to therapy and survival in oropharyngeal cancer","volume":"26","author":"Kumar","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib20","first-page":"780","article-title":"Molecular marker expression in oral and oropharyngeal squamous cell carcinoma","volume":"127","author":"Smith","year":"2001","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib21","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1158\/1078-0432.CCR-03-0354","article-title":"Prognostic significance of cyclooxygenase-2 in oropharyngeal squamous cell carcinoma","volume":"10","author":"Chang","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib22","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1245\/s10434-007-9771-3","article-title":"EGFR, HER2, and HER3 expression in laryngeal primary tumors and corresponding metastases","volume":"15","author":"Wei","year":"2008","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib23","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1056\/NEJMoa032641","article-title":"Postoperative irradiation with or without concomitant chemotherapy for locally advanced head and neck cancer","volume":"350","author":"Bernier","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2009.05.021_bib24","doi-asserted-by":"crossref","first-page":"1937","DOI":"10.1056\/NEJMoa032646","article-title":"Postoperative concurrent radiotherapy and chemotherapy for high-risk squamous-cell carcinoma of the head and neck","volume":"350","author":"Cooper","year":"2004","journal-title":"N Engl J Med"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030160900769X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030160900769X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T11:19:28Z","timestamp":1558523968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030160900769X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,6]]},"references-count":24,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,6]]}},"alternative-id":["S036030160900769X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.05.021","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,6]]}}}