{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T03:08:23Z","timestamp":1793329703757,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.ijrobp.2009.06.075","type":"journal-article","created":{"date-parts":[[2010,1,8]],"date-time":"2010-01-08T05:36:05Z","timestamp":1262928965000},"page":"1352-1359","source":"Crossref","is-referenced-by-count":28,"title":["Toxicity and Outcome Results of a Class Solution With Moderately Hypofractionated Radiotherapy in Inoperable Stage III Non\u2013Small Cell Lung Cancer Using Helical Tomotherapy"],"prefix":"10.1016","volume":"77","author":[{"given":"Samuel","family":"Bral","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micha\u00ebl","family":"Duchateau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harijati","family":"Versmessen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedikt","family":"Engels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Tournel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Vinh-Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"De Ridder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Schallier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Storme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.06.075_bib1","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/bmj.311.7010.899","article-title":"Chemotherapy in non-small cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials","volume":"311","year":"1995","journal-title":"Br Med J"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib2","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1200\/JCO.2004.09.053","article-title":"American Society of Clinical Oncology treatment of unresectable non-small-cell lung cancer guideline: Update 2003","volume":"22","author":"Pfister","year":"2004","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib3","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/jnci\/83.6.417","article-title":"Radiotherapy alone vs. combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: First analysis of a randomized trial in 353 patients","volume":"83","author":"Le","year":"1991","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib4","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1002\/1097-0142(19800601)45:11<2744::AID-CNCR2820451108>3.0.CO;2-U","article-title":"A prospective randomized study of various irradiation doses and fractionation schedules in the treatment of inoperable non-oat-cell carcinoma of the lung. Preliminary report by the Radiation Therapy Oncology Group","volume":"45","author":"Perez","year":"1980","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib5","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ijrobp.2005.02.010","article-title":"High-dose radiation improved local tumor control and overall survival in patients with inoperable\/unresectable non-small-cell lung cancer: Long-term results of a radiation dose escalation study","volume":"63","author":"Kong","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib6","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.1002\/cncr.21007","article-title":"Results of a phase I dose-escalation study using three-dimensional conformal radiotherapy in the treatment of inoperable nonsmall cell lung carcinoma","volume":"103","author":"Rosenzweig","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib7","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.ijrobp.2004.06.260","article-title":"Toxicity and outcome results of RTOG 9311: A phase I\u2013II dose-escalation study using three-dimensional conformal radiotherapy in patients with inoperable non-small-cell lung carcinoma","volume":"61","author":"Bradley","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ijrobp.2006.04.034","article-title":"Final results of a Phase I\/II dose escalation trial in non-small-cell lung cancer using three-dimensional conformal radiotherapy","volume":"66","author":"Belderbos","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib9","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.radonc.2003.09.006","article-title":"Escalated dose for non-small-cell lung cancer with accelerated hypofractionated three-dimensional conformal radiation therapy","volume":"71","author":"Thirion","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.ijrobp.2006.01.051","article-title":"Final toxicity results of a radiation-dose escalation study in patients with non-small-cell lung cancer (NSCLC): Predictors for radiation pneumonitis and fibrosis","volume":"65","author":"Kong","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0360-3016(00)01374-2","article-title":"A new approach to dose escalation in non-small-cell lung cancer","volume":"49","author":"Mehta","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/00000421-200302000-00014","article-title":"Reduction in radiation dose to lung and other normal tissues using helical tomotherapy to treat lung cancer, in comparison to conventional field arrangements","volume":"26","author":"Scrimger","year":"2003","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib13","doi-asserted-by":"crossref","first-page":"3675","DOI":"10.1088\/0031-9155\/49\/16\/014","article-title":"Planning evaluation of radiotherapy for complex lung cancer cases using helical tomotherapy","volume":"49","author":"Kron","year":"2004","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib14","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S1470-2045(08)70098-6","article-title":"Evidence behind use of intensity-modulated radiotherapy: A systematic review of comparative clinical studies","volume":"9","author":"Veldeman","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib15","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.ijrobp.2004.12.019","article-title":"Selective mediastinal node irradiation based on FDG-PET scan data in patients with non-small-cell lung cancer: A prospective clinical study","volume":"62","author":"De","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib16","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1378\/chest.111.6.1718","article-title":"Regional lymph node classification for lung cancer staging","volume":"111","author":"Mountain","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib17","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1088\/0031-9155\/54\/8\/004","article-title":"The validation of tomotherapy dose calculations in low-density lung media","volume":"54","author":"Chaudhari","year":"2009","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib18","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1118\/1.596958","article-title":"Tomotherapy: A new concept for the delivery of dynamic conformal radiotherapy","volume":"20","author":"Mackie","year":"1993","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib19","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1118\/1.2349698","article-title":"Automatic registration of megavoltage to kilovoltage CT images in helical tomotherapy: An evaluation of the setup verification process for the special case of a rigid head phantom","volume":"33","author":"Boswell","year":"2006","journal-title":"Med Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib20","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.ijrobp.2005.02.047","article-title":"Initial experience with megavoltage (MV) CT guidance for daily prostate alignments","volume":"62","author":"Langen","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib21","doi-asserted-by":"crossref","first-page":"N345","DOI":"10.1088\/0031-9155\/52\/15\/N04","article-title":"Optimization of megavoltage CT scan registration settings for thoracic cases on helical tomotherapy","volume":"52","author":"Woodford","year":"2007","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0167-8140(95)90055-1","article-title":"LENT SOMA tables","volume":"35","year":"1995","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.radonc.2008.02.005","article-title":"Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience","volume":"87","author":"Sura","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib24","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.ijrobp.2003.09.086","article-title":"Dose and volume reduction for normal lung using intensity-modulated radiotherapy for advanced-stage non-small-cell lung cancer","volume":"58","author":"Murshed","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.radonc.2008.06.006","article-title":"Treatment planning comparison between conformal radiotherapy and helical tomotherapy in the case of locally advanced-stage NSCLC","volume":"88","author":"Cattaneo","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib26","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1016\/j.ijrobp.2003.09.085","article-title":"Feasibility of sparing lung and other thoracic structures with intensity-modulated radiotherapy for non-small-cell lung cancer","volume":"58","author":"Liu","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijrobp.2006.12.031","article-title":"Initial evaluation of treatment-related pneumonitis in advanced-stage non-small-cell lung cancer patients treated with concurrent chemotherapy and intensity-modulated radiotherapy","volume":"68","author":"Yom","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib28","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.radonc.2004.07.033","article-title":"Results of a phase I study to dose escalate using intensity modulated radiotherapy guided by combined PET\/CT imaging with induction chemotherapy for patients with non-small cell lung cancer","volume":"73","author":"Holloway","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0360-3016(98)00196-5","article-title":"Radiation pneumonitis as a function of mean lung dose: An analysis of pooled data of 540 patients","volume":"42","author":"Kwa","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib30","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0360-3016(99)00183-2","article-title":"Clinical dose-volume histogram analysis for pneumonitis after 3D treatment for non-small cell lung cancer (NSCLC)","volume":"45","author":"Graham","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib31","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0272-5231(03)00126-6","article-title":"Pulmonary complications of radiation therapy","volume":"25","author":"Abratt","year":"2004","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib32","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ijrobp.2008.02.057","article-title":"Irradiation of varying volumes of rat lung to same mean lung dose: A little to a lot or a lot to a little?","volume":"71","author":"Semenenko","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib33","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1007\/s00066-003-1078-0","article-title":"A little to a lot or a lot to a little? An analysis of pneumonitis risk from dose-volume histogram parameters of the lung in patients with lung cancer treated with 3-D conformal radiotherapy","volume":"179","author":"Willner","year":"2003","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib34","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijrobp.2007.06.034","article-title":"Increasing tumor volume is predictive of poor overall and progression-free survival: Secondary analysis of the Radiation Therapy Oncology Group 93-11 phase I\u2013II radiation dose-escalation study in patients with inoperable non-small-cell lung cancer","volume":"70","author":"Werner-Wasik","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijrobp.2006.11.051","article-title":"High radiation dose may reduce the negative effect of large gross tumor volume in patients with medically inoperable early-stage non-small cell lung cancer","volume":"68","author":"Zhao","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib36","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.lungcan.2004.03.004","article-title":"Concurrent vs. sequential chemoradiotherapy with cisplatin and vinorelbine in locally advanced non-small cell lung cancer: A randomized study","volume":"46","author":"Zatloukal","year":"2004","journal-title":"Lung Cancer"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib37","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1200\/JCO.2005.03.070","article-title":"Randomized phase III trial of sequential chemoradiotherapy compared with concurrent chemoradiotherapy in locally advanced non-small-cell lung cancer: Groupe Lyon-Saint-Etienne d'Oncologie Thoracique-Groupe Francais de Pneumo-Cancerologie NPC 95-01 Study","volume":"23","author":"Fournel","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.06.075_bib38","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1200\/JCO.2005.09.108","volume":"23","author":"Belani","year":"2005","journal-title":"J\u00a0Clin Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609027692?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609027692?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T23:24:11Z","timestamp":1544743451000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609027692"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0360301609027692"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.06.075","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}