{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T20:32:46Z","timestamp":1791059566033,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T00:00:00Z","timestamp":1267401600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1016\/j.ijrobp.2009.10.020","type":"journal-article","created":{"date-parts":[[2010,3,4]],"date-time":"2010-03-04T09:44:25Z","timestamp":1267695865000},"page":"1199-1205","source":"Crossref","is-referenced-by-count":49,"title":["Increased Chromosomal Radiosensitivity in Women Carrying BRCA1\/BRCA2 Mutations Assessed With the G2 Assay"],"prefix":"10.1016","volume":"76","author":[{"given":"Beroukas","family":"Ernestos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pandis","family":"Nikolaos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giannoukakos","family":"Koulis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizou","family":"Eleni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beroukas","family":"Konstantinos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giatromanolaki","family":"Alexandra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koukourakis","family":"Michael","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.10.020_bib1","series-title":"Cancer facts & figures 2009","year":"2009"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib2","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1001\/jama.270.13.1563","article-title":"A comprehensive evaluation of family history and breast cancer risk. The Utah Population Database","volume":"270","author":"Slattery","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib3","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1093\/oxfordjournals.aje.a115616","article-title":"Age at onset as an indicator of familial risk of breast cancer","volume":"131","author":"Claus","year":"1990","journal-title":"Am J Epidemiol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib4","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1002\/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0.CO;2-Z","article-title":"The genetic attributable risk of breast and ovarian cancer","volume":"77","author":"Claus","year":"1996","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib5","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/S0140-6736(01)06524-2","article-title":"Collaborative reanalysis of individual data from 52 epidemiological studies including 58,209 women with breast cancer and 101,986 women without the disease","volume":"358","author":"Familial breast cancer","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/1098-2272(200102)20:2<239::AID-GEPI6>3.0.CO;2-Y","article-title":"Involvement of BRCA1 and BRCA2 in breast cancer in a western Finnish sub-population","volume":"20","author":"Paakkonen","year":"2001","journal-title":"Genet Epidemiol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib7","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1007\/s004320000140","article-title":"BRCA1 and BRCA2\u2014Breast cancer susceptibility genes","volume":"126","author":"Hofmann","year":"2000","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib8","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/jemt.10178","article-title":"Highlight: BRCA1 and BRCA2 proteins in breast cancer","volume":"59","author":"Daniel","year":"2002","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature01230","article-title":"Insights into DNA recombination from the structure of a RAD51-BRCA2 complex","volume":"420","author":"Pellegrini","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S1471-4914(02)02434-6","article-title":"The relationship between the roles of BRCA genes in DNA repair and cancer predisposition","volume":"8","author":"Tutt","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib11","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1101\/gad.11.10.1242","article-title":"Brca2 is required for embryonic cellular proliferation in the mouse","volume":"11","author":"Suzuki","year":"1997","journal-title":"Genes Dev"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib12","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0092-8674(00)81302-1","article-title":"The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse","volume":"85","author":"Hakem","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib13","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.1128\/MCB.21.10.3445-3450.2001","article-title":"Kim S-t, Kastan MB. Involvement of Brca1 in S-phase and G(2)-phase checkpoints after ionizing irradiation","volume":"21","author":"Xu","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib14","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1088\/0031-9155\/41\/2\/001","article-title":"From targets to genes: A brief history of radiosensitivity","volume":"41","author":"Steel","year":"1996","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.dnarep.2006.05.011","article-title":"Contribution of DNA repair and cell cycle checkpoint arrest to the maintenance of genomic stability","volume":"5","author":"Jeggo","year":"2006","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib16","doi-asserted-by":"crossref","first-page":"5706","DOI":"10.1128\/MCB.23.16.5706-5715.2003","article-title":"Pathways of DNA double-strand break repair during the mammalian cell cycle","volume":"23","author":"Rothkamm","year":"2003","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1097-2765(01)00174-5","article-title":"BRCA2 is required for homology-directed repair of chromosomal breaks","volume":"7","author":"Moynahan","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib18","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1038\/sj.onc.1203334","article-title":"BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a brca1 transgene","volume":"8","author":"Snouwaert","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib19","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S1097-2765(01)00175-7","article-title":"Role of BRCA2 in control of the RAD51 recombination and DNA repair protein","volume":"7","author":"Davies","year":"2001","journal-title":"Mol Cell"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib20","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S1097-2765(00)80276-2","article-title":"Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells","volume":"2","author":"Chen","year":"1998","journal-title":"Mol Cell"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib21","doi-asserted-by":"crossref","first-page":"32931","DOI":"10.1074\/jbc.274.46.32931","article-title":"Expression of BRC repeats in breast cancer cells disrupts the BRCA2-Rad51 complex and leads to radiation hypersensitivity and loss of G(2)\/M checkpoint control","volume":"12","author":"Chen","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0092-8674(00)81847-4","article-title":"Association of BRCA1 with RAD51 in mitotic and meiotic cells","volume":"88","author":"Scully","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib23","doi-asserted-by":"crossref","first-page":"3683","DOI":"10.1093\/nar\/gkh703","article-title":"Conservative homologous recombination preferentially repairs DNA double-strand breaks in the S phase of the cell cycle in human cells","volume":"32","author":"Saleh-Gohari","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib24","first-page":"270","article-title":"Nonhomologous end-joining of ionizing radiation-induced DNA double-stranded breaks in human tumor cells deficient in BRCA1 or BRCA2","volume":"61","author":"Wang","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib25","first-page":"1245","article-title":"DNA-dependent protein kinase stimulates an independently active, nonhomologous, end-joining apparatus","volume":"60","author":"DiBiase","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib26","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0167-8140(98)00023-1","article-title":"Response to radiation therapy and prognosis in breast cancer patients with BRCA1 and BRCA2 mutations","volume":"47","author":"Gaffney","year":"1998","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib27","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0360-3016(00)00728-8","article-title":"Mutation analysis of BRCA1 and BRCA2 cancer predisposition genes in radiation hypersensitive cancer patients","volume":"48","author":"Leong","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib28","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1200\/JCO.2000.18.19.3360","article-title":"Effect of radiotherapy after breast-conserving treatment in women with breast cancer and germline BRCA1\/2 mutations","volume":"18","author":"Pierce","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib29","doi-asserted-by":"crossref","first-page":"7025","DOI":"10.1158\/1078-0432.CCR-06-1244","article-title":"Late toxicity is not increased in BRCA1\/BRCA2 mutation carriers undergoing breast radiotherapy in the United Kingdom","volume":"12","author":"Shanley","year":"2006","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib30","doi-asserted-by":"crossref","first-page":"7334","DOI":"10.1038\/sj.onc.1203165","article-title":"Gamma-rays-induced death of human cells carrying mutations of BRCA1 or BRCA2","volume":"18","author":"Foray","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib31","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/ijc.10109","article-title":"Evidence of haplotype insufficiency in human cells containing a germline mutation in BRCA1 and BRCA2","volume":"97","author":"Buchholz","year":"2002","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib32","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/ijc.22915","article-title":"Lymphocyte radiosensitivity in BRCA1 and BRCA2 mutation carriers and implications for breast cancer susceptibility","volume":"121","author":"Barwell","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/095530099140744","article-title":"Increased chromosomal radiosensitivity in breast cancer patients: A comparison of two assays","volume":"75","author":"Scott","year":"1999","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib34","first-page":"607","article-title":"Increased G2 chromosomal radiosensitivity in cancer patients: The role of cdk1\/cyclin-B activity level in the mechanisms involved","volume":"76","author":"Terzoudi","year":"2002","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib35","first-page":"1223","article-title":"G2-checkpoint abrogation in irradiated lymphocytes: A new cytogenetic approach to assess individual radiosensitivity and predisposition to cancer","volume":"35","author":"Terzoudi","year":"2009","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib36","doi-asserted-by":"crossref","first-page":"11292","DOI":"10.1158\/0008-5472.CAN-05-2148","article-title":"Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells","volume":"65","author":"Terzoudi","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib37","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1080\/09553000210144484","article-title":"The G2 chromosomal radiosensitivity assay","volume":"78","author":"Bryant","year":"2002","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib38","series-title":"Human cytogenetics: A practical\u00a0approach. Volume II","first-page":"155","article-title":"Methods in solid tumors cytogenetics","author":"Mandahl","year":"1992"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib39","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/S1097-2765(00)80466-9","article-title":"Centrosome amplification and a defective G2-M cell cycle checkpoint induce genetic instability in BRCA1 exon 11 isoform-deficient cells","volume":"3","author":"Xu","year":"1999","journal-title":"Mol Cell"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib40","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/sj.bjc.6603528","article-title":"DNA repair capacity as a possible biomarker of breast cancer risk in female BRCA1 mutation carriers","volume":"96","author":"Kotsopoulos","year":"2007","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib41","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0027-5107(78)90045-3","article-title":"Unrepaired DNA strand breaks in irradiated ataxia telangiectasia lymphocytes suggested from cytogenetic observations","volume":"50","author":"Taylor","year":"1978","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib42","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/S0140-6736(94)90615-7","article-title":"Genetic predisposition to breast cancer","volume":"344","author":"Scott","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib43","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0167-8140(99)00158-9","article-title":"Relationship between in vitro chromosomal radiosensitivity of peripheral blood lymphocytes and the expression of normal tissue damage following radiotherapy for breast cancer","volume":"55","author":"Barber","year":"2000","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib44","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/sj.bjc.6602912","article-title":"Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers","volume":"94","author":"Kote-Jarai","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib45","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1016\/j.dnarep.2008.08.001","article-title":"Mitotic delay in lymphocytes from BRCA1 heterozygotes unable to reduce the radiation-induced chromosomal damage","volume":"7","author":"Febrer","year":"2008","journal-title":"DNA Repair (Amst)"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib46","first-page":"5948","article-title":"Correspondence re: A. Rothfuss et\u00a0al., Induced micronucleus frequencies in peripheral blood lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families. Cancer Res., 60: 390\u2013394, 2000 [Letter]","volume":"61","author":"Baria","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib47","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1080\/09553000110097974","article-title":"BRCA1 and BRCA2 heterozygosity and repair of X-ray-induced DNA damage","volume":"78","author":"Nieuwenhuis","year":"2002","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib48","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1080\/09553000400017937","article-title":"Chromosomal radiosensitivity in BRCA1 and BRCA2 mutation carriers","volume":"80","author":"Baeyens","year":"2004","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib49","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/35044000","article-title":"In search of the tumor-suppressor functions of BRCA1 and BRCA2","volume":"408","author":"Scully","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib50","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1126\/science.285.5428.747","article-title":"Association of BRCA1 with RAD50-hMrc11-p95 complex and the DNA damage response","volume":"285","author":"Zhong","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib51","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1073\/pnas.111125998","article-title":"Direct DNA binding by BRCA1","volume":"98","author":"Paull","year":"2001","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib52","first-page":"390","article-title":"Induced micronucleus frequencies in peripheral lymphocytes as a screening test for carriers of a BRCA1 mutation in breast cancer families","volume":"60","author":"Rothfuss","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib53","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0027-5107(01)00300-1","article-title":"Mutagen sensitivity of peripheral blood from women carrying a BRCA1 or BRCA2 mutation","volume":"500","author":"Trenz","year":"2002","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib54","first-page":"5548","article-title":"BRCA1 and BRCA2 are necessary for the transcription-coupled repair of the oxidative 8-oxoguanine lesion in human cells","volume":"60","author":"Le Page","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib55","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.mrrev.2003.06.011","article-title":"Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics","volume":"544","author":"Trenz","year":"2003","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2009.10.020_bib56","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/35077232","article-title":"Genome maintenance mechanisms for preventing cancer","volume":"411","author":"Hoeijmakers","year":"2001","journal-title":"Nature"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609034117?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609034117?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,26]],"date-time":"2019-05-26T12:32:43Z","timestamp":1558873963000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609034117"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":56,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,3]]}},"alternative-id":["S0360301609034117"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.10.020","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}