{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:22:02Z","timestamp":1761823322192},"reference-count":20,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ijrobp.2009.10.070","type":"journal-article","created":{"date-parts":[[2010,4,26]],"date-time":"2010-04-26T08:46:27Z","timestamp":1272271587000},"page":"496-502","source":"Crossref","is-referenced-by-count":23,"title":["Three-Dimensional Conformal Radiation Therapy and Intensity-Modulated Radiation Therapy Combined With Transcatheter Arterial Chemoembolization for Locally Advanced Hepatocellular Carcinoma: An Irradiation Dose Escalation Study"],"prefix":"10.1016","volume":"79","clinical-trial-number":[{"clinical-trial-number":"nct00848094","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Zhi-Gang","family":"Ren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Dong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Gu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun-Hua","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Yong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Gang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen-Hua","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Ming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Liang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.10.070_bib1","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/cncr.21811","article-title":"Radiation therapy for hepatocellular carcinoma: from palliation to cure","volume":"106","author":"Hawkins","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1046\/j.1440-1746.1999.01994.x","article-title":"A pilot study of three-dimensional conformal radiotherapy in unresectable hepatocellular carcinoma","volume":"14","author":"Cheng","year":"1999","journal-title":"J Gastroenterol Hepatol"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib3","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/j.ijrobp.2004.08.028","article-title":"Local radiotherapy for patients with unresectable hepatocellular carcinoma","volume":"61","author":"Park","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/S0360-3016(02)02864-X","article-title":"Dose-response relationship in local radiotherapy for hepatocellular carcinoma","volume":"54","author":"Park","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib5","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0360-3016(02)03929-9","article-title":"Clinical results and prognostic factors in radiotherapy for unresectable hepatocellular carcinoma: A retrospective study of 158 patients","volume":"55","author":"Seong","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib6","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1200\/JCO.2000.18.11.2210","article-title":"Escalated focal liver radiation and concurrent hepatic artery fluorodeoxyuridine for unresectable intrahepatic malignancies","volume":"18","author":"Dawson","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib7","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1002\/cncr.21012","article-title":"Hypofractionated three-dimensional conformal radiation therapy for primary liver carcinoma","volume":"103","author":"Liang","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib8","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1259\/bjr\/33521596","article-title":"Combined therapy of transcatheter arterial chemoembolization and three-dimensional conformal radiotherapy for hepatocellular carcinoma","volume":"80","author":"Zhou","year":"2007","journal-title":"Br J Radiol"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib9","unstructured":"Yang BH. Primary liver cancer. In: ChineseAnti-Cancer Association, editor. Guidelines for common cancers in China. Beijing: Associated Press of Peking Medical University and Peking Union Medical College; 1999. p. 389\u2013479."},{"key":"10.1016\/j.ijrobp.2009.10.070_bib10","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.radonc.2007.12.006","article-title":"Application of active breathing control in 3-dimensional conformal radiation therapy for hepatocellular carcinoma: The feasibility and benefit","volume":"87","author":"Zhao","year":"2008","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib11","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ijrobp.2005.12.031","article-title":"Radiation-induced liver disease in three-dimensional conformal radiation therapy for primary liver carcinoma: The risk factors and hepatic radiation tolerance","volume":"65","author":"Liang","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2307\/3577179","article-title":"Dose fractionation and hepatocyte clonogens: Alpha\/beta congruent to 1-2 Gy, and beta decreases with increasing delay before assay","volume":"113","author":"Fisher","year":"1988","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib13","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.ijrobp.2003.10.051","article-title":"In response to Dr.\u00a0Tome and Dr. Fenwick","volume":"58","author":"Dawson","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib14","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0360-3016(03)00091-9","article-title":"Dosimetric analysis and comparison of three-dimensional conformal radiotherapy and intensity-modulated radiation therapy for patients with hepatocellular carcinoma and radiation-induced liver disease","volume":"56","author":"Cheng","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib15","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.ijrobp.2005.02.033","article-title":"Benefit of using biologic parameters (EUD and NTCP) in IMRT optimization for treatment of intrahepatic tumors","volume":"62","author":"Thomas","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib16","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.ijrobp.2008.06.1496","article-title":"Treatment planning study to determine potential benefit of intensity-modulated radiotherapy versus conformal radiotherapy for unresectable hepatic malignancies","volume":"72","author":"Eccles","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib17","doi-asserted-by":"crossref","first-page":"S206","DOI":"10.1053\/j.gastro.2004.09.035","article-title":"External beam radiation therapy for hepatocellular carcinoma: Potential of intensity-modulated and image-guided radiation therapy","volume":"127","author":"Fuss","year":"2004","journal-title":"Gastroenterology"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib18","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ijrobp.2005.11.034","article-title":"Prediction of radiation-induced liver disease by Lyman normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary liver carcinoma","volume":"65","author":"Xu","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib19","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1200\/JCO.1993.11.7.1286","article-title":"Treatment of primary hepatobiliary cancers with conformal radiation therapy and regional chemotherapy","volume":"11","author":"Robertson","year":"1993","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.070_bib20","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.etp.2009.02.114","article-title":"Hepatocyte regeneration after partial liver irradiation in rats","volume":"61","author":"Zhao","year":"2009","journal-title":"Exp Toxicol Pathol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609035585?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609035585?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T16:25:25Z","timestamp":1544545525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609035585"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0360301609035585"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.10.070","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}