{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:20:02Z","timestamp":1790518802155,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2011,2,1]],"date-time":"2011-02-01T00:00:00Z","timestamp":1296518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1016\/j.ijrobp.2009.10.072","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T05:07:59Z","timestamp":1271308079000},"page":"514-523","source":"Crossref","is-referenced-by-count":140,"title":["Potential for Differentiation of Pseudoprogression From True Tumor Progression With Dynamic Susceptibility-Weighted Contrast-Enhanced Magnetic Resonance Imaging Using Ferumoxytol vs. Gadoteridol: A Pilot Study"],"prefix":"10.1016","volume":"79","author":[{"given":"Seymur","family":"Gahramanov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Raslan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie L.","family":"Muldoon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn E.","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Rooney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csanad G.","family":"Varallyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey M.","family":"Njus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Haluska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward A.","family":"Neuwelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.10.072_bib1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1470-2045(08)70125-6","article-title":"Clinical features, mechanisms, and management of pseudoprogression in malignant gliomas","volume":"9","author":"Brandsma","year":"2008","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib2","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.surneu.2008.09.023","article-title":"Pseudoprogression after radiotherapy with concurrent temozolomide for high-grade glioma: clinical observations and working recommendations","volume":"72","author":"Chaskis","year":"2009","journal-title":"Surg Neurol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib3","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s11060-006-9241-y","article-title":"Early necrosis following concurrent Temodar and radiotherapy in patients with glioblastoma","volume":"82","author":"Chamberlain","year":"2007","journal-title":"J Neurooncol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib4","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1667\/0033-7587(2000)153[0357:TROTCN]2.0.CO;2","article-title":"The radioresponse of the central nervous system: a dynamic process","volume":"153","author":"Tofilon","year":"2000","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1124\/mi.4.5.7","article-title":"Mechanisms of radiation injury to the central nervous system: Implications for neuroprotection","volume":"4","author":"Wong","year":"2004","journal-title":"Mol Interv"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib6","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1158\/1078-0432.CCR-03-0426","article-title":"Hypoxia and hypoxia-inducible factor-1 target genes in central nervous system radiation injury: A role for vascular endothelial growth factor","volume":"10","author":"Nordal","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib7","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1215\/15228517-2008-008","article-title":"Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: Pitfalls in neurooncology","volume":"10","author":"Brandes","year":"2008","journal-title":"Neuro Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib8","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1200\/JCO.2007.14.8163","article-title":"MGMT promoter methylation status can predict the incidence and outcome of pseudoprogression after concomitant radiochemotherapy in newly diagnosed glioblastoma patients","volume":"26","author":"Brandes","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib9","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1148\/radiology.191.1.8134596","article-title":"Cerebral blood volume maps of gliomas: Comparison with tumor grade and histologic findings","volume":"191","author":"Aronen","year":"1994","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib10","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1148\/radiology.211.3.r99jn46791","article-title":"Glial neoplasms: Dynamic contrast-enhanced T2\u2217-weighted MR imaging","volume":"211","author":"Knopp","year":"1999","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib11","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2214\/ajr.171.6.9843274","article-title":"Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas","volume":"171","author":"Sugahara","year":"1998","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib12","first-page":"214","article-title":"Glial tumor grading and outcome prediction using dynamic spin-echo MR susceptibility mapping compared with conventional contrast-enhanced MR: Confounding effect of elevated rCBV of oligodendrogliomas [corrected]","volume":"25","author":"Lev","year":"2004","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib13","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/j.ijrobp.2005.09.001","article-title":"Survival prediction in high-grade gliomas by MRI perfusion before and during early stage of RT [corrected]","volume":"64","author":"Cao","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1148\/radiol.2471062089","article-title":"Low-grade gliomas: Do changes in rCBV measurements at longitudinal perfusion-weighted MR imaging predict malignant transformation?","volume":"247","author":"Danchaivijitr","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib15","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1148\/radiol.2472070898","article-title":"Gliomas: Predicting time to progression or survival with cerebral blood volume measurements at dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging","volume":"247","author":"Law","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib16","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/jmri.20039","article-title":"Survival analysis in patients with glioblastoma multiforme: Predictive value of choline-to-N-acetylaspartate index, apparent diffusion coefficient, and relative cerebral blood volume","volume":"19","author":"Oh","year":"2004","journal-title":"J Magn Reson Imaging"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib17","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1148\/radiol.2532090007","article-title":"Differentiation of recurrent glioblastoma multiforme from radiation necrosis after external beam radiation therapy with dynamic susceptibility-weighted contrast-enhanced perfusion MR Imaging","volume":"253","author":"Barajas","year":"2009","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1007\/s00415-009-5034-5","article-title":"Radiological progression of cerebral metastases after radiosurgery: Assessment of perfusion MRI for differentiating between necrosis and recurrence","volume":"256","author":"Hoefnagels","year":"2009","journal-title":"J Neurol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib19","doi-asserted-by":"crossref","first-page":"552","DOI":"10.3174\/ajnr.A1377","volume":"30","author":"Hu","year":"2009","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1148\/radiol.2492081429","article-title":"Perfusion MR imaging: Moving forward","volume":"249","author":"Sorensen","year":"2008","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1227\/01.NEU.0000255350.71700.37","article-title":"The potential of ferumoxytol nanoparticle magnetic resonance imaging, perfusion, and angiography in central nervous system malignancy: A pilot study","volume":"60","author":"Neuwelt","year":"2007","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib22","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/jcbfm.2008.162","article-title":"Dynamic MRI using iron oxide nanoparticles to assess early vascular effects of antiangiogenic versus corticosteroid treatment in a\u00a0glioma model","volume":"29","author":"Varallyay","year":"2009","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib23","doi-asserted-by":"crossref","unstructured":"Weinstein J, Varallyay CG, Dosa E, et\u00a0al. Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and CNS inflammatory pathologies, a review. J Cereb Blood Flow Metab. epub ahead of print (16 September 2009).","DOI":"10.1038\/jcbfm.2009.192"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib24","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1245\/s10434-006-9337-9","article-title":"Gastrointestinal perforation due to bevacizumab in colorectal cancer","volume":"14","author":"Saif","year":"2007","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib25","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1227\/01.NEU.0000171642.49553.B0","article-title":"Positron emission tomography with O-(2-[18F]fluoroethyl)-l-tyrosine versus magnetic resonance imaging in the diagnosis of recurrent gliomas","volume":"57","author":"Rachinger","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/BF02984466","article-title":"Methionine positron emission tomography for differentiation of recurrent brain tumor and radiation necrosis after stereotactic radiosurgery\u2014in malignant glioma","volume":"18","author":"Tsuyuguchi","year":"2004","journal-title":"Ann Nucl Med"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib27","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1200\/JCO.2005.04.7233","article-title":"Physiologic and metabolic magnetic resonance imaging in gliomas","volume":"24","author":"Cao","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib28","first-page":"1316","article-title":"Proton MR spectroscopic evaluation of suspicious brain lesions after stereotactic radiotherapy","volume":"22","author":"Schlemmer","year":"2001","journal-title":"AJNR Am J Neuroradiol"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib29","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1007\/s002340100703","article-title":"Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy","volume":"44","author":"Schlemmer","year":"2002","journal-title":"Neuroradiology"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib30","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"Stupp","year":"2005","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ijrobp.2009.10.072_bib31","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1148\/radiol.2492071659","article-title":"Comparison of dynamic susceptibility-weighted contrast-enhanced MR methods: Recommendations for measuring relative cerebral blood volume in brain tumors","volume":"249","author":"Paulson","year":"2008","journal-title":"Radiology"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609035603?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609035603?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T07:40:46Z","timestamp":1559029246000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609035603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011,2]]}},"alternative-id":["S0360301609035603"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.10.072","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}