{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T09:07:31Z","timestamp":1764493651631},"reference-count":19,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.ijrobp.2009.11.011","type":"journal-article","created":{"date-parts":[[2010,4,15]],"date-time":"2010-04-15T05:07:59Z","timestamp":1271308079000},"page":"732-737","source":"Crossref","is-referenced-by-count":7,"title":["A Phase I Trial of Samarium-153-Lexidronam Complex for Treatment of Clinically Nonmetastatic High-Risk Prostate Cancer: First Report of a Completed Study"],"prefix":"10.1016","volume":"79","author":[{"given":"Richard K.","family":"Valicenti","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard","family":"Trabulsi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"Intenzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorosali","family":"Lavarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihuan","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Chervoneva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.11.011_bib1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.3322\/caac.20006","article-title":"Cancer statistics","volume":"59","author":"Jemal","year":"2009","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1016\/S0360-3016(01)01579-6","article-title":"Phase III Radiation Therapy Oncology Group (RTOG) trial 86-10 of androgen deprivation adjuvant to definitive radiotherapy in locally advanced carcinoma of the prostate","volume":"50","author":"Pilepich","year":"2001","journal-title":"Int J. Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/1097-0142(19880101)61:1<195::AID-CNCR2820610133>3.0.CO;2-Y","article-title":"Stratification of patients with metastatic prostate cancer base on extent of disease on initial bone scan","volume":"61","author":"Soloway","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib4","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/0360-3016(93)90309-J","article-title":"Results of a randomized Phase-III trial to evaluate the efficacy of strontium-89 adjuvant to local field external beam irradiation in the management of endocrine resistant metastatic prostate cancer","volume":"25","author":"Porter","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib5","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1002\/1097-0142(20000615)88:12+<2934::AID-CNCR9>3.0.CO;2-S","article-title":"Samarium sm-153 lexidronam for the palliation of bone pain associated with metastases","volume":"88","author":"Serafini","year":"2000","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib6","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1053\/srao.2000.6592","article-title":"Systemic radiopharmaceutical therapy of painful osteoblastic metastases","volume":"10","author":"Silberstein","year":"2000","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib7","first-page":"1839","article-title":"Samerium-153-EDTMP in bone metastases of hormone refractory prostate carcinoma: A Phase II trial","volume":"34","author":"Collins","year":"1993","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0936-6555(05)81078-7","article-title":"Samarium 153-labeled EDTMP for bone metastases from cancer of the prostate","volume":"4","author":"Sandeman","year":"1992","journal-title":"Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib9","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1016\/S0959-8049(97)00155-X","article-title":"A dose controlled study 153 Sm-ethylenediaminetetramethylenophosphate (EDTMP) in the treatment of patients with painful bone metastases","volume":"33","author":"Resche","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1200\/JCO.1998.16.4.1574","article-title":"Palliation of pain associated with metastatic bone cancer using Samarium 153 lexidronam: A double-blind placebo-controlled clinical rail","volume":"16","author":"Serafini","year":"1998","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.urology.2004.01.034","article-title":"Quadramet 424Sm10\/11 study group samarium 153-lexidronam complex for treatment of painful bone metastases in hormone-refractory prostate cancer","volume":"63","author":"Sartor","year":"2004","journal-title":"Urology"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib12","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0140-6736(00)03639-4","article-title":"Bone-targeted therapy for advanced androgen independent carcinoma of the prostate: A randomized Phase II trial","volume":"357","author":"Tu","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib13","doi-asserted-by":"crossref","first-page":"7904","DOI":"10.1200\/JCO.2005.01.2310","article-title":"Therapy tolerance in selected patients with androgen-independent prostate cancer following strontium-89 combined with chemotherapy","volume":"23","author":"Tu","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib14","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/1078-0432.CCR-08-1261","article-title":"A Phase I study of samarium lexidronam\/bortezomib combination therapy for the treatment of relapsed or refractory multiple myeloma","volume":"15","author":"Berenson","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib15","doi-asserted-by":"crossref","first-page":"741","DOI":"10.2307\/2531294","article-title":"Confidence limits for probability of response in multistage Phase II clinical trials","volume":"41","author":"Atkinson","year":"1985","journal-title":"Biometrics"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib16","series-title":"Practical nonparametric statistics","author":"Conover","year":"1980"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib17","doi-asserted-by":"crossref","first-page":"3972","DOI":"10.1200\/JCO.2003.11.023","article-title":"Phase III trial of long-term HT after neoadjuvant HT and radiotherapy in locally advanced carcinoma of the prostate. The Radiation Therapy Oncology Group Protcol 92-02","volume":"21","author":"Hanks","year":"2003","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib18","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1016\/j.ijrobp.2004.08.047","article-title":"Androgen suppression adjuvant to definitive radiotherapy in prostate carcinoma\u2014Long-term results of Phase III RTOG 85-31","volume":"61","author":"Pilepich","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.011_bib19","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.ijrobp.2008.05.020","volume":"73","author":"Rosenthal","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609035238?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609035238?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T17:29:12Z","timestamp":1544549352000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609035238"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0360301609035238"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.11.011","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}