{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:49:58Z","timestamp":1789739398713,"version":"4.0.1"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2011,3,1]],"date-time":"2011-03-01T00:00:00Z","timestamp":1298937600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,3]]},"DOI":"10.1016\/j.ijrobp.2009.11.040","type":"journal-article","created":{"date-parts":[[2010,5,17]],"date-time":"2010-05-17T02:21:26Z","timestamp":1274062886000},"page":"847-852","source":"Crossref","is-referenced-by-count":124,"title":["Distribution of Proliferating Bone Marrow in Adult Cancer Patients Determined Using FLT-PET Imaging"],"prefix":"10.1016","volume":"79","author":[{"given":"James A.","family":"Hayman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason W.","family":"Callahan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Herschtal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Everitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Binns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rod J.","family":"Hicks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mac Manus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.11.040_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.2214\/ajr.96.1.183","article-title":"Effect of focal irradiation on human bone marrow","volume":"96","author":"Lehar","year":"1966","journal-title":"AJR Am J Roentgenol Radium Ther Nucl Med"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib2","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.ijrobp.2008.12.039","article-title":"Imaging cellular proliferation during chemo-radiotherapy: A pilot study of serial 18F-FLT-PET\/CT imaging for non\u2013small-cell lung cancer","volume":"75","author":"Everitt","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib3","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1148\/83.6.1084","article-title":"The effects of varying dosages of irradiation upon sternal-marrow regeneration","volume":"83","author":"Sykes","year":"1964","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib4","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1002\/1097-0142(196409)17:9<1144::AID-CNCR2820170907>3.0.CO;2-4","article-title":"Long-term effects of therapeutic irradiation upon bone marrow","volume":"17","author":"Sykes","year":"1964","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib5","first-page":"326","article-title":"Effects of radiations on bone marrow","volume":"27","author":"Tubiana","year":"1979","journal-title":"Pathol Biol (Paris)"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib6","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1002\/1097-0142(197309)32:3<699::AID-CNCR2820320324>3.0.CO;2-V","article-title":"Bone marrow regeneration and extension after extended field irradiation in Hodgkin's disease","volume":"32","author":"Rubin","year":"1973","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib7","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1440-1673.1962.tb01112.x","article-title":"Bone marrow distribution as a factor in estimating radiation to the blood-forming organ: A survey of present knowledge","volume":"6","author":"Atkinson","year":"1962","journal-title":"J Coll Radiol Australas"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib8","series-title":"Atlas of Blood and Bone Marow","author":"Custer","year":"1949"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib9","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1088\/0031-9155\/5\/3\/302","article-title":"The distribution of active bone marrow in the adult","volume":"5","author":"Ellis","year":"1961","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib10","first-page":"103","article-title":"The distribution of active marrow in the bones of normal adult","volume":"11","author":"Hashimoto","year":"1960","journal-title":"Kyushu J Med Sci"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib11","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1007\/BF02118259","article-title":"Untersuchungen uber das gewicht des knochenmarkes des menschen [Studies on the weight of the bone marrow in man.]","volume":"79","author":"Mechanik","year":"1926","journal-title":"Zt Ges Anat"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib12","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1088\/0031-9155\/5\/1\/307","article-title":"A summary of the data of Mechanik on the distribution of human bone marrow","volume":"5","author":"Woodard","year":"1960","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0001-2998(85)80003-9","article-title":"The clinical use of radionuclide bone marrow imaging","volume":"15","author":"Datz","year":"1985","journal-title":"Semin Nucl Med"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib14","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1002\/1097-0142(197809)42:3<1057::AID-CNCR2820420304>3.0.CO;2-P","article-title":"Bone marrow regeneration following large field radiation: Influence of volume, age, dose, and time","volume":"42","author":"Sacks","year":"1978","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib15","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/j.jtcvs.2003.09.003","article-title":"[18F] 3-deoxy-3\u2032-fluorothymidine positron emission tomography: Alternative or diagnostic adjunct to 2-[18f]-fluoro-2-deoxy-d-glucose positron emission tomography in the workup of suspicious central focal lesions?","volume":"127","author":"Halter","year":"2004","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib16","first-page":"1210","article-title":"Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells","volume":"43","author":"Rasey","year":"2002","journal-title":"J Nucl Med"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib17","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s11307-006-0039-2","article-title":"Positron emission tomography measurement of tumor metabolism and growth: Its expanding role in oncology","volume":"8","author":"Shields","year":"2006","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1378\/chest.129.2.393","article-title":"Evaluation of thoracic tumors with 18F-fluorothymidine and 18F-fluorodeoxyglucose-positron emission tomography","volume":"129","author":"Yap","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib19","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1038\/3337","article-title":"Imaging proliferation in vivo with [F-18]FLT and positron emission tomography","volume":"4","author":"Shields","year":"1998","journal-title":"Nat Med"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib20","doi-asserted-by":"crossref","first-page":"8350","DOI":"10.1016\/S0021-9258(18)68484-4","article-title":"Regulation of human thymidine kinase during the cell cycle","volume":"263","author":"Sherley","year":"1988","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib21","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.ijrobp.2004.03.035","article-title":"IMRT dose escalation for positive para-aortic lymph nodes in patients with locally advanced cervical cancer while reducing dose to bone marrow and other organs at risk","volume":"60","author":"Ahmed","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib22","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0360-3016(02)03801-4","article-title":"Impact of intensity-modulated radiotherapy on acute hematologic toxicity in women with gynecologic malignancies","volume":"54","author":"Brixey","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib23","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1016\/j.ijrobp.2006.11.005","article-title":"Clinical outcome in posthysterectomy cervical cancer patients treated with concurrent Cisplatin and intensity-modulated pelvic radiotherapy: Comparison with conventional radiotherapy","volume":"67","author":"Chen","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib24","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/S0360-3016(02)02921-8","article-title":"IMRT of large fields: whole-abdomen irradiation","volume":"54","author":"Hong","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib25","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1016\/j.ijrobp.2008.04.046","article-title":"Dosimetric comparison of bone marrow-sparing intensity-modulated radiotherapy versus conventional techniques for treatment of cervical cancer","volume":"71","author":"Mell","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ics.2004.03.313","article-title":"Incorporation of magnetic resonance imaging into intensity modulated whole-pelvic radiation therapy treatment planning to reduce the volume of pelvic bone marrow irradiated","volume":"1268","author":"Roeske","year":"2004","journal-title":"Int Congress Series"},{"key":"10.1016\/j.ijrobp.2009.11.040_bib27","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.radonc.2005.06.017","article-title":"Incorporation of SPECT bone marrow imaging into intensity modulated whole-pelvic radiation therapy treatment planning for gynecologic malignancies","volume":"77","author":"Roeske","year":"2005","journal-title":"Radiother Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609036116?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301609036116?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,10,27]],"date-time":"2021-10-27T17:27:31Z","timestamp":1635355651000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301609036116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2011,3]]}},"alternative-id":["S0360301609036116"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.11.040","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}