{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,5]],"date-time":"2022-04-05T19:49:21Z","timestamp":1649188161466},"reference-count":36,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.ijrobp.2009.12.062","type":"journal-article","created":{"date-parts":[[2010,5,27]],"date-time":"2010-05-27T09:47:34Z","timestamp":1274953654000},"page":"877-885","source":"Crossref","is-referenced-by-count":4,"title":["Response to Multiple Radiation Doses of Human Colorectal Carcinoma Cells Infected With Recombinant Adenovirus Containing Dominant-Negative Ku70 Fragment"],"prefix":"10.1016","volume":"77","author":[{"given":"Muneyasu","family":"Urano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuqiu","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Minami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Clifton","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gloria C.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2009.12.062_bib1","first-page":"223","article-title":"The biology of Ku and its potential oncogenic role in cancer\u2014Review","volume":"1765","author":"Gullo","year":"2006","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib2","doi-asserted-by":"crossref","first-page":"5792","DOI":"10.1038\/sj.onc.1206679","article-title":"Regulation and mechanisms of mammalian double-strand break repair","volume":"22","author":"Velerie","year":"2003","journal-title":"Oncogene"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/35088000","article-title":"Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair","volume":"412","author":"Walker","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10409230091169177","article-title":"Ku autoantigen: A multifunctional DNA-binding protein","volume":"35","author":"Tuteja","year":"2000","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib5","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1074\/jbc.273.2.842","article-title":"Identification of two domains of the p70 Ku protein mediating dimerization with p80 and DNA binding","volume":"273","author":"Wang","year":"1998","journal-title":"J Biol Chem"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib6","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1073\/pnas.96.4.1403","article-title":"Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis","volume":"96","author":"Kurimasa","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/382551a0","article-title":"Requirement for Ku80 in growth and immunoglobulin V(D)J recombination","volume":"382","author":"Nussenzweig","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1084\/jem.186.6.921","article-title":"Ku70 is required for DNA repair but not for T cell antigen receptor gene recombination in vivo","volume":"186","author":"Ouyang","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib9","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1158\/0008-5472.CAN-06-1860","article-title":"Adenovirus-mediated expression of a dominant-negative Ku70 fragment radiosensitizes human tumor cells under aerobic and hypoxic conditions","volume":"67","author":"He","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib10","first-page":"3268","article-title":"Adenovirus-mediated heat-activated antisense Ku70 expression radiosensitizes tumor cells in vitro and in vivo","volume":"63","author":"Li","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib11","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.ijrobp.2007.12.061","article-title":"Response to multiple radiation doses of fibroblasts over-expressing dominant-negative KU70","volume":"71","author":"Urano","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0360-3016(82)90517-X","article-title":"Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships","volume":"8","author":"Thames","year":"1982","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib13","first-page":"1223","article-title":"Adenovirus-mediated wild-type p53 radiosensitizes human tumor cells by suppressing DNA repair capacity","volume":"2","author":"Sah","year":"2003","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib14","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2307\/3576311","article-title":"Cellular and molecular repair of x-ray-induced damage: Dependence on oxygen tension and nutritional status","volume":"101","author":"Spiro","year":"1985","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib15","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2307\/3576397","article-title":"Effect of hypoxia on recovery from damage induced by heat and radiation in plateau-phase CHO cells","volume":"101","author":"Rao","year":"1985","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib16","unstructured":"Urano M, He F, Minami A, et\u00a0al. Hypoxia-induced lethal damage is enhanced by inhibiting the repair of DNA damage but reparable when reoxygenated. Presented at the 55th Annual Radiation Research Meeting, October 3-7, 2009, Savannah, GA p. 156."},{"key":"10.1016\/j.ijrobp.2009.12.062_bib17","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0921-8777(95)00002-2","article-title":"Isolation of mammalian cell mutants that are X-ray sensitive, impaired in DNA double-strand break repair and defective for V(D)J recombination","volume":"336","author":"Lee","year":"1995","journal-title":"Mutat Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib18","doi-asserted-by":"crossref","first-page":"4778","DOI":"10.1093\/nar\/28.23.4778","article-title":"A Ku80 fragment with dominant-negative activity imparts a radiosensitive phenotype to CHO-K1 cells","volume":"28","author":"Marangoni","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib19","doi-asserted-by":"crossref","first-page":"13588","DOI":"10.1073\/pnas.94.25.13588","article-title":"Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage","volume":"94","author":"Nussenzweig","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1667\/RR3489.1","article-title":"Repair of DNA damage induced by accelerated heavy ions in mammalian cells proficient and deficient in the non-homologous end-joining pathway","volume":"165","author":"Okayasu","year":"2006","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib21","first-page":"1235","article-title":"DNA strand break rejoining defect in xrs-6i Is complemented by transfection with the human Ku80 gene1","volume":"55","author":"Ross","year":"1995","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib22","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1093\/nar\/gkn094","article-title":"Distinct roles of XRCC4 and Ku80 in non-homologous end-joining of endonuclease and ionizing radiation-induced DNA double-strand breaks","volume":"36","author":"Schulte-Uentrop","year":"2008","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib23","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1128\/MCB.17.3.1264","article-title":"Molecular and biochemical characterization of xrs mutants defective in Ku80","volume":"17","author":"Singleton","year":"1997","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib24","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.dnarep.2008.01.010","article-title":"The Ku-dependent non-homologous end-joining but not other repair pathway is inhibited by high linear energy transfer ionizing radiation","volume":"7","author":"Wang","year":"2008","journal-title":"DNA Repair"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib25","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1128\/MCB.16.4.1519","article-title":"Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants","volume":"16","author":"Errami","year":"1996","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib26","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1126\/science.7939667","article-title":"Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA","volume":"266","author":"Smider","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib27","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1126\/science.8073286","article-title":"Ku80: Product of the XRCC5 and its role in DNA repair and V(D)J recombination","volume":"265","author":"Taccioli","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib28","doi-asserted-by":"crossref","first-page":"12109","DOI":"10.1073\/pnas.201271098","article-title":"DNA ligase IV-deficient cells are more resistant to ionizing radiation in the absence of Ku70","volume":"98","author":"Adachi","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib29","doi-asserted-by":"crossref","first-page":"8076","DOI":"10.1073\/pnas.94.15.8076","article-title":"Ku70-deficient embryonic stem cells\u00a0have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination","volume":"94","author":"Gu","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib30","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1667\/0033-7587(2001)155[0680:RFRODD]2.0.CO;2","article-title":"Requirement for repair of DNA double-strand breaks by homologous recombination in split-dose recovery","volume":"155","author":"Utsumi","year":"2001","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib31","first-page":"5888","article-title":"An antisense oligonucleotide targeted to human Ku86 messenger RNA sensitizes M059K malignant glioma cells to ionizing radiation, bleomycin, and etoposide but not DNA cross-linking agents","volume":"62","author":"Belenkov","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib32","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/sj.cgt.7700111","article-title":"Transfer of Ku86 antisense decreases the radioresistance of human fibroblasts","volume":"7","author":"Marangoni","year":"2000","journal-title":"Cancer Gene Ther"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S1568-7864(02)00006-X","article-title":"Suppression of a DNA double-strand break repair gene, Ku70, increases radio- and chemo-sensitivity in a human lung carcinoma cell line","volume":"1","author":"Omori","year":"2002","journal-title":"DNA Repair"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib34","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1158\/1535-7163.MCT-04-0130","article-title":"Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and \u03b3 radiation","volume":"4","author":"Ayene","year":"2005","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib35","first-page":"1477","article-title":"Silencing Ku80 using small interfering RNA enhanced radiation sensitivity in vitro and in vivo","volume":"30","author":"Nimura","year":"2007","journal-title":"Int J Oncol"},{"key":"10.1016\/j.ijrobp.2009.12.062_bib36","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/09553000801953318","article-title":"Radioresistance in a tumour cell line correlates with radiation inducible Ku70\/80 end-binding activity","volume":"84","author":"Negroni","year":"2008","journal-title":"Int J Radiat Biol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161000012X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036030161000012X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T16:24:54Z","timestamp":1544459094000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036030161000012X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S036030161000012X"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2009.12.062","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}