{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T13:49:14Z","timestamp":1781531354917,"version":"3.54.5"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,5,1]],"date-time":"2011-05-01T00:00:00Z","timestamp":1304208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1016\/j.ijrobp.2010.01.026","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T04:35:34Z","timestamp":1275626134000},"page":"148-153","source":"Crossref","is-referenced-by-count":77,"title":["Hypofractionated Dose-Painting Intensity Modulated Radiation Therapy With Chemotherapy for Nasopharyngeal Carcinoma: A\u00a0Prospective Trial"],"prefix":"10.1016","volume":"80","author":[{"given":"Richard L.","family":"Bakst","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David G.","family":"Pfister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Zelefsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margie A.","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis H.","family":"Kraus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne L.","family":"Wolden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.01.026_bib1","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1016\/0360-3016(84)90229-3","article-title":"Irradiation of nasopharyngeal carcinoma: Correlations with treatment factors and stage","volume":"10","author":"Chu","year":"1984","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib2","doi-asserted-by":"crossref","first-page":"2605","DOI":"10.1002\/1097-0142(197606)37:6<2605::AID-CNCR2820370607>3.0.CO;2-W","article-title":"Carcinoma of the nasopharynx. Eighteen years' experience with megavoltage radiation therapy","volume":"37","author":"Hoppe","year":"1976","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/0360-3016(81)90129-2","article-title":"Megavoltage irradiation of epithelial tumors of the nasopharynx","volume":"7","author":"Mesic","year":"1981","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib4","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1288\/00005537-199209000-00002","article-title":"Nasopharyngeal carcinoma: Treatment results with primary radiation therapy","volume":"102","author":"Bailet","year":"1992","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib5","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.ijrobp.2006.03.054","article-title":"Preliminary results of a randomized study (NPC-9902 Trial) on therapeutic gain by concurrent chemotherapy and\/or accelerated fractionation for locally advanced nasopharyngeal carcinoma","volume":"66","author":"Lee","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib6","doi-asserted-by":"crossref","first-page":"6966","DOI":"10.1200\/JCO.2004.00.7542","article-title":"Preliminary results of a randomized study on therapeutic gain by concurrent chemotherapy for regionally-advanced nasopharyngeal carcinoma: NPC-9901 Trial by the Hong Kong Nasopharyngeal Cancer Study Group","volume":"23","author":"Lee","year":"2005","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib7","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/j.ijrobp.2004.07.702","article-title":"Treatment results for nasopharyngeal carcinoma in the modern era: The Hong Kong experience","volume":"61","author":"Lee","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib8","doi-asserted-by":"crossref","first-page":"6730","DOI":"10.1200\/JCO.2005.16.790","article-title":"Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer\/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety","volume":"23","author":"Wee","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib9","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1200\/JCO.1998.16.4.1310","article-title":"Chemoradiotherapy versus radiotherapy in patients with advanced nasopharyngeal cancer: Phase III randomized Intergroup study 0099","volume":"16","author":"Al-Sarraf","year":"1998","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib10","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1002\/1097-0142(19820915)50:6<1042::AID-CNCR2820500604>3.0.CO;2-Y","article-title":"Dose\u2013response analysis for nasopharyngeal carcinoma: An historical perspective","volume":"50","author":"Marks","year":"1982","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib11","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1016\/0360-3016(85)90332-3","article-title":"Patterns of failure in carcinoma of the nasopharynx: I. Failure at the primary site","volume":"11","author":"Vikram","year":"1985","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib12","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S0360-3016(00)01588-1","article-title":"Failure of a 3D conformal boost to improve radiotherapy for nasopharyngeal carcinoma","volume":"49","author":"Wolden","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib13","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0360-3016(00)00585-X","article-title":"Comparison of treatment plans involving intensity-modulated radiotherapy for nasopharyngeal carcinoma","volume":"48","author":"Xia","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0360-3016(03)00075-0","article-title":"Intensity-modulated radiotherapy in nasopharyngeal carcinoma: Dosimetric advantage over conventional plans and feasibility of dose escalation","volume":"56","author":"Kam","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib15","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0360-3016(02)02724-4","article-title":"Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: An update of the UCSF experience","volume":"53","author":"Lee","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ijrobp.2005.03.057","article-title":"Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: update of the Memorial Sloan-Kettering experience","volume":"64","author":"Wolden","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib17","doi-asserted-by":"crossref","first-page":"4873","DOI":"10.1200\/JCO.2007.11.5501","article-title":"Prospective randomized study of intensity-modulated radiotherapy on salivary gland function in early-stage nasopharyngeal carcinoma patients","volume":"25","author":"Kam","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib18","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ijrobp.2006.06.013","article-title":"Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized controlled clinical trial","volume":"66","author":"Pow","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib19","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/S0360-3016(99)00326-0","article-title":"Intracavitary brachytherapy significantly enhances local control of early T-stage nasopharyngeal carcinoma: The existence of a dose-tumor-control relationship above conventional tumoricidal dose","volume":"46","author":"Teo","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib20","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ijrobp.2007.10.027","article-title":"Excellent local control with stereotactic radiotherapy boost after external beam radiotherapy in patients with nasopharyngeal carcinoma","volume":"71","author":"Hara","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib21","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ijrobp.2004.03.010","article-title":"Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas: II\u2014clinical results","volume":"60","author":"Lauve","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib22","series-title":"AJCC cancer staging manual","year":"1997"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib23","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/S1053-4296(03)00045-6","article-title":"The biological basis of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"Williams","year":"2003","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib25","first-page":"32","article-title":"Histological classification of upper respiratory track tumors","volume":"19","year":"1978","journal-title":"World Health Organization"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib26","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/0360-3016(80)90071-1","article-title":"Prognostic factors of carcinoma of the nasopharynx","volume":"6","author":"Fu","year":"1980","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib27","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1200\/JCO.2008.19.9109","article-title":"Intensity-modulated radiation therapy with or without chemotherapy for nasopharyngeal carcinoma: radiation therapy oncology group phase II trial 0225","volume":"27","author":"Lee","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib28","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ijrobp.2008.05.023","article-title":"Major late toxicities after conformal radiotherapy for nasopharyngeal carcinoma-patient- and treatment-related risk factors","volume":"73","author":"Lee","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib29","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/1097-0142(19841101)54:9<1966::AID-CNCR2820540930>3.0.CO;2-4","article-title":"Cerebral radiation necrosis following treatment of extracranial malignancies","volume":"54","author":"Glass","year":"1984","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.01.026_bib30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0360-3016(02)02711-6","article-title":"Factors affecting risk of symptomatic temporal lobe necrosis: significance of fractional dose and treatment time","volume":"53","author":"Lee","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610001252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610001252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,10]],"date-time":"2018-12-10T11:54:54Z","timestamp":1544442894000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610001252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,5]]}},"alternative-id":["S0360301610001252"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.01.026","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}