{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T09:18:49Z","timestamp":1791019129332,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T00:00:00Z","timestamp":1301616000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1016\/j.ijrobp.2010.01.031","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T10:00:23Z","timestamp":1282903223000},"page":"1460-1466","source":"Crossref","is-referenced-by-count":132,"title":["Mometasone Furoate Effect on Acute Skin Toxicity in Breast Cancer Patients Receiving Radiotherapy: A Phase III Double-Blind, Randomized Trial From the North Central Cancer Treatment Group N06C4"],"prefix":"10.1016","volume":"79","clinical-trial-number":[{"clinical-trial-number":"nct00438659","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Robert C.","family":"Miller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff A.","family":"Sloan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard L.","family":"Deming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon C.","family":"Anders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Stoffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Haselow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Schaefer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"James D.","family":"Bearden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pamela J.","family":"Atherton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles L.","family":"Loprinzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James A.","family":"Martenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.01.031_bib1","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1080\/09553009014550911","article-title":"The skin: Its structure and response to ionizing radiation","volume":"57","author":"Hopewell","year":"1990","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0167-8140(01)00327-9","article-title":"Potent corticosteroid cream (mometasone furoate) significantly reduces acute radiation dermatitis: Results from a double-blind, randomized study","volume":"59","author":"Bostrom","year":"2001","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib3","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/S0360-3016(00)00782-3","article-title":"Randomized phase III study comparing best supportive care to biafine as a prophylactic agent for radiation-induced skin toxicity for women undergoing breast irradiation: Radiation Therapy Oncology Group (RTOG) 97-13","volume":"48","author":"Fisher","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.radonc.2004.07.032","article-title":"Does aqueous or sucralfate cream affect the severity of erythematous radiation skin reactions? A randomised controlled trial","volume":"73","author":"Wells","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1188\/04.ONF.237-247","article-title":"Prevention and treatment of acute radiation dermatitis: A literature review","volume":"31","author":"Wickline","year":"2004","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib6","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0360-3016(96)00320-3","article-title":"Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity","volume":"36","author":"Williams","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib7","unstructured":"Cancer Therapy Evaluation Program [Internet]. Rockville, MD: National Cancer Institute [cited 2009 Feb 4]. Common Terminology Criteria for Adverse Events v3.0 (CTCAE); 2006 Aug 9 [cited 2009 Feb 4]. Available from: www.ctep.cancer.gov\/protocolDevelopment\/electronic_applications\/docs\/ctcaev3.pdf. Accessed November 20, 2008."},{"key":"10.1016\/j.ijrobp.2010.01.031_bib8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/BF02737863","article-title":"Measurement properties of Skindex-16: A brief quality-of-life measure for patients with skin diseases","volume":"5","author":"Chren","year":"2001","journal-title":"J Cutan Med Surg"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib9","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1097\/01.coc.0000138965.97476.0f","article-title":"Preliminary reliability and validity testing of a new Skin Toxicity Assessment Tool (STAT) in breast cancer patients undergoing radiotherapy","volume":"27","author":"Berthelet","year":"2004","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib10","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0033-3182(99)71224-7","article-title":"Quality of life in hospice patients: A pilot study","volume":"40","author":"Bretscher","year":"1999","journal-title":"Psychosomatics"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF00435970","article-title":"Comparison of conditional quality of life terminology and visual analogue scale measurements","volume":"5","author":"Grunberg","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1007\/BF00439226","article-title":"Health state valuations from the general public using the visual analogue scale","volume":"5","author":"Gudex","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib13","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/BF00540019","article-title":"Development of a new type of global quality of life scale, and comparison of performance and preference for 12 global scales","volume":"5","author":"Hyland","year":"1996","journal-title":"Qual Life Res"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib14","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/01.coc.0000197661.09628.03","article-title":"Intensity modulated radiation therapy (IMRT) decreases acute skin toxicity for women receiving radiation for breast cancer","volume":"29","author":"Freedman","year":"2006","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib15","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/0360-3016(94)00423-I","article-title":"Pathophysiology of irradiated skin and breast","volume":"31","author":"Archambeau","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib16","first-page":"9","article-title":"Histochemical and biochemical modifications induced by experimental irradiation of human skin maintained in survival conditions and modulation by application of an emulsion containing trolamine","volume":"25","author":"Boisnic","year":"2003","journal-title":"Int J Tissue React"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib17","doi-asserted-by":"crossref","first-page":"9991","DOI":"10.1073\/pnas.89.21.9991","article-title":"A mechanism for the antiinflammatory effects of corticosteroids: the glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1","volume":"89","author":"Cronstein","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib18","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0360-3016(93)90958-X","article-title":"A double-blind, randomized, prospective trial to evaluate topical vitamin C solution for the prevention of radiation dermatitis","volume":"26","author":"Halperin","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib19","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1097\/00002820-200212000-00007","article-title":"A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue","volume":"25","author":"Heggie","year":"2002","journal-title":"Cancer Nurs"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0167-8140(96)01882-8","article-title":"Double-blind, randomized clinical study comparing hyaluronic acid cream to placebo in patients treated with radiotherapy","volume":"42","author":"Liguori","year":"1997","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib21","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.3109\/02841869609100721","article-title":"Skin treatment with bepanthen cream versus no cream during radiotherapy: A randomized controlled trial","volume":"35","author":"Lokkevik","year":"1996","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib22","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.ijrobp.2003.11.031","article-title":"Silver leaf nylon dressing to prevent radiation dermatitis in patients undergoing chemotherapy and external beam radiotherapy to the perineum","volume":"59","author":"Vuong","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/00016925309136687","article-title":"The action cortisone on experimental acute roentgen dermatitis","volume":"39","author":"Marshall","year":"1953","journal-title":"Acta Radiol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib24","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1038\/jid.1956.47","article-title":"The effect of the topical application of corticotrophin, hydrocortisone, and fluorocortisone on the process of cutaneous inflammation","volume":"26","author":"Scott","year":"1956","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib25","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3109\/02841866509133086","article-title":"Treatment of radiation dermatitis with fluocinolone acetonide","volume":"3","author":"Bjornberg","year":"1965","journal-title":"Acta Radiol Ther Phys Biol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib26","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S0009-9260(67)80064-3","article-title":"Topical treatment of radiation dermatitis with bethamethasone-17-valerate, Vaseline and Eucerine: A double-blind comparison","volume":"18","author":"Bjornberg","year":"1967","journal-title":"Clin Radiol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib27","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0009-9260(79)80217-2","article-title":"Effectiveness of topical steroids in the control of radiation dermatitis: A randomised trial using 1% hydrocortisone cream and 0.05% clobetasone butyrate (Eumovate)","volume":"30","author":"Glees","year":"1979","journal-title":"Clin Radiol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib28","first-page":"475","article-title":"[Radiation reaction of the skin in the use\u00a0of glucocorticoids (German).]","volume":"108","author":"Huter","year":"1959","journal-title":"Strahlentherapie"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib29","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1148\/radiology.143.3.7079509","article-title":"Prophylaxis of radiation dermatitis with a topical cortisone cream","volume":"143","author":"Potera","year":"1982","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib30","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1046\/j.1365-2133.2002.04751.x","article-title":"Topical corticosteroid therapy for acute radiation dermatitis: A prospective, randomized, double-blind study","volume":"146","author":"Schmuth","year":"2002","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib31","doi-asserted-by":"crossref","first-page":"5070","DOI":"10.1200\/JCO.2007.12.7670","article-title":"Integrating patient-reported outcomes into cancer symptom management clinical trials supported by the National Cancer Institute-sponsored clinical trials networks","volume":"25","author":"Sloan","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.01.031_bib32","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1200\/JCO.2007.12.4784","article-title":"Patient-reported outcomes and the evolution of adverse event reporting in oncology","volume":"25","author":"Trotti","year":"2007","journal-title":"J Clin Oncol"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610001318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610001318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,8]],"date-time":"2018-12-08T14:26:56Z","timestamp":1544279216000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610001318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":32,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["S0360301610001318"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.01.031","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}