{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:06:03Z","timestamp":1791140763648,"version":"4.1.0"},"reference-count":56,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.ijrobp.2010.07.1976","type":"journal-article","created":{"date-parts":[[2010,10,9]],"date-time":"2010-10-09T04:59:26Z","timestamp":1286600366000},"page":"239-246","source":"Crossref","is-referenced-by-count":50,"title":["Relative Biological Effectiveness of Carbon Ions for Local Tumor Control of a Radioresistant Prostate Carcinoma in the Rat"],"prefix":"10.1016","volume":"79","author":[{"given":"Peter","family":"Peschke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"Karger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Scholz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Debus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter E.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.07.1976_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF01210545","article-title":"Results of heavy ion radiotherapy","volume":"34","author":"Castro","year":"1995","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/0360-3016(94)90550-9","article-title":"Experience in charged particle irradia of tumors of the skull base: 1977-1992","volume":"29","author":"Castro","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1002\/pros.10328","article-title":"Phase I\/II clinical trials of carbon ion therapy for prostate cancer","volume":"58","author":"Akakura","year":"2004","journal-title":"Prostate"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.radonc.2006.08.015","article-title":"Carbon ion radiation therapy for prostate cancer: Results of a prospective phase II study","volume":"81","author":"Ishikawa","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib5","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1016\/j.ijrobp.2005.04.022","article-title":"Hypofractionated radiotherapy with carbon ion beams for prostate cancer","volume":"63","author":"Tsuji","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0360-3016(98)00544-6","article-title":"Biophysical characteristics of HIMAC clinical irradiation system for heavy-ion radiation therapy","volume":"44","author":"Kanai","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib7","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1016\/j.ijrobp.2004.01.032","article-title":"Results of the first prospective study of carbon ion radiotherapy for hepatocellular carcinoma with liver cirrhosis","volume":"59","author":"Kato","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"Suppl. A","key":"10.1016\/j.ijrobp.2010.07.1976_bib8","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1269\/jrr.48.A1","article-title":"Clinical results of carbon ion radiotherapy at NIRS","volume":"48","author":"Tsujii","year":"2007","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/cncr.21158","article-title":"Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques","volume":"104","author":"Schulz-Ertner","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ijrobp.2006.08.027","article-title":"Carbon ion radiotherapy of skull base chondrosarcomas","volume":"67","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib11","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.ijrobp.2006.12.059","article-title":"Effectiveness of carbon ion radiotherapy in the treatment of skull-base chordomas","volume":"68","author":"Schulz-Ertner","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib12","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/PPO.0b013e3181b01922","article-title":"The clinical experience with particle therapy in adults","volume":"15","author":"Schulz-Ertner","year":"2009","journal-title":"Cancer J"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib13","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1002\/cncr.24153","article-title":"Carbon ion radiotherapy for pediatric patients and young adults treated for tumors of the skull base","volume":"115","author":"Combs","year":"2009","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib14","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1177\/030089169808400217","article-title":"Radiotherapy with heavy ions: Radiobiology, clinical indications and experience at GSI Darmstadt","volume":"84","author":"Kraft","year":"1998","journal-title":"Tumori"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s00066-007-1645-x","article-title":"Current status and new developments in ion therapy","volume":"183","author":"Karger","year":"2007","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib16","doi-asserted-by":"crossref","first-page":"S126","DOI":"10.2307\/3579815","article-title":"Heavy-ion radiobiology: New approaches to delineate mechanisms underlying enhanced biological effectiveness","volume":"150","author":"Blakely","year":"1998","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib17","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1080\/095530098141744","article-title":"Cytotoxic effect of accelerated carbon beams on glioblastoma cell lines with p53 mutation: Clonogenic survival and cell-cycle analysis","volume":"74","author":"Tsuboi","year":"1998","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib18","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1080\/095530099139232","article-title":"RBE for carbon track-segment irradiation in cell lines of differing repair capacity","volume":"75","author":"Weyrather","year":"1999","journal-title":"Int\u00a0J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1667\/RR3113","article-title":"Response of Chinese hamster v79 multicellular spheroids exposed to high-energy carbon ions","volume":"161","author":"Staab","year":"2004","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib20","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1667\/RR3182","article-title":"Accumulation of the cell cycle regulators TP53 and CDKN1A (p21) in human fibroblasts after exposure to low- and high-LET radiation","volume":"161","author":"Fournier","year":"2004","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib21","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s004110050055","article-title":"Computation of cell survival in heavy ion beams for therapy. The model and its approximation","volume":"36","author":"Scholz","year":"1997","journal-title":"Radiat Environ Biophys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1269\/jrr.47.167","article-title":"Repair of skin damage during fractionated irradiation with gamma rays and low-LET carbon ions","volume":"47","author":"Ando","year":"2006","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib23","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2307\/3579574","article-title":"Response of mouse intestine after single and fractionated irradiation with accelerated carbon ions with a spread-out Bragg peak","volume":"148","author":"Fukutsu","year":"1997","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.2307\/3575694","article-title":"Response of rat spinal cord to single and fractionated doses of accelerated heavy ions","volume":"89","author":"Leith","year":"1982","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib25","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1667\/0033-7587(2002)158[0545:DRCFLF]2.0.CO;2","article-title":"Dose-response curves for late functional changes in the normal rat brain after single carbon-on doses evaluated by magnetic resonance imaging: Influence of follow-up time and calculation of relative biological effectiveness","volume":"158","author":"Karger","year":"2002","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib26","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1016\/j.ijrobp.2006.08.045","article-title":"Radiation tolerance of the rat spinal cord after 6 and 18 fractions of photons and carbon ions: Experimental results and clinical implications","volume":"66","author":"Karger","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib27","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1667\/3063","article-title":"Radiation tolerance of the rat spinal cord after single and split doses of photons and carbon ions","volume":"160","author":"Debus","year":"2003","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib28","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0304-3835(97)00386-8","article-title":"Effects of accelerated carbon-ions on growth inhibition of transplantable human esophageal cancer in nude mice","volume":"122","author":"Takahashi","year":"1998","journal-title":"Cancer Lett"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib29","first-page":"913","article-title":"Synergistic growth suppression induced in esophageal squamous cell carcinoma cells by combined treatment with docetaxel and heavy carbon-ion beam irradiation","volume":"15","author":"Kitabayashi","year":"2006","journal-title":"Oncol Rep"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib30","first-page":"2037","article-title":"Radiation-induced growth inhibition in transplanted human tongue carcinomas with different p53 gene status","volume":"22","author":"Asakawa","year":"2002","journal-title":"Anticancer Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib31","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1269\/jrr.43.247","article-title":"Relative biological effectiveness of 290 MeV\/u carbon ions for the growth delay of a radioresistant murine fibrosarcoma","volume":"43","author":"Koike","year":"2002","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1002\/1097-0045(20000601)43:4<295::AID-PROS9>3.0.CO;2-W","article-title":"The Dunning model","volume":"43","author":"Tennant","year":"2000","journal-title":"Prostate"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib33","first-page":"4353","article-title":"Animal models of the hormone-sensitive and -insensitive prostatic adenocarcinomas, Dunning R-3327-H, R-3327-HI, and R-3327-AT","volume":"38","author":"Isaacs","year":"1978","journal-title":"Cancer Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib34","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/0168-9002(93)91335-K","article-title":"Magnetic scanning system for heavy ion therapy","volume":"A330","author":"Haberer","year":"1993","journal-title":"Nucl Instrum Meth A"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib35","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1088\/0031-9155\/45\/11\/313","article-title":"Treatment planning for heavy-ion radiotherapy: Physical beam model and dose optimization","volume":"45","author":"Kr\u00e4mer","year":"2000","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib36","series-title":"Statistica for Windows 7.1","year":"2005"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib37","series-title":"Statistical method in biological assay","author":"Finney","year":"1978"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/pros.2990090306","article-title":"Establishment and characterization of seven Dunning rat prostatic cancer cell lines and their use in developing methods for predicting metastatic abilities of prostatic cancers","volume":"9","author":"Isaacs","year":"1986","journal-title":"Prostate"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib39","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1269\/jrr.45.515","article-title":"Fractionated irradiation augments inter-strain variation of skin reactions among three strains of mice","volume":"45","author":"Ohta","year":"2004","journal-title":"J Radiat Res (Tokyo)"},{"issue":"Suppl. 2","key":"10.1016\/j.ijrobp.2010.07.1976_bib40","doi-asserted-by":"crossref","first-page":"S38","DOI":"10.1016\/S0167-8140(04)80011-2","article-title":"Status of the clinical work at Hyogo","volume":"73","author":"Hishikawa","year":"2004","journal-title":"Radiother Oncol"},{"issue":"Suppl. 2","key":"10.1016\/j.ijrobp.2010.07.1976_bib41","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/S0167-8140(04)80046-X","article-title":"The Heidelberg Ion Therapy Center","volume":"73","author":"Haberer","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.radonc.2010.02.016","article-title":"Particle therapy at the Heidelberg Ion Therapy Center (HIT)\u2014integrated research-driven university-hospital-based radiation oncology service in Heidelberg, Germany","volume":"95","author":"Combs","year":"2010","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib43","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1200\/JCO.2006.09.7816","article-title":"Particle radiation therapy using proton and heavier ion beams","volume":"25","author":"Schulz-Ertner","year":"2007","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib44","first-page":"438","article-title":"Measurement of the proliferative activity of three different sublines of the Dunning rat prostate tumor R3327","volume":"169","author":"Lohr","year":"1993","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/0360-3016(94)90231-3","article-title":"Non-invasive determination of tumor oxygen tension and local variation with growth","volume":"29","author":"Mason","year":"1994","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib46","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2307\/3579661","article-title":"Differential sensitivity of three sublines of the rat Dunning prostate tumor system R3327 to radiation and\/or local tumor hyperthermia","volume":"150","author":"Peschke","year":"1998","journal-title":"Radiat Res"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/09553000210132324","article-title":"Dose-dependent differential effects of low and pulsed dose-rate brachytherapy in a radioresistant syngenic rat prostate tumour model","volume":"78","author":"Harms","year":"2002","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib48","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/S0360-3016(03)00539-X","article-title":"Effect of sequencing of androgen deprivation and radiotherapy on prostate cancer growth","volume":"57","author":"Kaminski","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib49","series-title":"Radiobiological experiments for carbon ion prostate cancer therapy: Interplay of normal and tumor cells in co-culture and measurement of the oxygen enhancement ratio [Ph.D. thesis]","author":"von Neubeck","year":"2009"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib50","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.ijrobp.2008.12.078","article-title":"Application of carbon-ion beams or gamma-rays on primary tumors does not change the expression profiles of metastatic tumors in an in vivo murine model","volume":"74","author":"Tamaki","year":"2009","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib51","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3181\/0806-RM-189","article-title":"The proangiogenic factor ephrin-A1 is up-regulated in radioresistant murine tumor by irradiation","volume":"234","author":"Nojiri","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib52","series-title":"Rodent tumor models in experimental cancer therapy","first-page":"138","article-title":"Radiation-dose response assays of tumor control","author":"Suit","year":"1987"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib53","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/095530099140438","article-title":"Accelerated reoxygenation of a murine fibrosarcoma after carbon-ion radiation","volume":"75","author":"Ando","year":"1999","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib54","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1269\/jrr.45.303","article-title":"Differences in pO2 peaks of a murine fibrosarcoma between carbon-ion and X-ray irradiation","volume":"45","author":"Fukawa","year":"2004","journal-title":"J Radiat Res (Tokyo)"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib55","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0360-3016(00)00568-X","article-title":"Relative biological effectiveness for cell-killing effect on various human cell lines irradiated with heavy-ion medical accelerator in Chiba (HIMAC) carbon-ion beams","volume":"48","author":"Suzuki","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.07.1976_bib56","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/PPO.0b013e3181b666c5","article-title":"Biology of charged particles","volume":"15","author":"Blakely","year":"2009","journal-title":"Cancer J"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610029500?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610029500?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T06:52:43Z","timestamp":1559717563000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610029500"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":56,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0360301610029500"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.07.1976","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}