{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T15:40:12Z","timestamp":1773243612155,"version":"3.50.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.ijrobp.2010.08.055","type":"journal-article","created":{"date-parts":[[2010,10,28]],"date-time":"2010-10-28T08:28:17Z","timestamp":1288254497000},"page":"321-326","source":"Crossref","is-referenced-by-count":19,"title":["FDG-PET Assessment of the Effect of Head and Neck Radiotherapy on Parotid Gland Glucose Metabolism"],"prefix":"10.1016","volume":"82","author":[{"given":"Michael C.","family":"Roach","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy G.","family":"Turkington","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin A.","family":"Higgins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas C.","family":"Hawk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny K.","family":"Hoang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Brizel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.08.055_bib1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/0360-3016(94)00421-G","article-title":"Late effects of radiation therapy in the head and neck region","volume":"31","author":"Cooper","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib2","doi-asserted-by":"crossref","first-page":"S58","DOI":"10.1016\/j.ijrobp.2009.06.090","article-title":"Radiotherapy dose\u2013volume effects on salivary gland function","volume":"76","author":"Deasy","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib3","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.ijrobp.2007.01.030","article-title":"Spatial and dosimetric variability of organs at risk in head-and-neck intensity-modulated radiotherapy","volume":"68","author":"Robar","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib4","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/j.ijrobp.2007.01.062","article-title":"3D MR sialography as a tool to investigate radiation-induced xerostomia: Feasibility study","volume":"68","author":"Astreinidou","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.radonc.2004.09.009","article-title":"11C-Methionine PET, a novel method for measuring regional salivary gland function after radiotherapy of head and neck cancer","volume":"73","author":"Buus","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib6","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.radonc.2004.09.015","article-title":"Dose\u2013response relationships within the parotid gland after radiotherapy for head and neck cancer","volume":"73","author":"Bussels","year":"2004","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00006231-200102000-00015","article-title":"The utility of SPECT in determining the relationship between radiation dose and salivary gland dysfunction after radiotherapy","volume":"22","author":"van Acker","year":"2001","journal-title":"Nucl Med Commun"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib8","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.radonc.2006.02.013","article-title":"Individual radiation response of parotid glands investigated by dynamic 11C-methionine PET","volume":"78","author":"Buus","year":"2006","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1056\/NEJMra050276","article-title":"Positron-emission tomography and assessment of cancer therapy","volume":"354","author":"Juweid","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib10","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1056\/NEJM199806183382503","article-title":"Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer","volume":"338","author":"Brizel","year":"1998","journal-title":"N Engl J Med"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib11","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.ijrobp.2004.07.710","article-title":"Pretreatment anemia is correlated with the reduced effectiveness of radiation and concurrent chemotherapy in advanced head and neck cancer","volume":"61","author":"Prosnitz","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib12","series-title":"AJCC cancer staging manual","author":"Greene","year":"2002"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib13","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1148\/radiol.2433060043","article-title":"Head and neck cancer: Dedicated FDG PET\/CT protocol for detection\u2014phantom and initial clinical studies","volume":"244","author":"Yamamoto","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib14","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1016\/j.ijrobp.2004.12.076","article-title":"Dose\u2013volume modeling of salivary function in patients with head-and-neck cancer receiving radiotherapy","volume":"62","author":"Blanco","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib15","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/j.ijrobp.2009.07.1685","article-title":"A comparison of dose-response models for the parotid gland in a large group of head-and-neck cancer patients","volume":"76","author":"Houweling","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib16","doi-asserted-by":"crossref","first-page":"1360","DOI":"10.1016\/j.ijrobp.2009.04.005","article-title":"Weekly volume and dosimetric changes during chemoradiotherapy with intensity-modulated radiation therapy for head and neck cancer: A prospective observational study","volume":"76","author":"Bhide","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib17","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1016\/j.ijrobp.2003.12.024","article-title":"Quantification of volumetric and geometric changes occurring during fractionated radiotherapy for head-and-neck cancer using an integrated CT\/linear accelerator system","volume":"59","author":"Barker","year":"2004","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib18","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/j.ijrobp.2004.12.051","article-title":"On the mechanism of salivary gland radiosensitivity","volume":"62","author":"Konings","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib19","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijrobp.2005.07.966","article-title":"Influence of intravenous amifostine on xerostomia, tumor control, and survival after radiotherapy for head-and- neck cancer: 2-year follow-up of a prospective, randomized, Phase III trial","volume":"63","author":"Wasserman","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11307-006-0075-y","article-title":"Standardized uptake value atlas: characterization of physiological 2-deoxy-2-[18F]-fluoro-D-glucose uptake in normal tissues","volume":"9","author":"Wang","year":"2007","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib21","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1148\/radiol.2343030301","article-title":"Normal FDG distribution patterns in the head and neck: PET\/CT evaluation","volume":"234","author":"Nakamoto","year":"2005","journal-title":"Radiology"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib22","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/S0360-3016(99)00247-3","article-title":"Dose, volume, and function relationships in parotid salivary glands following conformal and intensity-modulated irradiation of head and neck cancer","volume":"45","author":"Eisbruch","year":"1999","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib23","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0360-3016(01)01717-5","article-title":"Quantitative dose\u2013volume response analysis of changes in parotid gland function after radiotherapy in the head-and-neck region","volume":"51","author":"Roesink","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib24","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ijrobp.2006.09.021","article-title":"The impact of dose on parotid salivary recovery in head and neck cancer patients treated with radiation therapy","volume":"67","author":"Li","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib25","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S1470-2045(09)70231-1","article-title":"Evidence-based organ-sparing radiotherapy in head and neck cancer","volume":"11","author":"Dirix","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib26","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.ijrobp.2007.02.017","article-title":"Nonrigid image registration for head and neck cancer radiotherapy treatment planning with PET\/CT","volume":"68","author":"Ireland","year":"2007","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib27","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib28","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.ijrobp.2006.05.002","article-title":"Grading xerostomia by physicians or by patients after intensity-modulated radiotherapy of head-and-neck cancer","volume":"66","author":"Meirovitz","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.08.055_bib29","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.2307\/3576626","article-title":"Complication probability as assessed from dose\u2013volume histograms","volume":"8","author":"Lyman","year":"1985","journal-title":"Radiat Res"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610032621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610032621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,7]],"date-time":"2018-12-07T05:53:39Z","timestamp":1544162019000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610032621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0360301610032621"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.08.055","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}