{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:22:08Z","timestamp":1791588128380,"version":"4.3.4"},"reference-count":42,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,1]]},"DOI":"10.1016\/j.ijrobp.2010.10.009","type":"journal-article","created":{"date-parts":[[2010,12,17]],"date-time":"2010-12-17T09:16:34Z","timestamp":1292577394000},"page":"204-212","source":"Crossref","is-referenced-by-count":120,"title":["Comparison of Acute and Late Toxicities for Three Modern High-Dose Radiation Treatment Techniques for Localized Prostate Cancer"],"prefix":"10.1016","volume":"82","author":[{"given":"Nasiruddin","family":"Mohammed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Kestin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Ghilezan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Krauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Vicini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Brabbins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alavaro","family":"Martinez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.10.009_bib1","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1038\/sj.bjc.6602301","article-title":"Phase III pilot study of dose escalation using conformal radiotherapy in prostate cancer: PSA control and side effects","volume":"92","author":"Dearnaley","year":"2005","journal-title":"Br J Cancer"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib2","doi-asserted-by":"crossref","first-page":"3904","DOI":"10.1200\/JCO.2000.18.23.3904","article-title":"Preliminary results of a randomized radiotherapy dose-escalation study comparing 70\u00a0Gy with 78 Gy for prostate cancer","volume":"18","author":"Pollack","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib3","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0360-3016(02)02829-8","article-title":"Prostate cancer radiation dose response: Results of the M.D. Anderson phase III randomized trial","volume":"53","author":"Pollack","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib4","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/jama.294.10.1233","article-title":"Comparison of conventional-dose vs high-dose conformal radiation therapy in clinically localized adenocarcinoma of the prostate: A randomized controlled trial","volume":"294","author":"Zietman","year":"2005","journal-title":"JAMA"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijrobp.2007.06.054","article-title":"Long-term results of the M.D. Anderson randomized dose-escalation trial for prostate cancer","volume":"70","author":"Kuban","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib6","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.ijrobp.2007.10.004","article-title":"Ultra-high dose (86.4\u00a0Gy) IMRT for localized prostate cancer: Toxicity and biochemical outcomes","volume":"71","author":"Cahlon","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib7","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0360-3016(98)00091-1","article-title":"Dose escalation with three-dimensional conformal radiation therapy affects the outcome in prostate cancer","volume":"41","author":"Zelefsky","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/S0360-3016(00)00608-8","article-title":"An off-line strategy for constructing a patient-specific planning target volume in adaptive treatment process for prostate cancer","volume":"48","author":"Yan","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib9","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1016\/0360-3016(93)90546-8","article-title":"Concurrent treatment planning for outpatient high dose rate prostate template implants","volume":"27","author":"Edmundson","year":"1993","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib10","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/0360-3016(95)00276-6","article-title":"Intraoperative optimization of needle placement and dwell times for conformal prostate brachytherapy","volume":"33","author":"Edmundson","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib11","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.ijrobp.2006.04.045","article-title":"High-dose irradiation for prostate cancer via a high-dose-rate brachytherapy boost: Results of a phase I to II study","volume":"66","author":"Vargas","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib12","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.ijrobp.2004.06.001","article-title":"A dose-escalation trial with the adaptive radiotherapy process as a delivery system in localized prostate cancer: Analysis of chronic toxicity","volume":"61","author":"Brabbins","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ijrobp.2004.12.017","article-title":"Phase II dose escalation study of image-guided adaptive radiotherapy for prostate cancer: Use of dose-volume constraints to achieve rectal isotoxicity","volume":"63","author":"Vargas","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2307\/2281868","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J AM Stat Assoc"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib15","first-page":"163","article-title":"Evaluation of survival data and two new rank order statistics arising in its consideration","volume":"50","author":"Mantel","year":"1966","journal-title":"Cancer Chemother Rep"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0360-3016(01)02811-5","article-title":"Gastrointestinal toxicity of transperineal interstitial prostate brachytherapy","volume":"53","author":"Kang","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0360-3016(98)00080-7","article-title":"Clinical course of rectal bleeding following I-125 prostate brachytherapy","volume":"41","author":"Hu","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib18","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1097\/01.ju.0000113299.34404.22","article-title":"High dose rate brachytherapy as prostate cancer monotherapy reduces toxicity compared to low dose rate palladium seeds","volume":"171","author":"Grills","year":"2004","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib19","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/cncr.11595","article-title":"Late genitourinary and gastrointestinal toxicity after magnetic resonance image-guided prostate brachytherapy with or without neoadjuvant external beam radiation therapy","volume":"98","author":"Albert","year":"2003","journal-title":"Cancer"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0360-3016(00)00632-5","article-title":"Rectal complications associated with transperineal interstitial brachytherapy for prostate cancer","volume":"48","author":"Gelblum","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.radonc.2007.04.011","article-title":"High dose rate brachytherapy in combination with external beam radiotherapy in the radical treatment of prostate cancer: Initial results of a randomised phase three trial","volume":"84","author":"Hoskin","year":"2007","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1177\/030089160709300108","article-title":"Three-dimensional conformal external beam radiotherapy versus the combination of external radiotherapy with high-dose rate brachytherapy in localized carcinoma of the prostate: Comparison of acute toxicity","volume":"93","author":"Soumarova","year":"2007","journal-title":"Tumori"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib23","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/jjco\/hyn056","article-title":"Comparison of the outcome and morbidity for localized or locally advanced prostate cancer treated by high-dose-rate brachytherapy plus external beam radiotherapy (EBRT) versus EBRT alone","volume":"38","author":"Fang","year":"2008","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib24","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/j.ijrobp.2004.12.052","article-title":"Dose-volume analysis of predictors for chronic rectal toxicity after treatment of prostate cancer with adaptive image-guided radiotherapy","volume":"62","author":"Vargas","year":"2005","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib25","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s11604-009-0369-5","article-title":"Evaluation of rectal bleeding factors associated with prostate brachytherapy","volume":"27","author":"Aoki","year":"2009","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.urolonc.2007.03.026","article-title":"Defining the rectal dose constraint for permanent radioactive seed implantation of the prostate","volume":"26","author":"Albert","year":"2008","journal-title":"Urol Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/0360-3016(94)00599-G","article-title":"Dosimetry guidelines to minimize urethral and rectal morbidity following transperineal I-125 prostate brachytherapy","volume":"32","author":"Wallner","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib28","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0360-3016(01)01442-0","article-title":"Defining the risk of developing Grade 2 proctitis following 125I prostate brachytherapy using a rectal dose-volume histogram analysis","volume":"50","author":"Snyder","year":"2001","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/ijc.1037","article-title":"Dosimetric and radiographic correlates to prostate brachytherapy-related rectal complications","volume":"96","author":"Han","year":"2001","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib30","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0360-3016(02)03934-2","article-title":"Probability of late rectal morbidity in 125I prostate brachytherapy","volume":"55","author":"Waterman","year":"2003","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib31","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.ijrobp.2005.08.042","article-title":"Rectal toxicity profile after transperineal interstitial permanent prostate brachytherapy: Use of a comprehensive toxicity scoring system and identification of rectal dosimetric toxicity predictors","volume":"64","author":"Shah","year":"2006","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib32","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0360-3016(95)02103-5","article-title":"Conventional vs. conformal radiotherapy for prostate cancer: Preliminary results of dosimetry and acute toxicity","volume":"34","author":"Pollack","year":"1996","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib33","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.radonc.2008.11.013","article-title":"Urethral stricture following high dose rate brachytherapy for prostate cancer","volume":"91","author":"Sullivan","year":"2009","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib34","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/S0022-5347(05)00681-6","article-title":"Risk factors for the development of prostate brachytherapy related urethral strictures","volume":"175","author":"Merrick","year":"2006","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0360-3016(01)01811-9","article-title":"The dosimetry of prostate brachytherapy-induced urethral strictures","volume":"52","author":"Merrick","year":"2002","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2009.06.083","article-title":"Influence of dose on risk of acute urinary retention after iodine-125 prostate brachytherapy","author":"Roeloffzen","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib37","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0360-3016(00)00541-1","article-title":"Identifying the predictors of acute urinary retention following magnetic-resonance-guided prostate brachytherapy","volume":"47","author":"Thomas","year":"2000","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib38","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ijrobp.2007.12.024","article-title":"Health-related quality of life 2 years after treatment with radical prostatectomy, prostate brachytherapy, or external beam radiotherapy in patients with clinically localized prostate cancer","volume":"72","author":"Ferrer","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib39","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1016\/j.juro.2007.01.134","article-title":"An assessment of quality of life following radical prostatectomy, high dose external beam radiation therapy and brachytherapy iodine implantation as monotherapies for localized prostate cancer","volume":"177","author":"Frank","year":"2007","journal-title":"J Urol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib40","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1056\/NEJMoa074311","article-title":"Quality of life and satisfaction with outcome among prostate-cancer survivors","volume":"358","author":"Sanda","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib41","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/jjco\/hyp053","article-title":"Health-related quality of life using SF-8 and EPIC questionnaires after treatment with radical retropubic prostatectomy and permanent prostate brachytherapy","volume":"39","author":"Hashine","year":"2009","journal-title":"Jpn J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.009_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2009.05.054","article-title":"Health-related quality of life after single-fraction high-dose-rate brachytherapy and hypofractionated external beam radiotherapy for prostate cancer","author":"Morton","year":"2010","journal-title":"Int J Radiat Oncol Biol Phys"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610034279?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610034279?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,7]],"date-time":"2019-06-07T04:54:55Z","timestamp":1559883295000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610034279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2012,1]]}},"alternative-id":["S0360301610034279"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.10.009","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,1]]}}}