{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T03:07:11Z","timestamp":1790564831819,"version":"4.1.0"},"reference-count":18,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,4,1]],"date-time":"2012-04-01T00:00:00Z","timestamp":1333238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Radiation Oncology*Biology*Physics"],"published-print":{"date-parts":[[2012,4]]},"DOI":"10.1016\/j.ijrobp.2010.10.053","type":"journal-article","created":{"date-parts":[[2011,5,7]],"date-time":"2011-05-07T15:19:58Z","timestamp":1304781598000},"page":"1823-1830","source":"Crossref","is-referenced-by-count":85,"title":["Primary Tumor Volume Is an Important Predictor of Clinical Outcomes Among Patients With Locally Advanced Squamous Cell Cancer of the Head and Neck Treated With Definitive Chemoradiotherapy"],"prefix":"10.1016","volume":"82","author":[{"given":"Anna","family":"Strongin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susannah","family":"Yovino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Zimrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Strome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Regine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Suntharalingam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.ijrobp.2010.10.053_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3322\/CA.2007.0010","article-title":"Cancer statistics 2008","volume":"58","author":"Jemal","year":"2008","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib2","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0360-3016(95)00119-J","article-title":"The tumor volume and clonogen number relationship: Tumor control predictions based upon tumor volume estimates derived from computed tomography","volume":"33","author":"Johnson","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/02841860600815407","article-title":"Volumetric staging (VS) is superior to TNM and AJCC staging in predicting outcome of head and neck cancer treated with IMRT","volume":"46","author":"Studer","year":"2007","journal-title":"Acta Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib4","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/00016480701361921","article-title":"Primary tumor volume calculations as a predictive factor of prognosis in nasopharyngeal carcinoma","volume":"1","author":"Lee","year":"2008","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib5","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1002\/(SICI)1097-0347(200005)22:3<282::AID-HED11>3.0.CO;2-K","article-title":"The ability of tumor volume to predict local control in surgically treated squamous cell carcinoma of the supraglottic larynx","volume":"22","author":"Mukherji","year":"2000","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib6","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1200\/JCO.1999.17.2.631","article-title":"Preradiotherapy computed tomography as a predictor of local control in supraglottic carcinoma","volume":"17","author":"Mancuso","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib7","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1177\/000348948709600507","article-title":"Correlation of tumor volume with local control in laryngeal carcinoma treated by radiotherapy","volume":"96","author":"Gilbert","year":"1987","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib8","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2310\/7070.2004.03088","article-title":"Computed tomographic volumetric analysis as a predictor of local control in laryngeal cancer treated with conventional radiotherapy","volume":"33","author":"Hamilton","year":"2004","journal-title":"J Otolaryngol"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib9","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1159\/000091803","article-title":"Analysis of prognostic factors of chemoradiation therapy for advanced hypopharyngeal cancer\u2014Does tumor volume correlate with central necrosis and tumor pathology?","volume":"68","author":"Tsou","year":"2006","journal-title":"J Otorhinolaryngol Relat Spec"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib10","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3342\/ceo.2009.2.2.78","article-title":"Clinical efficacy of primary tumor volume measurements: Comparison of different primary sites","volume":"2","author":"Chung","year":"2009","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib11","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.1097\/00005537-200210000-00006","article-title":"Tumor volume predicts outcome for advanced head and neck cancer treated with targeted chemoradiotherapy","volume":"112","author":"Doweck","year":"2002","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib12","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/hed.20865","article-title":"Prognostic value of primary tumor volume after concurrent chemoradiation with daily low-dose cisplatin for advanced-stage head and neck carcinoma","volume":"9","author":"Hoebers","year":"2008","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib13","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/hed.21011","article-title":"Prognostic impact of tumor volume in patients with stage III-IVA hypopharyngeal cancer without bulky lymph nodes treated with definitive concurrent chemoradiotherapy","volume":"31","author":"Chen","year":"2009","journal-title":"Head Neck"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib14","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1097\/00005537-200106000-00028","article-title":"Delayed regional metastases, distant metastases, and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx","volume":"111","author":"Spector","year":"2001","journal-title":"Laryngoscope"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib15","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ijrobp.2007.09.058","article-title":"Adjuvant radiotherapy and survival for patients with node-positive head and neck cancer: An analysis by primary site and nodal stage","volume":"71","author":"Kao","year":"2008","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib16","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1001\/archotol.125.2.142","article-title":"Aggressive concurrent chemoradiotherapy for squamous cell head and neck cancer: An 8-year single institution experience","volume":"125","author":"Lavertu","year":"1999","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1002\/ijc.22851","article-title":"Survival of squamous cell carcinoma of the head and neck in relation to human papillomavirus infection: Review and meta-analysis","volume":"21","author":"Ragin","year":"2007","journal-title":"Int J Cancer"},{"key":"10.1016\/j.ijrobp.2010.10.053_bib18","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/jnci\/djn011","article-title":"Improved survival of patients with human papillomavirus: Positive head and neck squamous cell carcinoma in a prospective clinical trial","volume":"100","author":"Fakhry","year":"2008","journal-title":"J Natl Cancer Inst"}],"container-title":["International Journal of Radiation Oncology*Biology*Physics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610034851?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0360301610034851?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,2]],"date-time":"2018-12-02T20:28:43Z","timestamp":1543782523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0360301610034851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,4]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,4]]}},"alternative-id":["S0360301610034851"],"URL":"https:\/\/doi.org\/10.1016\/j.ijrobp.2010.10.053","relation":{},"ISSN":["0360-3016"],"issn-type":[{"value":"0360-3016","type":"print"}],"subject":[],"published":{"date-parts":[[2012,4]]}}}